Increased expression of adenylyl cyclase 3 in pancreatic islets and central nervous system of diabetic Goto-Kakizaki rats: A possible regulatory role in glucose homeostasis

Islets

Volumn 4, Issue 5, 2012, Pages 343-348

  Ahmed, Mohammed Seed ^a   Kovoor, Abraham ^b   Nordman, Sofia ^a   Seman, Norhashimah Abu ^a   Gu, Tianwei ^a   Efendic, Suad ^a   Brismar, Kerstin ^a   Östenson, Claes Gor̈an ^a   Gu, Harvest F ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

Adenylyl cyclase 3; Body weight; Central nervous system; Glucose; Pancreatic islets; Type 2 diabetes

Indexed keywords

ADENYLATE CYCLASE; ADENYLYL CYCLASE 3; GLUCOSE; INSULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CORPUS STRIATUM; DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HYPOTHALAMUS; INSULIN BLOOD LEVEL; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS ISLET; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADENYLATE CYCLASE; ANIMALS; BRAIN; DIABETES MELLITUS, TYPE 2; GLUCOSE; HOMEOSTASIS; INSULIN; ISLETS OF LANGERHANS; MALE; RATS; RATS, WISTAR; RGS PROTEINS; RNA, MESSENGER;

EID: 84871062820     PISSN: 19382014     EISSN: 19382022     Source Type: Journal    
DOI: 10.4161/islets.22283     Document Type: Article

References (27)

