Comparative study between bone marrow mononuclear fraction and mesenchymal stem cells treatment in sensorimotor recovery after focal cortical ablation in rats

Behavioral and Brain Functions

Volumn 8, Issue , 2012, Pages

  de Freitas, Helder T ^a   da Silva, Viviane G ^a   Giraldi Guimarães, Arthur ^a  

^a UNIVERSIDADE ESTADUAL DO NORTE FLUMINENSE DARCY RIBEIRO   (Brazil)

Author keywords

Cell therapy; Functional recovery; Motor cortex; Stem cell; Structural plasticity

Indexed keywords

ABLATION THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOTRANSPLANTATION; BONE MARROW CELL; BONE MARROW MONONUCLEAR CELL; BRAIN BLOOD VESSEL; BRAIN INJURY; BRAIN ISCHEMIA; CELL COUNT; CELL EXPANSION; COMPARATIVE STUDY; CONTROLLED STUDY; CONVALESCENCE; FUNCTIONAL STATUS; MALE; MESENCHYMAL STEM CELL; NERVE CELL PLASTICITY; NONHUMAN; PARIETAL CORTEX; PRIORITY JOURNAL; RAT; SENSORIMOTOR FUNCTION; THERMOCOAGULATION;

ANIMALS; BONE MARROW TRANSPLANTATION; BRAIN INJURIES; CEREBRAL CORTEX; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MOTOR SKILLS; RATS; RATS, WISTAR; RECOVERY OF FUNCTION;

EID: 84870908136     PISSN: None     EISSN: 17449081     Source Type: Journal    
DOI: 10.1186/1744-9081-8-58     Document Type: Article

References (22)

