HIV infection is associated with reduced serum alpha-1-antitrypsin concentrations

Clinical and Investigative Medicine

Volumn 33, Issue 6, 2010, Pages

  Bryan, Courtney L ^a,b   Beard, K Scott ^a,b   Pott, Gregory B ^a,b   Rahkola, Jeremy ^a,b   Gardner, Edward M ^b,c   Janoff, Edward N ^a,b   Shapiro, Leland ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c Institute of Health Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN;

ADULT; ARTICLE; BLOOD; CROSS-SECTIONAL STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; MIDDLE AGED;

ADULT; ALPHA 1-ANTITRYPSIN; CROSS-SECTIONAL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED;

EID: 78751563371     PISSN: 0147958X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Shapiro L, Pott GB, Ralston AR. Alpha-1-antitrypsin inhibits human immunodeficiency virus type-i. FASEB J 2001;15:115-122.
2. Münch j, Ständker L, Adermann K et al. Discovery and optimization of a natural RIV-i entry inhibitor targeting the gp4l fusion peptide. Cell 2007;129:263-75.
3. Blank CA, Brantly M. Clinical features and molecular characteristics of & alpha; -antitrypsin deficiency. Annals Allergy 1994;72:105-121.
4. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N EnglJ Med 1999;340:448-54.
5. Aldonyte R, Jansson L, Ljungberg O et al. Polymerized alpha-antitrypsin is present on lung vascular endothelium. New insights into the biological significance of alpha-antitrypsin polymerization. Ristopathology 2004;45: 587-92.
6. Dabbagh K, Laurent GJ, Shock A et al. Alpha-1-antitrypsin stimulates fibroblast proliferation and procollagen production and activates classical MAP kinase signalling pathways. J Cell Physiol 2001;186:73-81.
7. Cordelier P, Strayer DS. Mechanisms ofalphai-antitrypsin inhibition of cellular serine proteases and RIV- 1 protease that are essential for RIV-1 morphogenesis. Biochim Biophys Acta 2003;1638: 197-207.
8. Papuashvili MN, Savitskaya J, Kostrikin D et al. Low level alpha-1-antitrypsin in serum of RIV-infected patients demonstrates progression of disease. International Conference on AIDS,July 7-14 2002;Abstract number A1O1 13:
9. Bristow CL, Patel H, Arnold RR. Self antigen prognostic for human immunodeficiency virus disease progression. Clin Diagn Lab Immunol 2001;8:937-42.
10. Potthoff AV, Munchj, Kirchhoff F et al. HIV infection in a patient with alpha-i antitrypsin deficiency: a detrimental combination? AIDS 2007;21:2115-6.
11. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMW RRecomm Rep 1992;41:1-19.
12. StollerJK, Fromer L, Brantly M et al. Primary care diagnosis of alpha-i antitrypsin deficiency: issues and opportunities. Cleve ClinJ Med 2007;74:869-74.
13. American Thoracic Society/European Respiratory Society statement: standards for the diagnosis and management of individuals with alpha-i antitrypsin deficiency. AmJ Respir Grit Care Med 2003;168:818-900.
14. Nakashima H, Yamamoto N, Masuda M et al. Defensins inhibit HIV replication in vitro. AIDS 1993;7: 1129.
15. Elmaleh DR, Brown NV, Geiben-Lynn R. Anti-viral activity of human antithrombin III. IntJ Mol Med 2005;16:191-200.
16. McNeely TB, Dealy M, Dripps DJ et al. Secretory leukocyte protease inhibitor: a human saliva protein exhibiting anti-human immunodeficiency virus 1 activity in vitro. J Clin Invest 1995;96:456-64.
17. D'Souza MP, Harden VA. Chemokines and HIV-i second receptors. Nature Medicine 1996;2: 1293-1300.
18. Gulick RM, Lalezarij, Goodrichj etal. Maraviroc for previously treated patients with R5 HIV- 1 infection. N Engl J Med 2008;359: 1429-41.
19. de Serres FT Worldwide racial and ethnic distribution of α-antitrypsin deficiency: Summary of an analysis of published genetic epidemiologic surveys. Chest 2002; 122:1818-1829.
20. de Serres FJ, Blanco I, Fernandez-Bustillo E. Genetic epidemiology of alpha-i antitrypsin deficiency in North America and Australia/New Zealand: Australia, Canada, New Zealand, and the United States of America. Clin Genet 2003;64:382-397.
21. Lau B, Sharrett AR, Kingsley LA et al. C-reactive protein is a marker for human immunodeficiency virus disease progression. Arch ffitern Med 2006;166:64-70.