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Volumn 54, Issue 1, 2013, Pages 145-152

Molecular analysis of different FLT3-ITD mutations in acute myeloid leukemia

Author keywords

AML; FLT3 ITD; FLT3 ITD mutant wild type ratio; FLT3 JMD; FLT3 TKD1

Indexed keywords

CD135 ANTIGEN;

EID: 84870877865     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2012.704999     Document Type: Article
Times cited : (33)

References (36)
  • 2
    • 34249340637 scopus 로고    scopus 로고
    • Chromosome aberrations, gene mutations and expression changes, and prognosis in adult acute myeloid leukemia
    • Mr ó zek K, Bloomfi eld C D. C hromosome aberrations, gene mutations and expression changes, and prognosis in adult acute myeloid leukemia. Hematology Am Soc Hematol Educ Program 2006: 169-177.
    • (2006) Hematology Am Soc Hematol Educ Program , pp. 169-177
    • Mrózek, K.1    Bloomfield, C.D.2
  • 3
    • 77955914238 scopus 로고    scopus 로고
    • National cancer research institute adult leukaemia working group Refi nement of cytogenetic classifi cation in acute myeloid leukemia: Determination of prognostic signifi cance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials
    • Grimwade D, Hills RK, Moorman AV, et al.; National Cancer Research Institute Adult Leukaemia Working Group. Refi nement of cytogenetic classifi cation in acute myeloid leukemia: Determination of prognostic signifi cance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials. Blood 2010; 116: 354- 365.
    • (2010) Blood , Issue.116 , pp. 354-365
    • Grimwade, D.1    Hills, R.K.2    Moorman, A.V.3
  • 4
    • 79955043472 scopus 로고    scopus 로고
    • High cytogenetic or molecular genetic risk acute myeloid leukemia
    • Estey E. High cytogenetic or molecular genetic risk acute myeloid leukemia. Hematology Am Soc Hematol Educ Program 2010: 474- 480.
    • (2010) Hematology Am Soc Hematol Educ Program , pp. 474-480
    • Estey, E.1
  • 5
    • 34247858967 scopus 로고    scopus 로고
    • Clinical outcome of de novo acute myeloid leukaemia patients with normal cytogenetics is affected by molecular genetic alterations: A concise review
    • DOI 10.1111/j.1365-2141.2007.06566.x
    • B aldus C, M rozek K, M arcucci G, et al. C linical outcome of de novo acute myeloid leukemia patients with normal cytogenetics is aff ected by molecular genetic alterations: A concise review. Br J Haematol 2007 ; 137: 387-400. (Pubitemid 46698282)
    • (2007) British Journal of Haematology , vol.137 , Issue.5 , pp. 387-400
    • Baldus, C.D.1    Mrozek, K.2    Marcucci, G.3    Bloomfield, C.D.4
  • 6
  • 7
    • 46849122024 scopus 로고    scopus 로고
    • Molecular characterization of acute myeloid leukemia
    • DOI 10.3324/haematol.13345
    • D ö hner K, D ö hner H. Molecular characterization of acute myeloid leukemia. Haematologica 2008; 93: 976- 982. (Pubitemid 351957013)
    • (2008) Haematologica , vol.93 , Issue.7 , pp. 976-982
    • Dohner, K.1    Dohner, H.2
  • 8
    • 48749123878 scopus 로고    scopus 로고
    • Prognostic implications of gene mutations in acute myeloid leukemia with normal cytogenetics
    • G aidzik V, D ö h ner K. P rognostic implications of gene mutations in acute myeloid leukemia with normal cytogenetics. Semin Oncol 2008 ; 35: 346-355.
    • (2008) Semin Oncol , vol.35 , pp. 346-355
    • Gaidzik, V.1    Döhner, K.2
  • 9
    • 79952092487 scopus 로고    scopus 로고
    • Molecular genetics of adult acute myeloid leukemia: Prognostic and therapeutic implications
