-
1
-
-
0033532557
-
Amino-substituted thalidomide analogs: Potent inhibitors of TNF-alpha production
-
DOI 10.1016/S0960-894X(99)00250-4, PII S0960894X99002504
-
Muller, G.W., Chen, R., Huang, S.-Y. et al. Amino-substituted thalidomide analogs: Potent inhibitors of TNF-alpha production. Bioorg Med Chem Lett 1999, 9(11): 1625-30. (Pubitemid 29274209)
-
(1999)
Bioorganic and Medicinal Chemistry Letters
, vol.9
, Issue.11
, pp. 1625-1630
-
-
Muller, G.W.1
Chen, R.2
Huang, S.-Y.3
Corral, L.G.4
Wong, L.M.5
Patterson, R.T.6
Chen, Y.7
Kaplan, G.8
Stirling, D.I.9
-
2
-
-
84952982573
-
-
(Celgene Corp.). EP 0925294, EP 1285916, EP 2070920, EP 2177517, EP 2305663, JP 2008050368, US 5635517, WO 1998003502
-
Stirling, D.I., Chen, R.S.-C., Muller, G.W. (Celgene Corp.). Substituted 2- (2,6-dioxopiperidin-3-yl)-phthalimides and -1-oxoisoindolines and method of reducing TNFalpha levels. EP 0925294, EP 1285916, EP 2070920, EP 2177517, EP 2305663, JP 2008050368, US 5635517, WO 1998003502.
-
Substituted 2- (2,6-dioxopiperidin-3-yl)-phthalimides and -1-oxoisoindolines and Method of Reducing TNFalpha Levels
-
-
Stirling, D.I.1
Chen, R.S.-C.2
Muller, G.W.3
-
3
-
-
84952981038
-
-
(Celgene Corp.). EP 1907373, JP 2008544993, US 2007004920, US 7994327, WO 2007005972
-
Muller, G.W., Saindane, M.T., Ge, C., Chen, R. (Celgene Corp.). Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3- dione compounds. EP 1907373, JP 2008544993, US 2007004920, US 7994327, WO 2007005972.
-
Processes for the Preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl) isoindoline-1,3- Dione Compounds
-
-
Muller, G.W.1
Saindane, M.T.2
Ge, C.3
Chen, R.4
-
4
-
-
84952985626
-
-
(Children's Medical Center Corp.). CA 2430669, EP 1353672, JP 2004536784, JP 2009108077, US 2004147558, US 7812169, WO 2002064083
-
Shah, J.H., Hunsucker, K.A., Conner, B.P. et al. (Children's Medical Center Corp.). Synthesis of 3-amino-thalidomide and its enantiomers. CA 2430669, EP 1353672, JP 2004536784, JP 2009108077, US 2004147558, US 7812169, WO 2002064083.
-
Synthesis of 3-amino-thalidomide and Its Enantiomers
-
-
Shah, J.H.1
Hunsucker, K.A.2
Conner, B.P.3
-
5
-
-
0026080801
-
Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes
-
Sampaio, E.P., Sarno, E.N., Galilly, R., Cohn, Z.A., Kaplan, G. Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes. J Exp Med 1991, 173(3): 699-703.
-
(1991)
J Exp Med
, vol.173
, Issue.3
, pp. 699-703
-
-
Sampaio, E.P.1
Sarno, E.N.2
Galilly, R.3
Cohn, Z.A.4
Kaplan, G.5
-
6
-
-
10344249371
-
Thalidomide-derived immunomodulatory drugs as therapeutic agents
-
DOI 10.1517/14712598.4.12.1963
-
Galustian, C., Labarthe, M.C., Bartlett, J.B., Dalgleish, A.G. Thalidomidederived immunomodulatory drugs as therapeutic agents. Expert Opin Biol Ther 2004, 4(12): 1963-70. (Pubitemid 39627147)
-
(2004)
Expert Opinion on Biological Therapy
, vol.4
, Issue.12
, pp. 1963-1970
-
-
Galustian, C.1
Labarthe, M.-C.2
Bartlett, J.B.3
Dalgleish, A.G.4
-
7
-
-
0036381106
-
Thalidomide and its analogues have distinct and opposing effects on TNF-alpha and TNFR2 during co-stimulation of both CD4(+) and CD8(+) T cells
-
Marriott, J.B., Clarke, I.A., Dredge, K., Muller, G., Stirling, D., Dalgleish, A.G. Thalidomide and its analogues have distinct and opposing effects on TNF-alpha and TNFR2 during co-stimulation of both CD4(+) and CD8(+) T cells. Clin Exp Immunol 2002, 130(1): 75-84.
