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Volumn 7, Issue 12, 2012, Pages

Biodegradable Nanoparticle-Entrapped Vaccine Induces Cross-Protective Immune Response against a Virulent Heterologous Respiratory Viral Infection in Pigs

Author keywords

[No Author keywords available]

Indexed keywords

NANOPARTICLE; POLYGLACTIN; VIRUS ANTIGEN; VIRUS VACCINE;

EID: 84871117280     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051794     Document Type: Article
Times cited : (29)

References (50)
  • 1
    • 0026548699 scopus 로고
    • Controlled-release vaccines-biodegradable polylactide/polyglycolide (PL/PG) microspheres as antigen vehicles
    • Aguado MT, Lambert PH, (1992) Controlled-release vaccines-biodegradable polylactide/polyglycolide (PL/PG) microspheres as antigen vehicles. Immunobiology 184: 113-125.
    • (1992) Immunobiology , vol.184 , pp. 113-125
    • Aguado, M.T.1    Lambert, P.H.2
  • 2
    • 0028319146 scopus 로고
    • Degradation of poly(D,L-lactic acid) microspheres effect of molecular weight
    • Park TG, (1994) Degradation of poly(D,L-lactic acid) microspheres effect of molecular weight. J Control Release 30: 161-173.
    • (1994) J Control Release , vol.30 , pp. 161-173
    • Park, T.G.1
  • 3
    • 0037271852 scopus 로고    scopus 로고
    • A road less travelled: large animal models in immunological research
    • Hein WR, Griebel PJ, (2003) A road less travelled: large animal models in immunological research. Nat Rev Immunol 3: 79-84.
    • (2003) Nat Rev Immunol , vol.3 , pp. 79-84
    • Hein, W.R.1    Griebel, P.J.2
  • 6
    • 0030634897 scopus 로고    scopus 로고
    • Nidovirales: a new order comprising Coronaviridae and Arteriviridae
    • Cavanagh D, (1997) Nidovirales: a new order comprising Coronaviridae and Arteriviridae. Arch Virol 142: 629-633.
    • (1997) Arch Virol , vol.142 , pp. 629-633
    • Cavanagh, D.1
  • 7
    • 0029643342 scopus 로고
    • Porcine reproductive and respiratory syndrome: clinical disease, pathology and immunosuppression
    • Done SH, Paton DJ, (1995) Porcine reproductive and respiratory syndrome: clinical disease, pathology and immunosuppression. Vet Rec 136: 32-35.
    • (1995) Vet Rec , vol.136 , pp. 32-35
    • Done, S.H.1    Paton, D.J.2
  • 8
    • 0029266676 scopus 로고
    • Immunohistochemical identification of porcine reproductive and respiratory syndrome virus (PRRSV) antigen in the heart and lymphoid system of three-week-old colostrum-deprived pigs
    • Halbur PG, Miller LD, Paul PS, Meng XJ, Huffman EL, et al. (1995) Immunohistochemical identification of porcine reproductive and respiratory syndrome virus (PRRSV) antigen in the heart and lymphoid system of three-week-old colostrum-deprived pigs. Vet Pathol 32: 200-204.
    • (1995) Vet Pathol , vol.32 , pp. 200-204
    • Halbur, P.G.1    Miller, L.D.2    Paul, P.S.3    Meng, X.J.4    Huffman, E.L.5
  • 9
    • 84856944382 scopus 로고    scopus 로고
    • Evaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs during early stage of infection under farm conditions
    • Dwivedi V, Manickam C, Binjawadagi B, Linhares D, Murtaugh MP, et al. (2012) Evaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs during early stage of infection under farm conditions. Virol J 9: 45.
    • (2012) Virol J , vol.9 , pp. 45
    • Dwivedi, V.1    Manickam, C.2    Binjawadagi, B.3    Linhares, D.4    Murtaugh, M.P.5
  • 11
  • 12
    • 0031063090 scopus 로고    scopus 로고
    • Routes of immunization and antigen delivery systems for optimal mucosal immune responses in humans
    • Mestecky J, Michalek SM, Moldoveanu Z, Russell MW (1997) Routes of immunization and antigen delivery systems for optimal mucosal immune responses in humans. Behring Inst Mitt: 33-43.
