Mechanical stretch via transforming growth factor-β1 activates microRNA208a to regulate endoglin expression in cultured rat cardiac myoblasts

European Journal of Heart Failure

Volumn 15, Issue 1, 2013, Pages 36-45

  Shyu, Kou Gi ^a,b   Wang, Bao Wei ^a,c   Wu, Gong Jhe ^a,d   Lin, Chiu Mei ^a,b   Chang, Hang ^a,b  

^a SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Cardiac fibrosis; Cardiac myoblast; Endoglin; Mechanical stretch; MicroRNA; Transforming growth factor 1

Indexed keywords

ANTAGOMIR; ANTAGOMIR208A; COLLAGEN TYPE 1; ENDOGLIN; GENOMIC DNA; MICRORNA; MICRORNA 208A; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DNA BINDING; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HEART CELL CULTURE; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; MECHANICAL STRESS; MECHANICAL STRETCH; MYOBLAST; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; QUALITY CONTROL; RAT; RNA INTERFERENCE; RNA VECTOR; UPREGULATION; VACUUM;

ANIMALS; BLOTTING, WESTERN; CARDIOMYOPATHY, HYPERTROPHIC; CELLS, CULTURED; DISEASE MODELS, ANIMAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICRORNAS; MYOBLASTS, CARDIAC; RATS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 84871242226     PISSN: 13889842     EISSN: 18790844     Source Type: Journal    
DOI: 10.1093/eurjhf/hfs143     Document Type: Article

References (31)

1. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116:281-297.
2. Place RF, Li LC, Pookot D, Noonan EJ, Dahiya R. MicroRNA-373 induces expression of genes with complementary promoter sequences. Proc Natl Acad Sci USA 2008;105:1608-1613.
3. Ikeda S, Kong SW, Lu J, Bisping E, Zhang H, Allen PD, Golub TR, Pieske B, Pu WT. Altered microRNA expression in human heart disease. Physiol Genomics 2007;31: 367-373.
4. Sayed D, Hong C, Chen IY, Lypowy J, Abdellatif M. MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ Res 2007;100:416-424.
5. Berk BC, Fujiwara K, Lehoux S. ECM remodeling in hypertensive heart disease. J Clin Invest 2007;117:568-575.
6. Sutton MGSJ, Sharpe N. Left ventricular remodeling after myocardial infarction. Pathophysiology and therapy. Circulation 2000;101:2981-2988.
7. van Rooij E, Sutherland LB, Qi X, Richardson JA, Hill J, Olson EN. Control of stress dependent cardiac growth and gene expression by a microRNA. Science 2007;316:575-579.
8. Callis TE, Pandya K, Seok HY, Tang RH, Tatsuguchi M, Huang ZP, Chen JF, Deng Z, Gunn B, Shumate J, Willis MS, Selzman CH, Wang DZ. MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J Clin Invest 2009; 119:2772-2786.
9. Satoh M, Minami Y, Takahashi Y, Tabuchi T, Nakamura M. Expression of microRNA-208 is associated with adverse clinical outcomes in human dilated cardiomyopathy. J Cardiac Fail 2010;16:404-410.
10. Lijnen PJ, Petrov VV, Fagard RH. Induction of cardiac fibrosis by transforming growth factor-b1. Mol Genetic Metabol 2000;71:418-435.
11. Kuwahara F, Kai H, Tokuda K, Kai M, Takeshita A, Egashira K, Imaizumi T. Transforming growth factor-b function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats. Circulation 2002;106:130-135.
12. Lim H, Zhu YZ. Role of transforming growth factor-a in the progression of heart failure. Cell Mol Life Sci 2006;63:2584-2596.
13. Lopez-Novoa JM, Bernabeu C. The physiological role of endoglin in the cardiovascular system. Am J Physiol Heart Circ Physiol 2010;299:H959-H974.
14. Chen J, Mehta JL. Angiotensin II-mediated oxidative stress and procollagen-I expression in cardiac fibroblasts: blockade by pravastatin and pioglitazone. Am J Physiol Heart Circ Physiol 2006;291:H1738-H1745.
15. Liu X, Sun SQ, Hassid A, Ostrom RS. cAMP inhibits transforming growth factor-a stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts. Mol Pharmacol 2006;70:1992-2003.
16. Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008;3:1101-1108.
17. Cheng WP, Hung HF, Wang BW, Shyu KG. The molecular regulation of GADD153 in apoptosis of cultured vascular smooth muscle cells by cyclic mechanical stretch. Cardiovasc Res 2008;77:551-559.
18. Lin S, Huang HC, Chen LL, Lee CC, Huang TS. GL331 induces downregulation of cyclin D1 expression via enhanced proteolysis and repressed transcription. Mol Pharmacol 2001;60:768-774.
19. Ahmad F, Seidman JG, Seidman CE. The genetic basis for cardiac remodeling. Annu Rev Genomics Hum Genet 2005;6:185-216.
20. Brower G, Gardner JD, Forman MF, Murray DB, Voloshenyuk T, Levick SP, Janicki JS. The relationship between myocardial extracellular matrix remodeling and ventricular function. Eur J Cardiothorac Surg 2006;30:604-610.
21. Mishra PK, Tyagi N, Kumar M, Tyagi SC. MicroRNAs as a therapeutic target for cardiovascular disease. J Cell Mol Med 2009;13:778-789.
22. Ni CW, Qiu H, Jo H. MicroRNA-663 upregulated by oscillatory shear stress plays a role in inflammatory response of endothelial cells. Am. J. Physiol. Heart Circ Physiol 2011;300:H1762-H1769.
23. Zhou J, Wang KC, Wu W, Subramaniam S, Shyy JYJ, Chiu JJ, Li JYS, Chien S. MicroRNA-21 targets peroxisome proliferator-activated receptor-a in an autoregulatory loop to modulate flow-induced endothelail inflammation. Proc Natl Acad Sci USA 2011;106:10355-10360.
24. Mohamed JS, Lopez MA, Boriek AM. Mechanical stretch up-regulates microRNA-26a and induces human airway smooth muscle hypertrophy by suppressing glycogen synthase kinase-3b. J Biol Chem 2010;285:29336-29347.
25. Valeria B, Maddalena G, Entrica V, Onofrio T, Gaetano B. Endoglin (CD105) expression in the human heart through gestation: an immunohistochemical study. Reprod Sci 2008;15:1018-1026.
26. Hescheler J, Meyer R, Plant S, Krautwurst D, Rosenthal W, Schultz G. Morphological, biochemial, and electrophysiological characterization of a clonal cell (H9c2) line from rat heart. Circ Res 1991;69:1476-1486.
27. Chen K, Mehta JL, Li D, Joseph L, Joseph J. Transforming growth factor-b receptor endoglin is expressed in cardiac fibroblasts and modulates profibrogenic actions of angiotensin II. Circ Res 2004;95:1167-1173.
28. Rodŕguez-Barbero A, Obreo J, Alvarez-Munoz P, Pandiella A, Bernabéu C, López-Novoa JM. Endoglin modulation of TGF-b1-induced collagen synthesis is dependent on ERK1/2 MAPK activation. Cell Physiol Biochem 2006;18:135-142.
29. Shyu KG, Wang BW, ChenWJ, Kuan P, Hung CR. Mechanism of the inhibitory effect of atorvastatin on endoglin expression induced by transforming growth factor-b1 in cultured cardiac fibroblasts. Eur J Heart Fail 2010;12: 219-226.
30. Torsoni AS, Constancio SS, Nadruz W, Hanks SK, Franchini KG. Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytes. Circ Res 2003;93:140-147.
31. Koitabshi N, Danner T, Zaiman AL, Pinto YM, Rowell J, Mankowski J, Zhang D, Nakamura T, Takimoto E, Kass DA. Pivotal role of cardiomyocyte TGF-b signaling in the murine pathological response to sustained pressure overload. J Clin Invest 2011;121:2301-2312.