-
(2002)
Clin Exp Immunol
, vol.130
, Issue.1
, pp. 75-84
-
-
Marriott, J.B.1
Clarke, I.A.2
Dredge, K.3
Muller, G.4
Stirling, D.5
Dalgleish, A.G.6
-
8
-
-
0037093854
-
Protective antitumor immunity induced by a costimulatory thalidomide analog in conjunction with whole tumor cell vaccination is mediated by increased Th1-type immunity
-
Dredge, K., Marriott, J.B., Todryk, S.M., Muller, G.W., Chen, R., Stirling, D.I., Dalgleish, A.G. Protective antitumor immunity induced by a costimulatory thalidomide analog in conjunction with whole tumor cell vaccination is mediated by increased Th1-type immunity. J Immunol 2002, 168(10): 4914-9. (Pubitemid 34495953)
-
(2002)
Journal of Immunology
, vol.168
, Issue.10
, pp. 4914-4919
-
-
Dredge, K.1
Marriott, J.B.2
Todryk, S.M.3
Muller, G.W.4
Chen, R.5
Stirling, D.I.6
Dalgleish, A.G.7
-
9
-
-
0038476461
-
Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs
-
DOI 10.1124/jpet.102.048496
-
Schafer, P.H., Gandhi, A.K., Loveland, M.A. et al. Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs. J Pharmacol Exp Ther 2003, 305(3): 1222-32. (Pubitemid 36618002)
-
(2003)
Journal of Pharmacology and Experimental Therapeutics
, vol.305
, Issue.3
, pp. 1222-1232
-
-
Schafer, P.H.1
Gandhi, A.K.2
Loveland, M.A.3
Chen, R.S.4
Man, H.-W.5
Schnetkamp, P.P.M.6
Wolbring, G.7
Govinda, S.8
Corral, L.G.9
Payvandi, F.10
Muller, G.W.11
Stirling, D.I.12
-
10
-
-
27144458424
-
Immunomodulatory drugs (IMiDs) increase the production of IL-2 from stimulated T cells by increasing PKC-theta activation and enhancing the DNA-binding activity of AP-1 but not NF-kappaB, OCT-1, or NF-AT
-
DOI 10.1089/jir.2005.25.604
-
Payvandi, F., Wu, L., Naziruddin, S.D. et al. Immunomodulatory drugs (IMiDs) increase the production of IL-2 from stimulated T cells by increasing PKCtheta activation and enhancing the DNA-binding activity of AP-1 but not NFkappaB, OCT-1, or NF-AT. J Interferon Cytokine Res 2005, 25(10): 604-16. (Pubitemid 41507816)
-
(2005)
Journal of Interferon and Cytokine Research
, vol.25
, Issue.10
, pp. 604-616
-
-
Payvandi, F.1
Wu, L.2
Naziruddin, S.D.3
Haley, M.4
Parton, A.5
Schafer, P.H.6
Chen, R.S.7
Muller, G.W.8
Hughes, C.C.W.9
Stirling, D.I.10
-
11
-
-
49249117801
-
CC-4047 promotes Th1 cell differentiation and reprograms polarized human Th2 cells by enhancing transcription factor T-bet
-
Xu, W., Celeridad, M., Sankar, S., Webb, D.R., Bennett, B.L. CC-4047 promotes Th1 cell differentiation and reprograms polarized human Th2 cells by enhancing transcription factor T-bet. Clin Immunol 2008, 128(3): 392-9.
-
(2008)
Clin Immunol
, vol.128
, Issue.3
, pp. 392-399
-
-
Xu, W.1
Celeridad, M.2
Sankar, S.3
Webb, D.R.4
Bennett, B.L.5
-
12
-
-
77951820013
-
Dysregulation in T helper 1/T helper 2 cytokine ratios in patients with multiple myeloma
-
Sharma, A., Khan, R., Joshi, S., Kumar, L., Sharma, M. Dysregulation in T helper 1/T helper 2 cytokine ratios in patients with multiple myeloma. Leuk Lymphoma 2010, 51(5): 920-7.
