Stem cell-based therapies for osteoarthritis: Challenges and opportunities

Current Opinion in Rheumatology

Volumn 25, Issue 1, 2013, Pages 119-126

  Diekman, Brian O ^a   Guilak, Farshid ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b Duke University   (United States)

Author keywords

Arthritis; induced pluripotent stem cells; inflammation; mesenchymal stem cells; tissue engineering

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; COLLAGEN; GLYCOSAMINOGLYCAN; HYALURONIC ACID; MICRORNA; NOTCH RECEPTOR; SONIC HEDGEHOG PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; WNT PROTEIN;

ADIPOSE DERIVED STEM CELL; AGE; ANTIINFLAMMATORY ACTIVITY; AUTOLOGOUS STEM CELL TRANSPLANTATION; BIOMECHANICS; CELL REGENERATION; CELL THERAPY; HUMAN; IN VIVO STUDY; INFLAMMATION; MESENCHYMAL STEM CELL; NONHUMAN; OBESITY; OSTEOARTHRITIS; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REVIEW; STEM CELL TRANSPLANTATION; SYNOVIUM DERIVED STEM CELL; TISSUE ENGINEERING; TREATMENT OUTCOME;

AGING; DRUG EVALUATION, PRECLINICAL; HUMANS; OSTEOARTHRITIS; STEM CELL TRANSPLANTATION; STEM CELLS; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84871250440     PISSN: 10408711     EISSN: 15316963     Source Type: Journal    
DOI: 10.1097/BOR.0b013e32835aa28d     Document Type: Review

References (50)

