Spinal cord injury causes bone loss through peroxisome proliferator-activated receptor-γ and Wnt signalling

Journal of Cellular and Molecular Medicine

Volumn 16, Issue 12, 2012, Pages 2968-2977

  Yan, Jun ^a,b   Li, Bo ^a   Chen, Jiang Wei ^a   Jiang, Sheng Dan ^a   Jiang, Lei Sheng ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b LIAOCHENG PEOPLE'S HOSPITAL   (China)

Author keywords

Adipogenesis; Osteoblastogenesis; Spinal cord injury

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 2-CHLORO-5-NITROBENZANILIDE; ANILIDE; CHROMAN DERIVATIVE; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TNFRSF11B PROTEIN, RAT; TROGLITAZONE; WNT PROTEIN;

ADIPOGENESIS; ANIMAL; ARTICLE; BIOSYNTHESIS; BONE; BONE DENSITY; BONE DEVELOPMENT; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; DRUG ANTAGONISM; MALE; MESENCHYMAL STROMA CELL; METABOLISM; OSTEOBLAST; OSTEOLYSIS; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; RAT; SPINAL CORD INJURY; SPRAGUE DAWLEY RAT; WNT SIGNALING PATHWAY;

ADIPOGENESIS; ANILIDES; ANIMALS; BONE AND BONES; BONE DENSITY; BONE RESORPTION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CHROMANS; MALE; MESENCHYMAL STROMAL CELLS; OSTEOBLASTS; OSTEOGENESIS; OSTEOPROTEGERIN; PPAR GAMMA; RANDOM ALLOCATION; RANK LIGAND; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD INJURIES; THIAZOLIDINEDIONES; WNT PROTEINS; WNT SIGNALING PATHWAY;

RATTUS;

EID: 84871057488     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2012.01624.x     Document Type: Article

References (28)

1. Jiang SD, Jiang LS, Dai LY. Changes in bone mass, bone structure, bone biomechanical properties, and bone metabolism after spinal cord injury: a 6-month longitudinal study in growing rats. Calcif Tissue Int. 2007; 80: 167-75.
2. Garland DE, Adkins RH, Stewart CA, et al. Regional osteoporosis in women who have a complete spinal cord injury. J Bone Joint Surg Am. 2001; 83-A: 1195-200.
3. Roberts D, Lee W, Cuneo RC, et al. Longitudinal study of bone turnover after acute spinal cord injury. J Clin Endocrinol Metab. 1998; 83: 415-22.
4. Kiratli BJ, Smith AE, Nauenberg T, et al. Bone mineral and geometric changes through the femur with immobilization due to spinal cord injury. J Rehabil Res Dev. 2000; 37: 225-33.
5. Takata S, Yasui N. Disuse osteoporosis. J Med Invest. 2001; 48: 147-56.
6. Uebelhart D, Demiaux-Domenech B, Roth M, et al. Bone metabolism in spinal cord injured individuals and in others who have prolonged immobilisation. A review. Paraplegia. 1995; 33: 669-73.
7. Jiang SD, Jiang LS, Dai LY. Mechanisms of osteoporosis in spinal cord injury. Clin Endocrinol (Oxf). 2006; 65: 555-65.
8. Jiang SD, Jiang LS, Dai LY. Effects of spinal cord injury on osteoblastogenesis, osteoclastogenesis and gene expression profiling in osteoblasts in young rats. Osteoporos Int. 2007; 18: 339-49.
9. Krause DS, Theise ND, Collector MI, et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell. 2001; 105: 369-77.
10. Sanchez-Ramos J, Song S, Cardozo-Pelaez F, et al. Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol. 2000; 164: 247-56.
11. Ferrari G, Cusella-De Angelis G, Coletta M, et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science. 1998; 279: 1528-30.
12. Gregory CA, Green A, Lee N, et al. The promise of canonical Wnt signaling modulators in enhancing bone repair. Drug News Perspect. 2006; 19: 445-52.
13. Rawadi G, Vayssiere B, Dunn F, et al. BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop. J Bone Miner Res. 2003; 18: 1842-53.
14. Bain G, Muller T, Wang X, et al. Activated beta-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction. Biochem Biophys Res Commun. 2003; 301: 84-91.
15. Rosen ED, Spiegelman BM. PPARgamma: a nuclear regulator of metabolism, differentiation, and cell growth. J Biol Chem. 2001; 276: 37731-4.
16. Lecka-Czernik B, Gubrij I, Moerman EJ, et al. Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARgamma2. J Cell Biochem. 1999; 74: 357-71.
17. Moerman EJ, Teng K, Lipschitz DA, et al. Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways. Aging Cell. 2004; 3: 379-89.
18. Verma S, Rajaratnam JH, Denton J, et al. Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis. J Clin Pathol. 2002; 55: 693-8.
19. Kajkenova O, Lecka-Czernik B, Gubrij I, et al. Increased adipogenesis and myelopoiesis in the bone marrow of SAMP6, a murine model of defective osteoblastogenesis and low turnover osteopenia. J Bone Miner Res. 1997; 12: 1772-9.
20. Jilka RL, Weinstein RS, Takahashi K, et al. Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence. J Clin Invest. 1996; 97: 1732-40.
21. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987; 162: 156-9.
22. Nuttall ME, Gimble JM. Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications. Curr Opin Pharmacol. 2004; 4: 290-4.
23. Akune T, Ohba S, Kamekura S, et al. PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest. 2004; 113: 846-55.
24. Rzonca SO, Suva LJ, Gaddy D, et al. Bone is a target for the antidiabetic compound rosiglitazone. Endocrinology. 2004; 145: 401-6.
25. Lin C, Jiang X, Dai Z, et al. Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling. J Bone Miner Res. 2009; 24: 1651-61.
26. Battaglino RA, Sudhakar S, Lazzari A, et al. Circulating sclerostin is elevated in short-term and reduced in long-term SCI. Bone. 2012 May 7. [Epub ahead of print]
27. Krause U, Harris S, Green A, et al. Pharmaceutical modulation of canonical Wnt signaling in multipotent stromal cells for improved osteoinductive therapy. Proc Natl Acad Sci USA. 2010; 107: 4147-52.
28. Wan Y, Chong LW, Evans RM. PPAR-gamma regulates osteoclastogenesis in mice. Nat Med. 2007; 13: 1496-503.