-
(2010)
Leuk Lymphoma
, vol.51
, Issue.5
, pp. 920-927
-
-
Sharma, A.1
Khan, R.2
Joshi, S.3
Kumar, L.4
Sharma, M.5
-
13
-
-
78049386125
-
Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma
-
Gorgun, G., Calabrese, E., Soydan, E. et al. Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma. Blood 2010, 116(17): 3227-37.
-
(2010)
Blood
, vol.116
, Issue.17
, pp. 3227-3237
-
-
Gorgun, G.1
Calabrese, E.2
Soydan, E.3
-
14
-
-
67349107194
-
The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells
-
Galustian, C., Meyer, B., Labarthe, M.C. et al. The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells. Cancer Immunol Immunother 2009, 58(7): 1033-45.
-
(2009)
Cancer Immunol Immunother
, vol.58
, Issue.7
, pp. 1033-1045
-
-
Galustian, C.1
Meyer, B.2
Labarthe, M.C.3
-
15
-
-
52549088421
-
Immunomodulatory drugs Revlimid((R)) (lenalidomide) and CC-4047 induce apoptosis of both hematological and solid tumor cells through NK cell activation
-
Zhu, D., Corral, L.G., Fleming, Y.W., Stein, B. Immunomodulatory drugs Revlimid((R)) (lenalidomide) and CC-4047 induce apoptosis of both hematological and solid tumor cells through NK cell activation. Cancer Immunol Immunother 2008, 57(12): 1849-59.
-
(2008)
Cancer Immunol Immunother
, vol.57
, Issue.12
, pp. 1849-1859
-
-
Zhu, D.1
Corral, L.G.2
Fleming, Y.W.3
Stein, B.4
-
16
-
-
36849024949
-
Immunomodulatory drugs stimulate natural killer-cell function, alter cytokine production by dendritic cells, and inhibit angiogenesis enhancing the anti-tumour activity of rituximab in vivo
-
DOI 10.1111/j.1365-2141.2007.06841.x
-
Reddy, N., Hernandez-Ilizaliturri, F.J., Deeb, G. et al. Immunomodulatory drugs stimulate natural killer-cell function, alter cytokine production by dendritic cells, and inhibit angiogenesis enhancing the anti-tumour activity of rituximab in vivo. Br J Haematol 2008, 140(1): 36-45. (Pubitemid 350233246)
-
(2008)
British Journal of Haematology
, vol.140
, Issue.1
, pp. 36-45
-
-
Reddy, N.1
Hernandez-Ilizaliturri, F.J.2
Deeb, G.3
Roth, M.4
Vaughn, M.5
Knight, J.6
Wallace, P.7
Czuczman, M.S.8
-
17
-
-
77955415749
-
The proteasome inhibitor bortezomib disrupts tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression and natural killer (NK) cell killing of TRAIL receptor-positive multiple myeloma cells
-
Feng, X., Yan, J., Wang, Y. et al. The proteasome inhibitor bortezomib disrupts tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression and natural killer (NK) cell killing of TRAIL receptor-positive multiple myeloma cells. Mol Immunol, 47(14): 2388-96.
-
Mol Immunol
, vol.47
, Issue.14
, pp. 2388-2396
-
-
Feng, X.1
Yan, J.2
Wang, Y.3
-
18
-
-
33748564972
-
Immune parameters in multiple myeloma patients: Influence of treatment and correlation with opportunistic infections
-
DOI 10.1080/10428190500472503, PII N4K226U111571971
-
Schutt, P., Brandhorst, D., Stellberg, W. et al. Immune parameters in multiple myeloma patients: Influence of treatment and correlation with opportunistic infections. Leuk Lymphoma 2006, 47(8): 1570-82. (Pubitemid 44364023)
-
(2006)
Leukemia and Lymphoma
, vol.47
, Issue.8
, pp. 1570-1582
-
-
Schutt, P.1
Brandhorst, D.2
Stellberg, W.3
Poser, M.4
Ebeling, P.5
Muller, S.6
Buttkereit, U.7
Opalka, B.8
Lindemann, M.9
Grosse-Wilde, H.10
Seeber, S.11
Moritz, T.12
Nowrousian, M.R.13
-
19
-
-
33646421393
-
Bortezomib induces selective depletion of alloreactive T lymphocytes and decreases the production of Th1 cytokines
-
Blanco, B., Perez-Simon, J.A., Sanchez-Abarca, L.I. et al. Bortezomib induces selective depletion of alloreactive T lymphocytes and decreases the production of Th1 cytokines. Blood 2006, 107(9): 3575-83.
