Late-onset hypogonadism

Frontiers of Hormone Research

Volumn 37, Issue , 2009, Pages 62-73

  Gooren, Louis J G ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

AGING; ANDROGEN DEFICIENCY; ANDROGEN THERAPY; CANCER RISK; DISEASE COURSE; ERECTILE DYSFUNCTION; ERYTHROPOIESIS; GLUCOSE HOMEOSTASIS; HUMAN; HYPERINSULINEMIA; HYPOGONADISM; LEYDIG CELL; LIBIDO; LIPID METABOLISM; MEDICAL PRACTICE; MEDICAL SOCIETY; METABOLIC SYNDROME X; NOMENCLATURE; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROSTATE; PROSTATE CANCER; REVIEW; TESTOSTERONE BLOOD LEVEL; AGED; MALE; METABOLISM; PHYSIOLOGY;

AGED; AGING; HUMANS; HYPOGONADISM; LEYDIG CELLS; MALE; SEX HORMONE-BINDING GLOBULIN; TERMINOLOGY AS TOPIC; TESTOSTERONE;

EID: 59849091023     PISSN: 03013073     EISSN: None     Source Type: Book Series    
DOI: 10.1159/000176045     Document Type: Review

References (55)

1. Lunenfeld B: The Aging Male. Aging Male 2002;5:73.
2. Kaufman JM, Vermeulen A: The decline of andro-gen levels in elderly men and its clinical and therapeutic implications. Endocr Rev 2005;26:833-876.
3. Leifke E, Gorenoi V, et al: Age-related changes of serum sex hormones, insulin-like growth factor-1 and sex-hormone binding globulin levels in men: cross-sectional data. Clin Endocrinol 2000;53:689-695.
4. Gray A, Feldman HA, et al: Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study.' J Clin Endocrinol Metab 1991;73:1016-1025.
5. Feldman HA, Longcope C, et al: Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study. J Clin Endocrinol Metab 2002;87:589-598.
6. Svartberg J, Midtby M, et al: The associations of age, lifestyle factors and chronic disease with testosterone in men: the Tromso Study. Eur J Endocrinol 2003;149:145-152.
7. Travison TG, Shabsigh R, et al: The natural progression and remission of erectile dysfunction: results from the Massachusetts Male Aging Study. J Urol 2007;177:241-246; discussion 246.
8. Werner A: The male climacteric. JAMA 1939;112: 1441-1443.
9. Heller C, Myers GB: The male climacteric, its symptomatology, diagnosis and treatment. JAMA 1944; 126:472-477.
10. McGavack T: The male climacterium. J Am Geriatric Soc 1955;3:639-655.
11. Nieschlag E, Swerdloff R, et al: Investigation, treatment and monitoring of late-onset hypogonadism in males. Aging Male 2005;8:56-58.
12. Nieschlag E, Swerdloff R, et al: Investigation, treatment and monitoring of late-onset hypogonadism in males. ISA, ISSAM, and EAU recommendations. Eur Urol 2005;48:1-4.
13. Morales A, Schulman CC, et al: Testosterone deficiency syndrome (TDS) needs to be named appropriately: the importance of accurate terminology. Eur Urol 2006;50:407-409.
14. Handelsman DJ, Liu PY: Andropause: invention, prevention, rejuvenation. Trends Endocrinol Metab 2005;16:39-45.
15. Schultheiss D, Jonas U, et al: Some historical reflections on the ageing male. World J Urol 2002;20: 40-44.
16. Smith RG, Betancourt L, et al: Molecular endocri -nology and physiology of the aging central nervous system. Endocr Rev 2005;26:203-250.
17. NIH State-of-the-Science Conference Statement on Management of Menopause-Related Symptoms. NIH Consens State Sci Statements 2005;22:1-38.
18. Harman SM, Naftolin F, et al: Is the estrogen controversy over? Deconstructing the Women's Health Initiative Study: a critical evaluation of the evidence. Ann NY Acad Sci 2005;1052:43-56.
19. Veldhuis JD, Iranmanesh A: Short-term aromatase-enzyme blockade unmasks impaired feedback adaptations in luteinizing hormone and testosterone secretion in older men. J Clin Endocrinol Metab 2005;90:211-218.
20. Veldhuis JD, Iranmanesh A, et al: Age and testosterone feedback jointly control the dose-dependent actions of gonadotropin-releasing hormone in healthy men. J Clin Endocrinol Metab 2005;90: 302-309.
21. Vermeulen A, Kaufman JM, et al: Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men. J Clin Endocrinol Metab 1993;76:1140-1146.
22. Lima N, Cavaliere H, et al: Decreased androgen levels in massively obese men may be associated with impaired function of the gonadostat. Int J Obes Relat Metab Disord 2000;24:1433-1437.
23. Crawford BA, Liu PY, et al: Randomized placebo-controlled trial of androgen effects on muscle and bone in men requiring long-term systemic gluco-corticoid treatment. J Clin Endocrinol Metab 2003; 88:3167-3176.
24. Lamberts S W, Romijn JA, et al: The future endocrine patient. Reflections on the future of clinical endo -crinology. Eur J Endocrinol 2003;149:169-175.
25. Harman SM, Tsitouras PD: Reproductive hormones in aging men. I. Measurement of sex steroids, basal luteinizing hormone, and Leydig cell response to human chorionic gonadotropin. J Clin Endocrinol Metab 1980;51:35-40.
26. Mulligan T, Iranmanesh A, et al: Pulsatile iv infusion of recombinant human LH in leuprolide-sup-pressed men unmasks impoverished Leydig-cell secretory responsiveness to midphysiological LH drive in the aging male. J Clin Endocrinol Metab 2001; 86:5547-5553.
