Adjunctive effects to non-surgical periodontal therapy of systemic metronidazole and amoxycillin alone and combined: A placebo controlled study

Journal of Clinical Periodontology

Volumn 29, Issue 4, 2002, Pages 342-350

  Rooney, J ^a   Wade, W G ^b   Sprague, S V ^a   Newcombe, R G ^c   Addy, M ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Amoxycillin; Clinical trial; Metronidazole; Non surgical periodontal therapy; Periodontal disease; Systemic chemotherapy

Indexed keywords

AMOXICILLIN; ANTIINFECTIVE AGENT; METRONIDAZOLE; PENICILLIN DERIVATIVE; PLACEBO;

ABSCESS; ADULT; ANALYSIS OF VARIANCE; ARTICLE; BACTERIAL COUNT; CHRONIC DISEASE; CLASSIFICATION; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG COMBINATION; DRUG EFFECT; FOLLOW UP; GINGIVA BLEEDING; GROWTH, DEVELOPMENT AND AGING; HUMAN; MICROBIOLOGY; MICROCAPSULE; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; PERIODONTAL DISEASE; PERIODONTITIS; PREVENTIVE DENTISTRY; PREVOTELLA INTERMEDIA; RANDOMIZED CONTROLLED TRIAL; STATISTICAL MODEL; TABLET; TOOTH PLAQUE; TREATMENT OUTCOME;

ADULT; AMOXICILLIN; ANALYSIS OF VARIANCE; ANTI-BACTERIAL AGENTS; CAPSULES; CHRONIC DISEASE; COLONY COUNT, MICROBIAL; COMBINED MODALITY THERAPY; DENTAL PLAQUE; DENTAL SCALING; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; FOLLOW-UP STUDIES; GINGIVAL HEMORRHAGE; HUMANS; LINEAR MODELS; METRONIDAZOLE; MIDDLE AGED; PENICILLINS; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL DISEASES; PERIODONTAL POCKET; PLACEBOS; PREVOTELLA INTERMEDIA; ROOT PLANING; SUPPURATION; TABLETS; TREATMENT OUTCOME;

EID: 0036548510     PISSN: 03036979     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-051X.2002.290410.x     Document Type: Article

References (27)

