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Volumn 83, Issue 12, 2012, Pages 1480-1491

Azithromycin as an adjunctive treatment of generalized severe chronic periodontitis: Clinical, microbiologic, and biochemical parameters

Author keywords

Antibiotics; Azithromycin; Chronic periodontitis; Gingival crevicular fluid; Matrix metalloproteinase 8; Microbiology

Indexed keywords

ANTIINFECTIVE AGENT; AZITHROMYCIN; BACTERIAL DNA; NEUTROPHIL COLLAGENASE;

EID: 84871038025     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2012.110519     Document Type: Article
Times cited : (44)

References (47)
  • 1
    • 49449101942 scopus 로고    scopus 로고
    • Mapping the pathogenesis of periodontitis: A new look
    • Kornman KS. Mapping the pathogenesis of periodontitis: A new look. J Periodontol 2008;79(Suppl. 8):1560-1568.
    • (2008) J Periodontol , vol.79 , Issue.8 , pp. 1560-1568
    • Kornman, K.S.1
  • 2
    • 0033288546 scopus 로고    scopus 로고
    • Development of a classification system for periodontal diseases and conditions
    • Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1-6.
    • (1999) Ann Periodontol , vol.4 , pp. 1-6
    • Armitage, G.C.1
  • 3
    • 0031152001 scopus 로고    scopus 로고
    • The host response to the microbial challenge in periodontitis: Assembling the players
    • Kornman KS, Page RC, Tonetti MS. The host response to the microbial challenge in periodontitis: Assembling the players. Periodontol 2000 1997;14:33-53.
    • (1997) Periodontol 2000 , vol.14 , pp. 33-53
    • Kornman, K.S.1    Page, R.C.2    Tonetti, M.S.3
  • 4
    • 0031152116 scopus 로고    scopus 로고
    • Advances in the pathogenesis of periodontitis: Summary of developments, clinical implications and future directions
    • Page RC, Offenbacher S, Schroeder HE, Seymour GJ, Kornman KS. Advances in the pathogenesis of periodontitis: Summary of developments, clinical implications and future directions. Periodontol 2000 1997;14: 216-248.
    • (1997) Periodontol 2000 , vol.14 , pp. 216-248
    • Page, R.C.1    Offenbacher, S.2    Schroeder, H.E.3    Seymour, G.J.4    Kornman, K.S.5
  • 5
    • 33748638853 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Contribution to pathogenesis, diagnosis and treatment of periodontal inflammation
    • Sorsa T, Tjäderhane L, Konttinen YT, et al. Matrix metalloproteinases: Contribution to pathogenesis, diagnosis and treatment of periodontal inflammation. Ann Med 2006;38:306-321.
    • (2006) Ann Med , vol.38 , pp. 306-321
    • Sorsa, T.1    Tjäderhane, L.2    Konttinen, Y.T.3
  • 6
    • 0034186228 scopus 로고    scopus 로고
    • Matrix metalloproteinase-8 levels and elastase activities in gingival crevicular fluid from chronic adult periodontitis patients
    • Chen HY, Cox SW, Eley BM, Mäntylä P, Rönkä H, Sorsa T. Matrix metalloproteinase-8 levels and elastase activities in gingival crevicular fluid from chronic adult periodontitis patients. J Clin Periodontol 2000;27:366-369.
    • (2000) J Clin Periodontol , vol.27 , pp. 366-369
    • Chen, H.Y.1    Cox, S.W.2    Eley, B.M.3    Mäntylä, P.4    Rönkä, H.5    Sorsa, T.6
  • 7
    • 78249233559 scopus 로고    scopus 로고
    • Associations between matrix metalloproteinase-8 and -14 and myeloperoxidase in gingival crevicular fluid from subjects with progressive chronic periodontitis: A longitudinal study
    • Hernández M, Gamonal J, Tervahartiala T, et al. Associations between matrix metalloproteinase-8 and -14 and myeloperoxidase in gingival crevicular fluid from subjects with progressive chronic periodontitis: A longitudinal study. J Periodontol 2010;81:1644-1652.
    • (2010) J Periodontol , vol.81 , pp. 1644-1652
    • Hernández, M.1    Gamonal, J.2    Tervahartiala, T.3
  • 8
    • 0027326662 scopus 로고
    • Periodontal therapy: Prospects for the future
    • Page RC. Periodontal therapy: Prospects for the future. J Periodontol 1993;64(Suppl. 8):744-753.
