Novel alternative PBX3 isoforms in leukemia cells with distinct interaction specificities

Genes Chromosomes and Cancer

Volumn 32, Issue 3, 2001, Pages 275-280

  Milech, Nadia ^a   Kees, Ursula R ^a   Watt, Paul M ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HOMEODOMAIN PROTEIN; ISOPROTEIN; PROTEIN PBX3; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME TRANSLOCATION; HEMATOPOIESIS; HOMEOBOX; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INTERACTION; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION;

HOMEODOMAIN PROTEINS; HUMANS; LEUKEMIA, PRE-B-CELL; MOLECULAR SEQUENCE DATA; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS; TRANSCRIPTION FACTORS;

EID: 0034786669     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.1190     Document Type: Article

References (27)

1. Control of the nuclear localization of extradenticle by competing nuclear import and export signals
2. PKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17B/C
3. The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity
4. The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH
5. New motif in PBX genes
6. Analysis of TALE superclass homeobox genes (MEIS PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals
7. Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins
8. Cloning of a novel homeobox-containing gene PKNOX1, and mapping to human chromosome 21q22.3
9. Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice
10. HOX cofactors PBX1 and PBX2 are required for normal hematopoicsis
11. Correlation of two-hybrid affinity data with in vitro measurements
12. The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouse
13. Two-hybrid analysis of genetic regulatory networks
14. Searching for interacting proteins with the two-hybrid system III
15. A new homcobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL
16. The human t(1:19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials
17. Deletions of the p16 gene in pediatric leukemia and corresponding cell lines
18. Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1
19. Initial sequencing and analysis of the human genome. International Human Genome Sequencing Consortium
20. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1
21. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor
22. Structure of a HoxB1-Pbx1 heterodimer bound to DNA: Role of the hexapeptide and a fourth homeodomain helix in complex formation
23. HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells
24. Cloning and mapping of the MEIS1 gene, the human homolog of a murine leukemogenic gene
25. Identification of a conserved family of Meis1-related homeobox genes
26. A novel pbx family member expressed during early zebrafish embryogenesis forms trimeric complexes with Meis3 and Hoxb1b
27. Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription