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Volumn 7, Issue 11, 2012, Pages

Hepatitis C Virus Mediated Changes in miRNA-449a Modulates Inflammatory Biomarker YKL40 through Components of the NOTCH Signaling Pathway

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CCAAT ENHANCER BINDING PROTEIN ALPHA; CHITINASE; MICRORNA; MICRORNA 449A; NOTCH RECEPTOR; NOTCH1 RECEPTOR; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84870713267     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050826     Document Type: Article
Times cited : (53)

References (48)
  • 1
    • 0033584440 scopus 로고    scopus 로고
    • The prevalence of hepatitis C virus infection in the United States, 1988 through 1994
    • Alter MJ, Kruszon-Moran D, Nainan OV, McQuillan GM, Gao F, et al. (1999) The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N Engl J Med 341: 556-562.
    • (1999) N Engl J Med , vol.341 , pp. 556-562
    • Alter, M.J.1    Kruszon-Moran, D.2    Nainan, O.V.3    McQuillan, G.M.4    Gao, F.5
  • 2
    • 0035811625 scopus 로고    scopus 로고
    • Hepatitis C virus infection
    • Lauer GM, Walker BD, (2001) Hepatitis C virus infection. N Engl J Med 345: 41-52.
    • (2001) N Engl J Med , vol.345 , pp. 41-52
    • Lauer, G.M.1    Walker, B.D.2
  • 3
    • 0036829816 scopus 로고    scopus 로고
    • Natural history of chronic hepatitis C
    • Seeff LB, (2002) Natural history of chronic hepatitis C. Hepatology. 36: S35-46.
    • (2002) Hepatology , vol.36
    • Seeff, L.B.1
  • 4
    • 0031819084 scopus 로고    scopus 로고
    • YKL-40, a mammalian member of the chitinase family, is a matrix protein of specific granules in human neutrophils
    • Volck B, Price PA, Johansen JS, Sorensen O, Benfield TL, et al. (1998) YKL-40, a mammalian member of the chitinase family, is a matrix protein of specific granules in human neutrophils. Proc Assoc Am Physicians 110: 351-360.
    • (1998) Proc Assoc Am Physicians , vol.110 , pp. 351-360
    • Volck, B.1    Price, P.A.2    Johansen, J.S.3    Sorensen, O.4    Benfield, T.L.5
  • 6
    • 79951776429 scopus 로고    scopus 로고
    • Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury
    • Lee CG, Da Silva CA, Dela Cruz CS, Ahangari F, Ma B, et al. (2011) Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury. Annu Rev Physiol 73: 479-501.
    • (2011) Annu Rev Physiol , vol.73 , pp. 479-501
    • Lee, C.G.1    Da Silva, C.A.2    Dela Cruz, C.S.3    Ahangari, F.4    Ma, B.5
  • 7
    • 39749145083 scopus 로고    scopus 로고
    • A sodium dodecyl sulfate-polyacrylamide gel electrophoresis-liquid chromatography tandem mass spectrometry analysis of bovine cartilage tissue response to mechanical compression injury and the inflammatory cytokines tumor necrosis factor alpha and interleukin-1beta
    • Stevens AL, Wishnok JS, Chai DH, Grodzinsky AJ, Tannenbaum SR, (2008) A sodium dodecyl sulfate-polyacrylamide gel electrophoresis-liquid chromatography tandem mass spectrometry analysis of bovine cartilage tissue response to mechanical compression injury and the inflammatory cytokines tumor necrosis factor alpha and interleukin-1beta. Arthritis Rheum 58: 489-500.
    • (2008) Arthritis Rheum , vol.58 , pp. 489-500
    • Stevens, A.L.1    Wishnok, J.S.2    Chai, D.H.3    Grodzinsky, A.J.4    Tannenbaum, S.R.5
  • 8
    • 0037462802 scopus 로고    scopus 로고
    • Tumor necrosis factor-regulated biphasic activation of NF-kappa B is required for cytokine-induced loss of skeletal muscle gene products
    • Ladner KJ, Caligiuri MA, Guttridge DC, (2003) Tumor necrosis factor-regulated biphasic activation of NF-kappa B is required for cytokine-induced loss of skeletal muscle gene products. J Biol Chem 278: 2294-2303.
    • (2003) J Biol Chem , vol.278 , pp. 2294-2303
    • Ladner, K.J.1    Caligiuri, M.A.2    Guttridge, D.C.3
  • 9
    • 0035983295 scopus 로고    scopus 로고
    • NF-kappaB family of transcription factors: central regulators of innate and adaptive immune functions
