Carnosic acid is an efflux pumps modulator by dissipation of the membrane potential in Enterococcus faecalis and Staphylococcus aureus

World Journal of Microbiology and Biotechnology

Volumn 29, Issue 1, 2013, Pages 137-144

  Ojeda Sana, Adriana M ^a   Repetto, Victoria ^a   Moreno, Silvia ^a  

^a FUNDACIÓN INSTITUTO LELOIR   (Argentina)

Author keywords

Antibiotic resistance; Carnosic acid; Efflux pumps; Enterococcus faecalis; Membrane potential; Staphylococcus aureus

Indexed keywords

ANTIBIOTIC RESISTANCE; CARNOSIC ACID; EFFLUX PUMPS; ENTEROCOCCUS FAECALIS; MEMBRANE POTENTIALS; STAPHYLOCOCCUS AUREUS;

ANTIBIOTICS; BACILLI; BROMINE COMPOUNDS; CELL MEMBRANES; CYANIDES; CYTOLOGY; DRUG THERAPY; MEMBRANES;

ACID RESISTANCE;

ABIETANE DERIVATIVE; ANTIINFECTIVE AGENT; ETHIDIUM; PLANT EXTRACT; SALVIN;

ARTICLE; CELL MEMBRANE; DRUG EFFECT; ENTEROCOCCUS FAECALIS; MEMBRANE POTENTIAL; METABOLISM; MULTIDRUG RESISTANCE; PERMEABILITY; PROTON MOTIVE FORCE; STAPHYLOCOCCUS AUREUS; TRANSPORT AT THE CELLULAR LEVEL;

ANTI-BACTERIAL AGENTS; BIOLOGICAL TRANSPORT; CELL MEMBRANE; DITERPENES, ABIETANE; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ENTEROCOCCUS FAECALIS; ETHIDIUM; MEMBRANE POTENTIALS; PERMEABILITY; PLANT EXTRACTS; PROTON-MOTIVE FORCE; STAPHYLOCOCCUS AUREUS;

BACTERIA (MICROORGANISMS); ENTEROCOCCUS; ENTEROCOCCUS FAECALIS; STAPHYLOCOCCUS AUREUS;

EID: 84870733471     PISSN: 09593993     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11274-012-1166-3     Document Type: Article

References (29)

