Fishing for the mechanisms causing febrile seizures: Employing a novel model to uncover the physiological generators of seizures with fever

Experimental Neurology

Volumn 240, Issue 1, 2013, Pages 108-111

  Marsh, Eric D ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR GAMMA2; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 1BETA; SODIUM CHANNEL NAV1.1; SODIUM CHANNEL NAV1.2; VANILLOID RECEPTOR; VANILLOID RECEPTOR 4; VANILLOID RECEPTOR 5; VANILLOID RECEPTOR 6;

BODY TEMPERATURE; BRAIN REGION; CAUSAL ATTRIBUTION; CELL DEATH; DISEASE DURATION; EPILEPSY; FAMILY HISTORY; FEBRILE CONVULSION; GENE MUTATION; GENETIC LINKAGE; HIPPOCAMPUS; HUMAN; NONHUMAN; NOTE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; HYPERTHERMIA, INDUCED; RECEPTORS, GLUTAMATE; SEIZURES; TRPV CATION CHANNELS; ZEBRAFISH PROTEINS;

EID: 84870900971     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2012.11.016     Document Type: Note

References (45)

1. Ahmad S., Marsh E.D. Febrile status epilepticus: current state of clinical and basic research. Semin. Pediatr. Neurol. 2010, 17:150-154.
2. Baraban S.C., Dinday M.T., Castro P.A., Chege S., Guyenet S., Taylor M.R. A large-scale mutagenesis screen to identify seizure-resistant zebrafish. Epilepsia 2007, 48:1151-1157.
3. Baraban S.C., Taylor M.R., Castro P.A., Baier H. Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression. Neuroscience 2005, 131:759-768.
4. Baram T.Z., Gerth A., Schultz L. Febrile seizures: an appropriate-aged model suitable for long-term studies. Brain Res. Dev. Brain Res. 1997, 98:265-270.
5. Beck J.C., Gilland E., Baker R., Tank D.W. Instrumentation for measuring oculomotor performance and plasticity in larval organisms. Methods Cell Biol. 2004, 76:385-413.
6. Bender R.A., Dube C., Gonzalez-Vega R., Mina E.W., Baram T.Z. Mossy fiber plasticity and enhanced hippocampal excitability, without hippocampal cell loss or altered neurogenesis, in an animal model of prolonged febrile seizures. Hippocampus 2003, 13:399-412.
7. Berg A.T., Shinnar S., Levy S.R., Testa F.M. Childhood-onset epilepsy with and without preceding febrile seizures. Neurology 1999, 53:1742-1748.
8. Brewster A., Bender R.A., Chen Y., Dube C., Eghbal-Ahmadi M., Baram T.Z. Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner. J. Neurosci. 2002, 22:4591-4599.
9. Camfield P.R., Camfield C.S. Management and treatment of febrile seizures. Curr. Probl. Pediatr. 1997, 27:6-14.
10. Chen K., Aradi I., Thon N., Eghbal-Ahmadi M., Baram T.Z., Soltesz I. Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability. Nat. Med. 2001, 7:331-337.
11. Chen K., Baram T.Z., Soltesz I. Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits. Nat. Med. 1999, 5:888-894.
12. Dibbens L.M., Reid C.A., Hodgson B., Thomas E.A., Phillips A.M., Gazina E., Cromer B.A., Clarke A.L., Baram T.Z., Scheffer I.E., Berkovic S.F., Petrou S. Augmented currents of an HCN2 variant in patients with febrile seizure syndromes. Ann. Neurol. 2010, 67:542-546.
13. Dube C., Chen K., Eghbal-Ahmadi M., Brunson K., Soltesz I., Baram T.Z. Prolonged febrile seizures in the immature rat model enhance hippocampal excitability long term. Ann. Neurol. 2000, 47:336-344.
14. Dube C., Richichi C., Bender R.A., Chung G., Litt B., Baram T.Z. Temporal lobe epilepsy after experimental prolonged febrile seizures: prospective analysis. Brain 2006, 129:911-922.
15. Dube C., Vezzani A., Behrens M., Bartfai T., Baram T.Z. Interleukin-1beta contributes to the generation of experimental febrile seizures. Ann. Neurol. 2005, 57:152-155.
16. Dube C., Yu H., Nalcioglu O., Baram T.Z. Serial MRI after experimental febrile seizures: altered T2 signal without neuronal death. Ann. Neurol. 2004, 56:709-714.
17. Dube C.M., Brewster A.L., Richichi C., Zha Q., Baram T.Z. Fever, febrile seizures and epilepsy. Trends Neurosci. 2007, 30:490-496.
18. Dube, C. M., McClelland, S., Choy, M. K., Brewster, A. L., Noam, Y., and Baram, T. Z., Fever, febrile seizures and epileptogenesis.
19. Dube C.M., McClelland S., Choy M.K., Brewster A.L., Noam Y., Baram T.Z. Fever, febrile seizures and epileptogenesis. Jasper's Basic Mechanisms of the Epilepsies 2012, NCBI, Bethesda. J. Noebels, M. Avoli, M. Rogawski, R. Olsen, A.V. Delgado-Escueta (Eds.).
20. Gavva N.R. Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1. Trends Pharmacol. Sci. 2008, 29:550-557.
21. Gibson H.E., Edwards J.G., Page R.S., Van Hook M.J., Kauer J.A. TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron 2008, 57:746-759.
