Synthesis and antibiofilm activity of a second-generation reverse-amide oroidin library: A structure-activity relationship study

Chemistry - A European Journal

Volumn 14, Issue 34, 2008, Pages 10745-10761

  Eric Ballard, T ^a   Richards, Justin J ^a   Wolfe, Amanda L ^a   Melander, Christian ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Amino acids; Biological activity; Drug design; Medicinal chemistry; Structure activity relationships

Indexed keywords

AMINES; AMINO ACIDS; BIOCHEMISTRY; BIODIVERSITY; NITROGEN COMPOUNDS; ORGANIC ACIDS; SYNTHESIS (CHEMICAL);

ACTIVITY PROFILES; AERUGINOSA; ALIPHATIC CHAINS; AMIDE BONDS; ANTIBIOFILM; BIOLOGICAL ACTIVITY; DRUG DESIGN; MARINE NATURAL PRODUCTS; MEDICINAL CHEMISTRY; PROTEOBACTERIA; STRUCTURAL MODIFICATIONS; STRUCTURE-ACTIVITY RELATIONSHIPS;

AMIDES;

2 AMINOIMIDAZOLE; 2-AMINOIMIDAZOLE; ANTIINFECTIVE AGENT; IMIDAZOLE DERIVATIVE; OROIDIN; PYRROLE DERIVATIVE;

ACINETOBACTER BAUMANNII; ARTICLE; BIOFILM; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; MICROBIOLOGICAL EXAMINATION; MOLECULAR LIBRARY; PSEUDOMONAS AERUGINOSA; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACINETOBACTER BAUMANNII; ANTI-BACTERIAL AGENTS; BIOFILMS; DRUG DESIGN; IMIDAZOLES; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PSEUDOMONAS AERUGINOSA; PYRROLES; SMALL MOLECULE LIBRARIES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 56749131234     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200801419     Document Type: Article

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