Immuno-Isolation of Pancreatic Islet Allografts Using Pegylated Nanotherapy Leads to Long-Term Normoglycemia in Full MHC Mismatch Recipient Mice

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Dong, Huansheng ^a   Fahmy, Tarek M ^b   Metcalfe, Su M ^c   Morton, Steve L ^d   Dong, Xiao ^e   Inverardi, Luca ^f   Adams, David B ^a   Gao, Wenda ^g   Wang, Hongjun ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b Yale University   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d National Centers for Coastal Ocean Science   (United States)

^e QINGDAO AGRICULTURAL UNIVERSITY   (China)

^f UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^g Antagen Institute for Biomedical Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; LEUKEMIA INHIBITORY FACTOR; NANOPARTICLE;

ADAPTIVE IMMUNITY; ALLOGRAFT; ALLOTRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCOMPATIBILITY; CELL ENCAPSULATION; CELL FUNCTION; CELL ISOLATION; CELL STRUCTURE; CELL SURFACE; CELL VIABILITY; CONTROLLED STUDY; DIABETES CONTROL; DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; GRAFT RECIPIENT; HLA MATCHING; IMMUNOLOGICAL PROCEDURES; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; IN VIVO STUDY; INSULIN RELEASE; INSULIN SYNTHESIS; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MOUSE; NANOMEDICINE; NONHUMAN; PANCREAS ISLET CELL; PANCREAS ISLET TRANSPLANTATION; PEGYLATED NANOTHERAPY; STREPTOZOCIN DIABETES;

ANIMALS; BLOOD GLUCOSE; IMMUNOHISTOCHEMISTRY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICROSCOPY, ELECTRON, SCANNING; NANOMEDICINE; PANCREAS; PANCREAS TRANSPLANTATION; POLYETHYLENE GLYCOLS;

MUS;

EID: 84870813752     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050265     Document Type: Article

References (30)

