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Volumn 18, Issue 12, 2012, Pages 1797-1804

Abnormal development of NG2+ PDGFR-α+ neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse model

Author keywords

[No Author keywords available]

Indexed keywords

CELL ANTIGEN; LITHIUM; NEURON GLIAL ANTIGEN 2; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; UNCLASSIFIED DRUG;

EID: 84870899794     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2996     Document Type: Article
Times cited : (91)

References (54)
  • 1
    • 0021966405 scopus 로고
    • Ependyma: Normal and pathological. A review of the literature
    • Bruni, J.E., Del Bigio, M.R. & Clattenburg, R.E. Ependyma: normal and pathological. A review of the literature. Brain Res. 356, 1-19 (1985).
    • (1985) Brain Res. , vol.356 , pp. 1-19
    • Bruni, J.E.1    Del Bigio, M.R.2    Clattenburg, R.E.3
  • 2
    • 77649190846 scopus 로고    scopus 로고
    • Ependymal cells: Biology and pathology
    • Del Bigio, M.R. Ependymal cells: biology and pathology. Acta Neuropathol. 119, 55-73 (2010).
    • (2010) Acta Neuropathol. , vol.119 , pp. 55-73
    • Del Bigio, M.R.1
  • 3
    • 43149113938 scopus 로고    scopus 로고
    • Priorities for hydrocephalus research: Report from a national institutes of health-sponsored workshop
    • Williams, M.A. et al. Priorities for hydrocephalus research: report from a National Institutes of Health-sponsored workshop. J. Neurosurg. 107, 345-357 (2007).
    • (2007) J. Neurosurg. , vol.107 , pp. 345-357
    • Williams, M.A.1
  • 4
    • 84855363795 scopus 로고    scopus 로고
    • Congenital hydrocephalus in genetically engineered mice
    • Vogel, P. et al. Congenital hydrocephalus in genetically engineered mice. Vet. Pathol. 49, 166-181 (2012).
    • (2012) Vet. Pathol. , vol.49 , pp. 166-181
    • Vogel, P.1
  • 5
    • 40849088335 scopus 로고    scopus 로고
    • Hospital care for children with hydrocephalus in the United States: Utilization, charges, comorbidities, and deaths
    • Simon, T.D. et al. Hospital care for children with hydrocephalus in the United States: utilization, charges, comorbidities, and deaths. J. Neurosurg. Pediatr. 1, 131-137 (2008).
    • (2008) J. Neurosurg. Pediatr. , vol.1 , pp. 131-137
    • Simon, T.D.1
  • 6
    • 83055193725 scopus 로고    scopus 로고
    • The economic impact of ventriculoperitoneal shunt failure
    • Shannon, C.N. et al. The economic impact of ventriculoperitoneal shunt failure. Journal J. Neurosurg. Pediatr. 8, 593-599 (2011).
    • (2011) Journal J. Neurosurg. Pediatr. , vol.8 , pp. 593-599
    • Shannon, C.N.1
  • 7
    • 0027183109 scopus 로고
    • A duplication in the L1CAM gene associated with X-linked hydrocephalus
    • Van Camp, G. et al. A duplication in the L1CAM gene associated with X-linked hydrocephalus. Nat. Genet. 4, 421-425 (1993).
    • (1993) Nat. Genet. , vol.4 , pp. 421-425
    • Van Camp, G.1
  • 8
    • 33644673009 scopus 로고    scopus 로고
    • Time trends and demographics of deaths from congenital hydrocephalus in children in the United States: National center for health statistics data, 1979 to 1998
    • Chi, J.H., Fullerton, H.J. & Gupta, N. Time trends and demographics of deaths from congenital hydrocephalus in children in the United States: National Center for Health Statistics data, 1979 to 1998. J. Neurosurg. 103, 113-118 (2005).
    • (2005) J. Neurosurg. , vol.103 , pp. 113-118
    • Chi, J.H.1    Fullerton, H.J.2    Gupta, N.3
  • 9
    • 33750633677 scopus 로고    scopus 로고
    • Genetics of human hydrocephalus
    • Zhang, J., Williams, M.A. & Rigamonti, D. Genetics of human hydrocephalus. J. Neurol. 253, 1255-1266 (2006).
    • (2006) J. Neurol. , vol.253 , pp. 1255-1266
    • Zhang, J.1    Williams, M.A.2    Rigamonti, D.3
  • 10
    • 29644441705 scopus 로고    scopus 로고
    • Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalus
    • Banizs, B. et al. Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalus. Development 132, 5329-5339 (2005).
    • (2005) Development , vol.132 , pp. 5329-5339
    • Banizs, B.1
  • 11
    • 11144236688 scopus 로고    scopus 로고
    • Implanted ventricular shunts in the United States: The billion-dollar-A-year cost of hydrocephalus treatment
    • Patwardhan, R.V. & Nanda, A. Implanted ventricular shunts in the United States: the billion-dollar-a-year cost of hydrocephalus treatment. Neurosurgery 56, 139-144 (2005).
    • (2005) Neurosurgery , vol.56 , pp. 139-144
    • Patwardhan, R.V.1    Nanda, A.2
  • 13
    • 12144262775 scopus 로고    scopus 로고
    • Adult ependymal cells are postmitotic and are derived from radial glial cells during embryogenesis
    • Spassky, N. et al. Adult ependymal cells are postmitotic and are derived from radial glial cells during embryogenesis. J. Neurosci. 25, 10-18 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 10-18
    • Spassky, N.1
  • 14
    • 77952850722 scopus 로고    scopus 로고
    • Lack of cadherins celsr2 and celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus
    • Tissir, F. et al. Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nat. Neurosci. 13, 700-707 (2010).
    • (2010) Nat. Neurosci. , vol.13 , pp. 700-707
    • Tissir, F.1
  • 15
    • 78349237716 scopus 로고    scopus 로고
    • P73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis
    • Talos, F. et al. p73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis. Cell Death Differ. 17, 1816-1829 (2010).
    • (2010) Cell Death Differ. , vol.17 , pp. 1816-1829
    • Talos, F.1
  • 16
    • 17544363909 scopus 로고    scopus 로고
    • P73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours
    • Yang, A. et al. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 404, 99-103 (2000).
    • (2000) Nature , vol.404 , pp. 99-103
    • Yang, A.1
  • 17
    • 41849141928 scopus 로고    scopus 로고
    • The surgical management of pediatric hydrocephalus
    • Drake, J.M. The surgical management of pediatric hydrocephalus. Neurosurgery 62 (suppl. 2), 633-640 (2008).
    • (2008) Neurosurgery , vol.62 , Issue.SUPPL. 2 , pp. 633-640
    • Drake, J.M.1
  • 18
    • 0033647483 scopus 로고    scopus 로고
    • CSF shunts 50 years on - Past, present and future
    • Drake, J.M., Kestle, J.R. & Tuli, S. CSF shunts 50 years on - past, present and future. Childs Nerv. Syst. 16, 800-804 (2000).
    • (2000) Childs Nerv. Syst. , vol.16 , pp. 800-804
    • Drake, J.M.1    Kestle, J.R.2    Tuli, S.3
  • 19
    • 37649020306 scopus 로고    scopus 로고
    • A knockin mouse model of the bardet-biedl syndrome 1 M390R mutation has cilia defects, ventriculomegaly, retinopathy, and obesity
    • Davis, R.E. et al. A knockin mouse model of the Bardet-Biedl syndrome 1 M390R mutation has cilia defects, ventriculomegaly, retinopathy, and obesity. Proc. Natl. Acad. Sci. USA 104, 19422-19427 (2007).
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 19422-19427
    • Davis, R.E.1
  • 20
    • 5744244393 scopus 로고    scopus 로고
    • Dysfunction of axonemal dynein heavy chain mdnah5 inhibits ependymal flow and reveals a novel mechanism for hydrocephalus formation
    • Ibañez-Tallon, I. et al. Dysfunction of axonemal dynein heavy chain Mdnah5 inhibits ependymal flow and reveals a novel mechanism for hydrocephalus formation. Hum. Mol. Genet. 13, 2133-2141 (2004).
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 2133-2141
    • Ibañez-Tallon, I.1
  • 21
    • 79957911385 scopus 로고    scopus 로고
    • Subcellular spatial regulation of canonical wnt signalling at the primary cilium
    • Lancaster, M.A., Schroth, J. & Gleeson, J.G. Subcellular spatial regulation of canonical Wnt signalling at the primary cilium. Nat. Cell Biol. 13, 700-707 (2011).