    • (1993) J Periodontol , vol.64 , Issue.8 , pp. 744-753
    • Page, R.C.1
  • 9
    • 0032843093 scopus 로고    scopus 로고
    • The antimicrobial treatment of periodontal disease: Changing the treatment paradigm
    • Loesche WJ. The antimicrobial treatment of periodontal disease: Changing the treatment paradigm. Crit Rev Oral Biol Med 1999;10:245-275.
    • (1999) Crit Rev Oral Biol Med , vol.10 , pp. 245-275
    • Loesche, W.J.1
  • 10
    • 1442327411 scopus 로고    scopus 로고
    • Systemic anti-infective periodontal therapy. A systematic review
    • Haffajee AD, Socransky SS, Gunsolley JC. Systemic anti-infective periodontal therapy. A systematic review. Ann Periodontol 2003;8:115-181.
    • (2003) Ann Periodontol , vol.8 , pp. 115-181
    • Haffajee, A.D.1    Socransky, S.S.2    Gunsolley, J.C.3
  • 11
    • 50249142996 scopus 로고    scopus 로고
    • Antimicrobial therapy in periodontitis: The use of systemic antimicrobials against the subgingival biofilm
    • Herrera D, Alonso B, León R, Roldán S, Sanz M. Antimicrobial therapy in periodontitis: The use of systemic antimicrobials against the subgingival biofilm. J Clin Periodontol 2008;35(Suppl. 8):45-66.
    • (2008) J Clin Periodontol , vol.35 , Issue.8 , pp. 45-66
    • Herrera, D.1    Alonso, B.2    León, R.3    Roldán, S.4    Sanz, M.5
  • 12
    • 0025096817 scopus 로고
    • The pharmacokinetics of azithromycin in human serum and tissues
    • Foulds G, Shepard RM, Johnson RB. The pharmacokinetics of azithromycin in human serum and tissues. J Antimicrob Chemother 1990;25(Suppl. A):73-82.
    • (1990) J Antimicrob Chemother , vol.25 , pp. 73-82
    • Foulds, G.1    Shepard, R.M.2    Johnson, R.B.3
  • 13
    • 0035840852 scopus 로고    scopus 로고
    • Anti-inflammatory effects of macrolide antibiotics
    • Culic̈ O, Erakovic̈ V, Parnham MJ. Anti-inflammatory effects of macrolide antibiotics. Eur J Pharmacol 2001;429:209-229.
    • (2001) Eur J Pharmacol , vol.429 , pp. 209-229
    • Culic̈, O.1    Erakovic̈, V.2    Parnham, M.J.3
  • 14
    • 6844250096 scopus 로고    scopus 로고
    • Periodontal tissue disposition of azithromycin
    • Malizia T, Tejada MR, Ghelardi E, et al. Periodontal tissue disposition of azithromycin. J Periodontol 1997;68:1206-1209.
    • (1997) J Periodontol , vol.68 , pp. 1206-1209
    • Malizia, T.1    Tejada, M.R.2    Ghelardi, E.3
  • 15
    • 0032875787 scopus 로고    scopus 로고
    • Periodontal tissue disposition of azithromycin in patients affected by chronic inflammatory periodontal diseases
    • Blandizzi C, Malizia T, Lupetti A, et al. Periodontal tissue disposition of azithromycin in patients affected by chronic inflammatory periodontal diseases. J Periodontol 1999;70:960-966.
    • (1999) J Periodontol , vol.70 , pp. 960-966
    • Blandizzi, C.1    Malizia, T.2    Lupetti, A.3
  • 16
    • 33947681600 scopus 로고    scopus 로고
    • Drug concentration in inflamed periodontal tissues after systemically administered azithromycin
    • Gomi K, Yashima A, Iino F, et al. Drug concentration in inflamed periodontal tissues after systemically administered azithromycin. J Periodontol 2007;78:918-923.
    • (2007) J Periodontol , vol.78 , pp. 918-923
    • Gomi, K.1    Yashima, A.2    Iino, F.3
  • 17
    • 0036358087 scopus 로고    scopus 로고
    • A double-blind placebo-controlled trial of azithromycin as an adjunct to non-surgical treatment of periodontitis in adults: Clinical results
    • Smith SR, Foyle DM, Daniels J, et al. A double-blind placebo-controlled trial of azithromycin as an adjunct to non-surgical treatment of periodontitis in adults: Clinical results. J Clin Periodontol 2002;29:54-61.
    • (2002) J Clin Periodontol , vol.29 , pp. 54-61
    • Smith, S.R.1    Foyle, D.M.2    Daniels, J.3
  • 18
    • 18744397538 scopus 로고    scopus 로고
    • Clinical response of azithromycin as an adjunct to non-surgical periodontal therapy in smokers
    • Mascarenhas P, Gapski R, Al-Shammari K, et al. Clinical response of azithromycin as an adjunct to non-surgical periodontal therapy in smokers. J Periodontol 2005;76:426-436.
