UV-Light Exposure of Insulin: Pharmaceutical Implications upon Covalent Insulin Dityrosine Dimerization and Disulphide Bond Photolysis

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Correia, Manuel ^a   Neves Petersen, Maria Teresa ^a,b   Jeppesen, Per Bendix ^c   Gregersen, Søren ^c   Petersen, Steffen B ^a,b,d  

^a AALBORG UNIVERSITY   (Denmark)

^b INTERNATIONAL IBERIAN NANOTECHNOLOGY LABORATORY   (Portugal)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

^d UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISULFIDE; HUMAN INSULIN; INSULIN ANTIBODY; INSULIN DITYROSINE; PEPTIDE HORMONE; TYROSINE; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ARTICLE; CIRCULAR DICHROISM; COVALENT BOND; CROSS LINKING; DIMERIZATION; DISULFIDE BOND; DRUG ACTIVITY; DRUG PACKAGING; DRUG STORAGE; DRUG STRUCTURE; FLUORESCENCE ANALYSIS; GLUCOSE TRANSPORT; HORMONE STRUCTURE; ILLUMINATION; IN VITRO STUDY; INCUBATION TIME; MUSCLE CELL; PHOTOLYSIS; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; RADIATION EXPOSURE; SKELETAL MUSCLE; ULTRAVIOLET RADIATION; ULTRAVIOLET SPECTROSCOPY;

ABSORPTION; ANIMALS; BINDING SITES; CIRCULAR DICHROISM; CROSS-LINKING REAGENTS; DIMERIZATION; DISULFIDES; GLUCOSE; GUINEA PIGS; HUMANS; INSULIN; KINETICS; PHOTOLYSIS; PROTEIN STRUCTURE, TERTIARY; RADIOIMMUNOASSAY; SPECTROMETRY, FLUORESCENCE; SULFHYDRYL COMPOUNDS; TYROSINE; ULTRAVIOLET RAYS;

CAVIA;

EID: 84870809797     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050733     Document Type: Article

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