A modified live PRRSV vaccine and the pathogenic parent strain induce regulatory T cells in pigs naturally infected with Mycoplasma hyopneumoniae

Veterinary Immunology and Immunopathology

Volumn 140, Issue 3-4, 2011, Pages 312-316

  LeRoith, T ^a   Hammond, S ^a   Todd, S M ^a   Ni, Y ^a   Cecere, T ^a   Pelzer, K D ^b  

^a CENTER FOR MOLECULAR MEDICINE AND INFECTIOUS DISEASES   (United States)

^b VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

Author keywords

Mycoplasma hyopneumoniae; Porcine reproductive and respiratory syndrome virus; Regulatory T cells; Vaccine

Indexed keywords

PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS VACCINE; UNCLASSIFIED DRUG; VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIVIRUS; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL PIG; INOCULATION; MYCOPLASMA HYOPNEUMONIAE; MYCOPLASMAL PNEUMONIA OF SWINE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; REGULATORY T LYMPHOCYTE; VIRUS STRAIN; VIRUS VIRULENCE;

ANIMALS; INTERFERON-GAMMA; INTERLEUKIN-10; PNEUMONIA OF SWINE, MYCOPLASMAL; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SUS SCROFA; SWINE; T-LYMPHOCYTES, REGULATORY; VIRAL VACCINES;

MYCOPLASMA HYOPNEUMONIAE; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SUIDAE;

EID: 79952186058     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2010.12.011     Document Type: Article

References (27)