27. Neaves WB, Johnson L, et al: Age-related change in numbers of other interstitial cells in testes of adult men: evidence bearing on the fate of Leydig cells lost with increasing age. Biol Reprod 1985;33: 259-269.
28. Culty M, Luo L, et al: Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells. J Androl 2002;23:439-447.
29. Vermeulen A, Deslypere JP: Intratesticular uncon-jugated steroids in elderly men. J Steroid Biochem 1986;24:1079-1083.
30. Mahmoud AM, Goemaere S, et al: Testi cular volume in relation to hormonal indices of gonadal function in community-dwelling elderly men. J Clin Endocrinol Metab 2003;88:179-184.
31. Caprio M, Isidori AM, et al: Expression of functional leptin receptors in rodent Leydig cells. Endocrinology 1999;140:4939-4947.
32. Isidori AM, Caprio M, et al: Leptin and androgens in male obesity: evidence for leptin contribution to reduced androgen levels. J Clin Endocrinol Metab 1999;84:3673-3680.
33. Soderberg S, Olsson T, et al: A strong association between biologically active testosterone and leptin in non-obese men and women is lost with increasing (central) adiposity. Int J Obes Relat Metab Disord 2001;25:98-105.
34. Van Den Saffele JK, Goemaere S, et al: Serum leptin levels in healthy ageing men: are decreased serum testosterone and increased adiposity in elderly men the consequence of leptin deficiency? Clin Endocrinol (Oxf) 1999;51:81-88.
35. Doucet E, St-Pierre S, et al: Fasting insulin levels influence plasma leptin levels independently from the contribution of adiposity: evidence from both a cross-sectional and an intervention study. J Clin Endocrinol Metab 2000;85:4231-4237.
36. Pitteloud N, Hardin M, et al: Increasing insulin resistance is associated with a decrease in Leydig cell testosterone secretion in men. J Clin Endocrinol Metab 2005;90:2636-2641.
37. Pritchard J, Despres J P, et al: Plasma adrenal, gonadal, and conjugated steroids before and after long-term overfeeding in identical twins. J Clin Endocrinol Metab 1998;83:3277-3284.
38. Vermeulen A, Kaufman JM, et al: Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males. J Clin Endocrinol Metab 1996;81:1821-1826.
39. Pritchard J, Despres J P, et al: Plasma adrenal, gonadal, and conjugated steroids following long-term exercise-induced negative energy balance in identical twins. Metabolism 1999;48:1120-1127.
40. Strain G, Zumoff B, et al: The relationship between serum levels of insulin and sex hormone-binding globulin in men: the effect of weight loss. J Clin Endocrinol Metab 1994;79:1173-1176.
41. Niskanen L, Laaksonen DE, et al: Changes in sex hormone-binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome. Diabetes Obes Metab 2004;6:208-215.
42. Vermeulen A, Stoica T, et al: The apparent free testosterone concentration, an index of androgenic-ity. J Clin Endocrinol Metab 1971;33:759-767.
43. Gomez JM, Maravall FJ, et al: Determinants of sex hormone-binding globulin concentrations in a cross-sectional study of healthy men randomly selected. J Nutr Health Aging 2007;11:60-64.
44. de Ronde W, van der Schouw YT, et al: Serum levels of sex hormone-binding globulin (SHBG) are not associated with lower levels of non-SHBG-bound testosterone in male newborns and healthy adult men. Clin Endocrinol (Oxf) 2005;62:498-503.
45. Vermeulen A, Deslypere JP: Testicular endocrine function in the ageing male. Maturitas 1985;7: 273-279.
46. Handelsman DJ: Testicular dysfunction in systemic disease. Endocrinol Metab Clin N Am 1994;23: 839-856.
47. Travison TG, Araujo AB, et al: The relative contributions of aging, health, and lifestyle factors to serum testosterone decline in men. J Clin Endocrinol Metab 2007;92:549-555.
48. Mohr BA, Bhasin S, et al: The effect of changes in adiposity on testosterone levels in older men: longitudinal results from the Massachusetts Male Aging Study. Eur J Endocrinol 2006;155:443-452.
49. Rodriguez A, Muller DC, et al: Aging, androgens, and the metabolic syndrome in a longitudinal study of aging. J Clin Endocrinol Metab 2007.
50. Allan CA, Strauss BJ, et al: The association between obesity and the diagnosis of androgen deficiency in symptomatic ageing men. Med J Aust 2006;185: 424-427.
51. Kaplan SA, Meehan AG, et al: The age related decrease in testosterone is significantly exacerbated in obese men with the metabolic syndrome: what are the implications for the relatively high incidence of erectile dysfunction observed in these men? J Urol 2006;176:1524-1527; discussion 1527-1528.
52. Isidori AM, Lenzi A: Risk factors for androgen decline in older males: lifestyle, chronic diseases and drugs. J Endocrinol Invest 2005;28(3 suppl):14-22.
53. Bhasin S, Cunningham GR, et al: Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2006;91: 1995-2010.
54. Jacobeit J W, Gooren LJ, et al: Long-acting intramuscular testosterone undecanoate for treatment of female-to-male transgender individuals. J Sex Med 2007;4:1479-1484.
55. Saad F, Gooren LJ, et al: A dose response study of testosterone on sexual dysfunction and on features of the metabolic syndrome using testosterone gel and parenteral testosterone undecanoate. J Androl 2008;29:102-105.