Ac3: A novel gene plays a role in the regulation of body weight

Open Diabetes Journal

Volumn 3, Issue , 2010, Pages 11-13

  Gu, Harvest F ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Adenylyl cyclase 3; Obesity; Type 2 diabetes

Indexed keywords

AC 3 GENE; ADENYLATE CYCLASE; ANTIOBESITY AGENT; CYCLIC AMP; MEMBRANE PROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG;

ARTICLE; BODY WEIGHT; DNA POLYMORPHISM; ENZYME ACTIVITY; GENE FUNCTION; GENE MUTATION; GENE OVEREXPRESSION; GENE TARGETING; GENETIC ASSOCIATION; HUMAN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM;

EID: 77953766751     PISSN: None     EISSN: 18765246     Source Type: Journal    
DOI: 10.2174/1876524601003010011     Document Type: Article

References (18)

1. Kelly T, Yang W, Chen CS, Reynolds K, He J. Global burden of obesity in 2005 and projections to 2030. Int J Obes (Lond) 2008; 32: 1431-7.
2. Wang Y, Beydoun MA, Liang L, Caballero B, Kumanyika SK. Will all Americans become overweight or obese? estimating the progression and cost of the US obesity epidemic. Obesity (Silver Spring) 2008; 16: 2323-30.
3. Venables MC, Jeukendrup AE. Physical inactivity and obesity: links with insulin resistance and type 2 diabetes mellitus. Diabetes Metab Res Rev 2009; 25(Suppl 1): S18-23.
4. Freeman H, Cox RD. Type 2 diabetes: a cocktail of genetic discovery. Hum Mol Genet 2006; (Suppl 2): R202-9.
5. O'Rahilly S, Farooqi IS. Human obesity as a heritable disorder of the central control of energy balance. Int J Obes (Lond) 2008; 32(Suppl 7): S55-61.
6. Vella A, Camilleri M. Pharmacogenetics: potential role in the treatment of diabetes and obesity. Expert Opin Pharmacother 2008; 9: 1109-19.
7. Hanoune J, Defer N. Regulation and role of adenylyl cyclase isoforms. Annu Rev Pharmacol Toxicol 2001; 41: 145-7.
8. Galli J, Li LS, Glaser A, et al. Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nat Genet 1996; 12: 31-7.
9. Abdel-Halim SM, Guenifi A, Efendic S, Ostenson CG. Both somatostatin and insulin responses to glucose are impaired in the perfused pancreas of the spontaneously noninsulin-dependent diabetic GK (Goto-Kakizaki) rats. Acta Physiol Scand 1993; 148: 219-26.
10. Abdel-Halim SM, Guenifi A, Luthman H, Grill V, Efendic S, Ostenson CG. Impact of diabetic inheritance on glucose tolerance and insulin secretion in spontaneously diabetic GK-Wistar rats. Diabetes 1994; 43: 281-8.
11. Abdel-Halim SM, Guenifi A, Khan A, et al. Impaired coupling of glucose signal to the exocytotic machinery in diabetic GK rats: a defect ameliorated by cAMP. Diabetes 1996; 45: 934-40.
12. Ostenson CG, Efendic S. Islet gene expression and function in type 2 diabetes; studies in the Goto-Kakizaki rat and humans. Diabetes Obes Metab 2007; 9(Suppl 2): 180-6.
13. Abdel-Halim SM, Guenifi A, He B, et al. Mutations in the promoter of adenylyl cyclase (AC)-III gene, overexpression of ACIII mRNA, and enhanced cAMP generation in islets from the spontaneously diabetic GK rat model of type 2 diabetes. Diabetes 1998; 47: 498-504.
14. Begin-Heick N. Liver β-adrenergic receptors, G proteins, and adenylyl cyclase activity in obesity-diabetes syndromes. Am J Physiol 1994; 94: C1664-72.
15. Nordman S, Abulaiti A, Hilding A, et al. Genetic variation of the adenylyl cyclase 3 (AC3) locus and its influence on type 2 diabetes and obesity susceptibility in Swedish men. Int J Obes (Lond) 2008; 32(3): 407-12.
16. Wang Z, Li V, Chan GC, et al. Adult type 3 adenylyl cyclasedeficient mice are obese. PLoS One 2009; 4: e6979.
17. Dupuis J, Langenberg C, Prokopenko I, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010; 42: 105-16.
18. Saxena R, Hivert MF, Langenberg C, et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet 2010; 42: 142-8.