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Volumn 37, Issue 1, 2013, Pages 3-8

ER stress in diffuse large B cell lymphoma: GRP94 is a possible biomarker in germinal center versus activated B-cell type

Author keywords

DLBCL; GRP94; UPR

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BREFELDIN A; CYCLOPHOSPHAMIDE; DOXORUBICIN; GLUCOSE REGULATED PROTEIN 94; HEAT SHOCK PROTEIN 70; INITIATION FACTOR 2ALPHA; PREDNISONE; RITUXIMAB; STAUROSPORINE; THAPSIGARGIN; TUNICAMYCIN; VINCRISTINE; X BOX BINDING PROTEIN 1;

EID: 84870911687     PISSN: 01452126     EISSN: 18735835     Source Type: Journal    
DOI: 10.1016/j.leukres.2012.08.017     Document Type: Article
Times cited : (6)

References (45)
  • 1
    • 0034598746 scopus 로고    scopus 로고
    • Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
    • Alizadeh A.A., Eisen M.B., Davis R.E., Ma C., Lossos I.S., Rosenwald A., et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000, 403:503-511.
    • (2000) Nature , vol.403 , pp. 503-511
    • Alizadeh, A.A.1    Eisen, M.B.2    Davis, R.E.3    Ma, C.4    Lossos, I.S.5    Rosenwald, A.6
  • 2
    • 0037142053 scopus 로고    scopus 로고
    • The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
    • Rosenwald A., Wright G., Chan W.C., Connors J.M., Campo E., Fisher R.I., et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med 2002, 346:1937-1947.
    • (2002) N Engl J Med , vol.346 , pp. 1937-1947
    • Rosenwald, A.1    Wright, G.2    Chan, W.C.3    Connors, J.M.4    Campo, E.5    Fisher, R.I.6
  • 3
    • 0141672946 scopus 로고    scopus 로고
    • Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma
    • Rosenwald A., Wright G., Leroy K., Yu X., Gaulard P., Gascoyne R.D., et al. Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma. J Exp Med 2003, 198:851-862.
    • (2003) J Exp Med , vol.198 , pp. 851-862
    • Rosenwald, A.1    Wright, G.2    Leroy, K.3    Yu, X.4    Gaulard, P.5    Gascoyne, R.D.6
  • 4
    • 10744228934 scopus 로고    scopus 로고
    • The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma
    • Savage K.J., Monti S., Kutok J.L., Cattoretti G., Neuberg D., De Leval L., et al. The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma. Blood 2003, 102:3871-3879.
    • (2003) Blood , vol.102 , pp. 3871-3879
    • Savage, K.J.1    Monti, S.2    Kutok, J.L.3    Cattoretti, G.4    Neuberg, D.5    De Leval, L.6
  • 5
    • 0043192901 scopus 로고    scopus 로고
    • A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma
    • Wright G., Tan B., Rosenwald A., Hurt E.H., Wiestner A., Staudt L.M. A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma. Proc Natl Acad Sci USA 2003, 100:9991-9996.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 9991-9996
    • Wright, G.1    Tan, B.2    Rosenwald, A.3    Hurt, E.H.4    Wiestner, A.5    Staudt, L.M.6
  • 6
    • 0037698992 scopus 로고    scopus 로고
    • Rituximab plus CHOP (R-CHOP) overcomes bcl-2 associated resistance to chemotherapy in elderly patients with diffuse large B-cell lymphoma
    • Mounier N., Brière J., Gisselbrecht C., Emile J.-F., Lederlin P., Sebban C., et al. Rituximab plus CHOP (R-CHOP) overcomes bcl-2 associated resistance to chemotherapy in elderly patients with diffuse large B-cell lymphoma. Blood 2003, 101:4279-4284.
    • (2003) Blood , vol.101 , pp. 4279-4284
    • Mounier, N.1    Brière, J.2    Gisselbrecht, C.3    Emile, J.-F.4    Lederlin, P.5    Sebban, C.6
  • 7
    • 0037165261 scopus 로고    scopus 로고
    • CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma
    • Coiffier B., Lepage E., Brière J., Herbrecht R., Tilly H., Bouabdallah R., et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med 2002, 346:235-242.
