Nitric oxide synthase inhibition reduces leg glucose uptake but not blood flow during dynamic exercise in humans

Diabetes

Volumn 48, Issue 9, 1999, Pages 1815-1821

  Bradley, Scott J ^a,b   Kingwell, Bronwyn A ^a   McConell, Glenn K ^b  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; GLUCOSE; INSULIN; LACTIC ACID; N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE;

ADULT; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; EXERCISE; GAS EXCHANGE; GLUCOSE TRANSPORT; HEMODYNAMICS; HUMAN; LEG; LEG BLOOD FLOW; LEG MUSCLE; MALE; MUSCLE METABOLISM; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; THERMODILUTION;

ADULT; BLOOD GLUCOSE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENZYME INHIBITORS; EXERCISE; HEMODYNAMIC PROCESSES; HUMANS; INSULIN; LACTIC ACID; LEG; MALE; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; OXYGEN CONSUMPTION; REGIONAL BLOOD FLOW;

EID: 0032880516     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.9.1815     Document Type: Article

References (51)

1. Moncada S, Palmer R, Higgs E: Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacological Rev 43:109-142, 1991
2. Bredt DS, Snyder SH: Nitric oxide: a physiologic messenger molecule. Annu Rev Biochem 63:175-195, 1994
3. Reid MB: Role of nitric oxide in skeletal muscle: synthesis, distribution and functional importance. Acta Physiol Scand 162:401-409, 1998
4. Roberts CK, Barnard RJ, Scheck SH, Balon TW: Exercise-stimulated glucose transport in skeletal muscle is nitric oxide dependent. Am J Physiol 273: E220-E225, 1997
5. Balon T, Nadler J: Evidence that nitric oxide increases glucose transport in skeletal muscle. J Appl Physiol 82:359-363, 1997
6. Etgen GJ Jr, Fryburg DA, Gibbs EM: Nitric oxide stimulates skeletal muscle glucose transport through a calcium/contraction-and phosphatidylinositol-3-kinase-independent pathway. Diabetes 46:1915-1919, 1997
7. Young ME, Radda GK, Leighton B: Nitric oxide stimulates glucose transport and metabolism in rat skeletal muscle in vitro. Biochem J 322:223-228, 1997
8. Vallance P, Collier J, Moncada S: Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet 2:997-1000, 1989
9. Haynes W, Noon J, Walker B, Webb D: Inhibition of nitric oxide synthesis increases blood pressure in healthy humans. J Hypertension 11:1375-1380, 1993
10. Shen W, Lundborg M, Wang J, Stewart J, Xu X, Ochoa M, Hintze T: Role of EDRF in the regulation of regional blood flow and vascular resistance at rest and during exercise in conscious dogs. J Appl Physiol 77:165-172, 1994
11. Hirai T, Visneski M, Kearns K, Zelis R, Musch T: Effects of NO synthase inhibition on the muscular blood flow response to treadmill exercise in rats. J Appl Physiol 77:1288-1293, 1994
12. Sagach V, Kindybalyuk A, Kovalenko T: Functional hyperemia of skeletal muscle: role of endothelium. J Cardiovasc Pharmacol 20 (Suppl. 12): S170-S175, 1992
13. Hussain S, Stewart D, Ludemann J, Magder S: Role of endothelium-derived relaxing factor in active hyperemia of the canine diaphragm. J Appl Physiol 72:2393-2401, 1992
14. Hester R, Eraslan A, Saito Y: Differences in EDNO contribution to arteriolar diameters at rest and during functional dilation in striated muscle. Am J Physiol 265:H146-H151, 1993
15. Maxwell AJ, Schauble E, Bernstein D, Cooke JP: Limb blood flow during exercise is dependent on nitric oxide. Circulation 98:369-374, 1998
16. Ekeland U, Bjornberg J, Grande P-O, Albert U, Mellander S: Myogenic vascular regulation in skeletal muscle in vivo is not dependent of endothelium-derived nitric oxide. Acta Physiol Scand 144:199-207, 1992
17. King-Vanvlack CE, Curtis SE, Mewburn JD, Cain SM, Chapter CK: Role of endothelial factors in active hyperemic responses in contracting canine muscle. J Appl Physiol 79:107-112, 1995
18. Saito Y, Eraslan A, Hester R: Role of EDRFs in the control of arteriolar diameter during increased metabolism of striated muscle. Am J Physiol 267: H195-H200, 1994
19. Dyke C, Proctor D, Dietz N, Joyner M: Role of nitric oxide in exercise hyperemia during prolonged rhythmic hand gripping in humans. J Physiol 488: 259-265, 1995
20. Meredith I, Jain R, Anderson T, Ganz P, Creager M: Endothelium-derived nitric oxide contributes to exercise-induced hyperemia in the human forearm (Abstract). Circulation 90:1-295, 1994
21. Endo T, Imaizumi T, Tagawa T, Shiramoto M, Ando S-I, Takeshita A: Role of nitric oxide in exercise-induced vasodilation of the forearm. Circulation 90:2886-2890, 1994
22. Gilligan D, Panza J, Kilcoyne C, Waclawiw M, Casino P, Quyyumi A: Contribution of endothelium-derived nitric oxide to exercise-induced vasodilation. Circulation 90:2853-2858, 1994