-
(2006)
Blood
, vol.107
, Issue.9
, pp. 3575-3583
-
-
Blanco, B.1
Perez-Simon, J.A.2
Sanchez-Abarca, L.I.3
-
20
-
-
67650767034
-
Treatment with bortezomib of human CD4+ T cells preserves natural regulatory T cells and allows the emergence of a distinct suppressor T-cell population
-
Blanco, B., Perez-Simon, J.A., Sanchez-Abarca, L.I. et al. Treatment with bortezomib of human CD4+ T cells preserves natural regulatory T cells and allows the emergence of a distinct suppressor T-cell population. Haematologica 2009, 94(7): 975-83.
-
(2009)
Haematologica
, vol.94
, Issue.7
, pp. 975-983
-
-
Blanco, B.1
Perez-Simon, J.A.2
Sanchez-Abarca, L.I.3
-
21
-
-
0034331194
-
Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy
-
Hideshima, T., Chauhan, D., Shima, Y. et al. Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy. Blood 2000, 96(9): 2943-50.
-
(2000)
Blood
, vol.96
, Issue.9
, pp. 2943-2950
-
-
Hideshima, T.1
Chauhan, D.2
Shima, Y.3
-
22
-
-
33749331571
-
The thalidomide analogue, CC-4047, induces apoptosis signaling and growth arrest in childhood acute lymphoblastic leukemia cells in vitro and in vivo
-
DOI 10.1158/1078-0432.CCR-06-0719
-
Shalapour, S., Zelmer, A., Pfau, M. et al. The thalidomide analogue, CC- 4047, induces apoptosis signaling and growth arrest in childhood acute lymphoblastic leukemia cells in vitro and in vivo. Clin Cancer Res 2006, 12(18): 5526-32. (Pubitemid 44497270)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.18
, pp. 5526-5532
-
-
Shalapour, S.1
Zelmer, A.2
Pfau, M.3
Moderegger, E.4
Costa-Blechschmidt, C.5
Van Landeghem, F.K.H.6
Taube, T.7
Fichtner, I.8
Buhrer, C.9
Henze, G.10
Seeger, K.11
Wellmann, S.12
-
23
-
-
81155138586
-
The anti-proliferative effect of lenalidomide on MM cells in-vitro is ameliorated by prior exposure to pomalidomide, and agent with activity against lenalidmode resistant MM cells
-
st Annu Meet Am Soc Hematol (Dec 5-8, New Orleans) 2009] Abst 4926
-
st Annu Meet Am Soc Hematol (Dec 5-8, New Orleans) 2009] 2009, 114(22): Abst 4926.
-
(2009)
Blood
, vol.114
, Issue.22
-
-
Adams, M.1
Schafer, P.2
Bartlett, J.B.3
-
24
-
-
70349739288
-
Pomalidomide and lenalidomide induce p21 WAF-1 expression in both lymphoma and multiple myeloma through a LSD1-mediated epigenetic mechanism
-
Escoubet-Lozach, L., Lin, I.L., Jensen-Pergakes, K. et al. Pomalidomide and lenalidomide induce p21 WAF-1 expression in both lymphoma and multiple myeloma through a LSD1-mediated epigenetic mechanism. Cancer Res 2009, 69(18): 7347-56.
-
(2009)
Cancer Res
, vol.69
, Issue.18
, pp. 7347-7356
-
-
Escoubet-Lozach, L.1
Lin, I.L.2
Jensen-Pergakes, K.3
-
25
-
-
84952979984
-
Pomalidomide inhibits MM proliferation in vitro via enhanced expression of tumor suppressor genes
-
Schafer, P.H., Zhang, L.H., Muller, G., Stirling, D., Bartlett, B. Pomalidomide inhibits MM proliferation in vitro via enhanced expression of tumor suppressor genes. Clin Lymphoma Myeloma & Leukemia 2009, 9(Suppl. 1): B447.