1. Lawrence RC, Felson DT, Helmick CG, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum 2008; 58:26-35.
2. Kurtz S, Ong K, Lau E, et al. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am 2007; 89:780-785.
3. Murphy JM, Dixon K, Beck S, et al. Reduced chondrogenic and adipogenic activity of mesenchymal stem cells from patients with advanced osteoarthritis. Arthritis Rheum 2002; 46:704-713.
4. Garcia-Alvarez F, Alegre-Aguaron E, Desportes P, et al. Chondrogenic differentiation in femoral bone marrow-derived mesenchymal cells (MSC) from elderly patients suffering osteoarthritis orfemoral fracture. Arch Gerontol Geriatr 2011; 52:239-242.
5. Labusca L, Zugun-Eloae F, Shaw G, et al. Isolation and phenotypic char-acterisation of stem cells from late stage osteoarthritic mesenchymal tissues. Curr Stem Cell Res Ther 2012; 7:319-328.
6. Hare JM, Traverse JH, Henry TD, et al. A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J Am Coll Cardiol 2009; 54:2277-2286.
7. Dexheimer V, Mueller S, Braatz F, Richter W. Reduced reactivation from dormancy but maintained lineage choice of human mesenchymal stem cells with donor age. PLo S One 2011; 6:e22980.
8. Roldan M, Macias-Gonzalez M, Garcia R, et al. Obesity short-circuits stem-ness gene network in human adipose multipotent stem cells. FASEB J 2011; 25:4111-4126.
9. Wu CL, Diekman BO, Jain D, Guilak F. Diet-induced obesity alters the differentiation potential of stem cells isolated from bone marrow, adipose tissue, and infrapatellar fat pad: the effects of free fatty acids. Int J Obesity 2012 [In press].
10. Goldring MB, Otero M. Inflammation in osteoarthritis. Curr Opin Rheumatol 2011; 23:471-478.
11. Heldens GT, Blaney Davidson EN, Vitters EL, et al. Catabolic factors and osteoarthritis-conditioned medium inhibit chondrogenesis of human mesenchymal stem cells. Tissue Eng Part A 2012; 18:45-54.
12. Boeuf S, Graf F, Fischer J, et al. Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chon-drogenesis of human mesenchymal stem cells. Eur Cell Mater 2012; 23:320-332.
13. Ando W, Heard BJ, Chung M, et al. Ovine synovial membrane-derived mesenchymal progenitor cells retain the phenotype of the original tissue that was exposed to in-vivo inflammation: evidence for a suppressed chondro-genic differentiation potential of the cells. Inflamm Res 2012; 61:599-608.
14. Vinardell T, Sheehy EJ, Buckley CT, Kelly DJ. Acomparison ofthefunctionality and in vivo phenotypic stability of cartilaginous tissues engineered from different stem cell sources. Tissue Eng Part A 2012; 18:1161-1170.
15. Gawlitta D, Van Rijen MH, Schrijver EJ, et al. Hypoxia impedes hypertrophic chondrogenesis of human multipotent stromal cells. Tissue Eng Part A 2012; 18:1957-1966.
16. Sheehy EJ, Buckley CT, Kelly DJ. Oxygen tension regulates the osteogenic, chondrogenicand endochondral phenotypeofbone marrowderived mesench-ymal stem cells. Biochem Biophys Res Commun 2012; 417:305-310.
17. Erickson IE, Kestle SR, Zellars KH, et al. High mesenchymal stem cell seeding densities in hyaluronic acid hydrogels produce engineered cartilage with native tissue properties. Acta Biomater 2012; 8:3027-3034.
18. Schatti O, Grad S, Goldhahn J, et al. A combination of shear and dynamic compression leads to mechanically induced chondrogenesis of human mesenchymal stem cells. Eur Cell Mater 2011; 22:214-225.
19. Moutos FT, Freed LE, Guilak F. A biomimetic three-dimensional woven composite scaffold for functional tissue engineering of cartilage. Nat Mater 2007; 6:162-167.
20. Moutos FT, Estes BT, Guilak F. Multifunctional hybrid three-dimensionally woven scaffolds for cartilage tissue engineering. Macromol Biosci 2010; 10:1355-1364.
21. Coburn J, Gibson M, Bandalini PA, et al. Biomimetics of the extracellular matrix: an integrated three-dimensional fiber-hydrogel composite for cartilage tissue engineering. Smart Struct Syst 2011; 7:213-222.
22. Chen J, Chen H, Li P, et al. Simultaneous regeneration of articular cartilage and subchondral bone in vivo using MSCs induced by a spatially controlled gene delivery system in bilayered integrated scaffolds. Biomaterials 2011; 32:4793-4805.
23. Dormer NH, Singh M, Zhao L, et al. Osteochondral interface regeneration of the rabbit knee with macroscopic gradients of bioactive signals. J Biomed Mater Res A 2012; 100:162-170.
24. Koh YG, Choi YJ. Infrapatellarfat pad-derived mesenchymal stem cell therapy for knee osteoarthritis. Knee 2012 [Epub ahead of print].
