Mucosal Serpin A1 and A3 Levels in HIV Highly Exposed Sero-Negative Women are Affected by the Menstrual Cycle and Hormonal Contraceptives but are Independent of Epidemiological Confounders

American Journal of Reproductive Immunology

Volumn 69, Issue 1, 2013, Pages 64-72

  Rahman, Syeda ^a   Rabbani, Rasheda ^b   Wachihi, Charles ^c   Kimani, Joshua ^c   Plummer, Francis A ^a,c,d   Ball, Terry B ^a,c,d   Burgener, Adam ^a,d  

^a UNIVERSITY OF MANITOBA   (Canada)

^b MANITOBA INSTITUTE OF CHILD HEALTH   (Canada)

^c UNIVERSITY OF NAIROBI   (Kenya)

^d PUBLIC HEALTH AGENCY OF CANADA   (Canada)

Author keywords

Antitrypsin; Commercial sex workers; Female genital tract; highly exposed sero negative; HIV; HIV resistance; Innate immunity; Mucosal immunity; Serpin

Indexed keywords

CONTRACEPTIVE AGENT; SERINE PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR A1; SERINE PROTEINASE INHIBITOR A3; UNCLASSIFIED DRUG;

AGE; ARTICLE; CD4 LYMPHOCYTE COUNT; COHORT ANALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENITAL SYSTEM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION RESISTANCE; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; OPEN STUDY; PRIORITY JOURNAL; PROSTITUTION; PROTEIN EXPRESSION; SEXUAL BEHAVIOR; SEXUALLY TRANSMITTED DISEASE; UTERINE CERVIX CYTOLOGY;

ALPHA 1-ANTICHYMOTRYPSIN; ALPHA 1-ANTITRYPSIN; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; CONFOUNDING FACTORS (EPIDEMIOLOGY); CONTRACEPTIVES, ORAL, HORMONAL; ENVIRONMENTAL EXPOSURE; FEMALE; FOLLOW-UP STUDIES; GENITALIA, FEMALE; HIV; HIV INFECTIONS; HIV SERONEGATIVITY; HUMANS; IMMUNITY, MUCOSAL; KENYA; MENSTRUAL CYCLE; SEX WORKERS;

EID: 84870765745     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/aji.12014     Document Type: Article

References (35)