-
(2009)
Clin Lymphoma Myeloma & Leukemia
, vol.9
, Issue.SUPPL. 1
-
-
Schafer, P.H.1
Zhang, L.H.2
Muller, G.3
Stirling, D.4
Bartlett, B.5
-
26
-
-
79955969732
-
IMiD(R) immunomodulatory compounds block C/EBP{beta} translation through eIF4E downregulation resulting in inhibition of MM
-
Li, S., Pal, R., Monaghan, S.A. et al. IMiD(R) immunomodulatory compounds block C/EBP{beta} translation through eIF4E downregulation resulting in inhibition of MM. Blood 2011, 117(19): 5157-65.
-
(2011)
Blood
, vol.117
, Issue.19
, pp. 5157-5165
-
-
Li, S.1
Pal, R.2
Monaghan, S.A.3
-
27
-
-
33846665934
-
+ progenitor cells
-
DOI 10.1158/0008-5472.CAN-06-2317
-
Verhelle, D., Corral, L.G., Wong, K. et al. Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells. Cancer Res 2007, 67(2): 746-55. (Pubitemid 46192215)
-
(2007)
Cancer Research
, vol.67
, Issue.2
, pp. 746-755
-
-
Verhelle, D.1
Corral, L.G.2
Wong, K.3
Mueller, J.H.4
Parseval, L.M.-D.5
Jensen-Pergakes, K.6
Schafer, P.H.7
Chen, R.8
Glezer, E.9
Ferguson, G.D.10
Lopez-Girona, A.11
Muller, G.W.12
Brady, H.A.13
Chan, K.W.H.14
-
28
-
-
33645736007
-
Thalidomide derivative CC- 4047 inhibits osteoclast formation by down-regulation of PU.1
-
Anderson, G., Gries, M., Kurihara, N. et al. Thalidomide derivative CC- 4047 inhibits osteoclast formation by down-regulation of PU.1. Blood 2006, 107(8): 3098-105.
-
(2006)
Blood
, vol.107
, Issue.8
, pp. 3098-3105
-
-
Anderson, G.1
Gries, M.2
Kurihara, N.3
-
29
-
-
0037097595
-
Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: Therapeutic implications
-
DOI 10.1182/blood.V99.12.4525
-
Mitsiades, N., Mitsiades, C.S., Poulaki, V. et al. Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: Therapeutic implications. Blood 2002, 99(12): 4525-30. (Pubitemid 34627223)
-
(2002)
Blood
, vol.99
, Issue.12
, pp. 4525-4530
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Poulaki, V.3
Chauhan, D.4
Richardson, P.G.5
Hideshima, T.6
Munshi, N.C.7
Treon, S.P.8
Anderson, K.C.9
-
30
-
-
70249135225
-
Inhibition of metastatic potential in colorectal carcinoma in vivo and in vitro using immunomodulatory drugs (IMiDs)
-
Liu, W.M., Henry, J.Y., Meyer, B., Bartlett, J.B., Dalgleish, A.G., Galustian, C. Inhibition of metastatic potential in colorectal carcinoma in vivo and in vitro using immunomodulatory drugs (IMiDs). Br J Cancer 2009, 101(5): 803-12.
-
(2009)
Br J Cancer
, vol.101
, Issue.5
, pp. 803-812
-
-
Liu, W.M.1
Henry, J.Y.2
Meyer, B.3
Bartlett, J.B.4
Dalgleish, A.G.5
Galustian, C.6
-
31
-
-
20144375457
-
Orally administered lenalidomide (CC-5013) is anti-angiogenic in vivo and inhibits endothelial cell migration and Akt phosphorylation in vitro
-
DOI 10.1016/j.mvr.2005.01.002
-
Dredge, K., Horsfall, R., Robinson, S.P. et al. Orally administered lenalidomide (CC-5013) is anti-angiogenic in vivo and inhibits endothelial cell migration and Akt phosphorylation in vitro. Microvasc Res 2005, 69(1-2): 56-63. (Pubitemid 40410468)
-
(2005)
Microvascular Research
, vol.69
, Issue.1-2
, pp. 56-63
-
-
Dredge, K.1
Horsfall, R.2
Robinson, S.P.3
Zhang, L.-H.4
Lu, L.5
Tang, Y.6
Shirley, M.A.7
Muller, G.8
Schafer, P.9
Stirling, D.10
Dalgleish, A.G.11
Bartlett, J.B.12
-
32
-
-
60449115552
-
The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions
-
Lu, L., Payvandi, F., Wu, L. et al. The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions. Microvasc Res 2009, 77(2): 78-86.