1. Amed S, Daneman D, Mahmud FH, Hamilton J. Type 2 diabetes in children and adolescents. Expert Rev Cardiovasc Ther 2010; 8:393-406; PMID:20222817; http://dx.doi.org/10.1586/erc.10.15.
2. Marchetti P, Lupi R, Del Guerra S, Bugliani M, Marselli L, Boggi U. The beta-cell in human type 2 diabetes. Adv Exp Med Biol 2010; 654:501-14; PMID:20217512; http://dx.doi.org/10.1007/978-90-481-3271-3-22.
3. Polakof S. Diabetes therapy: novel patents targeting the glucose-induced insulin secretion. Recent Pat DNA Gene Seq 2010; 4:1-9; PMID:20218954; http://dx.doi.org/10.2174/187221510790410778.
4. Umegaki H. Neurodegeneration in diabetes mellitus. Adv Exp Med Biol 2012; 724:258-65; PMID:22411248; http://dx.doi.org/10.1007/978-1-4614-0653-2-19.
5. McCrimmon RJ. Update in the CNS response to hypoglycemia. J Clin Endocrinol Metab 2012; 97:1-8; PMID:22223763; http://dx.doi.org/10.1210/jc.2011- 1927.
6. Ketterer C, Tschritter O, Preissl H, Heni M, Häring HU, Fritsche A. Insulin sensitivity of the human brain. Diabetes Res Clin Pract 2011; 93(Suppl 1):S47-51; PMID:21864751; http://dx.doi.org/10.1016/S0168-8227(11)70013-4.
7. Defer N, Best-Belpomme M, Hanoune J. Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase. Am J Physiol Renal Physiol 2000; 279:F400-16; PMID:10966920.
8. Hanoune J, Defer N. Regulation and role of adenylyl cyclase isoforms. Annu Rev Pharmacol Toxicol 2001; 41:145-74; PMID:11264454; http://dx.doi.org/10. 1146/annurev.pharmtox.41.1.145.
9. Cooper DM. Regulation and organization of adenylyl cyclases and cAMP. Biochem J 2003; 375:517-29; PMID:12940771; http://dx.doi.org/10.1042/BJ20031061.
10. Valverde I, Vandermeers A, Anjaneyulu R, Malaisse WJ. Calmodulin activation of adenylate cyclase in pancreatic islets. Science 1979; 206:225-7; PMID:225798; http://dx.doi.org/10.1126/science.225798.
11. Ammälä C, Ashcroft FM, Rorsman P. Calcium-independent potentiation of insulin release by cyclic AMP in single beta-cells. Nature 1993; 363:356-8; PMID:7684514; http://dx.doi.org/10.1038/363356a0.
12. Östenson C-G, Khan A, Abdel-Halim SM, Guenifi A, Suzuki K, Goto Y, et al. Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat. Diabetologia 1993; 36:3-8; PMID:8436249; http://dx.doi.org/10.1007/BF00399086.
13. Abdel-Halim SM, Guenifi A, Luthman H, Grill V, Efendic S, Östenson C-G. Impact of diabetic inheritance on glucose tolerance and insulin secretion in spontaneously diabetic GK-Wistar rats. Diabetes 1994; 43:281-8; PMID:8288052; http://dx.doi.org/10.2337/diabetes.43.2.281.
14. Galli J, Li LS, Glaser A, Ostenson CG, Jiao H, Fakhrai-Rad H, et al. Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nat Genet 1996; 12:31-7; PMID:8528247; http://dx.doi.org/10.1038/ng0196-31.
15. Ostenson CG, Efendic S. Islet gene expression and function in type 2 diabetes; studies in the Goto-Kakizaki rat and humans. Diabetes Obes Metab 2007; 9(Suppl 2):180-6; PMID:17919192; http://dx.doi.org/10.1111/j.1463-1326.2007. 00787.x.
16. Abdel-Halim SM, Guenifi A, He B, Yang B, Mustafa M, Höjeberg B, et al. Mutations in the promoter of adenylyl cyclase (AC)-III gene, overexpression of AC-III mRNA, and enhanced cAMP generation in islets from the spontaneously diabetic GK rat model of type 2 diabetes. Diabetes 1998; 47:498-504; PMID:9519762; http://dx.doi.org/10.2337/diabetes.47.3.498.
17. Nordman S, Abulaiti A, Hilding A, Långberg EC, Humphreys K, Ostenson CG, et al. Genetic variation of the adenylyl cyclase 3 (AC3) locus and its influence on type 2 diabetes and obesity susceptibility in Swedish men. Int J Obes (Lond) 2008; 32:407-12; PMID:17895882; http://dx.doi.org/10.1038/sj.ijo. 0803742.
18. Wang H, Wu M, Zhu W, Shen J, Shi X, Yang J, et al. Evaluation of the association between the AC3 genetic polymorphisms and obesity in a Chinese Han population. PLoS One 2010; 5:e13851; PMID:21079816; http://dx.doi.org/10.1371/ journal.pone.0013851.
19. Wang Z, Li V, Chan GC, Phan T, Nudelman AS, Xia Z, et al. Adult type 3 adenylyl cyclase-deficient mice are obese. PLoS One 2009; 4:e6979; PMID:19750222; http://dx.doi.org/10.1371/journal.pone.0006979.
20. Gu HF. AC3: a novel gene plays a role in the regulation of body weight. Open Diabetes J 2010; 3:11-3.
21. Harris BA, Robishaw JD, Mumby SM, Gilman AG. Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase. Science 1985; 229:1274-7; PMID:3839937; http://dx.doi.org/10. 1126/science.3839937.
22. Taussig R, Iñiguez-Lluhi JA, Gilman AG. Inhibition of adenylyl cyclase by Gi alpha. Science 1993; 261:218-21; PMID:8327893; http://dx.doi.org/10.1126/science.8327893.
23. Sethakorn N, Yau DM, Dulin NO. Non-canonical functions of RGS proteins. Cell Signal 2010; 22:1274-81; PMID:20363320; http://dx.doi.org/10.1016/j. cellsig.2010.03.016.
24. Chen CK, Burns ME, He W, Wensel TG, Baylor DA, Simon MI. Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1. Nature 2000; 403:557-60; PMID:10676965; http://dx.doi.org/10.1038/35000601.
25. Waugh JL, Celver J, Sharma M, Dufresne RL, Terzi D, Risch SC, et al. Association between regulator of G protein signaling 9-2 and body weight. PLoS One 2011; 6:e27984; PMID:22132185; http://dx.doi.org/10.1371/journal.pone. 0027984.
26. Yamada T, Oka Y, Katagiri H. Inter-organ metabolic communication involved in energy homeostasis: potential therapeutic targets for obesity and metabolic syndrome. Pharmacol Ther 2008; 117:188-98; PMID:18006064; http://dx.doi.org/10. 1016/j.pharmthera.2007.09.006.
27. Katagiri H, Imai J, Oka Y. Neural relay from the liver induces proliferation of pancreatic beta cells: a path to regenerative medicine using the self-renewal capabilities. Commun Integr Biol 2009; 2:425-7; PMID:19907708; http://dx.doi.org/10.4161/cib.2.5.9053.