    • (2011) Nat. Cell Biol. , vol.13 , pp. 700-707
    • Lancaster, M.A.1    Schroth, J.2    Gleeson, J.G.3
  • 22
    • 79957611891 scopus 로고    scopus 로고
    • Complex interactions between genes controlling trafficking in primary cilia
    • Ocbina, P.J., Eggenschwiler, J.T., Moskowitz, I. & Anderson, K.V. Complex interactions between genes controlling trafficking in primary cilia. Nat. Genet. 43, 547-553 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 547-553
    • Ocbina, P.J.1    Eggenschwiler, J.T.2    Moskowitz, I.3    Anderson, K.V.4
  • 23
    • 84859219770 scopus 로고    scopus 로고
    • BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes
    • Zhang, Q., Seo, S., Bugge, K., Stone, E.M. & Sheffield, V.C. BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes. Hum. Mol. Genet. 21, 1945-1953 (2012).
    • (2012) Hum. Mol. Genet. , vol.21 , pp. 1945-1953
    • Zhang, Q.1    Seo, S.2    Bugge, K.3    Stone, E.M.4    Sheffield, V.C.5
  • 24
    • 27144529532 scopus 로고    scopus 로고
    • PDGFRαα signaling is regulated through the primary cilium in fibroblasts
    • Schneider, L. et al. PDGFRαα signaling is regulated through the primary cilium in fibroblasts. Curr. Biol. 15, 1861-1866 (2005).
    • (2005) Curr. Biol. , vol.15 , pp. 1861-1866
    • Schneider, L.1
  • 25
    • 67651036549 scopus 로고    scopus 로고
    • The glial nature of embryonic and adult neural stem cells
    • Kriegstein, A. & Alvarez-Buylla, A. The glial nature of embryonic and adult neural stem cells. Annu. Rev. Neurosci. 32, 149-184 (2009).
    • (2009) Annu. Rev. Neurosci. , vol.32 , pp. 149-184
    • Kriegstein, A.1    Alvarez-Buylla, A.2
  • 26
    • 39749112475 scopus 로고    scopus 로고
    • Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells
    • Han, Y.G. et al. Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells. Nat. Neurosci. 11, 277-284 (2008).
    • (2008) Nat. Neurosci. , vol.11 , pp. 277-284
    • Han, Y.G.1
  • 27
    • 51349167818 scopus 로고    scopus 로고
    • Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling
    • Breunig, J.J. et al. Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling. Proc. Natl. Acad. Sci. USA 105, 13127-13132 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 13127-13132
    • Breunig, J.J.1
  • 28
    • 31944434903 scopus 로고    scopus 로고
    • New neurons follow the flow of cerebrospinal fluid in the adult brain
    • Sawamoto, K. et al. New neurons follow the flow of cerebrospinal fluid in the adult brain. Science 311, 629-632 (2006).
    • (2006) Science , vol.311 , pp. 629-632
    • Sawamoto, K.1
  • 29
    • 79956205463 scopus 로고    scopus 로고
    • Lake-front property: A unique germinal niche by the lateral ventricles of the adult brain
    • Ihrie, R.A. & Alvarez-Buylla, A. Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain. Neuron 70, 674-686 (2011).
    • (2011) Neuron , vol.70 , pp. 674-686
    • Ihrie, R.A.1    Alvarez-Buylla, A.2
  • 30
    • 34250012834 scopus 로고    scopus 로고
    • A core complex of BBS proteins cooperates with the GTPase rab8 to promote ciliary membrane biogenesis
    • Nachury, M.V. et al. A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell 129, 1201-1213 (2007).
    • (2007) Cell , vol.129 , pp. 1201-1213
    • Nachury, M.V.1
  • 31
    • 78650657113 scopus 로고    scopus 로고
    • Neocortical and hippocampal volume loss in a human ciliopathy: A quantitative MRI study in bardet-biedl syndrome
    • Baker, K. et al. Neocortical and hippocampal volume loss in a human ciliopathy: a quantitative MRI study in Bardet-Biedl syndrome. Am. J. Med. Genet. A. 155A, 1-8 (2011).
    • (2011) Am. J. Med. Genet. A. , vol.155 A , pp. 1-8
    • Baker, K.1
  • 32
    • 79960661515 scopus 로고    scopus 로고
    • Brain tissue- and region-specific Abnormalities on volumetric MRI scans in 21 patients with bardet-biedl syndrome (BBS)
    • Keppler-Noreuil, K.M. et al. Brain tissue- and region-specific abnormalities on volumetric MRI scans in 21 patients with Bardet-Biedl syndrome (BBS). BMC Med. Genet. 12, 101 (2011).