1. Mendez-Otero R, de Freitas GR, André C, de Mendonça ML, Friedrich M, Oliveira-Filho J. Potential roles of bone marrow stem cells in stroke therapy. Regen Med 2007, 2:417-423. 10.2217/17460751.2.4.417, 17635049.
2. Maltman DJ, Hardy SA, Przyborski SA. Role of mesenchymal stem cells in neurogenesis and nervous system repair. Neurochem Int 2011, 59:347-356.
3. Giraldi-Guimarães A, Rezende-Lima M, Bruno FP, Mendez-Otero R. Treatment with bone marrow mononuclear cells induces functional recovery and decreases neurodegeneration after sensorimotor cortical ischemia in rats. Brain Res 2009, 1266:108-120.
4. Yang B, Strong R, Sharma S, Brenneman M, Mallikarjunarao K, Xi X, Grotta JC, Aronowski J, Savitz SI. Therapeutic time window and dose response of autologous bone marrow mononuclear cells for ischemic stroke. J Neurosci Res 2011, 89:833-839. 10.1002/jnr.22614, 3412881, 21412816.
5. de Vasconcelos Dos Santos A, da Costa Reis J, Diaz Paredes B, Moraes L, Jasmin, Giraldi-Guimarães A, Mendez-Otero R. Therapeutic window for treatment of cortical ischemia with bone marrow-derived cells in rats. Brain Res 2010, 1306:149-158.
6. Pastor D, Viso-León MC, Jones J, Jaramillo-Merchán J, Toledo-Aral JJ, Moraleda JM, Martínez S. Comparative effects between bone marrow and mesenchymal stem cell transplantation in GDNF expression and motor function recovery in a motorneuron degenerative mouse mode. Stem Cell Rev and Rep 2011,
7. Samdani AF, Paul C, Betz RR, Fischer I, Neuhuber B. Transplantation of human marrow stromal cells and mono-nuclear bone marrow cells into the injured spinal cord: a comparative study. Spine 2009, 34:2605-2612. 10.1097/BRS.0b013e3181bdca87, 19881401.
8. Carmichael ST. Plasticity of cortical projections after stroke. Neuroscientist 2003, 9:64-75. 10.1177/1073858402239592, 12580341.
9. Gonzalez CL, Kolb B. A comparison of different models of stroke on behaviour and brain morphology. Eur J Neurosci 2003, 18:1950-1962. 10.1046/j.1460-9568.2003.02928.x, 14622227.
10. Voorhies AC, Jones TA. The behavioral and dendritic growth effects of focal sensorimotor cortical damage depend on the method of lesion induction. Behav Brain Res 2002, 133:237-246. 10.1016/S0166-4328(02)00029-3, 12110457.
11. Chen S, Hillman DE. Robust synaptic plasticity of striatal cells following partial deafferentation. Brain Res 1990, 520:103-114. 10.1016/0006-8993(90)91695-D, 2207624.
12. Napieralski JA, Banks RJ, Chesselet MF. Motor and somatosensory deficits following uni- and bilateral lesions of the cortex induced by aspiration or thermocoagulation in the adult rat. Exp Neurol 1998, 154:80-88. 10.1006/exnr.1998.6893, 9875270.
13. Szele FG, Alexander C, Chesselet MF. Expression of molecules associated with neuronal plasticity in the striatum after aspiration and thermocoagulatory lesions of the cerebral cortex in adult rats. J Neurosci 1995, 15:4429-4448.
14. Borlongan CV, Randall TS, Cahill DW, Sanberg PR. Asymmetrical motor behavior in rats with unilateral striatal excitotoxic lesions as revealed by the elevated body swing test. Brain Res 1995, 676:231-234. 10.1016/0006-8993(95)00150-O, 7796175.
15. Wakayama A, Kataoka K, Taneda M, Yamada K, Hayakawa T. Evaluation of masked neurological disorders in the chronic stage after middle cerebral artery occlusion in rats-methamphetamine-induced rotation and regional glucose metabolism in basal ganglia. Neurol Med Chir (Tokyo) 1993, 33:801-808.
16. Barry FP, Murphy JM. Mesenchymal stem cells: clinical applications and biological characterization. Int J Biochem Cell Biol 2004, 36:568-584. 10.1016/j.biocel.2003.11.001, 15010324.
17. Akiyama Y, Radtke C, Honmou O, Kocsis JD. Remyelination of the spinal cord following intravenous delivery of bone marrow cells. Glia 2002, 39:229-236. 10.1002/glia.10102, 2605380, 12203389.
18. Battistella V, de Freitas GR, da Fonseca LM, Mercante D, Gutfilen B, Goldenberg RC, Dias JV, Kasai-Brunswick TH, Wajnberg E, Rosado-de-Castro PH, Alves-Leon SV, Mendez-Otero R, Andre C. Safety of autologous bone marrow mononuclear cell transplantation in patients with nonacute ischemic stroke. Regen Med 2011, 6:45-52. 10.2217/rme.10.97, 21175286.
19. Savitz SI, Misra V, Kasam M, Juneja H, Cox CS, Alderman S, Aisiku I, Kar S, Gee A, Grotta JC. Intravenous autologous bone marrow mononuclear cells for ischemic stroke. Ann Neurol 2011, 70:59-69. 10.1002/ana.22458, 21786299.
20. Benowitz LI, Popovich PG. Inflammation and axon regeneration. Curr Opin Neurol 2011, 24:577-583. 10.1097/WCO.0b013e32834c208d, 21968547.
21. de Vasconcelos Dos Santos A, Rosado-de-Castro PH, de Souza SA L, da Costa Silva J, Ramos AB, Rodriguez De Freitas G, da Fonseca LM B, Gutfilen B, Mendez-Otero R. Intravenous and intra-arterial administration of bone marrow mononuclear cells after focal cerebral ischemia: Is there a difference in biodistribution and efficacy?. Stem Cell Res 2012, 9:1-8. 10.1016/j.scr.2012.02.002, 22445868.
22. Takahashi M, Li TS, Suzuki R, Kobayashi T, Ito H, Ikeda Y, Matsuzaki M, Hamano K. Cytokines produced by bone marrow cells can contribute to functional improvement of the infarcted heart by protecting cardiomyocytes from ischemic injury. Am J Physiol Heart Circ Physiol 2006, 291:886-893.