25. Mokbel AN, El Tookhy OS, Shamaa AA, et al. Homing and reparative effect of intra-articular injection of autologus mesenchymal stem cells in osteoarthritic animal model. BMC Musculoskelet Disord 2011; 12:259.
26. Ansboro S, Greiser U, Barry F, Murphy M. Strategies for improved targeting of therapeuticcells: implicationsfortissue repair. Eur Cell Mater2012;23:310-319.
27. Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J Cell Biochem 2006; 98:1076-1084.
28. Prockop DJ, Oh JY. Mesenchymal stem/stromal cells (MSCs): role as guardians of inflammation. Mol Ther 2012; 20:14-20.
29. Diekman BO, Wu CL, Louer CR, et al. Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/Mp J superhealer mice prevents posttraumatic arthritis. Cell Transplant 2012 [Epub ahead of print].
30. Horie M, Choi H, Lee RH, et al. Intra-articular injection of human mesenchymal stem cells (MSCs) promote rat meniscal regeneration by being activated to express Indian hedgehog that enhances expression of type II collagen. Osteoarthritis Cartilage 2012; 20:1197-1207.
31. Van Buul GM, Villafuertes E, Bos PK, et al. Mesenchymal stem cells secrete factors that inhibit inflammatory processes in short-term osteoarthritic syno-vium and cartilage explant culture. Osteoarthritis Cartilage 2012; 20:1186-1196.
32. Gerter R, Kruegel J, Miosge N. New insights into cartilage repair: the role of migratory progenitor cells in osteoarthritis. Matrix Biol 2012; 31:206-213.
33. Nie H, Lee CH, Tan J, et al. Musculoskeletal tissue engineering by endogen-ous stem/progenitor cells. Cell Tissue Res 2012; 347:665-676.
34. Lee CH, Cook JL, Mendelson A, et al. Regeneration of the articularsurface of therabbitsynovialjoint bycell homing: aproofofconceptstudy. Lancet2010; 376:440-448.
35. Mendelson A, Frank E, Allred C, et al. Chondrogenesis by chemotactic homing of synovium, bone marrow, and adipose stem cells in vitro. FASEB J 2011; 25:3496-3504.
36. Re'em T, Witte F, Willbold E, et al. Simultaneous regeneration of articular cartilage and subchondral bone induced by spatially presented TGF-beta and BMP-4 in a bilayer affinity binding system. Acta Biomater 2012; 8:3283-3293.
37. Unterman S, Gibson M, Lee JH, et al. Hyaluronic acid-binding scaffold for articular cartilage repair. Tissue Eng Part A 2012 [Epub ahead of print].
38. Coburn JM, Gibson M, Monagle S, et al. Bioinspired nanofibers support chondrogenes is for articul arcartilage repair. Proc Natl Acad Sci USA 2012;109:10012-10017.
39. Koelling S, Kruegel J, Irmer M, et al. Migratory chondrogenic progenitor cells from repair tissue during the later stages of human osteoarthritis. Cell Stem Cell 2009; 4:324-335.
40. Lee DH, Sonn CH, Han SB, et al. Synovial fluid CD34(-) CD44(+) CD90(+) mesenchymal stem cell levels are associated with the severity of primary knee osteoarthritis. Osteoarthritis Cartilage 2012; 20:106-109.
41. Sekiya I, Ojima M, Suzuki S, et al. Human mesenchymal stem cells in synovial fluid increase in the knee with degenerated cartilage and osteoarthritis. J Orthop Res 2012; 30:943-949.
42. Johnson K, Zhu S, Tremblay MS, et al. Astemcell-based approachtocartilage repair. Science 2012; 336:717-721.
43. Haleem-Smith H, Calderon R, Song Y, et al. Cartilage oligomeric matrix protein enhances matrix assembly during chondrogenesis of human me-senchymal stem cells. J Cell Biochem 2012; 113:1245-1252.
44. Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131:861-872.
45. Yu J, Vodyanik MA, Smuga-Otto K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007; 318: 1917-1920.
46. Kim MJ, Son MJ, Son MY, et al. Generation of human induced pluripotentstem cells from osteoarthritis patient-derived synovial cells. Arthritis Rheum 2011; 63:3010-3021.
47. Wei Y, Zeng W, Wan R, et al. Chondrogenic differentiation of induced pluripotent stem cells from osteoarthritic chondrocytes in alginate matrix. Eur Cell Mater 2012; 23:1-12.
48. Diekman BO, Christoforou N, Willard VP, et al. Cartilage tissue engineering using differentiated and purified induced pluripotent stem cells. Proc Natl Acad Sci USA 2012 [In press].
49. Hiramatsu K, Sasagawa S, Outani H, et al. Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors. J Clin Invest 2011; 121:640-657.
50. Outani H, Okada M, Hiramatsu K, et al. Induction of chondrogenic cells from dermal fibroblast culture by defined factors does not involve a pluripotent state. Biochem Biophys Res Commun 2011; 411:607-612.