Discovery, synthesis,andevaluation of small-molecule signal transducer and activator of transcription 3 inhibitors

Chemical and Pharmaceutical Bulletin

Volumn 60, Issue 12, 2012, Pages 1574-1580

  Shi, Zhi Bing ^a   Zhao, Dan ^a   Huang, Yan Yan ^b   Du, Yun ^a   Cao, Xiang Rong ^c   Gong, Zhu Nan ^c   Zhao, Rui ^b   Li, Jian Xin ^a  

^a NANJING UNIVERSITY   (China)

^b INSTITUTE OF CHEMISTRY   (China)

^c NANJING NORMAL UNIVERSITY   (China)

Author keywords

Bibenzoxazole; Cancer; Inhibitor; Signal transducer and activator of transcription 3

Indexed keywords

6,6' BIBENZOXAZOLE; ANTINEOPLASTIC AGENT; BENZOXAZOLE DERIVATIVE; STAT3 INHIBITOR; STAT3 PROTEIN; UNCLASSIFIED DRUG; STAT3 PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER CELL CULTURE; CELL ASSAY; CELL PROLIFERATION; CELL STRAIN MCF 7; CELL VIABILITY; CONTROLLED STUDY; DATA BASE; DRUG DESIGN; DRUG INHIBITION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; FLOW INJECTION ANALYSIS; HUMAN; HUMAN CELL; MOLECULE; PROTEIN EXPRESSION; QUARTZ CRYSTAL MICROBALANCE; VIRTUAL REALITY; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG DEVELOPMENT; DRUG EFFECT; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BENZOXAZOLES; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MCF-7 CELLS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STAT3 TRANSCRIPTION FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84871214593     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.c12-00745     Document Type: Article

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