1. Biancone L, Ricordi C, (2002) Pancreatic islet transplantation: an update. Cell Transplant 11: 309-311.
2. Merani S, Shapiro AM, (2006) Current status of pancreatic islet transplantation. Clin Sci (Lond) 110: 611-625.
3. Fort A, Fort N, Ricordi C, Stabler CL, (2008) Biohybrid devices and encapsulation technologies for engineering a bioartificial pancreas. Cell Transplant 17: 997-1003.
4. Giraldo JA, Weaver JD, Stabler CL, (2010) Tissue engineering approaches to enhancing clinical islet transplantation through tissue engineering strategies. J Diabetes Sci Technol 4: 1238-1247.
5. Kobayashi T, Aomatsu Y, Kanehiro H, Hisanaga M, Nakajima Y, (2003) Protection of NOD islet isograft from autoimmune destruction by agarose microencapsulation. Transplant Proc 35: 484-485.
6. Wilson JT, Chaikof EL, (2008) Challenges and emerging technologies in the immunoisolation of cells and tissues. Adv Drug Deliv Rev 60: 124-145.
7. Orive G, Hernandez RM, Gascon AR, Calafiore R, Chang TM, et al. (2003) Cell encapsulation: promise and progress. Nat Med 9: 104-107.
8. Sawhney AS, Pathak CP, Hubbell JA, (1994) Modification of islet of langerhans surfaces with immunoprotective poly(ethylene glycol) coatings via interfacial photopolymerization. Biotechnol Bioeng 44: 383-386.
9. Murad KL, Gosselin EJ, Eaton JW, Scott MD, (1999) Stealth cells: prevention of major histocompatibility complex class II-mediated T-cell activation by cell surface modification. Blood 94: 2135-2141.
10. Murad KL, Mahany KL, Brugnara C, Kuypers FA, Eaton JW, et al. (1999) Structural and functional consequences of antigenic modulation of red blood cells with methoxypoly(ethylene glycol). Blood 93: 2121-2127.
11. Scott MD, Murad KL, (1998) Cellular camouflage: fooling the immune system with polymers. Curr Pharm Des 4: 423-438.
12. Scott MD, Murad KL, Koumpouras F, Talbot M, Eaton JW, (1997) Chemical camouflage of antigenic determinants: stealth erythrocytes. Proc Natl Acad Sci U S A 94: 7566-7571.
13. Teramura Y, Iwata H, (2008) Islets surface modification prevents blood-mediated inflammatory responses. Bioconjug Chem 19: 1389-1395.
14. Lee DY, Park SJ, Lee S, Nam JH, Byun Y, (2007) Highly poly(ethylene) glycolylated islets improve long-term islet allograft survival without immunosuppressive medication. Tissue Eng 13: 2133-2141.
15. Yun Lee D, Hee Nam J, Byun Y, (2007) Functional and histological evaluation of transplanted pancreatic islets immunoprotected by PEGylation and cyclosporine for 1 year. Biomaterials 28: 1957-1966.
16. Elcin YM, Elcin AE, Bretzel RG, Linn T, (2003) Pancreatic islet culture and transplantation using chitosan and PLGA scaffolds. Advances in experimental medicine and biology 534: 255-264.
17. Giovagnoli S, Luca G, Casaburi I, Blasi P, Macchiarulo G, et al. (2005) Long-term delivery of superoxide dismutase and catalase entrapped in poly(lactide-co-glycolide) microspheres: in vitro effects on isolated neonatal porcine pancreatic cell clusters. Journal of controlled release: official journal of the Controlled Release Society 107: 65-77.
18. Mao GH, Chen GA, Bai HY, Song TR, Wang YX, (2009) The reversal of hyperglycaemia in diabetic mice using PLGA scaffolds seeded with islet-like cells derived from human embryonic stem cells. Biomaterials 30: 1706-1714.
19. Basarkar A, Singh J, (2009) Poly (lactide-co-glycolide)-polymethacrylate nanoparticles for intramuscular delivery of plasmid encoding interleukin-10 to prevent autoimmune diabetes in mice. Pharmaceutical research 26: 72-81.
20. Jain R, Shah NH, Malick AW, Rhodes CT, (1998) Controlled drug delivery by biodegradable poly(ester) devices: different preparative approaches. Drug Dev Ind Pharm 24: 703-727.
21. Jain RA, (2000) The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomaterials 21: 2475-2490.
22. Park J, Gao W, Whiston R, Strom TB, Metcalfe S, et al. (2010) Modulation of CD4+ T lymphocyte lineage outcomes with targeted, nanoparticle-mediated cytokine delivery. Mol Pharm 8: 143-152.
23. Baeyens L, Bonne S, German MS, Ravassard P, Heimberg H, et al. (2006) Ngn3 expression during postnatal in vitro beta cell neogenesis induced by the JAK/STAT pathway. Cell death and differentiation 13: 1892-1899.
24. Baeyens L, De Breuck S, Lardon J, Mfopou JK, Rooman I, et al. (2005) In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells. Diabetologia 48: 49-57.
25. De Breuck S, Baeyens L, Bouwens L, (2006) Expression and function of leukemia inhibitory factor and its receptor in normal and regenerating rat pancreas. Diabetologia 49: 108-116.
26. Wang H, Lee SS, Gao W, Czismadia E, McDaid J, et al. (2005) Donor treatment with carbon monoxide can yield islet allograft survival and tolerance. Diabetes 54: 1400-1406.
27. Mfopou JK, Baeyens L, Bouwens L, (2012) Hedgehog signals inhibit postnatal beta cell neogenesis from adult rat exocrine pancreas in vitro. Diabetologia 55: 1024-1034.
28. Gao W, Thompson L, Zhou Q, Putheti P, Fahmy TM, et al. (2009) Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6. Cell Cycle 8: 1444-1450.
29. Metcalfe SM, Watson TJ, Shurey S, Adams E, Green CJ, (2005) Leukemia inhibitory factor is linked to regulatory transplantation tolerance. Transplantation 79: 726-730.
30. Metcalfe SM, (2011) LIF in the regulation of T-cell fate and as a potential therapeutic. Genes Immun 12: 157-168.