    • (2011) BMC Med. Genet. , vol.12 , pp. 101
    • Keppler-Noreuil, K.M.1
  • 33
    • 34547802614 scopus 로고    scopus 로고
    • Immunohistological markers for staging neurogenesis in adult hippocampus
    • von Bohlen Und Halbach, O. Immunohistological markers for staging neurogenesis in adult hippocampus. Cell Tissue Res. 329, 409-420 (2007).
    • (2007) Cell Tissue Res. , vol.329 , pp. 409-420
    • Von Bohlen Und Halbach, O.1
  • 34
    • 33845924454 scopus 로고    scopus 로고
    • S100B expression defines a state in which GFAP-expressing cells lose their neural stem cell potential and acquire a more mature developmental stage
    • Raponi, E. et al. S100B expression defines a state in which GFAP-expressing cells lose their neural stem cell potential and acquire a more mature developmental stage. Glia 55, 165-177 (2007).
    • (2007) Glia , vol.55 , pp. 165-177
    • Raponi, E.1
  • 35
    • 33745880884 scopus 로고    scopus 로고
    • + B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling
    • + B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling. Neuron 51, 187-199 (2006).
    • (2006) Neuron , vol.51 , pp. 187-199
    • Jackson, E.L.1
  • 36
    • 56749156453 scopus 로고    scopus 로고
    • PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
    • Rivers, L.E. et al. PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice. Nat. Neurosci. 11, 1392-1401 (2008).
    • (2008) Nat. Neurosci. , vol.11 , pp. 1392-1401
    • Rivers, L.E.1
  • 37
    • 79956221125 scopus 로고    scopus 로고
    • NG2-glia as multipotent neural stem cells: Fact or fantasy?
    • Richardson, W.D., Young, K.M., Tripathi, R.B. & McKenzie, I. NG2-glia as multipotent neural stem cells: fact or fantasy? Neuron 70, 661-673 (2011).
    • (2011) Neuron , vol.70 , pp. 661-673
    • Richardson, W.D.1    Young, K.M.2    Tripathi, R.B.3    McKenzie, I.4
  • 38
    • 78649757441 scopus 로고    scopus 로고
    • NG2 glia generate new oligodendrocytes but few astrocytes in a murine experimental autoimmune encephalomyelitis model of demyelinating disease
    • Tripathi, R.B., Rivers, L.E., Young, K.M., Jamen, F. & Richardson, W.D. NG2 glia generate new oligodendrocytes but few astrocytes in a murine experimental autoimmune encephalomyelitis model of demyelinating disease. J. Neurosci. 30, 16383-16390 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 16383-16390
    • Tripathi, R.B.1    Rivers, L.E.2    Young, K.M.3    Jamen, F.4    Richardson, W.D.5
  • 39
    • 57749172539 scopus 로고    scopus 로고
    • Polydendrocytes (NG2 cells): Multifunctional cells with lineage plasticity
    • Nishiyama, A., Komitova, M., Suzuki, R. & Zhu, X. Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity. Nat. Rev. Neurosci. 10, 9-22 (2009).
    • (2009) Nat. Rev. Neurosci. , vol.10 , pp. 9-22
    • Nishiyama, A.1    Komitova, M.2    Suzuki, R.3    Zhu, X.4
  • 40
    • 0034622930 scopus 로고    scopus 로고
    • Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells
    • Kondo, T. & Raff, M. Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science 289, 1754-1757 (2000).
    • (2000) Science , vol.289 , pp. 1754-1757
    • Kondo, T.1    Raff, M.2
  • 41
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta, S.R. et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241 (1997).
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1
  • 42
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco, I. & Sawyers, C.L. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer 2, 489-501 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 43
    • 0035489468 scopus 로고    scopus 로고
    • PKB/AKT: Functional insights from genetic models
    • Scheid, M.P. & Woodgett, J.R. PKB/AKT: functional insights from genetic models. Nat. Rev. Mol. Cell Biol. 2, 760-768 (2001).