    • (1997) Behring Inst Mitt , pp. 33-43
    • Mestecky, J.1    Michalek, S.M.2    Moldoveanu, Z.3    Russell, M.W.4
  • 13
    • 79953832337 scopus 로고    scopus 로고
    • Aerosolized PLA and PLGA Nanoparticles Enhance Humoral, Mucosal and Cytokine Responses to Hepatitis B Vaccine
    • Thomas C, Rawat A, Hope-Weeks L, Ahsan F, (2011) Aerosolized PLA and PLGA Nanoparticles Enhance Humoral, Mucosal and Cytokine Responses to Hepatitis B Vaccine. Mol Pharm 8: 405-415.
    • (2011) Mol Pharm , vol.8 , pp. 405-415
    • Thomas, C.1    Rawat, A.2    Hope-Weeks, L.3    Ahsan, F.4
  • 14
    • 0035936976 scopus 로고    scopus 로고
    • A novel bioadhesive intranasal delivery system for inactivated influenza vaccines
    • Singh M, Briones M, O'Hagan DT, (2001) A novel bioadhesive intranasal delivery system for inactivated influenza vaccines. J Control Release 70: 267-276.
    • (2001) J Control Release , vol.70 , pp. 267-276
    • Singh, M.1    Briones, M.2    O'Hagan, D.T.3
  • 15
    • 0032921895 scopus 로고    scopus 로고
    • Single-dose mucosal immunization with biodegradable microparticles containing a Schistosoma mansoni antigen
    • Baras B, Benoit MA, Dupre L, Poulain-Godefroy O, Schacht AM, et al. (1999) Single-dose mucosal immunization with biodegradable microparticles containing a Schistosoma mansoni antigen. Infect Immun 67: 2643-2648.
    • (1999) Infect Immun , vol.67 , pp. 2643-2648
    • Baras, B.1    Benoit, M.A.2    Dupre, L.3    Poulain-Godefroy, O.4    Schacht, A.M.5
  • 16
    • 0037414476 scopus 로고    scopus 로고
    • Strain specificity of the immune response of pigs following vaccination with various strains of porcine reproductive and respiratory syndrome virus
    • Mengeling WL, Lager KM, Vorwald AC, Koehler KJ, (2003) Strain specificity of the immune response of pigs following vaccination with various strains of porcine reproductive and respiratory syndrome virus. Vet Microbiol 93: 13-24.
    • (2003) Vet Microbiol , vol.93 , pp. 13-24
    • Mengeling, W.L.1    Lager, K.M.2    Vorwald, A.C.3    Koehler, K.J.4
  • 17
    • 84874068949 scopus 로고    scopus 로고
    • Mucosal vaccines to prevent porcine reproductive and respiratory syndrome: a new perspective
    • doi: 10.1017/S1466252312000023
    • Renukaradhya GJ, Dwivedi V, Manickama C, Binjawadagia B, Benfield D, (2012) Mucosal vaccines to prevent porcine reproductive and respiratory syndrome: a new perspective. Animal Health Research Review 13: 1-17 doi:10.1017/S1466252312000023.
    • (2012) Animal Health Research Review , vol.13 , pp. 1-17
    • Renukaradhya, G.J.1    Dwivedi, V.2    Manickama, C.3    Binjawadagia, B.4    Benfield, D.5
  • 18
    • 79952186058 scopus 로고    scopus 로고
    • A modified live PRRSV vaccine and the pathogenic parent strain induce regulatory T cells in pigs naturally infected with Mycoplasma hyopneumoniae
    • Leroith T, Hammond S, Todd SM, Ni Y, Cecere T, et al. (2011) A modified live PRRSV vaccine and the pathogenic parent strain induce regulatory T cells in pigs naturally infected with Mycoplasma hyopneumoniae. Vet Immunol Immunopathol 140: 312-316.
    • (2011) Vet Immunol Immunopathol , vol.140 , pp. 312-316
    • Leroith, T.1    Hammond, S.2    Todd, S.M.3    Ni, Y.4    Cecere, T.5
  • 19
    • 73949119588 scopus 로고    scopus 로고
    • Recombination in vaccine and circulating strains of porcine reproductive and respiratory syndrome viruses
    • Li B, Fang L, Xu Z, Liu S, Gao J, et al. (2009) Recombination in vaccine and circulating strains of porcine reproductive and respiratory syndrome viruses. Emerg Infect Dis 15: 2032-2035.