    • (2002) N Engl J Med , vol.346 , pp. 235-242
    • Coiffier, B.1    Lepage, E.2    Brière, J.3    Herbrecht, R.4    Tilly, H.5    Bouabdallah, R.6
  • 9
    • 79955944673 scopus 로고    scopus 로고
    • Gene-expression profiling and not-immunophenotypic algorithms predicts prognosis in patients with diffuse large B-cell lymphoma treated with immunochemotherapy
    • Gutierrez-García G., Cardessa-Salzmann T., Climent F., González-Barca E., Mercadal S., Mate J.L., et al. Gene-expression profiling and not-immunophenotypic algorithms predicts prognosis in patients with diffuse large B-cell lymphoma treated with immunochemotherapy. Blood 2011, 117:4836-4843.
    • (2011) Blood , vol.117 , pp. 4836-4843
    • Gutierrez-García, G.1    Cardessa-Salzmann, T.2    Climent, F.3    González-Barca, E.4    Mercadal, S.5    Mate, J.L.6
  • 10
    • 31344438651 scopus 로고    scopus 로고
    • I Braakman. Endoplasmic reticulum stress and the making of a professional secretory cell
    • Van Anken E. I Braakman. Endoplasmic reticulum stress and the making of a professional secretory cell. Crit Rev Biochem Mol Biol 2005, 40:269-283.
    • (2005) Crit Rev Biochem Mol Biol , vol.40 , pp. 269-283
    • Van Anken, E.1
  • 11
    • 34047192683 scopus 로고    scopus 로고
    • The endoplasmic reticulum: a target for new anticancer drugs
    • Boelens J., Lust S., Offner F., Bracke M., Vanhoecke B. The endoplasmic reticulum: a target for new anticancer drugs. In Vivo 2007, 21:215-226.
    • (2007) In Vivo , vol.21 , pp. 215-226
    • Boelens, J.1    Lust, S.2    Offner, F.3    Bracke, M.4    Vanhoecke, B.5
  • 12
    • 7444240833 scopus 로고    scopus 로고
    • The ER function BiP is a master regulator of ER function
    • Hendershot L.M., The ER function BiP is a master regulator of ER function. Mt Sinai J Med 2004, 71:289-297.
    • (2004) Mt Sinai J Med , vol.71 , pp. 289-297
    • Hendershot, L.M.1
  • 13
    • 22244446505 scopus 로고    scopus 로고
    • The mammalian unfolded protein response
    • Schroder M., Kaufman R.J. The mammalian unfolded protein response. Annu Rev Biochem 2005, 74:739-789.
    • (2005) Annu Rev Biochem , vol.74 , pp. 739-789
    • Schroder, M.1    Kaufman, R.J.2
  • 14
    • 33748789479 scopus 로고    scopus 로고
    • Mediators of endoplasmic reticulum stress-induced apoptosis
    • Szegezdi E., Logue S.E., Gorman A.M., Samali A. Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 2006, 7:880-885.
    • (2006) EMBO Rep , vol.7 , pp. 880-885
    • Szegezdi, E.1    Logue, S.E.2    Gorman, A.M.3    Samali, A.4
  • 15
    • 0037073712 scopus 로고    scopus 로고
    • Activation of an unfolded protein response during differentiation of antibody-secreting B cells
    • Gass J.N., Gifford N.M., Brewer J.W. Activation of an unfolded protein response during differentiation of antibody-secreting B cells. J Biol Chem 2002, 277:49047-49054.
    • (2002) J Biol Chem , vol.277 , pp. 49047-49054
    • Gass, J.N.1    Gifford, N.M.2    Brewer, J.W.3
  • 16
    • 30844472027 scopus 로고    scopus 로고
    • Activation of the endoplasmic reticulum stress pathway is associated with survival of myeloma cells
    • Nakamura M., Gotoh T., Okuno Y., Tatetsu H., Sonoki T., Uneda S., et al. Activation of the endoplasmic reticulum stress pathway is associated with survival of myeloma cells. Leuk Lymphoma 2006, 47:531-539.
    • (2006) Leuk Lymphoma , vol.47 , pp. 531-539
    • Nakamura, M.1    Gotoh, T.2    Okuno, Y.3    Tatetsu, H.4    Sonoki, T.5    Uneda, S.6
  • 17
    • 1542381046 scopus 로고    scopus 로고
    • Plasma cell differentiation and multiple myeloma
    • Shapiro-Shelef M., Calame K. Plasma cell differentiation and multiple myeloma. Curr Opin Immunol 2004, 16:226-234.