    • (2001) Nat. Rev. Mol. Cell Biol. , vol.2 , pp. 760-768
    • Scheid, M.P.1    Woodgett, J.R.2
  • 44
    • 0033587742 scopus 로고    scopus 로고
    • Lithium activates the serine/threonine kinase akt-1 and suppresses glutamate-induced inhibition of akt-1 activity in neurons
    • Chalecka-Franaszek, E. & Chuang, D.M. Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons. Proc. Natl. Acad. Sci. USA 96, 8745-8750 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 8745-8750
    • Chalecka-Franaszek, E.1    Chuang, D.M.2
  • 45
    • 34447649395 scopus 로고    scopus 로고
    • Lithium enhances proliferation and neuronal differentiation of neural progenitor cells in vitro and after transplantation into the adult rat spinal cord
    • Su, H., Chu, T.H. & Wu, W. Lithium enhances proliferation and neuronal differentiation of neural progenitor cells in vitro and after transplantation into the adult rat spinal cord. Exp. Neurol. 206, 296-307 (2007).
    • (2007) Exp. Neurol. , vol.206 , pp. 296-307
    • Su, H.1    Chu, T.H.2    Wu, W.3
  • 46
    • 80053570706 scopus 로고    scopus 로고
    • Lithium-mediated long-term neuroprotection in neonatal rat hypoxiaischemia is associated with antiinflammatory effects and enhanced proliferation and survival of neural stem/progenitor cells
    • Li, H. et al. Lithium-mediated long-term neuroprotection in neonatal rat hypoxiaischemia is associated with antiinflammatory effects and enhanced proliferation and survival of neural stem/progenitor cells. J. Cereb. Blood Flow Metab. 31, 2106-2115 (2011).
    • (2011) J. Cereb. Blood Flow Metab. , vol.31 , pp. 2106-2115
    • Li, H.1
  • 48
    • 44749088016 scopus 로고    scopus 로고
    • Loss of fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development
    • Goto, J., Tezuka, T., Nakazawa, T., Sagara, H. & Yamamoto, T. Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development. Mol. Cell. Neurosci. 38, 203-212 (2008).
    • (2008) Mol. Cell. Neurosci. , vol.38 , pp. 203-212
    • Goto, J.1    Tezuka, T.2    Nakazawa, T.3    Sagara, H.4    Yamamoto, T.5
  • 49
    • 84862932899 scopus 로고    scopus 로고
    • Dysregulation of kruppel-like factor 4 during brain development leads to hydrocephalus in mice
    • Qin, S., Liu, M., Niu, W. & Zhang, C.L. Dysregulation of Kruppel-like factor 4 during brain development leads to hydrocephalus in mice. Proc. Natl. Acad. Sci. USA 108, 21117-21121 (2011).
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 21117-21121
    • Qin, S.1    Liu, M.2    Niu, W.3    Zhang, C.L.4
  • 50
    • 80052595682 scopus 로고    scopus 로고
    • Lysophosphatidic acid signaling may initiate fetal hydrocephalus
    • Yung, Y.C. et al. Lysophosphatidic acid signaling may initiate fetal hydrocephalus. Sci. Transl. Med. 3, 99ra87 (2011).
    • (2011) Sci. Transl. Med. , vol.3
    • Yung, Y.C.1
  • 51
    • 84864400015 scopus 로고    scopus 로고
    • De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes
    • Rivière, J.B. et al. De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes. Nat. Genet. 44, 934-940 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 934-940
    • Rivière, J.B.1
  • 52
    • 79851503308 scopus 로고    scopus 로고
    • GSK3β negatively regulates oligodendrocyte differentiation and myelination in vivo
    • Azim, K. & Butt, A.M. GSK3β negatively regulates oligodendrocyte differentiation and myelination in vivo. Glia 59, 540-553 (2011).
    • (2011) Glia , vol.59 , pp. 540-553
    • Azim, K.1    Butt, A.M.2
  • 53
    • 41949116864 scopus 로고    scopus 로고
    • Bardet-biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia
    • Berbari, N.F., Lewis, J.S., Bishop, G.A., Askwith, C.C. & Mykytyn, K. Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia. Proc. Natl. Acad. Sci. USA 105, 4242-4246 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 4242-4246
    • Berbari, N.F.1    Lewis, J.S.2    Bishop, G.A.3    Askwith, C.C.4    Mykytyn, K.5
  • 54
    • 63149175815 scopus 로고    scopus 로고
    • Requirement of bardet-biedl syndrome proteins for leptin receptor signaling
    • Seo, S. et al. Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling. Hum. Mol. Genet. 18, 1323-1331 (2009).
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 1323-1331
    • Seo, S.1


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