    • (2009) Emerg Infect Dis , vol.15 , pp. 2032-2035
    • Li, B.1    Fang, L.2    Xu, Z.3    Liu, S.4    Gao, J.5
  • 20
    • 0034991023 scopus 로고    scopus 로고
    • Reversion of a live porcine reproductive and respiratory syndrome virus vaccine investigated by parallel mutations
    • Nielsen HS, Oleksiewicz MB, Forsberg R, Stadejek T, Botner A, et al. (2001) Reversion of a live porcine reproductive and respiratory syndrome virus vaccine investigated by parallel mutations. J Gen Virol 82: 1263-1272.
    • (2001) J Gen Virol , vol.82 , pp. 1263-1272
    • Nielsen, H.S.1    Oleksiewicz, M.B.2    Forsberg, R.3    Stadejek, T.4    Botner, A.5
  • 21
    • 1542723012 scopus 로고    scopus 로고
    • Impact of immunizations with porcine reproductive and respiratory syndrome virus on lymphoproliferative recall responses of CD8+ T cells
    • Bassaganya-Riera J, Thacker BJ, Yu S, Strait E, Wannemuehler MJ, et al. (2004) Impact of immunizations with porcine reproductive and respiratory syndrome virus on lymphoproliferative recall responses of CD8+ T cells. Viral Immunol 17: 25-37.
    • (2004) Viral Immunol , vol.17 , pp. 25-37
    • Bassaganya-Riera, J.1    Thacker, B.J.2    Yu, S.3    Strait, E.4    Wannemuehler, M.J.5
  • 22
    • 34250180906 scopus 로고    scopus 로고
    • Effect of genotypic and biotypic differences among PRRS viruses on the serologic assessment of pigs for virus infection
    • Kim WI, Lee DS, Johnson W, Roof M, Cha SH, et al. (2007) Effect of genotypic and biotypic differences among PRRS viruses on the serologic assessment of pigs for virus infection. Vet Microbiol 123: 1-14.
    • (2007) Vet Microbiol , vol.123 , pp. 1-14
    • Kim, W.I.1    Lee, D.S.2    Johnson, W.3    Roof, M.4    Cha, S.H.5
  • 23
    • 29244488151 scopus 로고    scopus 로고
    • Incorporation of microspheres into nerve guidance channels for drug delivery purposes
    • University of Toronto, Toronto
    • Piotrowicz A (2005) Incorporation of microspheres into nerve guidance channels for drug delivery purposes. Applied Chemistry and Chemical Enginnering, University of Toronto, Toronto: p. 108.
    • (2005) Applied Chemistry and Chemical Enginnering , pp. 108
    • Piotrowicz, A.1
  • 24
    • 0033081516 scopus 로고    scopus 로고
    • Delivering neuroactive molecules from biodegradable microspheres for application in central nervous system disorders
    • Cao X, Schoichet MS, (1999) Delivering neuroactive molecules from biodegradable microspheres for application in central nervous system disorders. Biomaterials 20: 329-339.
    • (1999) Biomaterials , vol.20 , pp. 329-339
    • Cao, X.1    Schoichet, M.S.2
  • 25
    • 77954902656 scopus 로고    scopus 로고
    • Intranasal M cell uptake of nanoparticles is independently influenced by targeting ligands and buffer ionic strength
    • Rajapaksa TE, Bennett KM, Hamer M, Lytle C, Rodgers VG, et al. (2010) Intranasal M cell uptake of nanoparticles is independently influenced by targeting ligands and buffer ionic strength. J Biol Chem 285: 23739-23746.
    • (2010) J Biol Chem , vol.285 , pp. 23739-23746
    • Rajapaksa, T.E.1    Bennett, K.M.2    Hamer, M.3    Lytle, C.4    Rodgers, V.G.5
  • 26
    • 77957931679 scopus 로고    scopus 로고
    • Swine influenza H1N1 virus induces acute inflammatory immune responses in pig lungs: a potential animal model for human H1N1 influenza virus
    • Khatri M, Dwivedi V, Krakowka S, Manickam C, Ali A, et al. (2010) Swine influenza H1N1 virus induces acute inflammatory immune responses in pig lungs: a potential animal model for human H1N1 influenza virus. J Virol 84: 11210-11218.
    • (2010) J Virol , vol.84 , pp. 11210-11218
    • Khatri, M.1    Dwivedi, V.2    Krakowka, S.3    Manickam, C.4    Ali, A.5
  • 27
    • 0034762753 scopus 로고    scopus 로고
    • Porcine dendritic cells generated in vitro: morphological, phenotypic and functional properties
    • Carrasco CP, Rigden RC, Schaffner R, Gerber H, Neuhaus V, et al. (2001) Porcine dendritic cells generated in vitro: morphological, phenotypic and functional properties. Immunology 104: 175-184.