    • (2004) Curr Opin Immunol , vol.16 , pp. 226-234
    • Shapiro-Shelef, M.1    Calame, K.2
  • 18
    • 0036884169 scopus 로고    scopus 로고
    • Lymphoid malignancies: the dark side of B-cell differentiation
    • Shaffer A.L., Rosenwald A., Staudt L.M. Lymphoid malignancies: the dark side of B-cell differentiation. Nat Rev Immunol 2002, 2:920-933.
    • (2002) Nat Rev Immunol , vol.2 , pp. 920-933
    • Shaffer, A.L.1    Rosenwald, A.2    Staudt, L.M.3
  • 19
    • 54049093957 scopus 로고    scopus 로고
    • The expression of 16 genes related to the cell of origin and immune response predicts survival in elderly patients with diffuse large B-cell lymphoma treated with CHOP and rituximab
    • Jais J.-P., Haioun C., Molina T.J., Rickman D.S., De Reynies A., Berger F., et al. The expression of 16 genes related to the cell of origin and immune response predicts survival in elderly patients with diffuse large B-cell lymphoma treated with CHOP and rituximab. Leukemia 2008, 22:1917-1924.
    • (2008) Leukemia , vol.22 , pp. 1917-1924
    • Jais, J.-P.1    Haioun, C.2    Molina, T.J.3    Rickman, D.S.4    De Reynies, A.5    Berger, F.6
  • 20
    • 20144382754 scopus 로고    scopus 로고
    • Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response
    • Monti S., Savaga K.J., Kutok J.L., Feuerhake F., Kurtin P., Mihm M., et al. Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood 2005, 105:1851-1861.
    • (2005) Blood , vol.105 , pp. 1851-1861
    • Monti, S.1    Savaga, K.J.2    Kutok, J.L.3    Feuerhake, F.4    Kurtin, P.5    Mihm, M.6
  • 21
    • 0002658306 scopus 로고
    • The median-effect principle and the combination index for quantitation of synergism and antagonism
    • Academic Press, San Diego, T.C. Chou, D. Rideout (Eds.)
    • Chou TC The median-effect principle and the combination index for quantitation of synergism and antagonism. Synergism and antagonism in chemotherapy 1991, 61-102. Academic Press, San Diego. T.C. Chou, D. Rideout (Eds.).
    • (1991) Synergism and antagonism in chemotherapy , pp. 61-102
    • Chou, T.C.1
  • 23
    • 23044503407 scopus 로고    scopus 로고
    • Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d'Etude des Lymphomes de l'Adulte
    • Feugier P., Van Hoof A., Sebban C., Solal-Celigny P., Bouabdallah R., Fermé C., et al. Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d'Etude des Lymphomes de l'Adulte. J Clin Oncol 2005, 23:4117-4126.
    • (2005) J Clin Oncol , vol.23 , pp. 4117-4126
    • Feugier, P.1    Van Hoof, A.2    Sebban, C.3    Solal-Celigny, P.4    Bouabdallah, R.5    Fermé, C.6
  • 25
    • 35748932852 scopus 로고    scopus 로고
    • R Development Core Team. R Foundation for statistical computing, Vienna, Austria
    • R Development Core Team R: a language and environment for statistical computing 2007, R Foundation for statistical computing, Vienna, Austria.
    • (2007) R: a language and environment for statistical computing
  • 28
    • 67049109264 scopus 로고    scopus 로고
    • Activation of the endoplasmic reticulum stress-associated transcription factor x box-binding protein-1 occurs in a subset of normal germinal-center B cells and in aggressive B-cell lymphomas with prognostic implications
    • Balague O., Mozos A., Martinez D., Hernandez L., Colome L., Mate J.L., et al. Activation of the endoplasmic reticulum stress-associated transcription factor x box-binding protein-1 occurs in a subset of normal germinal-center B cells and in aggressive B-cell lymphomas with prognostic implications. Am J Pathol 2009, 174:2337-2346.
    • (2009) Am J Pathol , vol.174 , pp. 2337-2346
    • Balague, O.1    Mozos, A.2    Martinez, D.3    Hernandez, L.4    Colome, L.5    Mate, J.L.6
  • 30
    • 33744539521 scopus 로고    scopus 로고
    • Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells
    • Obeng E.A., Carlson L.M., Gutman D.M., Harrington W.J., Lee K.P., Boise L.H. Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood 2006, 107:4907-4916.