-
(2009)
Microvasc Res
, vol.77
, Issue.2
, pp. 78-86
-
-
Lu, L.1
Payvandi, F.2
Wu, L.3
-
33
-
-
0035195019
-
Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: Therapeutic applications
-
Gupta, D., Treon, S.P., Shima, Y. et al. Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: Therapeutic applications. Leukemia 2001, 15(12): 1950-61. (Pubitemid 33115003)
-
(2001)
Leukemia
, vol.15
, Issue.12
, pp. 1950-1961
-
-
Gupta, D.1
Treon, S.P.2
Shima, Y.3
Hideshima, T.4
Podar, K.5
Tai, Y.T.6
Lin, B.7
Lentzsch, S.8
Davies, F.E.9
Chauhan, D.10
Schlossman, R.L.11
Richardson, P.12
Ralph, P.13
Wu, L.14
Payvandi, F.15
Muller, G.16
Stirling, D.I.17
Anderson, K.C.18
-
34
-
-
67651111993
-
Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases
-
Xu, Y., Li, J., Ferguson, G.D. et al. Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases. Blood 2009, 114(2): 338-45.
-
(2009)
Blood
, vol.114
, Issue.2
, pp. 338-345
-
-
Xu, Y.1
Li, J.2
Ferguson, G.D.3
-
35
-
-
34547591127
-
Cancer prevention by dietary bioactive components that target the immune response
-
DOI 10.2174/156800907781386605
-
Ferguson, L.R., Philpott, M. Cancer prevention by dietary bioactive components that target the immune response. Curr Cancer Drug Targets 2007, 7(5): 459-64. (Pubitemid 47196205)
-
(2007)
Current Cancer Drug Targets
, vol.7
, Issue.5
, pp. 459-464
-
-
Ferguson, L.R.1
Philpott, M.2
-
36
-
-
0036096363
-
Use of IMiD3, a thalidomide analog, as an adjunct to therapy for experimental tuberculous meningitis
-
DOI 10.1128/AAC.46.6.1887-1895.2002
-
Tsenova, L., Mangaliso, B., Muller, G., Chen, Y., Freedman, V.H., Stirling, D., Kaplan, G. Use of IMiD3, a thalidomide analog, as an adjunct to therapy for experimental tuberculous meningitis. Antimicrob Agents Chemother 2002, 46(6): 1887-95. (Pubitemid 34535212)
-
(2002)
Antimicrobial Agents and Chemotherapy
, vol.46
, Issue.6
, pp. 1887-1895
-
-
Tsenova, L.1
Mangaliso, B.2
Muller, G.3
Chen, Y.4
Freedman, V.H.5
Stirling, D.6
Kaplan, G.7
-
38
-
-
0037263658
-
Chiral inversion of the second generation IMiD CC-4047 (ACTIMID) in human plasma and phosphate-buffered saline
-
DOI 10.1002/chir.10221
-
Teo, S.K., Chen, Y., Muller, G.W., Chen, R.S., Thomas, S.D., Stirling, D.I., Chandula, R.S. Chiral inversion of the second generation IMiD CC-4047 (ACTIMID) in human plasma and phosphate-buffered saline. Chirality 2003, 15(4): 348-51. (Pubitemid 36459442)
-
(2003)
Chirality
, vol.15
, Issue.4
, pp. 348-351
-
-
Teo, S.K.1
Chen, Y.2
Muller, G.W.3
Chen, R.S.4
Thomas, S.D.5
Stirling, D.I.6
Chandula, R.S.7
-
39
-
-
19944430437
-
Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: Clinical application
-
Hayashi, T., Hideshima, T., Akiyama, M. et al. Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: Clinical application. Br J Haematol 2005, 128(2): 192-203.
-
(2005)
Br J Haematol
, vol.128
, Issue.2
, pp. 192-203
-
-
Hayashi, T.1
Hideshima, T.2
Akiyama, M.3
-
40
-
-
40449135275
-
Alternate day pomalidomide retains anti-myeloma effect with reduced adverse events and evidence of in vivo immunomodulation
-
DOI 10.1111/j.1365-2141.2008.07013.x
-
Streetly, M.J., Gyertson, K., Daniel, Y., Zeldis, J.B., Kazmi, M., Schey, S.A. Alternate day pomalidomide retains anti-myeloma effect with reduced adverse events and evidence of in vivo immunomodulation. Br J Haematol 2008, 141(1): 41-51. (Pubitemid 351350609)
-
(2008)
British Journal of Haematology
, vol.141
, Issue.1
, pp. 41-51
-
-
Streetly, M.J.1
Gyertson, K.2
Daniel, Y.3
Zeldis, J.B.4
Kazmi, M.5
Schey, S.A.6
-
41
-
-
79953228454
-
A phase 1/2 multi-center, randomized, open label dose escalation study to determine the maximum tolerated dose, safety and efficacy of pomalidomide alone or in combination with low-dose dexamethasone in patients with relapsed and refractory multiple myeloma who have received prior treatment that includes lenalidomide and bortezomib
-
nd Am Soc Hematol Annu Meet (Dec 4-7, Orlando) 2010] Abst 864
-
nd Am Soc Hematol Annu Meet (Dec 4-7, Orlando) 2010] 2010, 116(21): Abst 864.
-
(2010)
Blood
, vol.116
, Issue.21
-
-
Richardson, P.1
Siegel, D.2
Baz, R.3
-
42
-
-
84952978077
-
Phase I dose escalation study of pomalidomide in combination with gemcitabine in patients (pts) with untreated metastatic carcinoma of the pancreas
-
Abst 206
-
Infante, J.R., Jones, S.F., Bendell, J. et al. Phase I dose escalation study of pomalidomide in combination with gemcitabine in patients (pts) with untreated metastatic carcinoma of the pancreas. Gastrointest Cancers Symp (Jan 15-17, San Francisco) 2009, Abst 206.
-
Gastrointest Cancers Symp (Jan 15-17, San Francisco) 2009
-
-
Infante, J.R.1
Jones, S.F.2
Bendell, J.3
-
43
-
-
49649096625
-
Thalidomide in multiple myeloma - Clinical trials and aspects of drug metabolism and toxicity
-
Breitkreutz, I., Anderson, K.C. Thalidomide in multiple myeloma - Clinical trials and aspects of drug metabolism and toxicity. Expert Opin Drug Metab Toxicol 2008, 4(7): 973-85.
-
(2008)
Expert Opin Drug Metab Toxicol
, vol.4
, Issue.7
, pp. 973-985
-
-
Breitkreutz, I.1
Anderson, K.C.2
-
44
-
-
4344693453
-
Phase I study of an immunomodulatory thalidomide analog, CC-4047, in relapsed or refractory multiple myeloma
-
DOI 10.1200/JCO.2004.10.052
-
Schey, S.A., Fields, P., Bartlett, J.B. et al. Phase I study of an immunomodulatory thalidomide analog, CC-4047, in relapsed or refractory multiple myeloma. J Clin Oncol 2004, 22(16): 3269-76. (Pubitemid 41103682)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.16
, pp. 3269-3276
-
-
Schey, S.A.1
Fields, P.2
Bartlett, J.B.3
Clarke, I.A.4
Ashan, G.5
Knight, R.D.6
Streetly, M.7
Dalgleish, A.G.8
-
45
-
-
77249160361
-
A phase 1/2 multi-center, randomized, open label dose escalation study to determine the maximum tolerat-ed dose, safety, and efficacy of pomalidomide alone or in combination with low-dose dexamethasone in patients with relapsed and refractory multiple myeloma who have received prior treatment that includes lenalidomide and bortezomib
-
st Annu Soc Hematol Annu Meet (Dec 5-8, New Orleans) 2009] Abst 301
-
st Annu Soc Hematol Annu Meet (Dec 5-8, New Orleans) 2009] 2009, 114(22): Abst 301.
-
(2009)
Blood
, vol.114
, Issue.22
-
-
Richardson, P.1
Siegel, D.2
Baz, R.3
-
46
-
-
73849086725
-
Pomalidomide (CC4047) plus low-dose dexamethasone as therapy for relapsed multiple myeloma
-
Lacy, M.Q., Hayman, S.R., Gertz, M.A. et al. Pomalidomide (CC4047) plus low-dose dexamethasone as therapy for relapsed multiple myeloma. J Clin Oncol 2009, 27(30): 5008-14.