    • Marcucci G, Hafelach T, D ö hner H. Molecular genetics of adult acute myeloid leukemia: Prognostic and therapeutic implications. J Clin Oncol 2011 ; 10: 475-486.
    • (2011) J Clin Oncol , vol.10 , pp. 475-486
    • Marcucci, G.1    Hafelach, T.2    Döhner, H.3
  • 10
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the fi rst cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis PD, Gale RE, Frew ME, et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the fi rst cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood 2001 ; 98: 1752-1759.
    • (2001) Blood , vol.98 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3
  • 12
    • 0037114829 scopus 로고    scopus 로고
    • Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML study group Ulm
    • DOI 10.1182/blood-2002-05-1440
    • Frohling S, Schlenk RF, Breitruck J, et al. Prognostic signifi cance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML Study Group Ulm. Blood 2002; 100: 4372- 4380. (Pubitemid 35434129)
    • (2002) Blood , vol.100 , Issue.13 , pp. 4372-4380
    • Frohling, S.1    Schlenk, R.F.2    Breitruck, J.3    Benner, A.4    Kreitmeier, S.5    Tobis, K.6    Dohner, H.7    Dohner, K.8
  • 14
    • 41949090673 scopus 로고    scopus 로고
    • The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
    • Gale RE, Green C, Allen C, et al. The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood 2008 ; 111: 2776-2784.
    • (2008) Blood , vol.111 , pp. 2776-2784
    • Gale, R.E.1    Green, C.2    Allen, C.3
  • 15
    • 77955364207 scopus 로고    scopus 로고
    • FLT3 mutations at diagnosis and relapse in acute myeloid leukemia: Cytogenetic and pathologic correlations, including cuplike blast morphology
    • McCormick SR, McCormick MJ, Grutkoski PS, et al. FLT3 mutations at diagnosis and relapse in acute myeloid leukemia: Cytogenetic and pathologic correlations, including cuplike blast morphology. Arch Pathol Lab Med 2010; 134: 1143- 1151.
    • (2010) Arch Pathol Lab Med , vol.134 , pp. 1143-1151
    • McCormick, S.R.1    McCormick, M.J.2    Grutkoski, P.S.3
  • 19
    • 0041743233 scopus 로고    scopus 로고
    • + hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express flt3: Distinct flt3 and c-kit expression and response patterns on mouse and candidate human hematopoietic stem cells
    • DOI 10.1182/blood-2002-06-1694
    • Sitnicka E, B uza-Vidas N, L arsson S, et al. H uman CD34 hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express fl t3: Distinct fl t3 and c-kit expression and response patterns on mouse and candidate human hematopoietic stem cells. Blood 2003 ; 102: 881-886. (Pubitemid 36917779)
    • (2003) Blood , vol.102 , Issue.3 , pp. 881-886
    • Sitnicka, E.1    Buza-Vidas, N.2    Larsson, S.3    Nygren, J.M.4    Liuba, K.5    Jacobsen, S.E.W.6
  • 20
    • 0036167084 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways cooperate in mediating cytokine-induced proliferation of a leukemic cell line
    • DOI 10.1038/sj/leu/2402367
    • Srinivasa SP, Doshi PD. Extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways cooperate in mediating cytokine-induced proliferation of a leukemic cell line. Leukemia 2002 ; 16: 244-253. (Pubitemid 34145142)
    • (2002) Leukemia , vol.16 , Issue.2 , pp. 244-253
    • Srinivasa, S.P.1    Doshi, P.D.2
  • 21
    • 0034605042 scopus 로고    scopus 로고
    • Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling
    • Zhang S, Fukuda S, Lee Y, et al. Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling. J Exp Med 2000; 192: 719- 728.
