Susceptibility to chronic hepatitis C virus infection is influenced by sequence differences in immunodominant CD8+ T cell epitopes

Journal of Hepatology

Volumn 58, Issue 1, 2013, Pages 24-30

  Ziegler, Susanne ^a   Ruhl, Marianne ^a   Tenckhoff, Hannelore ^b   Wiese, Manfred ^c   Heinemann, Falko M ^d   Horn, Peter A ^d   Spengler, Ulrich ^e   Neumann Haefelin, Christoph ^f   Nattermann, Jacob ^e   Timm, Jörg ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c Group Practice for Digestive and Metabolic Diseases   (Germany)

^d UNIVERSITY OF DUISBURG ESSEN   (Germany)

^e UNIVERSITY OF BONN   (Germany)

^f UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Anti D; HLA class I; IL28B; Immune escape; Selection

Indexed keywords

EPITOPE; HLA ANTIGEN CLASS 1; HLA B27 ANTIGEN; INTERLEUKIN 28B;

ALLELE; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; EVOLUTION; FEMALE; GENE SEQUENCE; GENETIC SELECTION; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IMMUNE RESPONSE; INFECTION RISK; INFECTION SENSITIVITY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; VIRUS GENE;

CD8-POSITIVE T-LYMPHOCYTES; DISEASE OUTBREAKS; DISEASE SUSCEPTIBILITY; EPITOPES, T-LYMPHOCYTE; GENOTYPE; GERMANY; HEPATITIS C, CHRONIC; HLA-A3 ANTIGEN; HLA-B ANTIGENS; HLA-B27 ANTIGEN; HLA-B8 ANTIGEN; HUMANS; IMMUNODOMINANT EPITOPES; IRELAND; RISK FACTORS;

EID: 84871229038     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.08.016     Document Type: Article

References (28)

1. B. Rehermann, and C. Hepatitis Virus versus innate and adaptive immune responses: a tale of coevolution and coexistence J Clin Invest 119 2009 1745 1754
2. J.T. Gerlach, H.M. Diepolder, R. Zachoval, N.H. Gruener, M.C. Jung, and A. Ulsenheimer Acute hepatitis C: high rate of both spontaneous and treatment-induced viral clearance Gastroenterology 125 2003 80 88
3. N.H. Shoukry, A. Grakoui, M. Houghton, D.Y. Chien, J. Ghrayeb, and K.A. Reimann Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection J Exp Med 197 2003 1645 1655
4. F. Pereyra, X. Jia, P.J. McLaren, A. Telenti, P.I. de Bakker, and B.D. Walker The major genetic determinants of HIV-1 control affect HLA class I peptide presentation Science 330 2010 1551 1557
5. M. Carrington, and S.J. O'Brien The influence of HLA genotype on AIDS Annu Rev Med 54 2003 535 551
6. A.J. McMichael, P. Borrow, G.D. Tomaras, N. Goonetilleke, and B.F. Haynes The immune response during acute HIV-1 infection: clues for vaccine development Nat Rev Immunol 10 2010 11 23
7. M.A. Brockman, Z.L. Brumme, C.J. Brumme, T. Miura, J. Sela, and P.C. Rosato Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection J Virol 84 2010 11937 11949
8. P.A. Goepfert, W. Lumm, P. Farmer, P. Matthews, A. Prendergast, and J.M. Carlson Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients J Exp Med 205 2008 1009 1017
9. A. Kosmrlj, E.L. Read, Y. Qi, T.M. Allen, M. Altfeld, and S.G. Deeks Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection Nature 465 2010 350 354
10. C. Neumann-Haefelin, and R. Thimme Impact of the genetic restriction of virus-specific T-cell responses in hepatitis C virus infection Genes Immunol 8 2007 181 192
11. C.L. Thio, X. Gao, J.J. Goedert, D. Vlahov, K.E. Nelson, and M.W. Hilgartner HLA-Cw*04 and hepatitis C virus persistence J Virol 76 2002 4792 4797
12. A.Y. Kim, T. Kuntzen, J. Timm, B.E. Nolan, M.A. Baca, and L.L. Reyor Spontaneous control of HCV is associated with expression of HLA-B*57 and Preservation of targeted epitopes Gastroenterology 140 686-696 2011 e681
13. S.M. McKiernan, R. Hagan, M. Curry, G.S. McDonald, A. Kelly, and N. Nolan Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source Hepatology 40 2004 108 114
14. P. Hraber, C. Kuiken, and K. Yusim Evidence for human leukocyte antigen heterozygote advantage against hepatitis C virus infection Hepatology 46 2007 1713 1721
15. M. Wiese, F. Berr, M. Lafrenz, H. Porst, and U. Oesen Low frequency of cirrhosis in a hepatitis C (genotype 1b) single-source outbreak in germany: a 20-year multicenter study Hepatology 32 2000 91 96
16. M. Ruhl, T. Knuschke, K. Schewior, L. Glavinic, C. Neumann-Haefelin, and D.I. Chang CD8+ T-cell response promotes evolution of hepatitis C virus nonstructural proteins Gastroenterology 140 2011 2064 2073
17. M. Oudshoorn, P.A. Horn, M. Tilanus, and N. Yu Typing of potential and selected donors for transplant: methodology and resolution Tissue Antigens 69 Suppl. 1 2007 10 12
18. H.L. Tillmann, A.J. Thompson, K. Patel, M. Wiese, H. Tenckhoff, and H.D. Nischalke A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice Gastroenterology 139 2010 1586 1592 1592 e1581
19. S.C. Ray, L. Fanning, X.H. Wang, D.M. Netski, E. Kenny-Walsh, and D.L. Thomas Divergent and convergent evolution after a common-source outbreak of hepatitis C virus J Exp Med 201 2005 1753 1759
20. S. Salloum, C. Oniangue-Ndza, C. Neumann-Haefelin, L. Hudson, S. Giugliano, and M. Aus dem Siepen Escape from HLA-B*08-restricted CD8 T cells by hepatitis C virus is associated with fitness costs J Virol 82 2008 11803 11812
21. S. Merani, D. Petrovic, I. James, A. Chopra, D. Cooper, and E. Freitas Effect of immune pressure on hepatitis C virus evolution: insights from a single-source outbreak Hepatology 53 2011 396 405
22. C. Neumann-Haefelin, S. McKiernan, S. Ward, S. Viazov, H.C. Spangenberg, and T. Killinger Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution Hepatology 43 2006 563 572
23. K. Fitzmaurice, D. Petrovic, S. Gaudieri, E. Freitas, S. Sims, and A. Long HLA footprinting reveals a novel protective CD8+ T cell response in hepatitis C virus infection J Infect 59 2009 S428 S429
24. C. Neumann-Haefelin, J. Timm, J. Schmidt, N. Kersting, K. Fitzmaurice, and C. Oniangue-Ndza Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope Hepatology 51 2010 54 62
25. R.A. Bull, F. Luciani, K. McElroy, S. Gaudieri, S.T. Pham, and A. Chopra Sequential bottlenecks drive viral evolution in early acute hepatitis C virus infection PLoS Pathog 7 2011 e1002243
26. K. Fitzmaurice, D. Petrovic, N. Ramamurthy, R. Simmons, S. Merani, and S. Gaudieri Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection Gut 2011
27. K.M. Chang, B. Rehermann, J.G. McHutchison, C. Pasquinelli, S. Southwood, and A. Sette Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus J Clin Invest 100 1997 2376 2385
28. E. Dazert, C. Neumann-Haefelin, S. Bressanelli, K. Fitzmaurice, J. Kort, and J. Timm Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response J Clin Invest 119 2009 376 386