Novel carbocyclic nucleoside analogs suppress glomerular mesangial cells proliferation and matrix protein accumulation through ROS-dependent mechanism in the diabetic milieu

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 1, 2013, Pages 174-178

  Eid, Assaad A ^a   Koubeissi, Ali ^a   Bou Mjahed, Ribal ^a   Khalil, Nadine Al ^a   Farah, Manal ^a   Maalouf, Rita ^b   Nasser, Niveen ^a   Bouhadir, Kamal H ^a  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^b NOTRE DAME UNIVERSITY   (Lebanon)

Author keywords

Carbocyclic nucleosides; Diabetic nephropathy; Mitsunobu reaction; Thymine; Uracil

Indexed keywords

CARBOCYCLIC NUCLEOSIDE; MATRIX PROTEIN; REACTIVE OXYGEN METABOLITE; THYMINE; URACIL;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL PROLIFERATION; DIABETIC NEPHROPATHY; DRUG STRUCTURE; DRUG SYNTHESIS; GLOMERULUS; IN VITRO STUDY; MESANGIUM CELL; MITSUNOBU REACTION; MOLECULE; NONHUMAN; RAT;

ACTINS; ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; DIABETIC NEUROPATHIES; EXTRACELLULAR MATRIX PROTEINS; FIBRONECTINS; GLOMERULAR MESANGIUM; GLUCOSE; NUCLEOSIDES; RATS; REACTIVE OXYGEN SPECIES;

EID: 84871016522     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.10.122     Document Type: Article

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