    • (2001) Immunology , vol.104 , pp. 175-184
    • Carrasco, C.P.1    Rigden, R.C.2    Schaffner, R.3    Gerber, H.4    Neuhaus, V.5
  • 28
    • 37049002454 scopus 로고    scopus 로고
    • Altered pathogenesis of porcine respiratory coronavirus in pigs due to immunosuppressive effects of dexamethasone: implications for corticosteroid use in treatment of severe acute respiratory syndrome coronavirus
    • Jung K, Alekseev KP, Zhang X, Cheon DS, Vlasova AN, et al. (2007) Altered pathogenesis of porcine respiratory coronavirus in pigs due to immunosuppressive effects of dexamethasone: implications for corticosteroid use in treatment of severe acute respiratory syndrome coronavirus. J Virol 81: 13681-13693.
    • (2007) J Virol , vol.81 , pp. 13681-13693
    • Jung, K.1    Alekseev, K.P.2    Zhang, X.3    Cheon, D.S.4    Vlasova, A.N.5
  • 29
    • 15744363493 scopus 로고    scopus 로고
    • An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema
    • Grumelli S, Corry DB, Song LZ, Song L, Green L, et al. (2004) An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. PLoS Med 1: e8.
    • (2004) PLoS Med , vol.1
    • Grumelli, S.1    Corry, D.B.2    Song, L.Z.3    Song, L.4    Green, L.5
  • 30
    • 0035290362 scopus 로고    scopus 로고
    • Detection and duration of porcine reproductive and respiratory syndrome virus in semen, serum, peripheral blood mononuclear cells, and tissues from Yorkshire, Hampshire, and Landrace boars
    • Christopher-Hennings J, Holler LD, Benfield DA, Nelson EA, (2001) Detection and duration of porcine reproductive and respiratory syndrome virus in semen, serum, peripheral blood mononuclear cells, and tissues from Yorkshire, Hampshire, and Landrace boars. J Vet Diagn Invest 13: 133-142.
    • (2001) J Vet Diagn Invest , vol.13 , pp. 133-142
    • Christopher-Hennings, J.1    Holler, L.D.2    Benfield, D.A.3    Nelson, E.A.4
  • 31
    • 79955651326 scopus 로고    scopus 로고
    • Cross-protective immunity to porcine reproductive and respiratory syndrome virus by intranasal delivery of a live virus vaccine with a potent adjuvant
    • Dwivedi V, Manickam C, Patterson R, Dodson K, Murtaugh M, et al. (2011) Cross-protective immunity to porcine reproductive and respiratory syndrome virus by intranasal delivery of a live virus vaccine with a potent adjuvant. Vaccine 29: 4058-4066.
    • (2011) Vaccine , vol.29 , pp. 4058-4066
    • Dwivedi, V.1    Manickam, C.2    Patterson, R.3    Dodson, K.4    Murtaugh, M.5
  • 32
    • 0032145655 scopus 로고    scopus 로고
    • Induction of protective immune responses against Venezuelan equine encephalitis (VEE) virus aerosol challenge with microencapsulated VEE virus vaccine
    • Greenway TE, Eldridge JH, Ludwig G, Staas JK, Smith JF, et al. (1998) Induction of protective immune responses against Venezuelan equine encephalitis (VEE) virus aerosol challenge with microencapsulated VEE virus vaccine. Vaccine 16: 1314-1323.
    • (1998) Vaccine , vol.16 , pp. 1314-1323
    • Greenway, T.E.1    Eldridge, J.H.2    Ludwig, G.3    Staas, J.K.4    Smith, J.F.5
  • 33
    • 0345505224 scopus 로고    scopus 로고
    • Immunogenicity of bovine parainfluenza type 3 virus proteins encapsulated in nanoparticle vaccines, following intranasal administration to mice
    • Shephard MJ, Todd D, Adair BM, Po AL, Mackie DP, et al. (2003) Immunogenicity of bovine parainfluenza type 3 virus proteins encapsulated in nanoparticle vaccines, following intranasal administration to mice. Res Vet Sci 74: 187-190.
