Geminal bismethylation prevents polyketide oxidation and dimerization in the benastatin pathway

Angewandte Chemie - International Edition

Volumn 46, Issue 37, 2007, Pages 7035-7038

  Schenk, Angéla ^a   Xu, Zhongli ^a   Pfeiffer, Corina ^a   Steinbeck, Christoph ^b   Hertweck, Christian ^a  

^a HANS KNÖLL INSTITUTE   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Biosynthesis; Bisanthrones; Enzymes; Natural products; Polyketides

Indexed keywords

BISANTHRONES; NATURAL PRODUCTS; POLYKETIDES;

COMPUTER SIMULATION; DIMERIZATION; METHYLATION; MUTAGENESIS; OXIDATION;

ENZYMES;

ANTINEOPLASTIC AGENT; BENASTATIN A; GLUTATHIONE TRANSFERASE; MACROLIDE; NAPHTHACENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; DRUG ANTAGONISM; METABOLISM; METHYLATION; OXIDATION REDUCTION REACTION; STREPTOMYCES LIVIDANS;

ANTINEOPLASTIC AGENTS; DIMERIZATION; GLUTATHIONE TRANSFERASE; MACROLIDES; METHYLATION; MOLECULAR STRUCTURE; NAPHTHACENES; OXIDATION-REDUCTION; STREPTOMYCES LIVIDANS;

EID: 34848817039     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200702033     Document Type: Article

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