Design, synthesis and bioevalution of novel benzamides derivatives as HDAC inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 1, 2013, Pages 179-182

  Li, Yanyang ^a,b   Zhou, Yan ^b   Qian, Pengyu ^c   Wang, Yongzhen ^b   Jiang, Falong ^b   Yao, Zhenglin ^b   Hu, Wenxiang ^d   Zhao, Yanjin ^b   Li, Shuxin ^b,c  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^c JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^d CAPITAL NORMAL UNIVERSITY   (China)

Author keywords

Antiproliferative activity; Benzamide derivatives; Bioavailability; HDAC

Indexed keywords

ANTINEOPLASTIC AGENT; BENZAMIDE DERIVATIVE; HISTONE DEACETYLASE INHIBITOR; MOCETINOSTAT;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; IC 50; IN VITRO STUDY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZAMIDES; CELL LINE, TUMOR; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; DRUG SCREENING ASSAYS, ANTITUMOR; HALF-LIFE; HCT116 CELLS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; MCF-7 CELLS; PYRIMIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 84871024364     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.10.114     Document Type: Article

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