    • (2006) Blood , vol.107 , pp. 4907-4916
    • Obeng, E.A.1    Carlson, L.M.2    Gutman, D.M.3    Harrington, W.J.4    Lee, K.P.5    Boise, L.H.6
  • 31
    • 79957887434 scopus 로고    scopus 로고
    • Accurate classification of diffuse large B-cell lymphoma into germinal center and activated B-cell subtypes using a nuclease protection assay on formalin-fixed, paraffin-embedded tissues
    • Rimsza L.M., Wright G., Schwartz M., Chan W.C., Jaffe E.S., Gascoyne R.D., et al. Accurate classification of diffuse large B-cell lymphoma into germinal center and activated B-cell subtypes using a nuclease protection assay on formalin-fixed, paraffin-embedded tissues. Clin Cancer Res 2011, 17:3727-3732.
    • (2011) Clin Cancer Res , vol.17 , pp. 3727-3732
    • Rimsza, L.M.1    Wright, G.2    Schwartz, M.3    Chan, W.C.4    Jaffe, E.S.5    Gascoyne, R.D.6
  • 32
    • 34948890040 scopus 로고    scopus 로고
    • Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells
    • Davenport E.L., Moore H.E., Dunlop A.S., Sharp S.Y., Workman P., Morgan G.J., et al. Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells. Blood 2007, 110:2641-2649.
    • (2007) Blood , vol.110 , pp. 2641-2649
    • Davenport, E.L.1    Moore, H.E.2    Dunlop, A.S.3    Sharp, S.Y.4    Workman, P.5    Morgan, G.J.6
  • 33
    • 80054969637 scopus 로고    scopus 로고
    • The expression of the endoplasmic reticulum stress sensor BiP/GRP78 predicts response to chemotherapy and determines the efficacy of proteasome inhibitors in diffuse large B-cell lymphoma
    • Mozos A., Roue G., López-Guillermo, Jares P., Campo E., Colomer D., et al. The expression of the endoplasmic reticulum stress sensor BiP/GRP78 predicts response to chemotherapy and determines the efficacy of proteasome inhibitors in diffuse large B-cell lymphoma. Am J Pathol 2011, 179:2601-2610.
    • (2011) Am J Pathol , vol.179 , pp. 2601-2610
    • Mozos, A.1    Roue, G.2    López-Guillermo3    Jares, P.4    Campo, E.5    Colomer, D.6
  • 34
    • 28744450158 scopus 로고    scopus 로고
    • Overexpression of endoplasmic reticulum molecular chaperone GRP94 and GRP78 in human lung cancer tissues and its significance
    • Wang Q., He Z., Zhang J., Wang Y., Wang T., Tong S., et al. Overexpression of endoplasmic reticulum molecular chaperone GRP94 and GRP78 in human lung cancer tissues and its significance. Cancer Detect Prev 2005, 29:544-551.
    • (2005) Cancer Detect Prev , vol.29 , pp. 544-551
    • Wang, Q.1    He, Z.2    Zhang, J.3    Wang, Y.4    Wang, T.5    Tong, S.6
  • 35
    • 0033014498 scopus 로고    scopus 로고
    • De-regulation of GRP stress protein expression in human breast cancer cell lines
    • Gazit G., Lu J., Lee A.S. De-regulation of GRP stress protein expression in human breast cancer cell lines. Breast Cancer Res Treat 1999, 54:135-146.
    • (1999) Breast Cancer Res Treat , vol.54 , pp. 135-146
    • Gazit, G.1    Lu, J.2    Lee, A.S.3
  • 36
    • 14844282315 scopus 로고    scopus 로고
    • Correlation between clinicopathology and expression of heat shock protein 70 and glucose-regulated protein 94 in human colonic adenocarcinoma
    • Wang X.P., Qiu F.R., Liu G.Z., Chen R.F. Correlation between clinicopathology and expression of heat shock protein 70 and glucose-regulated protein 94 in human colonic adenocarcinoma. World J Gastroenterol 2005, 11:1056-1059.
    • (2005) World J Gastroenterol , vol.11 , pp. 1056-1059
    • Wang, X.P.1    Qiu, F.R.2    Liu, G.Z.3    Chen, R.F.4
  • 37
    • 45049088225 scopus 로고    scopus 로고
    • Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas
    • Zheng H.C., Takahashi H., Li X.H., Hara T., Masuda S., Guan Y., et al. Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas. Hum Pathol 2008, 39:1042-1049.
