Chemical and microbial semi-synthesis of tetrahydroprotoberberines as inhibitors on tissue factor procoagulant activity

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 1, 2013, Pages 62-69

  Ge, Hai Xia ^a,b   Zhang, Jian ^a   Chen, Ling ^a   Kou, Jun Ping ^a   Yu, Bo Yang ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b HUZHOU UNIVERSITY   (China)

Author keywords

Biotransformation; Cardiovascular diseases; Structure and activity relationship (SAR); Tetrahydroprotoberberines; Tissue factor

Indexed keywords

2,3,10 TRIMETHOXY 9 BETA DEXTRO GLUCOSYL 5,6,13,14 TETRAHYDRO 8H DIBENZO[A,G]QUINOLIZINE; 2,3,10 TRIMETHOXY 9 HYDROXY 5,6,13,14 TETRAHYDRO 8H DIBENZO[A,G]QUINOLIZINE; 2,3,9 TRIMETHOXY 10 HYDROXY 5,6,13,14 TETRAHYDRO 8H DIBENZO[A,G]QUINOLIZINE; 2,3,9 TRIMETHOXY 5,6,13,14 TETRAHYDRO 8H DIBENZO[A,G]QUINOLIZINE; 5,6,13,14 TETRAHYDRO 9 (2 ACETOXY)BENZOYLOXY 10 METHOXY 2,3 (METHYLENEDIOXY) 8H DIBENZO[A,G]QUINOLIZINE; 5,6,13,14 TETRAHYDRO 9 (3 PHENYL)ACRYLOXY 10 METHOXY 2,3 (METHYLENEDIOXY) 8H DIBENZO[A,G]QUINOLIZINE; 5,6,13,14 TETRAHYDRO 9 [3 (3 METHOXYL 4 ACETOXY)PHENYL]ACRYLOXY 10 METHOXY 2,3 (METHYLENEDIOXY) 8H DIBENZO[A,G]QUINOLIZINE; 5,6,13,14 TETRAHYDRO 9 BENZOYLOXY 10 METHOXY 2,3 (METHYLENEDIOXY) 8H DIBENZO[A,G]QUINOLIZINE; 5,6,13,14 TETRAHYDRO 9 BETA DEXTRO 10 METHOXY 2,3 (METHYLENEDIOXY) 8H DIBENZO[A,G]QUINOLIZINE; 5,6,13,14 TETRAHYDRO 9 HEXANOYLOXY 10 METHOXY 2,3 (METHYLENEDIOXY) 8H DIBENZO[A,G]QUINOLIZINE; 5,6,13,14 TETRAHYDRO 9 HYDROXY 10 METHOXY 2,3 (METHYLENEDIOXY) 8H DIBENZO[A,G]QUINOLIZINE; 5,6,13,14 TETRAHYDRO 9 PROPIONYLOXY 10 METHOXY 2,3 (METHYLENEDIOXY) 8H DIBENZO[A,G]QUINOLIZINE; 9,10 DIMETHOXY 2,3 DIHYDROXY 5,6,13,14 TETRAHYDRO 8H DIBENZO[A,G]QUINOLIZINE; BERBINE DERIVATIVE; LIPOPOLYSACCHARIDE; THROMBOPLASTIN; UNCLASSIFIED DRUG;

ANTICOAGULATION; ARTICLE; BIOTRANSFORMATION; CELL STIMULATION; CELL STRAIN; CHIRALITY; CONTROLLED STUDY; DEMETHYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; GLIOCLADIUM; GLIOCLADIUM DELIQUESCENS; GLYCOSYLATION; HUMAN; HUMAN CELL; IC 50; NONHUMAN; STREPTOMYCES GRISEUS; STRUCTURE ACTIVITY RELATION;

BERBERINE ALKALOIDS; CELL LINE; GLIOCLADIUM; GLYCOSYLATION; HUMANS; STREPTOMYCES GRISEUS; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOPLASTIN;

GLIOCLADIUM DELIQUESCENS; STREPTOMYCES GRISEUS;

EID: 84870945150     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.11.002     Document Type: Article

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