1. Allende R., Laegreid W.W., Kutish G.F., Galeota J.A., Wills R.W., Osorio F.A. Porcine reproductive and respiratory syndrome virus: description of persistence in individual pigs upon experimental infection. Journal of Virology 2000, 74:10834-10837.
2. Carter Q.L., Curiel R. Interleukin-12 (IL-12) ameliorates the effects of porcine respiratory and reproductive syndrome virus (PRRSV) infection. Veterinary Immunology and Immunopathology 2005, 107:105-118.
3. Collins J.E., Benfield D.A., Christianson W.T., Harris L., Hennings J.C., Shaw D.P., Goyal S.M., McCullough S., Morrison R.B., Joo H.S., Gorcyca D.E., Chladek D.W. Isolation of swine infertility and respiratory syndrome virus (isolate ATCC VR-2332) in North America and experimental reproduction of the disease in gnotobiotic pigs. Journal of Veterinary Diagnostic Investigation 1992, 4:117-126.
4. Díaz I., Darwich L., Pappaterra G., Pujols J., Mateu E. Different European-type vaccines against porcine reproductive and respiratory syndrome virus have different immunological properties and confer different protection to pigs. Virology 2006, 351:249-259.
5. Fang Y., Rowland R.R., Roof M., Lunney J.K., Christopher-Hennings J., Nelson E.A. A full-length cDNA infectious clone of North American type 1 porcine reproductive and respiratory syndrome virus: expression of green fluorescent protein in the Nsp2 region. Journal of Virology 2006, 80:11447-11455.
6. Feng W., Laster S.M., Tompkins M., Brown T., Xu J.S., Altier C., Gomez W., Benfield D., McCaw M.B. In utero infection by porcine reproductive and respiratory syndrome virus is sufficient to increase susceptibility of piglets to challenge by Streptococcus suis type II. Journal of Virology 2001, 75:4889-4895.
7. Feng W.H., Tompkins M.B., Xu J.S., Zhang H.X., McCaw M.B. Analysis of constitutive cytokine expression by pigs infected in-utero with porcine reproductive and respiratory syndrome virus. Veterinary Immunology and Immunopathology 2003, 94:35-45.
8. Käser T., Gerner W., Hammer S.E., Patzl M., Saalmüller A. Detection of Foxp3 protein expression in porcine T lymphocytes. Veterinary Immunology and Immunopathology 2008, 125:92-101.
9. Keffaber K. Reproductive failure of unknown etiology. American Association of Swine Practitioners Newsletter 1989, 1:1-9.
10. Kimman T.G., Cornelissen L.A., Moormann R.J., Rebel J.M., Stockhofe-Zurwieden N. Challenges for porcine reproductive and respiratory syndrome virus (PRRSV) vaccinology. Vaccine 2009, 27:3704-3718.
11. Lopez O.J., Osorio F.A. Role of neutralizing antibodies in PRRSV protective immunity. Veterinary Immunology and Immunopathology 2004, 102:155-163.
12. Martelli P., Gozio S., Ferrari L., Rosina S., De Angelis E., Quintavalla C., Bottarelli E., Borghetti P. Efficacy of a modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine in pigs naturally exposed to a heterologous European (Italian cluster) field strain: Clinical protection and cell-mediated immunity. Vaccine 2009, 27:3788-3799.
13. Mateu E., Diaz I. The challenge of PRRS immunology. The Veterinary Journal 2007, 177:345-351.
14. Meng X. Heterogeneity of porcine reproductive and respiratory syndrome virus: implications for current vaccine efficacy and future vaccine development. Veterinary Microbiology 2000, 74:309-329.
15. Opriessnig T., Halbur P.G., Yoon K.J., Pogranichniy R.M., Harmon K.M., Evans R., Key K.F., Pallares F.J., Thomas P., Meng X.J. Comparison of molecular and biological characteristics of a modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine (ingelvac PRRS MLV), the parent strain of the vaccine (ATCC VR2332) ATCC VR2385, and two recent field isolates of PRRSV. Journal of Virology 2002, 76:11837-11844.
16. Opriessnig T., Thacker E.L., Fenaux M., Meng X.J., Halbur P.G. Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumoniae and porcine circovirus type 2. Veterinary Pathology 2004, 41:624-640.
17. Riber U., Nielsen J., Lind P. In utero infection with PRRS virus modulates cellular functions of blood monocytes and alveolar lung macrophages in piglets. Veterinary Immunology and Immunopathology 2004, 99:169-177.
18. Rossow K.D., Collins J.E., Goyal S.M., Nelson E.A., Christopher-Hennings J., Benfield D.A. Pathogenesis of procine reproductive and respiratory syndrome virus infection in gnotobiotic pigs. Veterinary Pathology 1995, 32:361-373.
19. Silva-Campa E., Flores-Mendoza L., Reséndiz M., Pinelli-Saavedra A., Mata-Haro V., Mwangi W., Hernández J. Induction of T helper 3 regulatory cells by dendritic cells infected with porcine reproductive and respiratory syndrome virus. Virology 2009, 387:373-379.
20. Suradhat S., Thanawongnuwech R. Upregulation of interleukin-10 gene expression in the leukocytes of pigs infected with porcine reproductive and respiratory syndrome virus. Journal of General Virology 2003, 84:2755-2760.
21. Thacker E.L., Thacker B.J., Young T.F., Halbur P.G. Effect of vaccination on the potentiation of porcine reproductive and respiratory syndrome virus (PRRSV)-induced pneumonia by Mycoplasma hyopneumoniae. Vaccine 2000, 18:1244-1252.
22. van Rooij E.M., de Bruin M.G., de Visser Y.E., Middel W.G., Boersma W.J., Bianchi A.T. Vaccine-induced T cell-mediated immunity plays a critical role in early protection against pseudorabies virus (suid herpes virus type 1) infection in pigs. Veterinary Immunology and Immunopathology 2004, 99:113-125.
23. Wills R.W., Doster A.R., Galeota J.A., Sur J.H., Osorio F.A. Duration of infection and proportion of pigs persistently infected with porcine reproductive and respiratory syndrome virus. Journal of Clinical Microbiology 2003, 41:58-62.
24. + regulatory T lymphocytes by porcine reproductive and respiratory syndrome virus (PRRSV). Veterinary Immunology and Immunopathology 2010, 133:170-182.
25. Xiao Z., Batista L., Dee S., Halbur P., Murtaugh M.P. The level of virus-specific T-cell and macrophage recruitment in porcine reproductive and respiratory syndrome virus infection in pigs is independent of virus load. Journal of Virology 2004, 78:5923-5933.
26. Zeman D., Neiger R., Yaeger M., Nelson E., Benfield D., Leslie-Steen P., Thomson J., Miskimins D., Daly R., Minehart M. Laboratory investigation of PRRS virus in three swine herds. Journal of Veterinary Diagnostic Investigation 1993, 5:522-528.
27. Zhou Y.J., Hao X.F., Tian Z.J., Tong G.Z., Yoo D., An T.Q., Zhou T., Li G.X., Qiu H.J., Wei T.C., Yuan X.F. Highly virulent porcine reproductive and respiratory syndrome virus emerged in China. Transboundary and Emerging Diseases 2008, 55:152-164.