1. Barni MV, Fontanals A, Moreno S (2009) Study of the antibiotic efficacy of an ethanolic extract from Rosmarinus officinalis against Staphylococcus aureus in two skin infection models in mice. BLACPMA 8: 219-223.
2. Barni MV, Carlini MJ, Cafferata EG, Puricelli L, Moreno S (2012) Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells. Oncol Rep 27: 1041-1048.
3. Brogden KA (2005) Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat Rev Microbiol 3: 238-250.
4. Brooijmans RJ, Poolman B, Schuurman-Wolters GK, de Vos WM, Hugenholtz J (2007) Generation of a membrane potential by Lactococcus lactis through aerobic electron transport. J Bacteriol 189: 5203-5209.
5. CLSI, Clinical and Laboratory Standards Institute (2009-2011) Performance standards for antimicrobial susceptibility testing. Document M100. Wayne, PA.
6. Horiuchi K, Shiota S, Kuroda T, Hatano T, Yoshida T, Tsuchiya T (2007) Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis. Biol Pharm Bull 30: 287-290.
7. Jonas BM, Murray BE, Weinstock GM (2001) Characterization of emeA, a NorA homolog and multidrug efflux pump, in Enterococcus faecalis. Antimicrob Agents Chemother 45: 3574-3579.
8. Kaatz GW, Seo SM, O'Brien L, Wahiduzzaman M, Foster TJ (2000) Evidence for the existence of a multidrug efflux transporter distinct from NorA in Staphylococcus aureus. Antimicrob Agents Chemother 44: 1404-1406.
9. Leclercq R (2009) Epidemiological and resistance issues in multidrug-resistant staphylococci and enterococci. Clin Microbiol Infect 15: 224-231.
10. Lee EW, Huda MN, Kuroda T, Mizushima T, Tsuchiya T (2003) EfrAB, an ABC multidrug efflux pump in Enterococcus faecalis. Antimicrob Agents Chemother 47: 3733-3738.
11. Li XZ, Nikaido H (2009) Efflux-mediated resistance in bacteria: an update. Drugs 69: 1555-1623.
12. Mengoni ES, Vichera G, Rigano LA, Rodriguez-Puebla ML, Galliano SR, Cafferata EE, Pivetta OH, Moreno S, Vojnov AA (2011) Suppression of COX-2, IL-1beta and TNF-alpha expression and leukocyte infiltration in inflamed skin by bioactive compounds from Rosmarinus officinalis L. Fitoterapia 82: 414-421.
13. ® Outcomes Registry and Experience (CORE). Int J Antimicrob Agents 33: 543-548.
14. Moreno S, Scheyer T, Romano CS, Vojnov AA (2006) Antioxidant and antimicrobial activities of rosemary extracts linked to their polyphenol composition. Free Rad Res 40: 223-231.
15. Moreno S, Ojeda Sana AM, Gaya M, Barni MV, Castro OA, van Baren C (2012) Rosemary compounds as nutraceutical health products. In: El-Samragy Y (ed) Food additives Chapter 9. Intech-open Science.
16. Nikaido H (2001) Preventing drug access to targets: cell surface permeability barriers and active efflux in bacteria. Semin Cell Dev Biol 12: 215-223.
17. Oluwatuyi M, Kaatz GW, Gibbons S (2004) Antibacterial and resistance modifying activity of Rosmarinus officinalis. Phytochem 65: 3249-3254.
18. Paixão L, Rodrigues L, Couto I, Martins M, Fernandes P, de Carvalho CC, Monteiro GA, Sansonetty F, Amaral L, Viveiros M (2009) Fluorometric determination of EtBr efflux kinetics in Escherichia coli. J Biol Eng 3: 18.
19. Paulsen IT, Brown MH, Skurray RA (1996) Proton-dependent multidrug efflux systems. Microbiol Rev 60: 575-608.
20. Piddock LJV (2006) Multidrug-resistance efflux pumps? not just for resistance. Nature Rev Microbiol 4: 629-636.
21. Poole K (2005) Efflux-mediated antimicrobial resistance. J Antimicrob Chemother 56: 20-51.
22. Roth BL, Poot M, Yue ST, Millard PJ (1997) Bacterial viability and antibiotic susceptibility testing with SYTOX Green nucleic acid stain. Appl Environ Microbiol 63: 2421-2431.
23. van Bambeke F, Balzi E, Tulkens PM (2000) Antibiotic efflux pumps. Biochem Pharmacol 60: 457-470.
24. van Bambeke F, Pagés JM, Lee VJ (2006) Inhibitors of bacterial efflux pumps as adjuvants in antibiotic treatments and diagnostic tools for detection of resistance by efflux. Recent Pat Antiinfect Drug Discov 1: 157-175.
25. van Bambeke F, Mingeot-Leclercq MP, Struelens MJ, Tulkens PM (2008) The bacterial envelope as a target for novel anti-MRSA antibiotics. Trends Pharmacol Sci 29: 124-134.
26. Wu M, Hancock RE (1999) Interaction of the cyclic antimicrobial cationic peptide bactenecin with the outer and cytoplasmic membrane. J Biol Chem 274: 29-35.
27. Xiao-Ning Y, Xue-Liang C, Hao L, Xiang-Xin L, Hui-Qing L, Wen-Rui J (2008) Reversion of P-Glycoprotein-mediated multidrug resistance in human leukemic cell line by carnosic Acid. Chin J Physiol 51: 348-356.
28. Yan H, Li W, Li X, Yu C, Zhang K, Jiang Y, Wu L, Lu W, Tu P (2009) High-performance liquid chromatography method for determination of carnosic acid in rat plasma and its application to pharmacokinetic study. Biomed Chromatogr 23: 776-781.
29. Zechini B, Versace I (2009) Inhibitors of multidrug resistant efflux systems in bacteria. Recent Pat Antiinfect Drug Discov 4: 37-50.