    • (2005) J Periodontol , vol.76 , pp. 426-436
    • Mascarenhas, P.1    Gapski, R.2    Al-Shammari, K.3
  • 19
    • 33846931770 scopus 로고    scopus 로고
    • Clinical changes following four different periodontal therapies for the treatment of chronic periodontitis: 1-year results
    • Haffajee AD, Torresyap G, Socransky SS. Clinical changes following four different periodontal therapies for the treatment of chronic periodontitis: 1-year results. J Clin Periodontol 2007;34:243-253.
    • (2007) J Clin Periodontol , vol.34 , pp. 243-253
    • Haffajee, A.D.1    Torresyap, G.2    Socransky, S.S.3
  • 20
    • 33947675798 scopus 로고    scopus 로고
    • Effects of full-mouth scaling and root planing in conjunction with systemically administered azithromycin
    • Gomi K, Yashima A, Nagano T, Kanazashi M, Maeda N, Arai T. Effects of full-mouth scaling and root planing in conjunction with systemically administered azithromycin. J Periodontol 2007;78:422-429.
    • (2007) J Periodontol , vol.78 , pp. 422-429
    • Gomi, K.1    Yashima, A.2    Nagano, T.3    Kanazashi, M.4    Maeda, N.5    Arai, T.6
  • 21
    • 69949133697 scopus 로고    scopus 로고
    • One-stage fullmouth versus partial-mouth scaling and root planing during the effective half-life of systemically administered azithromycin
    • Yashima A, Gomi K, Maeda N, Arai T. One-stage fullmouth versus partial-mouth scaling and root planing during the effective half-life of systemically administered azithromycin. J Periodontol 2009;80:1406-1413.
    • (2009) J Periodontol , vol.80 , pp. 1406-1413
    • Yashima, A.1    Gomi, K.2    Maeda, N.3    Arai, T.4
  • 22
    • 35649027926 scopus 로고    scopus 로고
    • Effect of adjunctive systemic azithromycin with periodontal surgery in the treatment of chronic periodontitis in smokers: A pilot study
    • Dastoor SF, Travan S, Neiva RF, Rayburn LA, Giannobile WV, Wang HL. Effect of adjunctive systemic azithromycin with periodontal surgery in the treatment of chronic periodontitis in smokers: A pilot study. J Periodontol 2007;78:1887-1896.
    • (2007) J Periodontol , vol.78 , pp. 1887-1896
    • Dastoor, S.F.1    Travan, S.2    Neiva, R.F.3    Rayburn, L.A.4    Giannobile, W.V.5    Wang, H.L.6
  • 23
    • 78449241311 scopus 로고    scopus 로고
    • Azithromycin as an adjunct to scaling and root planing in the treatment of Porphyromonas gingivalisassociated periodontitis: A pilot study
    • Oteo A, Herrera D, Figuero E, O'Connor A, Gonzá lez I, Sanz M. Azithromycin as an adjunct to scaling and root planing in the treatment of Porphyromonas gingivalisassociated periodontitis: A pilot study. J Clin Periodontol 2010;37:1005-1015.
    • (2010) J Clin Periodontol , vol.37 , pp. 1005-1015
    • Oteo, A.1    Herrera, D.2    Figuero, E.3    O'Connor, A.4    Gonzá Lez, I.5    Sanz, M.6
  • 24
    • 47849129519 scopus 로고    scopus 로고
    • Azithromycin as an adjunctive treatment of aggressive periodontitis: 12-months randomized clinical trial
    • Haas AN, de Castro GD, Moreno T, et al. Azithromycin as an adjunctive treatment of aggressive periodontitis: 12-months randomized clinical trial. J Clin Periodontol 2008;35:696-704.
    • (2008) J Clin Periodontol , vol.35 , pp. 696-704
    • Haas, A.N.1    De Castro, G.D.2    Moreno, T.3
  • 25
    • 80051787065 scopus 로고    scopus 로고
    • Clinical and microbiological effects of azithromycin in the treatment of generalized chronic periodontitis: A randomized placebo-controlled clinical trial
    • Sampaio E, Rocha M, Figueiredo LC, et al. Clinical and microbiological effects of azithromycin in the treatment of generalized chronic periodontitis: A randomized placebo-controlled clinical trial. J Clin Periodontol 2011;38:838-846.
    • (2011) J Clin Periodontol , vol.38 , pp. 838-846
    • Sampaio, E.1    Rocha, M.2    Figueiredo, L.C.3
  • 27
    • 0022155655 scopus 로고
    • Development of a biochemical profile for gingival crevicular fluid. Methodological considerations and evaluation of collagendegrading and ground substance-degrading enzyme activity during experimental gingivitis
    • Lamster IB, Hartley LJ, Vogel RI. Development of a biochemical profile for gingival crevicular fluid. Methodological considerations and evaluation of collagendegrading and ground substance-degrading enzyme activity during experimental gingivitis. J Periodontol 1985;56(Suppl. 11):13-21.
    • (1985) J Periodontol , vol.56 , Issue.11 , pp. 13-21
    • Lamster, I.B.1    Hartley, L.J.2    Vogel, R.I.3
  • 28
    • 0002641211 scopus 로고
    • Method of collection
    • Basel: Karger
    • Cimasoni G. Method of collection. In: Crevicular Fluid Updated. Basel: Karger;1983:29-36.
    • (1983) Crevicular Fluid Updated , pp. 29-36
    • Cimasoni, G.1
  • 29
    • 15444347160 scopus 로고    scopus 로고
    • Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-α and doxycycline
    • Hanemaaijer R, Sorsa T, Konttinen YT, et al. Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-α and doxycycline. J Biol Chem 1997;272:31504-31509.
    • (1997) J Biol Chem , vol.272 , pp. 31504-31509
    • Hanemaaijer, R.1    Sorsa, T.2    Konttinen, Y.T.3
  • 30
    • 79955959967 scopus 로고    scopus 로고
    • Anti-microbial effect of adjunctive use of chlorhexidine mouthrinse in untreated gingivitis: A randomized, placebo-controlled study
    • Becerik S, Türkoglu O, Emingil G, Vural C, Özdemir G, Atilla G. Anti-microbial effect of adjunctive use of chlorhexidine mouthrinse in untreated gingivitis: A randomized, placebo-controlled study. APMIS 2011;119:364-372.
    • (2011) APMIS , vol.119 , pp. 364-372
    • Becerik, S.1    Türkoglu, O.2    Emingil, G.3    Vural, C.4    Özdemir, G.5    Atilla, G.6
  • 31
    • 0034184932 scopus 로고    scopus 로고
    • Parameter on chronic periodontitis with slight to moderate loss of periodontal support
    • American Academy of Periodontology
    • American Academy of Periodontology. Parameter on chronic periodontitis with slight to moderate loss of periodontal support. J Periodontol 2000;71(Suppl. 5): 853-855.
    • (2000) J Periodontol , vol.71 , Issue.5 , pp. 853-855
  • 32
    • 0034182982 scopus 로고    scopus 로고
    • Parameter on chronic periodontitis with advanced loss of periodontal support
    • American Academy of Periodontology
    • American Academy of Periodontology. Parameter on chronic periodontitis with advanced loss of periodontal support. J Periodontol 2000;71(Suppl. 5):856-858.
    • (2000) J Periodontol , vol.71 , Issue.5 , pp. 856-858
  • 33
    • 0030278547 scopus 로고    scopus 로고
    • Non-surgical pocket therapy: Mechanical
    • Cobb CM. Non-surgical pocket therapy: Mechanical. Ann Periodontol 1996;1:443-490.
    • (1996) Ann Periodontol , vol.1 , pp. 443-490
    • Cobb, C.M.1
  • 34
    • 0036835862 scopus 로고    scopus 로고
    • Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss
    • Hung HC, Douglass CW. Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss. J Clin Periodontol 2002;29:975-986.
    • (2002) J Clin Periodontol , vol.29 , pp. 975-986
    • Hung, H.C.1    Douglass, C.W.2
  • 35
    • 3142566118 scopus 로고
    • Metronidazole in periodontitis V: Debridement should precede medication
    • 1201, 1203 passim, quiz 1218
    • Loesche WJ, Giordano JR. Metronidazole in periodontitis V: Debridement should precede medication. Compendium 1994;15: 1198-1201, 1201, 1203 passim, quiz 1218.
    • (1994) Compendium , vol.15 , pp. 1198-1201
    • Loesche, W.J.1    Giordano, J.R.2
  • 36
    • 0036359947 scopus 로고    scopus 로고
    • Dental biofilms: Difficult therapeutic targets
    • Socransky SS, Haffajee AD. Dental biofilms: Difficult therapeutic targets. Periodontol 2000 2002;28:12-55.