    • (2008) Hum Pathol , vol.39 , pp. 1042-1049
    • Zheng, H.C.1    Takahashi, H.2    Li, X.H.3    Hara, T.4    Masuda, S.5    Guan, Y.6
  • 38
    • 34548591307 scopus 로고    scopus 로고
    • Network-based analysis of calcium-binding protein genes identifies Grp94 as a target in human oral carcinogenesis
    • Nomura H., Uzawa K., Yamano Y., Fushimi K., Ishigami T., Kato Y., et al. Network-based analysis of calcium-binding protein genes identifies Grp94 as a target in human oral carcinogenesis. Br J Cancer 2007, 97:792-801.
    • (2007) Br J Cancer , vol.97 , pp. 792-801
    • Nomura, H.1    Uzawa, K.2    Yamano, Y.3    Fushimi, K.4    Ishigami, T.5    Kato, Y.6
  • 39
    • 31644447446 scopus 로고    scopus 로고
    • Increased expression of GRP94 protein is associated with decreased sensitivity to X-rays in cervical cancer cell lines
    • Kubota H., Suzuki T., Lu J., Takahashi S., Suqita K., Sekiya S., et al. Increased expression of GRP94 protein is associated with decreased sensitivity to X-rays in cervical cancer cell lines. Int J Radiat Biol 2005, 81:701-709.
    • (2005) Int J Radiat Biol , vol.81 , pp. 701-709
    • Kubota, H.1    Suzuki, T.2    Lu, J.3    Takahashi, S.4    Suqita, K.5    Sekiya, S.6
  • 40
    • 41449094913 scopus 로고    scopus 로고
    • Expression and clinical significance of glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus
    • Langer R., Feith M., Siewert J.R., Wester H.J., Hoefler H. Expression and clinical significance of glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus. BMC Cancer 2008, 8:70.
    • (2008) BMC Cancer , vol.8 , pp. 70
    • Langer, R.1    Feith, M.2    Siewert, J.R.3    Wester, H.J.4    Hoefler, H.5
  • 41
    • 77950601859 scopus 로고    scopus 로고
    • Gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis
    • Staron M., Yang Y., Liu B., Li J., Shen Y., Zúniga-Pflücker J.C., et al. gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis. Blood 2010, 115:2380-2390.
    • (2010) Blood , vol.115 , pp. 2380-2390
    • Staron, M.1    Yang, Y.2    Liu, B.3    Li, J.4    Shen, Y.5    Zúniga-Pflücker, J.C.6
  • 42
    • 14944371187 scopus 로고    scopus 로고
    • The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis
    • Zhang K., Wong H.N., Song B., Miller C.N., Scheuner D., Kaufman R.J. The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis. J Clin Invest 2005, 115:268-281.
    • (2005) J Clin Invest , vol.115 , pp. 268-281
    • Zhang, K.1    Wong, H.N.2    Song, B.3    Miller, C.N.4    Scheuner, D.5    Kaufman, R.J.6
  • 43
    • 51649117657 scopus 로고    scopus 로고
    • Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B-cell function via chaperoning integrin and TLR but not immunoglobulin
    • Liu B., Li Z. Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B-cell function via chaperoning integrin and TLR but not immunoglobulin. Blood 2008, 112:1223-1230.
    • (2008) Blood , vol.112 , pp. 1223-1230
    • Liu, B.1    Li, Z.2
  • 44
    • 79956352798 scopus 로고    scopus 로고
    • The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche
    • Luo B., Lam B.S., Lee S.H., Wey S., Zhou H., Wang M., et al. The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche. PLOS One 2011, 6:e20364.
    • (2011) PLOS One , vol.6
    • Luo, B.1    Lam, B.S.2    Lee, S.H.3    Wey, S.4    Zhou, H.5    Wang, M.6
  • 45
    • 78650338184 scopus 로고    scopus 로고
    • The endoplasmic reticulum protein folding factory and its chaperones: new targets for drug discovery?
    • McLaughlin M., Vandenbroeck K. The endoplasmic reticulum protein folding factory and its chaperones: new targets for drug discovery?. Br J Pharmacol 2011, 162:245-328.
    • (2011) Br J Pharmacol , vol.162 , pp. 245-328
    • McLaughlin, M.1    Vandenbroeck, K.2


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