    • (2000) J Exp Med , vol.192 , pp. 719-728
    • Zhang, S.1    Fukuda, S.2    Lee, Y.3
  • 23
    • 33747189188 scopus 로고    scopus 로고
    • Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD
    • DOI 10.1182/blood-2005-11-011429
    • Rocnik J, Okabe R, Yu JC, et al. Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD. Blood 2006 ; 108: 1339-1345. (Pubitemid 44232034)
    • (2006) Blood , vol.108 , Issue.4 , pp. 1339-1345
    • Rocnik, J.L.1    Okabe, R.2    Yu, J.-C.3    Lee, B.H.4    Giese, N.5    Schenkein, D.P.6    Gilliland, D.G.7
  • 24
    • 33846230449 scopus 로고    scopus 로고
    • Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: Are we ready for a prognostically prioritized molecular classification?
    • DOI 10.1182/blood-2006-06-001149
    • Mr ó zek K, Marcucci G, Paschka P, et al. Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: Are we ready for a prognostically prioritized molecular classifi cation? Blood 2007; 109: 431- 448. (Pubitemid 46105936)
    • (2007) Blood , vol.109 , Issue.2 , pp. 431-448
    • Mrozek, K.1    Marcucci, G.2    Paschka, P.3    Whitman, S.P.4    Bloomfield, C.D.5
  • 26
    • 65449180371 scopus 로고    scopus 로고
    • Identification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor
    • B retenbuecher F, S hnittger S, G rundler R, et al. I dentification of a novel type of ITD mutations located in nonjuxtamembrane domains of the FLT3 tyrosine kinase receptor. Blood 2008 ; 113: 4074-4077.
    • (2008) Blood , vol.113 , pp. 4074-4077
    • Bretenbuecher, F.1    Shnittger, S.2    Grundler, R.3
  • 27
    • 70350504884 scopus 로고    scopus 로고
    • Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome
    • Kayser S, Schlenk RF, Londono MC, et al. Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome. Blood 2009 ; 114: 2386-2392.
    • (2009) Blood , vol.114 , pp. 2386-2392
    • Kayser, S.1    Schlenk, R.F.2    Londono, M.C.3
  • 28
    • 46749104163 scopus 로고    scopus 로고
    • Structural and numerical variation of FLT3/ITD in pediatric AML
    • Meshinchi S, Stirewalt D, Alonzo TA, et al. Structural and numerical variation of FLT3/ITD in pediatric AML. Blood 2008 ; 111: 4930-4933.
    • (2008) Blood , vol.111 , pp. 4930-4933
    • Meshinchi, S.1    Stirewalt, D.2    Alonzo, T.A.3
  • 29
    • 33646431111 scopus 로고    scopus 로고
    • Size of FLT3 internal tandem duplication has prognostic signifi cance in patients with acute myeloid leukemia
    • Stirewalt DL, Kopecky KJ, Meshinchi S, et al. Size of FLT3 internal tandem duplication has prognostic signifi cance in patients with acute myeloid leukemia. Blood 2006 ; 107: 3724-3726.
    • (2006) Blood , vol.107 , pp. 3724-3726
    • Stirewalt, D.L.1    Kopecky, K.J.2    Meshinchi, S.3
  • 30
    • 33745628343 scopus 로고    scopus 로고
    • More on prognostic significance of FLT3/ITD size in acute myeloid leukemia (AML) [8]
    • DOI 10.1182/blood-2005-12-5128
    • Kusec R, Jaksic O, Ostojic S, et al. More on prognostic signifi cance of FLT3/ITD size in acute myeloid leukemia (AML). Blood 2006 ; 108: 405-406. (Pubitemid 43990662)
    • (2006) Blood , vol.108 , Issue.1 , pp. 405-406
    • Kusec, R.1    Jaksic, O.2    Ostojic, S.3    Kardum-Skelin, I.4    Vrhovac, R.5    Jaksic, B.6
  • 34
    • 0026023833 scopus 로고
    • Median follow-up in clinical trials
    • Shuster JJ. Median follow-up in clinical trials. J Clin Oncol 1991 ; 9: 191-192.
    • (1991) J Clin Oncol , vol.9 , pp. 191-192
    • Shuster, J.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.