Spatial tethering of kinases to their substrates relaxes evolutionary constraints on specificity

Molecular Microbiology

Volumn 86, Issue 6, 2012, Pages 1393-1403

  Capra, Emily J ^a   Perchuk, Barrett S ^a   Ashenberg, Orr ^a   Seid, Charlotte A ^a   Snow, Hana R ^a   Skerker, Jeffrey M ^b   Laub, Michael T ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b University of California   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN HISTIDINE KINASE;

ARTICLE; COVALENT BOND; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HYBRID; IN VITRO STUDY; MOLECULAR EVOLUTION; NONHUMAN; PHOSPHOTRANSFER; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; TRANSPORT KINETICS;

BACTERIAL PROTEINS; EVOLUTION, MOLECULAR; GENE FUSION; PHOSPHATES; PROTEIN KINASES; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS);

EID: 84870997524     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/mmi.12064     Document Type: Article

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