Presence of a defect in karyokinesis during megakaryocyte endomitosis

Cell Cycle

Volumn 11, Issue 23, 2012, Pages 4385-4389

  Lordier, Larissa ^a,b   Pan, Jiajia ^a,b   Naim, Valeria ^a,b   Jalil, Abdelali ^a   Badirou, Idinath ^a,b   Rameau, Philippe ^a   Larghero, Jerôme ^c   Debili, Najet ^a,b   Rosselli, Filippo ^a,b   Vainchenker, William ^a,b   Chang, Yunhua ^a,b  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Cytokinesis; Endomitosis; Karyokinesis; Megakaryocyte; Polyploidy

Indexed keywords

ACTIN; BLOOM SYNDROME HELICASE; DNA;

ARTICLE; CELL NUCLEUS; CELL NUCLEUS MEMBRANE; CHROMOSOME SEGREGATION; CONTROLLED STUDY; CYTOKINESIS; HUMAN; HUMAN CELL; KARYOKINESIS; MEGAKARYOCYTE; MITOSIS; MULTINUCLEAR CELL; POLYPLOIDY; SISTER CHROMATID; TELOPHASE;

EID: 84870931187     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.22712     Document Type: Article

References (18)

1. Geddis AE, Fox NE, Tkachenko E, Kaushansky K. Endomitotic megakaryocytes that form a bipolar spindle exhibit cleavage furrow ingression followed by furrow regression. Cell Cycle 2007; 6:455-60; PMID:17312391; http://dx.doi.org/10.4161/cc.6.4.3836.
2. Lordier L, Jalil A, Aurade F, Larbret F, Larghero J, Debili N, et al. Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling. Blood 2008; 112:3164-74; PMID:18684864; http://dx.doi.org/10.1182/blood-2008-03-144956.
3. Gao Y, Smith E, Ker E, Campbell P, Cheng EC, Zou S, et al. Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes. Dev Cell 2012; 22:573-84; PMID:22387001; http://dx.doi.org/10. 1016/j.devcel.2011.12.019.
4. Lordier L, Bluteau D, Jalil A, Legrand C, Pan J, Rameau P, et al. RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization. Nat Commun 2012; 3:717; PMID:22395608; http://dx.doi.org/10.1038/ncomms1704.
5. Margalit A, Vlcek S, Gruenbaum Y, Foisner R. Breaking and making of the nuclear envelope. J Cell Biochem 2005; 95:454-65; PMID:15832341; http://dx.doi.org/10.1002/jcb.20433.
6. Nagata Y, Muro Y, Todokoro K. Thrombopoietin-induced polyploidization of bone marrow megakaryocytes is due to a unique regulatory mechanism in late mitosis. J Cell Biol 1997; 139:449-57; PMID:9334347; http://dx.doi.org/10.1083/ jcb.139.2.449.
7. Vitrat N, Cohen-Solal K, Pique C, Le Couedic JP, Norol F, Larsen AK, et al. Endomitosis of human mega-karyocytes are due to abortive mitosis. Blood 1998; 91:3711-23; PMID:9573008.
8. Hans F, Dimitrov S. Histone H3 phosphorylation and cell division. Oncogene 2001; 20:3021-7; PMID:11420717; http://dx.doi.org/10.1038/sj.onc. 1204326.
9. Naim V, Rosselli F. The FANC pathway and mitosis: a replication legacy. Cell Cycle 2009; 8:2907-11; PMID:19729998; http://dx.doi.org/10.4161/cc.8.18. 9538.
10. Naim V, Rosselli F. The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities. Nat Cell Biol 2009; 11:761-8; PMID:19465921; http://dx.doi.org/10.1038/ncb1883.
11. Liu ZJ, Sola-Visner M. Neonatal and adult megakaryopoiesis. Curr Opin Hematol 2011; 18:330-7; PMID:21738028; http://dx.doi.org/10.1097/MOH. 0b013e3283497ed5.
12. Roy L, Coullin P, Vitrat N, Hellio R, Debili N, Weinstein J, et al. Asymmetrical segregation of chromosomes with a normal metaphase/anaphase checkpoint in polyploid megakaryocytes. Blood 2001; 97:2238-47; PMID:11290584; http://dx.doi.org/10.1182/blood.V97.8.2238.
13. Leysi-Derilou Y, Robert A, Duchesne C, Garnier A, Boyer L, Pineault N. Polyploid megakaryocytes can complete cytokinesis. Cell Cycle 2010; 9:2589-99; PMID:20647776; http://dx.doi.org/10.4161/cc.9.13.12078.
14. Gao Y, Krause D. Discovery that polyploid cells can undergo mitosis. Cell Cycle 2010; 9:2500; PMID:20647753; http://dx.doi.org/10.4161/cc.9.13.12325.
15. Pampalona J, Frías C, Genescà A, Tusell L. Progressive telomere dysfunction causes cytokinesis failure and leads to the accumulation of polyploid cells. PLoS Genet 2012; 8:e1002679; PMID:22570622; http://dx.doi.org/10.1371/journal.pgen.1002679.
16. Steigemann P, Wurzenberger C, Schmitz MH, Held M, Guizetti J, Maar S, et al. Aurora B-mediated abscission checkpoint protects against tetraploidization. Cell 2009; 136:473-84; PMID:19203582; http://dx.doi.org/10.1016/j.cell.2008.12. 020.
17. Lordier L, Chang Y, Jalil A, Aurade F, Garçon L, Lécluse Y, et al. Aurora B is dispensable for megakaryocyte polyploidization, but contributes to the endomitotic process. Blood 2010; 116:2345-55; PMID:20548097; http://dx.doi.org/10.1182/blood-2010-01-265785.
18. Li Y, Lu J, Prochownik EV. c-Myc-mediated genomic instability proceeds via a megakaryocytic endomitosis pathway involving Gp1balpha. Proc Natl Acad Sci USA 2007; 104:3490-5; PMID:17360671; http://dx.doi.org/10.1073/pnas.0610163104.