    • (2003) Res Vet Sci , vol.74 , pp. 187-190
    • Shephard, M.J.1    Todd, D.2    Adair, B.M.3    Po, A.L.4    Mackie, D.P.5
  • 34
    • 0031903841 scopus 로고    scopus 로고
    • Interferon-alpha response to swine arterivirus (PoAV), the porcine reproductive and respiratory syndrome virus
    • Albina E, Carrat C, Charley B, (1998) Interferon-alpha response to swine arterivirus (PoAV), the porcine reproductive and respiratory syndrome virus. J Interferon Cytokine Res 18: 485-490.
    • (1998) J Interferon Cytokine Res , vol.18 , pp. 485-490
    • Albina, E.1    Carrat, C.2    Charley, B.3
  • 35
    • 0027313677 scopus 로고
    • Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo
    • Inaba K, Inaba M, Naito M, Steinman RM, (1993) Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo. J Exp Med 178: 479-488.
    • (1993) J Exp Med , vol.178 , pp. 479-488
    • Inaba, K.1    Inaba, M.2    Naito, M.3    Steinman, R.M.4
  • 36
    • 0031637377 scopus 로고    scopus 로고
    • Biodegradable polymer microspheres as vaccine adjuvants and delivery systems
    • Gupta RK, Chang AC, Siber GR, (1998) Biodegradable polymer microspheres as vaccine adjuvants and delivery systems. Dev Biol Stand 92: 63-78.
    • (1998) Dev Biol Stand , vol.92 , pp. 63-78
    • Gupta, R.K.1    Chang, A.C.2    Siber, G.R.3
  • 37
    • 33750485375 scopus 로고    scopus 로고
    • Differential effects of agarose and poly(lactic-co-glycolic acid) on dendritic cell maturation
    • Yoshida M, Babensee JE, (2006) Differential effects of agarose and poly(lactic-co-glycolic acid) on dendritic cell maturation. J Biomed Mater Res A 79: 393-408.
    • (2006) J Biomed Mater Res A , vol.79 , pp. 393-408
    • Yoshida, M.1    Babensee, J.E.2
  • 38
    • 24044543562 scopus 로고    scopus 로고
    • Differential levels of dendritic cell maturation on different biomaterials used in combination products
    • Babensee JE, Paranjpe A, (2005) Differential levels of dendritic cell maturation on different biomaterials used in combination products. J Biomed Mater Res A 74: 503-510.
    • (2005) J Biomed Mater Res A , vol.74 , pp. 503-510
    • Babensee, J.E.1    Paranjpe, A.2
  • 39
    • 0031265657 scopus 로고    scopus 로고
    • Cellular variables in bronchoalveolar lavage fluids (BALF) in selected healthy pigs
    • Ganter M, Hensel A, (1997) Cellular variables in bronchoalveolar lavage fluids (BALF) in selected healthy pigs. Res Vet Sci 63: 215-217.
    • (1997) Res Vet Sci , vol.63 , pp. 215-217
    • Ganter, M.1    Hensel, A.2
  • 40
    • 5144235287 scopus 로고    scopus 로고
    • Metal-rich ambient particles (particulate matter 2.5) cause airway inflammation in healthy subjects
    • Schaumann F, Borm PJ, Herbrich A, Knoch J, Pitz M, et al. (2004) Metal-rich ambient particles (particulate matter 2.5) cause airway inflammation in healthy subjects. Am J Respir Crit Care Med 170: 898-903.
    • (2004) Am J Respir Crit Care Med , vol.170 , pp. 898-903
    • Schaumann, F.1    Borm, P.J.2    Herbrich, A.3    Knoch, J.4    Pitz, M.5
  • 41
    • 0026749078 scopus 로고
    • Studies on chitosan: 4. Lysozymic hydrolysis of partially N-acetylated chitosans
    • Aiba S, (1992) Studies on chitosan: 4. Lysozymic hydrolysis of partially N-acetylated chitosans. Int J Biol Macromol 14: 225-228.
    • (1992) Int J Biol Macromol , vol.14 , pp. 225-228
    • Aiba, S.1
  • 43
    • 0030901437 scopus 로고    scopus 로고
    • Alveolar macrophage priming by intravenous administration of chitin particles, polymers of N-acetyl-D-glucosamine, in mice
    • Shibata Y, Foster LA, Metzger WJ, Myrvik QN, (1997) Alveolar macrophage priming by intravenous administration of chitin particles, polymers of N-acetyl-D-glucosamine, in mice. Infect Immun 65: 1734-1741.
