Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 1, 2013, Pages 360-365

  Ruchelman, Alexander L ^a   Man, Hon Wah ^a   Zhang, Weihong ^a   Chen, Roger ^a   Capone, Lori ^a   Kang, Jian ^a   Parton, Anastasia ^a   Corral, Laura ^a   Schafer, Peter H ^a   Babusis, Darius ^a   Moghaddam, Mehran F ^a   Tang, Yang ^a   Shirley, Michael A ^a   Muller, George W ^a  

^a CELGENE CORPORATION   (United States)

Author keywords

Anti cancer; Immunomodulatory; Lenalidomide; Pomalidomide; Thalidomide; Tumor necrosis factor (TNF )

Indexed keywords

INTERLEUKIN 2; LENALIDOMIDE; LIPOPOLYSACCHARIDE; METHYL GROUP; POMALIDOMIDE; THALIDOMIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASSAY; CANCER CELL CULTURE; DRUG BIOAVAILABILITY; DRUG INHIBITION; DRUG POTENCY; DRUG SYNTHESIS; IMMUNOMODULATION; LYMPHOMA CELL LINE; NONHUMAN; RAT; T CELL CO STIMULATION ASSAY;

ADMINISTRATION, ORAL; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; HALF-LIFE; HUMANS; INTERLEUKIN-2; LEUKOCYTES, MONONUCLEAR; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES; THALIDOMIDE; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS;

EID: 84871009309     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.10.071     Document Type: Article

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