1. Addy, M. & Renton-Harper, P (1996) Local and systemic chemotherapy in the management of periodontal disease. An opinion and review of the concept. Journal of Oral Rehabilitation 23, 219-231.
2. Baelum, V., Fejerskov, O. & Karring, T. (1986) Oral Hygiene, gingivitis and periodontal breakdown in adult Tanzanians. Journal of Periodontal Research 21, 221-232.
3. Berglundh, T., Krok, L., Liljenberg, B., Westfelt, E., Serino, G. & Lindhe, J. (1998) The use of metronidazole and amoxycillin in the treatment of advanced periodontal disease. A prospective, controlled clinical trial. Journal of Clinical Periodontology 25, 354-362.
4. Bowden, G. H. & Hardie, J. M. (1971) Anaerobic organisms from the human mouth. In: Shapton, D. A. & Board, R. G., eds. Isolation of anaerobes. London: Academic Press, 177-205.
5. Consensus Report (1996) Periodontal diseases: pathogenesis and microbial factors. Proceeding of the 1996 World Workshop in Periodontics. Annals of Periodontology 1, 926-932.
6. Cutress, T. W., Powell, R. N. & Ball, M. E. (1982) Differing profiles of periodontal disease in two similar South Pacific island populations. Community Dentistry and Oral Epidemiology 10, 193-203.
7. Flemmig, T. F., Milian, E., Karch, H. & Klaiber, B. (1998a) Differential clinical treatment outcome after systemic metronidazole and amoxycillin in patients harbouring Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis. Journal of Clinical Periodontology 25, 380-387.
8. Flemmig, T. F., Milian, E., Kopp, C., Karch, H. & Klaiber, B. (1998b) Differential effects of systemic metronidazole and amoxycillin on Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in intraoral sites. Journal of Clinical Periodontology 25, 1-10.
9. Genco, R. J. (1981) Antibiotics in the treatment of human periodontal diseases. Journal of Periodontology 52, 545-558.
10. Goene, R. J., Winkel, E. G., Abbas, F., Rodenburg, J. P., van Winkelhoff, A. J. & de Graaff, J. (1990) Microbiology in diagnosis and treatment of severe periodontitis. A report of four cases. Journal of Periodontology 61, 61-64.
11. Gordon, J. M. & Walker, C. B. J. (1993) Current status of antibiotic usage in destructive periodontal disease. Journal of Periodontology 64, 760-771.
12. Greene, J. C. & Vermillion, J. R. (1960) Oral hygiene index: a method of classifying oral hygiene status. Journal of the American Dental Association 61, 172-179.
13. Haffajee, A. D. & Socransky, S. S. (1994) Microbial etiological agents of destructive periodontal diseases. Periodontology 2000 5, 78-111.
14. Lang, N. P., Joss, A., Orsanic, T., Gusberti, F. A. & Siegrist, E. (1986) Bleeding on probing; a predictor for the progression of periodontal disease. Journal of Clinical Periodontology 13, 590-596.
15. Lang, N. P., Adler, R., Joss, A. & Nyman, S. (1990) Absence of bleeding on probing. Journal of Clinical Periodontology 17, 714-721.
16. Loesche, W. J., Lopatin, D. E., Stoll, J., van Poperin, N. & Hujoel, P. P. (1992) Comparison of various detection methods for periodontopathic bacteria - can culture be considered the primary reference-standard? Journal of Clinical Microbiology 30, 418-426.
17. Mombelli, A. W. & van Winkelhoff, A. J. (1997) The systemic use of antibiotics in periodontal therapy. In: Proceedings of the 2nd European Workshop on Periodontology. eds. Lang, N. P., Karring, T. & Lindhe, J., pp. 38-77. Quintessence: Berlin.
18. Moore, W. E. C. & Moore, L. V. H. (1994) The bacteria of periodontal diseases. Periodontology 2000 5, 66-77.
19. Papapanou, P., Wennstrom, J. L. & Grondahl, K. (1988) Periodontal status in relation to age and tooth type: a cross-sectional radiographic study. Journal of Clinical Periodontology 15, 469-478.
20. Papapanou, P. N. (1996) Periodontal Diseases: Epidemiology. Proceedings of the 1996 World Workshop in Periodontics. Annals of Periodontology 1, 1-36.
21. Pavicic, M. J. A. M. P., Van Winkelhoff, A. J., Douque, N. H., Steures, R.W.R. & de Graaff, J. (1994) Microbiological and clinical effects of metronidazole and amoxycillin in Actinobacillus actinomycetemcomitans-associated periodontitis. Journal of Clinical Periodontology 21, 107-112.
22. Slots, J. (1982) Selective medium for isolation of Actinobacillus actinomycetemcomitans. Journal of Clinical Microbiology 15, 606-609.
23. Slots, J. & Rams, T. E. (1990) Antibiotics in periodontal therapy: advantages and disadvantages. Journal of Clinical Periodontology 17, 479-493.
24. Van Winkelhoff, A. A., Rodenburg, J. J., Goene, R. R., Abbas, F., Winkel, E. G. & De Graaff, J. (1989) Metronidazole plus amoxycillin in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis. Journal of Clinical Periodontology 16, 128-131.
25. Van Winkelhoff, A. J., Tijhof, C. J. & De Graaff, J. (1992) Microbiological and clinical results of metronidazole plus amoxycillin therapy in Actinobacillus actinomycetemcomitans associated periodontitis. Journal of Periodontology 63, 52-57.
26. Winkel, E. G., van Winkelhoff, A. J. & van der Velden, U. (1998) Additional clinical and microbiological effects of amoxycillin and metronidazole after initial periodontal therapy. Journal of Clinical Periodontology 25, 857-865.
27. Zambon, J. J. (1996) Periodontal Diseases: Microbial factors. Proceedings of the 1996 World Workshop in Periodontics. Annals of Periodontology 1, 879-925.