    • (1997) Infect Immun , vol.65 , pp. 1734-1741
    • Shibata, Y.1    Foster, L.A.2    Metzger, W.J.3    Myrvik, Q.N.4
  • 44
    • 79952819081 scopus 로고    scopus 로고
    • Role of lipid rafts in innate immunity and phagocytosis of polystyrene latex microspheres
    • Nagao G, Ishii K, Hirota K, Makino K, Terada H, (2011) Role of lipid rafts in innate immunity and phagocytosis of polystyrene latex microspheres. Colloids Surf B Biointerfaces 84: 317-324.
    • (2011) Colloids Surf B Biointerfaces , vol.84 , pp. 317-324
    • Nagao, G.1    Ishii, K.2    Hirota, K.3    Makino, K.4    Terada, H.5
  • 45
    • 2542505511 scopus 로고    scopus 로고
    • Induction of HIV-specific antibody response and protection against vaginal SHIV transmission by intranasal immunization with inactivated SHIV-capturing nanospheres in macaques
    • Miyake A, Akagi T, Enose Y, Ueno M, Kawamura M, et al. (2004) Induction of HIV-specific antibody response and protection against vaginal SHIV transmission by intranasal immunization with inactivated SHIV-capturing nanospheres in macaques. J Med Virol 73: 368-377.
    • (2004) J Med Virol , vol.73 , pp. 368-377
    • Miyake, A.1    Akagi, T.2    Enose, Y.3    Ueno, M.4    Kawamura, M.5
  • 46
    • 32944475955 scopus 로고    scopus 로고
    • Gammadelta lymphocyte response to porcine reproductive and respiratory syndrome virus
    • Olin MR, Batista L, Xiao Z, Dee SA, Murtaugh MP, et al. (2005) Gammadelta lymphocyte response to porcine reproductive and respiratory syndrome virus. Viral Immunol 18: 490-499.
    • (2005) Viral Immunol , vol.18 , pp. 490-499
    • Olin, M.R.1    Batista, L.2    Xiao, Z.3    Dee, S.A.4    Murtaugh, M.P.5
  • 47
    • 0030670976 scopus 로고    scopus 로고
    • Alpha beta and gamma delta T-cell networks and their roles in natural resistance to viral infections
    • Welsh RM, Lin MY, Lohman BL, Varga SM, Zarozinski CC, et al. (1997) Alpha beta and gamma delta T-cell networks and their roles in natural resistance to viral infections. Immunol Rev 159: 79-93.
    • (1997) Immunol Rev , vol.159 , pp. 79-93
    • Welsh, R.M.1    Lin, M.Y.2    Lohman, B.L.3    Varga, S.M.4    Zarozinski, C.C.5
  • 48
    • 79955652343 scopus 로고    scopus 로고
    • Intranasal delivery of whole cell lysate of Mycobacterium tuberculosis induces protective immune responses to a modified live porcine reproductive and respiratory syndrome virus vaccine in pigs
    • Dwivedi V, Manickam C, Patterson R, Dodson K, Weeman M, et al. (2011) Intranasal delivery of whole cell lysate of Mycobacterium tuberculosis induces protective immune responses to a modified live porcine reproductive and respiratory syndrome virus vaccine in pigs. Vaccine 29: 4067-4076.
    • (2011) Vaccine , vol.29 , pp. 4067-4076
    • Dwivedi, V.1    Manickam, C.2    Patterson, R.3    Dodson, K.4    Weeman, M.5
  • 49
    • 0014532783 scopus 로고
    • Distribution of poliovirus antibody in serum, nasopharynx and alimentary tract following segmental immunization of lower alimentary tract with poliovaccine
    • Ogra PL, Karzon DT, (1969) Distribution of poliovirus antibody in serum, nasopharynx and alimentary tract following segmental immunization of lower alimentary tract with poliovaccine. J Immunol 102: 1423-1430.
    • (1969) J Immunol , vol.102 , pp. 1423-1430
    • Ogra, P.L.1    Karzon, D.T.2
  • 50
    • 0021343130 scopus 로고
    • Cross-protection in mice infected with influenza A virus by the respiratory route is correlated with local IgA antibody rather than serum antibody or cytotoxic T cell reactivity
    • Liew FY, Russell SM, Appleyard G, Brand CM, Beale J, (1984) Cross-protection in mice infected with influenza A virus by the respiratory route is correlated with local IgA antibody rather than serum antibody or cytotoxic T cell reactivity. Eur J Immunol 14: 350-356.
    • (1984) Eur J Immunol , vol.14 , pp. 350-356
    • Liew, F.Y.1    Russell, S.M.2    Appleyard, G.3    Brand, C.M.4    Beale, J.5


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