1. Silverman GA, Whisstock JC, Bottomley SP, Huntington JA, Kaiserman D, Luke CJ, Pak SC, Reichhart JM, Bird PI: Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems. J Biol Chem 2010; 285:24299-24305.
2. Mangan MS, Kaiserman D, Bird PI: The role of serpins in vertebrate immunity. Tissue Antigens 2008; 72:1-10.
3. van Gent D, Sharp P, Morgan K, Kalsheker N: Serpins: structure, function and molecular evolution. Int J Biochem Cell Biol 2003; 35:1536-1547.
4. Silverman GA, Bird PI, Carrell RW, Church FC, Coughlin PB, Gettins PG, Irving JA, Lomas DA, Luke CJ, Moyer RW, Pemberton PA, Remold-O'Donnell E, Salvesen GS, Travis J, Whisstock JC: The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature. J Biol Chem 2001; 276:33293-33296.
5. Law RH, Zhang Q, McGowan S, Buckle AM, Silverman GA, Wong W, Rosado CJ, Langendorf CG, Pike RN, Bird PI, Whisstock JC: An overview of the serpin superfamily. Genome Biol 2006; 7:216.
6. Whisstock JC, Silverman GA, Bird PI, Bottomley SP, Kaiserman D, Luke CJ, Pak SC, Reichhart JM, Huntington JA: Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions. J Biol Chem 2010; 285:24307-24312.
7. Irving JA, Pike RN, Lesk AM, Whisstock JC: Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function. Genome Res 2000; 10:1845-1864.
8. Congote LF: The C-terminal 26-residue peptide of serpin A1 is an inhibitor of HIV-1. Biochem Biophys Res Commun 2006; 343:617-622.
9. Shapiro L, Pott GB, Ralston AH: Alpha-1-antitrypsin inhibits human immunodeficiency virus type 1. FASEB J 2001; 15:115-122.
10. Zhou X, Shapiro L, Fellingham G, Willardson BM, Burton GF: HIV replication in CD4 + T lymphocytes in the presence and absence of follicular dendritic cells: inhibition of replication mediated by alpha}-1-antitrypsin through altered I{kappa}B{alpha ubiquitination. J Immunol 2011; 186:3148-3155.
11. Munch J, Standker L, Adermann K, Schulz A, Schindler M, Chinnadurai R, Pohlmann S, Chaipan C, Biet T, Peters T, Meyer B, Wilhelm D, Lu H, Jing W, Jiang S, Forssmann WG, Kirchhoff F: Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide. Cell 2007; 129:263-275.
12. Kramer HB, Lavender KJ, Qin L, Stacey AR, Liu MK, di Gleria K, Simmons A, Gasper-Smith N, Haynes BF, McMichael AJ, Borrow P, Kessler BM: Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection. PLoS Pathog 2010; 6:e1000893.
13. Moriuchi H, Moriuchi M, Fauci AS: Cathepsin G, a neutrophil-derived serine protease, increases susceptibility of macrophages to acute human immunodeficiency virus type 1 infection. J Virol 2000; 74:6849-6855.
14. Burgener A, Boutilier J, Wachihi C, Kimani J, Carpenter M, Westmacott G, Cheng K, Ball TB, Plummer F: Identification of differentially expressed proteins in the cervical mucosa of HIV-1-resistant sex workers. J Proteome Res 2008; 7:4446-4454.
15. Burgener A, Rahman S, Ahmad R, Lajoie J, Ramdahin S, Mesa C, Brunet S, Wachihi C, Kimani J, Fowke K, Carr S, Plummer F, Ball TB: Comprehensive proteomic study identifies serpin and cystatin antiproteases as novel correlates of HIV-1 resistance in the cervicovaginal mucosa of female sex workers. J Proteome Res 2011; 10:5139-5149.
16. Benarafa C, Priebe GP, Remold-O'Donnell E: The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection. J Exp Med 2007; 204:1901-1909.
17. Chertov O, Ueda H, Xu LL, Tani K, Murphy WJ, Wang JM, Howard OM, Sayers TJ, Oppenheim JJ: Identification of human neutrophil-derived cathepsin G and azurocidin/CAP37 as chemoattractants for mononuclear cells and neutrophils. J Exp Med 1997; 186:739-747.
18. Janciauskiene S, Larsson S, Larsson P, Virtala R, Jansson L, Stevens T: Inhibition of lipopolysaccharide-mediated human monocyte activation, in vitro, by alpha1-antitrypsin. Biochem Biophys Res Commun 2004; 321:592-600.
19. Elmaleh DR, Brown NV, Geiben-Lynn R: Anti-viral activity of human antithrombin III. Int J Mol Med 2005; 16:191-200.
20. Subramaniyam D, Virtala R, Pawlowski K, Clausen IG, Warkentin S, Stevens T, Janciauskiene S: TNF-alpha-induced self expression in human lung endothelial cells is inhibited by native and oxidized alpha1-antitrypsin. Int J Biochem Cell Biol 2008; 40:258-271.
21. Pott GB, Chan ED, Dinarello CA, Shapiro L: Alpha-1-antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood. J Leukoc Biol 2009; 85:886-895.
22. Wang Y, Lehner T: Induction of innate immunity in control of mucosal transmission of HIV. Curr Opin HIV AIDS 2011; 6:398-404.
23. Lehner T, Wang Y, Whittall T, Seidl T: Innate immunity and HIV-1 infection. Adv Dent Res 2011; 23:19-22.
24. Borrow P, Shattock RJ, Vyakarnam A: Innate immunity against HIV: a priority target for HIV prevention research. Retrovirology 2010; 7:84.
25. Wira CR, Fahey JV, Ghosh M, Patel MV, Hickey DK, Ochiel DO: Sex hormone regulation of innate immunity in the female reproductive tract: the role of epithelial cells in balancing reproductive potential with protection against sexually transmitted pathogens. Am J Reprod Immunol 2010; 63:544-565.
26. Marks MA, Gravitt PE, Burk RD, Studentsov Y, Farzadegan H, Klein SL: Progesterone and 17beta-estradiol enhance regulatory responses to human papillomavirus type 16 virus-like particles in peripheral blood mononuclear cells from healthy women. Clin Vaccine Immunol 2010; 17:609-617.
27. Anderson BL, Cu-Uvin S: Clinical parameters essential to methodology and interpretation of mucosal responses. Am J Reprod Immunol 2011; 65:352-360.
28. Heffron R, Donnell D, Rees H, Celum C, Mugo N, Were E, de Bruyn G, Nakku-Joloba E, Ngure K, Kiarie J, Coombs RW, Baeten JM: Use of hormonal contraceptives and risk of HIV-1 transmission: a prospective cohort study. Lancet Infect Dis 2012; 12:19-26.
29. Tessari P: Changes in protein, carbohydrate, and fat metabolism with aging: possible role of insulin. Nutr Rev 2000; 58:11-19.
30. Hirbod T, Broliden K: Mucosal immune responses in the genital tract of HIV-1-exposed uninfected women. J Intern Med 2007; 262:44-58.
31. Fleck A: Clinical and nutritional aspects of changes in acute-phase proteins during inflammation. Proc Nutr Soc 1989; 48:347-354.
32. Baltzer H, Chege D, Rebbapragada A, Wachihi C, Shin LY, Kimani J, Ball TB, Jaoko W, Plummer FA, Kaul R: Relative HIV resistance in kenyan sex workers is not due to an altered prevalence or mucosal immune impact of herpes simplex virus type 2 infection. Curr HIV Res 2009; 7:504-507.
33. Bryan CL, Beard KS, Pott GB, Rahkola J, Gardner EM, Janoff EN, Shapiro L: HIV infection is associated with reduced serum alpha-1-antitrypsin concentrations. Clin Invest Med 2010; 33:E384-E389.
34. Biasin M, Caputo SL, Speciale L, Colombo F, Racioppi L, Zagliani A, Ble C, Vichi F, Cianferoni L, Masci AM, Villa ML, Ferrante P, Mazzotta F, Clerici M: Mucosal and systemic immune activation is present in human immunodeficiency virus-exposed seronegative women. J Infect Dis 2000; 182:1365-1374.
35. Lajoie J, Juno JA, Burgener A, Rahman S, Mogk K, Kimani J, Mwanjewe J, Plummer F, Ball B, Fowke K: A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV exposed seronegative commercial sex workers. Mucosal Immunol 2012; 5:277-287.