    • (2002) Periodontol 2000 , vol.28 , pp. 12-55
    • Socransky, S.S.1    Haffajee, A.D.2
  • 37
    • 50249119670 scopus 로고    scopus 로고
    • Group A of European Workshop on Periodontology. Innovations in non-surgical periodontal therapy: Consensus Report of the Sixth European Workshop on Periodontology
    • Sanz M, Teughels W; Group A of European Workshop on Periodontology. Innovations in non-surgical periodontal therapy: Consensus Report of the Sixth European Workshop on Periodontology. J Clin Periodontol 2008;35(Suppl. 8):3-7.
    • (2008) J Clin Periodontol , vol.35 , Issue.8 , pp. 3-7
    • Sanz, M.1    Teughels, W.2
  • 38
    • 0141560401 scopus 로고    scopus 로고
    • Gingival crevicular fluid collagenase-2 (MMP-8) test stick for chair-side monitoring of periodontitis
    • Mäntylä P, Stenman M, Kinane DF, et al. Gingival crevicular fluid collagenase-2 (MMP-8) test stick for chair-side monitoring of periodontitis. J Periodontal Res 2003;38:436-439.
    • (2003) J Periodontal Res , vol.38 , pp. 436-439
    • Mäntylä, P.1    Stenman, M.2    Kinane, D.F.3
  • 39
    • 74049098607 scopus 로고    scopus 로고
    • Gingival crevicular fluid levels of MMP-8, MMP-9, TIMP-2, and MPO decrease after periodontal therapy
    • Marcaccini AM, Meschiari CA, Zuardi LR, et al. Gingival crevicular fluid levels of MMP-8, MMP-9, TIMP-2, and MPO decrease after periodontal therapy. J Clin Periodontol 2010;37:180-190.
    • (2010) J Clin Periodontol , vol.37 , pp. 180-190
    • Marcaccini, A.M.1    Meschiari, C.A.2    Zuardi, L.R.3
  • 40
    • 0026847143 scopus 로고
    • The bacterial etiology of destructive periodontal disease: Current concepts
    • Socransky SS, Haffajee AD. The bacterial etiology of destructive periodontal disease: Current concepts. J Periodontol 1992;63(Suppl. 4):322-331.
    • (1992) J Periodontol , vol.63 , Issue.4 , pp. 322-331
    • Socransky, S.S.1    Haffajee, A.D.2
  • 42
    • 33747826870 scopus 로고    scopus 로고
    • The effect of periodontal therapy on the composition of the subgingival microbiota
    • Haffajee AD, Teles RP, Socransky SS. The effect of periodontal therapy on the composition of the subgingival microbiota. Periodontol 2000 2006;42:219-258.
    • (2006) Periodontol 2000 , vol.42 , pp. 219-258
    • Haffajee, A.D.1    Teles, R.P.2    Socransky, S.S.3
  • 44
    • 0027675350 scopus 로고
    • In vitro antimicrobial susceptibility of Porphyromonas gingivalis to azithromycin, A novel macrolide
    • Pajukanta R. In vitro antimicrobial susceptibility of Porphyromonas gingivalis to azithromycin, A novel macrolide. Oral Microbiol Immunol 1993;8:325-326.
    • (1993) Oral Microbiol Immunol , vol.8 , pp. 325-326
    • Pajukanta, R.1
  • 45
    • 0030279506 scopus 로고    scopus 로고
    • Azithromycin in the treatment of periodontal disease. Effect on microbial flora
    • Sefton AM, Maskell JP, Beighton D, et al. Azithromycin in the treatment of periodontal disease. Effect on microbial flora. J Clin Periodontol 1996;23:998-1003.
    • (1996) J Clin Periodontol , vol.23 , pp. 998-1003
    • Sefton, A.M.1    Maskell, J.P.2    Beighton, D.3
  • 46
    • 0034184711 scopus 로고    scopus 로고
    • Parameter on periodontal maintenance
    • American Academy of Periodontology
    • American Academy of Periodontology. Parameter on periodontal maintenance. J Periodontol 2000;71 (Suppl. 5):849-850.
    • (2000) J Periodontol , vol.71 , Issue.5 , pp. 849-850
  • 47
    • 0036548510 scopus 로고    scopus 로고
    • Adjunctive effects to non-surgical periodontal therapy of systemic metronidazole and amoxycillin alone and combined. A placebo controlled study
    • Rooney J, Wade WG, Sprague SV, Newcombe RG, Addy M. Adjunctive effects to non-surgical periodontal therapy of systemic metronidazole and amoxycillin alone and combined. A placebo controlled study. J Clin Periodontol 2002;29:342-350.
    • (2002) J Clin Periodontol , vol.29 , pp. 342-350
    • Rooney, J.1    Wade, W.G.2    Sprague, S.V.3    Newcombe, R.G.4    Addy, M.5


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