Ferroportin expression in haem oxygenase 1-deficient mice

Biochemical Journal

Volumn 449, Issue 1, 2013, Pages 69-78

  Starzy, Rafał R ^a   Canonne Hergaux, François ^b,c,d   Lenartowicz, Małgorzata ^e   Krzeptowski, Wojciech ^e   Willemetz, Alexandra ^f   Stys, Agnieszka ^a   Biera, Joanna ^g   Pietrzak, Piotr ^h   Dziaman, Tomasz ⁱ   Lipínski, Paweł ^a  

^a INSTITUTE OF GENETICS AND ANIMAL BREEDING   (Poland)

^b INSERM   (France)

^c CNRS   (France)

^d UNIVERSITÉ PAUL SABATIER   (France)

^e JAGIELLONIAN UNIVERSITY   (Poland)

^f INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES   (France)

^g MEDICAL UNIVERSITY OF WARSAW   (Poland)

^h WARSAW UNIVERSITY OF LIFE SCIENCES   (Poland)

ⁱ NICOLAUS COPERNICUS UNIVERSITY   (Poland)

Author keywords

Ferroportin; Haem; Haem oxygenase; Hepcidin; Kidney; Macrophage

Indexed keywords

FERROPORTIN; HEME OXYGENASE 1; HEPCIDIN;

ANIMAL EXPERIMENT; ARTICLE; BASOLATERAL MEMBRANE; CONTROLLED STUDY; CULTURE MEDIUM; FEMALE; KIDNEY TUBULE; KUPFFER CELL; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACUTE KIDNEY INJURY; ANIMALS; BONE MARROW CELLS; CATION TRANSPORT PROTEINS; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION; HEME; HEME OXYGENASE-1; IRON; KIDNEY; MACROPHAGES; MALE; MEMBRANE PROTEINS; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT;

FELIDAE; MUS; SUBGROUP C;

EID: 84870862135     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20121139     Document Type: Article

References (39)

