The SLE-associated Pbx1-d isoform acts as a dominant-negative transcriptional regulator

Genes and Immunity

Volumn 13, Issue 8, 2012, Pages 653-657

  Sengupta, M ^a,b   Liang, S ^a,b,c   Potula, H H S ^a,b   Chang, L J ^a,b   Morel, L ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c WEIFANG MEDICAL UNIVERSITY   (China)

Author keywords

Lupus; Pbx1; T cells

Indexed keywords

ISOPROTEIN; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR PBX1; TRANSCRIPTION FACTOR PBX1D; TRANSCRIPTION FACTOR SOX3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CELL DIFFERENTIATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA BINDING; GENE SILENCING; HEMATOPOIETIC STEM CELL; MOUSE; NEWBORN; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; TRANSACTIVATION; TRANSCRIPTION REGULATION;

ALTERNATIVE SPLICING; ANIMALS; AUTOIMMUNITY; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; HOMEODOMAIN PROTEINS; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, TRANSGENIC; OSTEOBLASTS; PROMOTER REGIONS, GENETIC; PROTEIN ISOFORMS; SIGNAL TRANSDUCTION; SOXB1 TRANSCRIPTION FACTORS; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; TRANSDUCTION, GENETIC;

EID: 84870940084     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/gene.2012.43     Document Type: Article

References (28)

1. Chen Y, Cuda C, Morel L. Genetic determination of T cell help in loss of tolerance to nuclear antigens. J Immunol 2005; 174: 7692-7702.
2. Cuda CM, Zeumer L, Sobel ES, Croker BP, Morel L. Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells. Genes Immun 2010; 11: 542-553.
3. Cuda CM, Li S, Liang S, Yin Y, Potula HH, Xu Z et al. Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans. J Immunol 2012; 188: 604-614.
4. Cuda CM, Wan S, Sobel ES, Croker BP, Morel L. Murine lupus susceptibility locus Sle1a controls regulatory T cell number and function through multiple mechanisms. J Immunol 2007; 179: 7439-7447.
5. Sobel ES, Brusko TM, Butfiloski EJ, Hou W, Li S, Cuda CM et al. Defective response of CD4\+ T cells to retinoic acid and TGFb in systemic lupus erythematosus. Arthritis Res Ther 2011; 13: R106.
6. Mann RS, Chan SK. Extra specificity from extradenticle: the partnership between HOX and PBX/EXD homeodomain proteins. Trends Genet 1996; 12: 258-262.
7. Berkes CA, Bergstrom DA, Penn BH, Seaver KJ, Knoepfler PS, Tapscott SJ. Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential. Mol Cell 2004; 14: 465-477.
8. Laurent A, Bihan R, Omilli F, Deschamps S, Pellerin I. PBX proteins: much more than Hox cofactors. Int J Dev Biol 2008; 52: 9-20.
9. DiMartino JF, Selleri L, Traver D, Firpo MT, Rhee J, Warnke R et al. The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver. Blood 2001; 98: 618-626.
10. Selleri L, Depew MJ, Jacobs Y, Chanda SK, Tsang KY, Cheah KS et al. Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation. Development 2001; 128: 3543-3557.
11. Ficara F, Murphy MJ, Lin M, Cleary ML. Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence. Cell Stem Cell 2008; 2: 484-496.
12. Sanyal M, Tung JW, Karsunky H, Zeng H, Selleri L, Weissman IL et al. B-cell development fails in the absence of the Pbx1 proto-oncogene. Blood 2007; 109: 4191-4199.
13. Penkov D, Palazzolo M, Mondino A, Blasi F. Cytosolic sequestration of Prep1 influences early stages of T cell development. PLoS ONE 2008; 3: e2424.
14. Di Rocco G, Mavilio F, Zappavigna V. Functional dissection of a transcriptionally active, target-specific Hox-Pbx complex. EMBO J 1997; 16: 3644-3654.
15. Asahara H, Dutta S, Kao HY, Evans RM, Montminy M. Pbx-Hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner. Mol Cell Biol 1999; 19: 8219-8225.
16. Asahara H, Dutta S, Kao H-Y, Evans RM, Montminy M. Pbx-Hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner. Mol Cell Biol 1999; 19: 8219-8225.
17. Gordon JA, Hassan MQ, Saini S, Montecino M, van Wijnen AJ, Stein GS et al. Pbx1 represses osteoblastogenesis by blocking Hoxa10-mediated recruitment of chromatin remodeling factors. Mol Cell Biol 2010; 30: 3531-3541.
18. Brunelli S, Silva Casey E, Bell D, Harland R, Lovell-Badge R. Expression of Sox3 throughout the developing central nervous system is dependent on the combined action of discrete, evolutionarily conserved regulatory elements. Genesis 2003; 36: 12-24.
19. Mojsin M, M Stevanovic. PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region. Biochem J 2010; 425: 107-116.
20. Milech N, Kees UR, Watt PM. Novel alternative PBX3 isoforms in leukemia cells with distinct interaction specificities. Genes Chrom Cancer 2001; 32: 275-280.
21. Laurent A, Bihan R, Deschamps S, Guerrier D, Dupé V, Omilli F et al. Identification of a new type of PBX1 partner that contains zinc finger motifs and inhibits the binding of HOXA9-PBX1 to DNA. Mech Develop 2007; 124: 364-376.
22. Manavathi B, Lo D, Bugide S, Dey O, Imren S, Weiss MJ et al. Functional regulation of pre-B-cell leukemia homeobox interacting protein 1 (PBXIP1/HPIP) in erythroid differentiation. J Biol Chem 2012; 287: 5600-5614.
23. Abramovich C, Shen W-F, Pineault N, Imren S, Montpetit B, Largman C et al. Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA. J Biol Chem 2000; 275: 26172-26177.
24. Eberth S, Schneider B, Rosenwald A, Hartmann E, Romani J, Zaborski M et al. Epigenetic regulation of CD44 in Hodgkin and non-Hodgkin lymphoma. BMC Cancer 2010; 10: 517.
25. Shaffer AL, Yu X, He Y, Boldrick J, Chan EP, Staudt LM. BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity 2000; 13: 199-212.
26. Thiaville MM, Stoeck A, Chen L, Wu R-C, Magnani L, Oidtman J et al. Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites. PLoS ONE 2012; 7: e36054.
27. Xu Z, Potula HH, Vallurupalli A, Perry D, Baker H, Croker BP et al. Cyclin-dependent kinase inhibitor Cdkn2c regulates B cell homeostasis and function in the NZM2410-derived murine lupus susceptibility locus Sle2c1. J Immunol 2011; 186: 6673-6682.
28. Potula HH, Morel L. Genetic variation at an YY-1 response site regulates the transcription of cyclin-dependent kinase inhibitor p18 INK4C transcript in lupusprone mice. J Immunol 2012; 188: 4992-5002.