Mitochondrial network in Glioma's invadopodia displays an activated state both in situ and in vitro: Potential functional implications

Ultrastructural Pathology

Volumn 36, Issue 6, 2012, Pages 409-414

  Arismendi Morillo, Gabriel ^a   Hoa, Neil T ^b   Ge, Lisheng ^b   Jadus, Martin R ^b,c  

^a UNIVERSIDAD DEL ZULIA   (Venezuela)

^b VA LONG BEACH HEALTHCARE SYSTEM   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cancer; Glioma; Invadopodia; Mitochondria; Mitochondrial network

Indexed keywords

ARTICLE; BIOPSY; CELL MOTION; ENDOPLASMIC RETICULUM; FLUORESCENCE MICROSCOPY; GLIOMA; HUMAN; METABOLISM; MICROVASCULATURE; MITOCHONDRION; PSEUDOPODIUM; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL LINE; TUMOR INVASION; ULTRASTRUCTURE; VASCULARIZATION;

BIOPSY; CELL LINE, TUMOR; CELL MOVEMENT; ENDOPLASMIC RETICULUM; GLIOMA; HUMANS; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; MICROVESSELS; MITOCHONDRIA; NEOPLASM INVASIVENESS; PSEUDOPODIA;

EID: 84870784470     PISSN: 01913123     EISSN: 15210758     Source Type: Journal    
DOI: 10.3109/01913123.2012.694582     Document Type: Article

References (31)

1. Drappatz J, Norden AD, Wen PY. Therapeutic strategies for inhibiting invasion in glioblastoma. 2009;Expert Rev Neurother. 9:519-534.
2. Albiges-Rizo C, Destaing O, Fourcade B, Planus E, Block MC. Acting machinery and mechanosensitivity in invado-podia, podosomes and focal adhesions. 2009;Cell Sci. 122: 3037-3049.
3. Stylli SS, Kaye AH, Lock P. Invadopodia: at the cutting edge of tumour invasion. 2008;J Clin Neurosci. 15:725-737.
4. Hoa N, Ge L, Kuznetsov Y, McPherson A, Cornforth AN, Pham J, Myers M, Ahmed N, Salsman V, Lamb L, Bowersock J, Hu Y, Zhou YH, Jadus M. (2010): Glioma cells display complex cell surface topographies that resist the actions of cytolytic effector lymphocytes. J. Immunology 185:4793-4803.
5. Pelicano H, Lu W, Zhou Y, et al. Mitochondrial dysfunction and reactive oxygen species imbalance promote breast cancer cell motility through a CXCL14-mediated mechanism. Cancer Res. 2009;69:2375-2384.
6. Arismendi-Morillo G, Castellano-Ramirez A. Ultrastructural mitochondrial pathology in human astrocytic tumors: potentials implications pro-therapeutics strategies. 2008;J Electron Microsc. 57:33-39.
7. Arismendi-Morillo, G. Electron microscopy morphology of the mitocondrial network in gliomas and their vascular microenvironment. 2011;Biochim Biophys Acta Bioenergetics. 1807:602-608.
8. Ikrenyi K, Dora E, Hajos F, Kovach AG. Metabolic and electron microscopic studies postmortem in brain mitochondria. 1976;Adv Exp Med Biol. 7:159-164.
9. Rossignol R, Gilkerson R, Aggeler R, Yamagata K, Remington SJ, Capaldi RA. Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells. 2004;Cancer Res. 64:985-993.
10. Beckner ME, Gobbel GT, Abonader R, et al. Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of P13K and gluconeogenesis. 2005; Lab Invest. 85:1457-1470.
11. Beckner ME, Fellows-Mayle W, Zhang Z, et al. Identifcation of ATP citrate lyase as a positive regulatos of glycolytic function in glioblastomas. 2010; Int J Cancer. 126:2282-2295.
12. Van der Bliek AM. Fussy mitochondria fuse in response to stress. 2009;EMBO J. 28:1533-1534.
13. Peng JY, Lin CC, Chen YJ, et al. Automatic morphological subtyping reveals new roles of caspases in mitochon-drial dynamics. PLoS Comput Biol. 2011; 7(10): e1002212. Doi:10.1371/journal.pcbi.1002212.
14. Pani G, Galeotti T. Role of MnSOD and p66shc in mito-chondrial response to p53. Antioxid Redox Signal. 2011; Doi:10.1089/ars 2010.3499.
15. Smolková K, Plecitá-Hlavatá L, Bellance N, et al. Waves of gene regulation suppress and then restore oxidative phos phorylation in cancer cells. Int J Biochem Cell Biol. 2010;1-19.
16. Molina JR, Hayashi Y, Stephens C, Georgescu MM. Invasive glioblastoma cells acquire stemness and increased Akt activation. 2010;Neoplasia. 12:455-463.
17. Kumar B, Koul S, Khandrika L, Meacham RB, Koul HK. Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype. 2008;Cancer Res. 15: 1777-1785.
18. Wu RF, Gu Y, Xu YC, Nwariaku FE, Terada LS. Vascular endothelial growth factor causes translocation of p47phox to membrane ruffes through WAVE1. 2003;J Biol Chem. 278:36830-36840.
19. Park HS, Lee SH, Park D, et al. Sequential activation of phosphatidylinositol3-kinase, beta Pix, Rac1, and Nox1 in growth factor-induced production of H2O2. Mol Cell Biol. 2004;24:4384-4394.
20. Ushio-Fukai M. Compartmentalization of redox signaling through NADPH oxidase-derived ROS. 2009; Antioxid Redox Signal. 11:1289-1299.
21. Disanza A, Steffen A, Hertzog M, Fritoli E, Rottner K, Scita G. Actin polymerization machinery: the fnish line of signaling networks, the starting point of cellular movement. Cell Mol Life Sci. 2005;62:955-970.
22. Yamazaki D, Kurisu S, Takenawa T. Regulation of cancer cell motility through actin reorganization. Cancer Sci. 2005;96:379-386.
23. Joy AM, Beaudry CE, Tran NL, et al. Migrating glioma cells activate the PI3-K pathway and display decreased susceptibility to apoptosis. 2003 (pt 21); J Cell Sci. 116: 4409-4417.
24. Vance JE. Phospholipid synthesis in a membrane fraction associated with mitochondria. J Biol Chem. 1990;265:7248-7256.
25. Lebiedzinska M, Szabadkai G, Jones AWE, Duszynski J, Wieckowski MR. Interactions between the endoplasmic retic-ulum mitochondria, plasma membrane and other subcellular organelles. 2009; Int J Biochem Cell Biol. 41: 1805-1816.
26. Giorgio M, Migliaccio E, Orsini F, et al. Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell. 2005;122:221-233.
27. Pinton P, Rizzuto R. P66Shc, oxidative stress and aging: importing a lifespan determinant into mitochondria. 2008; Cell Cycle. 7:1-5.
28. Trinei M, Berniakovich I, Beltrami E, et al. P66Shc signals to age. Aging. 2009; 1:503-510.
29. Pacini S, Pellegrini M, Migliaccio E, et al. p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells. Mol Cell Biol. 2004;24:1747-1757.
30. Pani G, Koch OR, Galeotti T. The p53-p66-manganese superoxide dismutase (MnSOD) network: a mitochondrial intrigue to generate reactive oxygen species. Int J Biochem Cell Biol. 2009;41:1002-1005.
31. Atukeren P, Kemerdere R, Kacira T, et al. Expressions of some vital molecules: glioblastoma multiforme versus normal tissues. w. 2010;32:492-501.