-
(2009)
J Clin Oncol
, vol.27
, Issue.30
, pp. 5008-5014
-
-
Lacy, M.Q.1
Hayman, S.R.2
Gertz, M.A.3
-
47
-
-
78149468560
-
Pomalidomide (CC4047) plus low dose dexamethasone (Pom/dex) is active and well tolerated in lenalidomide refractory multiple myeloma (MM)
-
Lacy, M.Q., Hayman, S.R., Gertz, M.A. et al. Pomalidomide (CC4047) plus low dose dexamethasone (Pom/dex) is active and well tolerated in lenalidomide refractory multiple myeloma (MM). Leukemia 2010, 24(11): 1934-9.
-
(2010)
Leukemia
, vol.24
, Issue.11
, pp. 1934-1939
-
-
Lacy, M.Q.1
Hayman, S.R.2
Gertz, M.A.3
-
49
-
-
79957456049
-
Phase 2 study of 2 modalities of pomalidomide (CC4047) plus low-dose dexamethasone as therapy for relapsed multiple myeloma. IFM 2009-02
-
nd Am Soc Hematol Annu Meet (Dec 4-7, Orlando) 2010] Abst 859
-
nd Am Soc Hematol Annu Meet (Dec 4-7, Orlando) 2010] 2010, 116(21): Abst 859.
-
(2010)
Blood
, vol.116
, Issue.21
-
-
Leleu, X.1
Attal, M.2
Moreau, P.3
-
50
-
-
79953193717
-
Pomalidomide plus lowdose dexamethasone in myeloma refractory to both bortezomib and lenalidomide: Comparison of two dosing strategies in dual-refractory disease
-
nd Am Soc Hematol Annu Meet (Dec 4-7, Orlando) 2010] Abst 863
-
nd Am Soc Hematol Annu Meet (Dec 4-7, Orlando) 2010] 2010, 116(21): Abst 863.
-
(2010)
Blood
, vol.116
, Issue.21
-
-
Lacy, M.1
Mandrekar, S.2
Gertz, M.A.A.3
-
51
-
-
71949121402
-
Pomalidomide is active in the treatment of anemia associated with myelofibrosis
-
Tefferi, A., Verstovsek, S., Barosi, G. et al. Pomalidomide is active in the treatment of anemia associated with myelofibrosis. J Clin Oncol 2009, 27(27): 4563-9.
-
(2009)
J Clin Oncol
, vol.27
, Issue.27
, pp. 4563-4569
-
-
Tefferi, A.1
Verstovsek, S.2
Barosi, G.3
-
52
-
-
75449087842
-
Phase1/-2 study of pomalidomide in myelofibrosis
-
Mesa, R.A., Pardanani, A.D., Hussein, K. et al. Phase1/-2 study of pomalidomide in myelofibrosis. Am J Hematol 2010, 85(2): 129-30.
-
(2010)
Am J Hematol
, vol.85
, Issue.2
, pp. 129-130
-
-
Mesa, R.A.1
Pardanani, A.D.2
Hussein, K.3
-
53
-
-
80054123263
-
A phase-2 trial of low-dose pomalidomide in myelofibrosis with anemia
-
nd Am Soc Hematol Annu Meet (Dec 4-7, Orlando) 2010] Abst 4109
-
nd Am Soc Hematol Annu Meet (Dec 4-7, Orlando) 2010] 2010, 116(21): Abst 4109.
-
(2010)
Blood
, vol.116
, Issue.21
-
-
Begna, K.1
Mesa, R.2
Pardanani, A.3
Hogan, W.4
Litzoq, M.5
McClure, R.6
Tefferi, A.7
-
54
-
-
78650690372
-
Phase 1 trial of daily pomalidomide in patients with advanced solid tumors
-
th Annu Meet Am Soc Clin Oncol (ASCO) (June 4-8, Chicago) 2010] Abst e13077
-
th Annu Meet Am Soc Clin Oncol (ASCO) (June 4-8, Chicago) 2010] 2010, 28 (18, Suppl.): Abst e13077.
-
(2010)
J Clin Oncol
, vol.28
, Issue.18 SUPPL.
-
-
Cooney, M.1
Bokar, J.2
Dreicer, R.3
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