23. Wilson JR, Kapoor S: Contribution of endothelium-derived relaxing factor to exercise-induced vasodilation in humans. J Appl Physiol 75:2740-2744, 1993
24. Rådegran G, Saltin B: Nitric oxide in the regulation of vasomotor tone in human skeletal muscle. Am J Physiol 276:H1951-H1960, 1999
25. Hickner R, Fisher J, Ehsani A, Kohrt W: Role of nitric oxide in skeletal muscle blood flow at rest and during dynamic exercise in humans. Am J Physiol 273:H405-H410, 1997
26. Perrault H, Cantin M, Thibault G, Brisson GR, Brisson G, Beland M: Plasma atrial natriuretic peptide during brief upright and supine exercise in humans. J Appl Physiol 66:2159-2167, 1989
27. Kim C, Strange S, Bangsbo J, Saltin B: Skeletal muscle perfusion in electrically induced dynamic exercise in humans. Acta Physiol Scand 153:279-287, 1995
28. Anderson P, Saltin B: Maximal perfusion of skeletal muscle in man. J Physiol 366:233-249, 1985
29. Foëx P, Prys-Roberts C, Hahn CEW, Fenton M: Comparison of oxygen content of blood measured directly with values derived from measurements of oxygen tension. Br J Anaesth 42:803-804, 1970
30. 2 content. J Appl Physiol 65:473-477, 1988
31. Kaley G, Koller A, Rodenburg JM, Messina EJ, Wolin MS: Regulation of arteriolar tone and responses via L-arginine pathway in skeletal muscle. Am J Physiol 262:H987-H992, 1992
32. Frandsen U, Lopez-Figueroa M, Hellsten Y: Localization of nitric oxide synthase in human skeletal muscle. Biochem Biophys Res Commun 227:88-93, 1996
33. Nakane M, Schmidt H, Pollock J, Forstermann U, Murad F: Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle. FEBS Lett 316:175-180, 1993
34. Balon T, Nadler J: Nitric oxide release is present from incubated skeletal muscle preparations. J Appl Physiol 77:2519-2521, 1994
35. McDonald LJ, Murad F: Nitric oxide and cyclic GMP signaling. Proc Soc Exp Biol Med 211:1-6, 1996
36. Balon T, Jasman A, Balon E: Skeletal muscle glucose transport is mediated by nitric oxide via a cGMP-related mechanism (Abstract). Med Sci Sports Exerc 28:S58, 1996
37. Young ME, Leighton B: Evidence for altered sensitivity of the nitric oxide/ cGMP signalling cascade in insulin-resistant skeletal muscle. Biochem J 329:73-79, 1998
38. Moncada S, Higgs E, Hodson H, Knowles R, Lopez-Jaramillo P, McCall T, Palmer R, Radomski M, Rees D, Schulz R: The L-arginine: nitric oxide pathway. J Cardiovasc Pharmacol 17:S1-S9, 1991
39. Clark MG, Colquhoun EQ, Rattigan S, Dora KA, Eldershaw TPD, Hall JL, Ye J: Vascular and endocrine control of muscle metabolism. Am J Physiol 268:E797-E812, 1995
40. Bauer JA, Wald JA, Doran S, Soda D: Endogenous nitric oxide in expired air effects of acute exercise in humans. Life Sciences 55:1903-1909, 1994
41. Chirpaz-Oddou MF, Favre-Juvin A, Flore P, Eterradossi J, Delaire M, Grimbert F, Therminarias A: Nitric oxide response in exhaled air during an incremental exhaustive exercise. J Appl Physiol 82:1311-1318, 1997
42. Iwamoto J, Pendergast D, Suzuki H, Krasaney J: Effect of graded exercise on nitric oxide in expired air in humans. Respir Physiol 97:333-345, 1994
43. Matsumoto A, Hirata Y, Momomura S-I, Fujita H, Yao A, Sata M, Serizawa T: Increased nitric oxide production during exercise. Lancet 343:849-850, 1994
44. Jungersten L, Ambling A, Wall B, Wennhalm A: Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans. J Appl Physiol 82:760-764, 1997
45. Node K, Kitakaze M, Sato H, Koretsune Y, Katsube Y, Karita M, Kosaka H, Hori M: Effect of acute dynamic exercise on circulating plasma nitric oxide level and correlation to norepinephrine release in normal subjects. Am J Cardiol 79:526-528, 1997
46. Bode-Boger S, Boger R, Schroder E, Frolich J: Exercise increases systemic nitric oxide production in men. J Cardiovasc Risk 1:173-178, 1994
47. Brett SE, Cockcroft JR, Mant TGK, Ritter JM, Chowienczyk PJ: Haemodynamic effects of inhibition of nitric oxide synthase and of L-arginine at rest and during exercise. J Hypertension 16:429-435, 1998
48. Stamler J, Loh E, Roddy M-A, Currie K, Creager M: Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. Circulation 89:2035-2040, 1995
49. Anderson P, Adams R, Sjogaard G, Thorboe A, Saltin B: Dynamic knee extension as model for study of isolated exercising muscle in humans. J Appl Physiol 59:1647-1653, 1985
50. Rådegran G, Pilegaard H, Nielsen JJ, Bangsbo J: Microdialysis ethanol removal reflects probe recovery rather than local blood flow in skeletal muscle. J Appl Physiol 85:751-757, 1998
51. Madar Z, Zierrath J, Nollte L, Thorne A, Voet H, Wallberg-Henriksson H: Human skeletal muscle nitric oxide synthase-characterization and its activity in obese subjects (Abstract). Diabetes 46 (Suppl. 1):24A, 1997