1. Ponka, P. (1999) Cell biology of haem. Am. J. Med. Sci. 318, 241-256
2. Mense, S. M. and Zhang, L. (2006) Heme: a versatile signaling molecule controlling the activities of diverse regulators ranging from transcription factors to MAP kinases. Cell Res. 16, 681-692 (Pubitemid 44258921)
3. Kumar, S. and Bandyopadhyay, U. (2005) Free heme toxicity and its detoxification systems in human. Toxicol. Lett. 157, 175-188 (Pubitemid 40726102)
4. Maines, M. D. (2005) The heme oxygenase system: update. Antioxid. Redox Signaling 7, 1761-1766
5. Beaumont, C. and Delaby, C. (2009) Recycling iron in normal and pathological states. Semin. Hematol. 46, 328-338
6. Hentze, M. W., Muckenthaler, M. U., Galy, B. and Camaschella, C. (2010) Two to tango: regulation of mammalian iron metabolism. Cell 142, 24-38
7. Poss, K. D. and Tonegawa, S. (1997) Heme oxygenase 1 is required for mammalian iron reutilization. Proc. Natl. Acad. Sci. U.S.A. 94, 10919-10924 (Pubitemid 27430836)
8. Yachie, A., Niida, Y., Wada, T., Igarashi, N., Kaneda, H., Toma, T., Ohta, K., Kasahara, Y. and Koizumi, S. (1999) Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J. Clin. Invest. 103, 129-135 (Pubitemid 29031171)
9. Kovtunovych, G., Eckhaus, M. A., Ghosh, M. C., Ollivierre-Wilson, H. and Rouault, T. A. (2010) Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron distribution. Blood 116, 6054-6062
10. Quigley, J. G., Yang, Z., Worthington, M. T., Phillips, J. D., Sabo, K. M., Sabath, D. E., Berg, C. L., Sassa, S., Wood, B. L. and Abkowitz, J. L. (2004) Identification of a human heme exporter that is essential for erythropoiesis. Cell 118, 757-766 (Pubitemid 39221734)
11. Styś, A., Galy, B., Starzyński, R. R., Smuda, E., Drapier, J. C., Lipiński, P. and Bouton, C. (2011) Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide. J. Biol. Chem. 286, 22846-22854
12. Epsztejn, S., Kakhlon, O., Glickstein, H., Breuer, W. and Cabantchik, I. (1997) Fluorescence analysis of the labile iron pool of mammalian cells. Anal. Biochem. 248, 31-40 (Pubitemid 27218221)
13. Motterlini, R., Foresti, R., Vandegriff, K., Intaglietta, M. and Winslow, R. M. (1995) Oxidative-stress response in vascular endothelial cells exposed to a cellular hemoglobin solutions. Am. J. Physiol. 269, H648-H655
14. Torrance, J. D. and Bothwell, T. H. (1980) Iron stores. Methods Hematol. 1, 90-115
15. Canonne-Hergaux, F., Gruenheid, S., Ponka, P. and Gros, P. (1999) Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood 93, 4406-4417 (Pubitemid 29279284)
16. Starzyński, R. R., Canonne-Hergaux, F., Willemetz, A., Gralak, M. A., Woliński, J., Styś, A., Olszak, J. and Lipiński, P. (2009) Haemolytic anaemia and alterations in hepatic iron metabolism in aged mice lacking Cu,Zn-superoxide dismutase. Biochem. J. 420, 383-390
17. Leong, L. M., Tan, B. H. and Ho, K. K. (1992) A specific stain for the detection of nonheme iron proteins in polyacrylamide gels. Anal. Biochem. 207, 317-320 (Pubitemid 23144305)
18. Siomek, A., Gackowski, D., Rozalski, R., Dziaman, T., Szpila, A., Guz, J. and Olinski, R. (2007) Higher leukocyte 8-oxo-7,8-dihydro-2′- deoxyguanosine and lower plasma ascorbate in aging humans? Antioxid. Redox Signaling 9, 143-150 (Pubitemid 44901880)
19. Knutson, M. D., Vafa, M. R., Haile, D. J. and Wessling-Resnick, M. (2003) Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages. Blood 102, 4191-4197 (Pubitemid 37487007)
20. Knutson, M. D., Oukka, M., Koss, L. M., Avdemir, F. and Wessling-Resnick, M. (2005) Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin. Proc. Natl. Acad. Sci. U.S.A. 102, 1324-1328 (Pubitemid 40209169)
21. Delaby, C., Pilard, N., Puy, H. and Canonne-Hergaux, F. (2008) Sequential regulation of ferroportin expression after erythrophagocytosis in murine macrophages: early mRNA induction by haem, followed by iron-dependent protein expression. Biochem. J. 411, 123-131 (Pubitemid 351482354)
22. Beaumont, C. (2010) Multiple regulatory mechanisms act in concert to control ferroportin expression and heme iron recycling by macrophages. Haematologica 95, 1233-1236
23. Keel, S. B., Doty, R. T., Yang, Z., Quigley, J. G., Chen, J., Knoblaugh, S., Kingsley, P. D., De Domenico, I., Vaughn, M. B., Kaplan, J. et al. (2008) A heme export protein is required for red blood cell differentiation and iron homeostasis. Science 319, 825-828 (Pubitemid 351225875)
24. Khan, A. A. and Quigley, J. G. (2011) Control of intracellular heme levels: heme transporters and heme oxygenases. Biochim. Biophys. Acta 1813, 668-682
25. Tolosano, E., Fagoonee, S., Morello, N., Vinchi, F. and Fiorito, V. (2010) Heme scavenging and the other facets of hemopexin. Antioxid. Redox Signaling 12, 305-320
26. Yang, Z., Philips, J. D., Doty, R. T., Giraudi, P., Ostrow, J. D., Tiribelli, C., Smith, A. and Abkowitz, J. L. (2010) Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin. J. Biol. Chem. 285, 28874-28882
27. Lenartowicz, M., Kowal, M., Buda-Lewandowska, D. and Styrna, J. (2002) Pathological structure of the kidney from adult mice with mosaic mutation. J. Inherit. Metab. Dis. 25, 647-659 (Pubitemid 36416635)
28. Marro, S., Chiabrando, D., Messana, E., Stolte, J., Turco, E., Tolosano, E. and Muckenthaler, M. U. (2010) Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position - 7007 of the FPN1 promoter. Haematologica 95, 1261-1268
29. Kartikasari, A. E., Wagener, F. A., Yachie, A., Wiegerinck, E. T., Kemna, E. H. and Swinkels, D. W. (2009) Hepcidin suppression and defective iron recycling account for dysregulation of iron homeostasis in heme oxygenase-1 deficiency. J. Cell. Mol. Med. 13, 3091-3102
30. Yang, F., Liu, X. B., Quinones, M., Melby, P. C., Ghio, A. and Haile, D. J. (2002) Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation. J. Biol. Chem. 277, 39786-39791 (Pubitemid 35190962)
31. Auriac, A., Willemetz, A. and Canonne-Hergaux, F. (2010) Lipid raft-dependent endocytosis: a new route for hepcidin-mediated regulation of ferroportin in macrophages. Haematologica 95, 1269-1277
32. Kim, H. P., Wang, X., Galbiati, F., Ryter, S. W. and Choi, A. M. (2004) Caveolae compartmentalization of heme oxygenase-1 in endothelial cells. FASEB J. 18, 1080-1089 (Pubitemid 38859216)
33. Marques, L., Auriac, A., Willemetz, A., Banha, J, Silva, B., Canonne-Hergaux, F. and Costa, L. (2012) Immune cells and hepatocytes express glycosylphosphatidylinositol-anchored ceruloplasmin at their cell surface. Blood Cells Mol. Dis. 48, 110-120
34. Kono, S., Yoshida, K., Tomosugi, N., Terada, T, Hamaya, Y., Kanaoka, S. and Miyajima, H. (2010) Biological effects of mutant ceruloplasmin on hepcidin-mediated internalization of ferroportin. Biochim. Biophys. Acta 1802, 968-975
35. Viatte, L. and Vaulont, S. (2009) Hepcidin, the iron watcher. Biochimie 91, 1223-1228
36. Galanello, R. and Origa, R. (2010) Beta-thalassemia. Orphanet J. Rare Dis. 5, 11
37. Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A. and Vaulont, S. (2002) The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J. Clin. Invest. 110, 1037-1044
38. Wolff, N. A., Liu, W., Fenton, R. A., Lee, W. K., Thévenod, F. and Smith, C. P. (2011) Ferroportin 1 is expressed basolaterally in rat kidney proximal tubule cells and iron excess increases its membrane trafficking. J. Cell. Mol. Med. 15, 209-219
39. Smith, C. P. and Thévenod, F. (2009) Iron transport and the kidney. Biochim. Biophys. Acta 1790, 724-730