Identification of BfmR, a response regulator involved in biofilm development, as a target for a 2-aminoimidazole-based antibiofilm agent

Biochemistry

Volumn 51, Issue 49, 2012, Pages 9776-9778

  Thompson, Richele J ^a   Bobay, Benjamin G ^a   Stowe, Sean D ^a   Olson, Andrew L ^a   Peng, Lingling ^a   Su, Zhaoming ^a   Actis, Luis A ^b   Melander, Christian ^a   Cavanagh, John ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b MIAMI UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACINETOBACTERS; ANTI-BIOFILM; ANTIBIOTIC RESISTANCE; BAUMANNII; BINDING ASSAYS; BIOFILM DEVELOPMENT; BIOFILM FORMATION; CELL-PERMEABLE; COMPUTATIONAL DOCKINGS; MECHANISM OF ACTION; PROTECTION MECHANISMS; RESPONSE REGULATORS; SMALL MOLECULES;

BIOFILMS; CONFOCAL MICROSCOPY;

PLANTS (BOTANY);

BACTERIAL PROTEIN; BFMR PROTEIN; IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; ARTICLE; BINDING ASSAY; BIOFILM; CELL MEMBRANE PERMEABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL;

ACINETOBACTER BAUMANNII; BACTERIAL PROTEINS; BIOFILMS; IMIDAZOLES; MICROSCOPY, CONFOCAL; MODELS, MOLECULAR;

ACINETOBACTER BAUMANNII; BACTERIA (MICROORGANISMS);

EID: 84870879179     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi3015289     Document Type: Article

References (30)

1. Mussi, M. A., Gaddy, J. A., Cabruja, M., Arivett, B. A., Viale, A. M., Rasia, R., and Actis, L. A. (2010) J. Bacteriol. 24, 6336-6345
2. Vidal, R., Dominguez, M., Urrutia, H., Bello, H., Gonzalez, G., Garcia, A., and Zemelman, R. (1996) Microbios 86, 49-58
3. Fux, C. A., Costerton, J. W., Stewart, P. S., and Stoodley, P. (2005) Trends Microbiol. 13, 34-40
4. Villers, D., Espaze, E., Coste-Burel, M., Giauffret, F., Ninin, E., Nicolas, F., and Richet, H. (1998) Ann. Intern. Med. 129, 182-189
5. Richards, J. J. and Melander, C. (2009) Anti-Infect. Agents Med. Chem. 8, 295-314
6. Huigens, R. W., Richards, J. J., Parise, G., Ballard, T. E., Zeng, W., Deora, R., and Melander, C. (2007) J. Am. Chem. Soc. 129, 6966-6967
7. Richards, J. J., Huigens, R. W., Ballard, T. E., Basso, A., Cavanagh, J., and Melander, C. (2008) Chem. Commun. 14, 1698-1700
8. Richards, J. J., Ballard, T. E., Huigens, R. W., and Melander, C. (2008) ChemBioChem 9, 1267-1279
9. Huigens, R. W., Ma, L., Gambino, C., Basso, A., Moeller, P. D. R., Cavanagh, J., Wozniak, D. J., and Melander, C. (2008) Mol. BioSyst. 4, 614-621
10. Richards, J. J., Reyes, S., Stowe, S. D., Tucker, A. T., Ballard, T. E., Mathies, L. D., Cavanagh, J., and Melander, C. (2009) J. Med. Chem. 52, 4582-4585
11. Rogers, S. A. and Melander, C. (2008) Angew. Chem., Int. Ed. 47, 5229-5231
12. Rogers, S. A., Huigens, R. W., Cavanagh, J., and Melander, C. (2010) Antimicrob. Agents Chemother. 54, 2112-2118
13. Tomaras, A. P., Flagler, M. J., Dorsey, C. W., Gaddy, J. A., and Actis, L. A. (2008) Microbiology 154, 3398-3409
14. Stock, A. M., Robinson, V. L., and Goudreau, P. N. (2000) Annu. Rev. Biochem. 69, 183-215
15. Beier, D. and Gross, R. (2006) Curr. Opin. Microbiol. 9, 143-152
16. Stephenson, K. and Hoch, J. A. (2002) Pharmacol. Ther. 93, 293-305
17. Barrett, J. F., Goldschmidt, R. M., Lawrence, L. E., Foleno, B., Chen, R., Demers, J. P., Johnson, S., Kanojia, R., Fernandez, J., Bernstein, J., Licata, L., Donetz, A., Huang, S., Hlasta, D. J., Macielag, M. J., Ohemeng, K., Frechette, R., Frosco, M. B., Klaubert, D. H., Whiteley, J. M., Wang, L., and Hoch, J. A. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 5317-5322
18. Stephenson, K. and Hoch, J. A. (2002) Curr. Drug Targets: Infect. Disord. 2, 235-246
19. Gotoh, Y., Eguchi, Y., Watanabe, T., Okamoto, S., Doi, A., and Utsumi, R. (2010) Curr. Opin. Microbiol. 13, 232-239
20. Matsushita, M. and Janda, K. D. (2002) Bioorg. Med. Chem. 10, 855-867
21. Tang, Y. T., Gao, R., Havranek, J. J., Groisman, E. A., Stock, A. M., and Marshall, G. R. (2012) Chem. Biol. Drug Des. 79, 1007-1017
22. Ballard, T. E., Richards, J. J., Wolfe, A. L., and Melander, C. (2008) Chem.-Eur. J. 14, 10745-10761
23. Peng, L., DeSousa, J., Su, Z., Novak, B. M., Nevzorov, A. A., Garland, E. R., and Melander, C. (2001) Chem. Commun. 47, 4896-4898
24. Keller, P. M., Person, S., and Snipes, W. (1977) J. Cell Sci. 28, 167-177
25. Richards, J. J., Ballard, T. E., and Melander, C. (2008) Org. Biomol. Chem. 6, 1356-1363
26. Kojetin, D. J., Sullivan, D. M., Thompson, R. J., and Cavanagh, J. (2007) Methods Enzymol. 422, 141-169
27. Menon, S. and Wang, S. (2011) Biochemistry 50, 5948-5957
28. Morris, G. M., Huey, R., Lindstrom, W., Sanner, M. F., Belew, R. K., Goodsell, D. S., and Olson, A. J. (2009) J. Comput. Chem. 16, 2785-2791
29. Stephenson, K. and Hoch, J. A. (2004) Curr. Med. Chem. 11, 765-773
30. Stephenson, K. and Hoch, J. A. (2002) Curr. Opin. Pharmacol. 2, 507-512