22. Gilland E., Miller A.L., Karplus E., Baker R., Webb S.E. Imaging of multicellular large-scale rhythmic calcium waves during zebrafish gastrulation. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:157-161.
23. Harkin L.A., Bowser D.N., Dibbens L.M., Singh R., Phillips F., Wallace R.H., Richards M.C., Williams D.A., Mulley J.C., Berkovic S.F., Scheffer I.E., Petrou S. Truncation of the GABA(A)-receptor gamma2 subunit in a family with generalized epilepsy with febrile seizures plus. Am. J. Hum. Genet. 2002, 70:530-536.
24. Hauser W.A. Incidence and prevalence. Epilepsy: A Comprehensive Textbook 1997, 47-57. Lippincott-Raven, Philadelphia. J.A.P. Engel, P (Eds.).
25. Heida J.G., Pittman Q.J. Causal links between brain cytokines and experimental febrile convulsions in the rat. Epilepsia 2005, 46:1906-1913.
26. Hunt R.F., Hortopan G.A., Gillespie A., Baraban S.C. A novel zebrafish model of hyperthermia-induced seizures reveals a role for TRPV4 channels and NMDA-type glutamate receptors. Exp. Neurol. 2012, 237:199-206.
27. Karatas H., Gurer G., Pinar A., Soylemezoglu F., Tezel G.G., Hascelik G., Akalan N., Tuncer S., Ciger A., Saygi S. Investigation of HSV-1, HSV-2, CMV, HHV-6 and HHV-8 DNA by real-time PCR in surgical resection materials of epilepsy patients with mesial temporal lobe sclerosis. J. Neurol. Sci. 2008, 264:151-156.
28. Kauer J.A., Gibson H.E. Hot flash: TRPV channels in the brain. Trends Neurosci. 2009, 32:215-224.
29. Maroso M., Balosso S., Ravizza T., Liu J., Bianchi M.E., Vezzani A. Interleukin-1 type 1 receptor/Toll-like receptor signalling in epilepsy: the importance of IL-1beta and high-mobility group box 1. J Intern Med 2011, 270:319-326.
30. Matta J.A., Ahern G.P. TRPV1 and synaptic transmission. Curr Pharm Biotechnol 2011, 12:95-101.
31. McClelland S., Dube C.M., Yang J., Baram T.Z. Epileptogenesis after prolonged febrile seizures: mechanisms, biomarkers and therapeutic opportunities. Neurosci. Lett. 2011, 497:155-162.
32. Nelson K.B., Ellenberg J.H. Antecedents of seizure disorders in early childhood. Am. J. Dis. Child. 1986, 140:1053-1061.
33. Nelson K.B., Ellenberg J.H. Predisposing and causative factors in childhood epilepsy. Epilepsia 1987, 28(Suppl. 1):S16-S24.
34. Piperidou H.N., Heliopoulos I.N., Maltezos E.S., Stathopoulos G.A., Milonas I.A. Retrospective study of febrile seizures: subsequent electroencephalogram findings, unprovoked seizures and epilepsy in adolescents. J Int Med Res 2002, 30:560-565.
35. Scheffer I.E., Berkovic S.F. Generalized epilepsy with febrile seizures plus. A genetic disorder with heterogeneous clinical phenotypes. Brain 1997, 120(Pt 3):479-490.
36. Scheffer I.E., Harkin L.A., Dibbens L.M., Mulley J.C., Berkovic S.F. Neonatal epilepsy syndromes and generalized epilepsy with febrile seizures plus (GEFS+). Epilepsia 2005, 46(Suppl. 10):41-47.
37. Scheffer I.E., Harkin L.A., Grinton B.E., Dibbens L.M., Turner S.J., Zielinski M.A., Xu R., Jackson G., Adams J., Connellan M., Petrou S., Wellard R.M., Briellmann R.S., Wallace R.H., Mulley J.C., Berkovic S.F. Temporal lobe epilepsy and GEFS+ phenotypes associated with SCN1B mutations. Brain 2007, 130:100-109.
38. Sijben A.E., Sithinamsuwan P., Radhakrishnan A., Badawy R.A., Dibbens L., Mazarib A., Lev D., Lerman-Sagie T., Straussberg R., Berkovic S.F., Scheffer I.E. Does a SCN1A gene mutation confer earlier age of onset of febrile seizures in GEFS+?. Epilepsia 2009, 50:953-956.
39. Steenland H.W., Ko S.W., Wu L.J., Zhuo M. Hot receptors in the brain. Mol Pain 2006, 2:34.
40. Takao T., Tracey D.E., Mitchell W.M., De Souza E.B. Interleukin-1 receptors in mouse brain: characterization and neuronal localization. Endocrinology 1990, 127:3070-3078.
41. Theodore W.H., Epstein L., Gaillard W.D., Shinnar S., Wainwright M.S., Jacobson S. Human herpes virus 6B: a possible role in epilepsy?. Epilepsia 2008, 49:1828-1837.
42. Toth Z., Yan X.X., Haftoglou S., Ribak C.E., Baram T.Z. Seizure-induced neuronal injury: vulnerability to febrile seizures in an immature rat model. J. Neurosci. 1998, 18:4285-4294.
43. Veliskova J., Claudio O.I., Galanopoulou A.S., Lado F.A., Ravizza T., Velisek L., Moshe S.L. Seizures in the developing brain. Epilepsia 2004, 45(Suppl. 8):6-12.
44. Vezzani, A., Maroso, M., Balosso, S., Sanchez, M. A., and Bartfai, T., IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures. Brain Behav Immun 25, 1281-1289.
45. Virta M., Hurme M., Helminen M. Increased frequency of interleukin-1beta (-511) allele 2 in febrile seizures. Pediatr. Neurol. 2002, 26:192-195.