    • Caamano J, Hunter CA, (2002) NF-kappaB family of transcription factors: central regulators of innate and adaptive immune functions. Clin Microbiol Rev 15: 414-429.
    • (2002) Clin Microbiol Rev , vol.15 , pp. 414-429
    • Caamano, J.1    Hunter, C.A.2
  • 11
    • 77955496321 scopus 로고    scopus 로고
    • Nuclear factor-kappaB/p65 responds to changes in the Notch signaling pathway in murine BV-2 cells and in amoeboid microglia in postnatal rats treated with the gamma-secretase complex blocker DAPT
    • Cao Q, Li P, Lu J, Dheen ST, Kaur C, et al. (2010) Nuclear factor-kappaB/p65 responds to changes in the Notch signaling pathway in murine BV-2 cells and in amoeboid microglia in postnatal rats treated with the gamma-secretase complex blocker DAPT. J Neurosci Res 88: 2701-2714.
    • (2010) J Neurosci Res , vol.88 , pp. 2701-2714
    • Cao, Q.1    Li, P.2    Lu, J.3    Dheen, S.T.4    Kaur, C.5
  • 12
    • 0035887655 scopus 로고    scopus 로고
    • Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells
    • Cheng P, Zlobin A, Volgina V, Gottipati S, Osborne B, et al. (2001) Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells. J Immunol 167: 4458-4467.
    • (2001) J Immunol , vol.167 , pp. 4458-4467
    • Cheng, P.1    Zlobin, A.2    Volgina, V.3    Gottipati, S.4    Osborne, B.5
  • 13
    • 30444450802 scopus 로고    scopus 로고
    • Notch1 augments NF-kappaB activity by facilitating its nuclear retention
    • Shin HM, Minter LM, Cho OH, Gottipati S, Fauq AH, et al. (2006) Notch1 augments NF-kappaB activity by facilitating its nuclear retention. EMBO J 25: 129-138.
    • (2006) EMBO J , vol.25 , pp. 129-138
    • Shin, H.M.1    Minter, L.M.2    Cho, O.H.3    Gottipati, S.4    Fauq, A.H.5
  • 14
    • 39049183044 scopus 로고    scopus 로고
    • Regulation and function of IKK and IKK-related kinases
    • Hacker H, Karin M, (2006) Regulation and function of IKK and IKK-related kinases. Sci STKE 2006: re13.
    • (2006) Sci STKE , vol.2006
    • Hacker, H.1    Karin, M.2
  • 15
    • 21644462493 scopus 로고    scopus 로고
    • Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors
    • Johnson PF, (2005) Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors. J Cell Sci 118: 2545-2555.
    • (2005) J Cell Sci , vol.118 , pp. 2545-2555
    • Johnson, P.F.1
  • 16
    • 78049506983 scopus 로고    scopus 로고
    • A novel GSK-3 beta-C/EBP alpha-miR-122-insulin-like growth factor 1 receptor regulatory circuitry in human hepatocellular carcinoma
    • Zeng C, Wang R, Li D, Lin XJ, Wei QK, et al. (2010) A novel GSK-3 beta-C/EBP alpha-miR-122-insulin-like growth factor 1 receptor regulatory circuitry in human hepatocellular carcinoma. Hepatology 52: 1702-1712.
    • (2010) Hepatology , vol.52 , pp. 1702-1712
    • Zeng, C.1    Wang, R.2    Li, D.3    Lin, X.J.4    Wei, Q.K.5
  • 17
    • 77955507119 scopus 로고    scopus 로고
    • C/EBPalpha is up-regulated in a subset of hepatocellular carcinomas and plays a role in cell growth and proliferation
    • Lu GD, Leung CH, Yan B, Tan CM, Low SY, et al. (2010) C/EBPalpha is up-regulated in a subset of hepatocellular carcinomas and plays a role in cell growth and proliferation. Gastroenterology 139: 632-643, 643 e631-634.
    • (2010) Gastroenterology , vol.139
    • Lu, G.D.1    Leung, C.H.2    Yan, B.3    Tan, C.M.4    Low, S.Y.5
  • 18
    • 0345818258 scopus 로고    scopus 로고
    • MicroRNAs and cancer
    • McManus MT, (2003) MicroRNAs and cancer. Semin Cancer Biol 13: 253-258.
    • (2003) Semin Cancer Biol , vol.13 , pp. 253-258
    • McManus, M.T.1
  • 19
    • 80053590170 scopus 로고    scopus 로고
    • MicroRNAs: key components of immune regulation
    • Gracias DT, Katsikis PD, (2011) MicroRNAs: key components of immune regulation. Adv Exp Med Biol 780: 15-26.
    • (2011) Adv Exp Med Biol , vol.780 , pp. 15-26
    • Gracias, D.T.1    Katsikis, P.D.2
  • 20
    • 24344494340 scopus 로고    scopus 로고
    • How microRNAs control cell division, differentiation and death
    • Miska EA, (2005) How microRNAs control cell division, differentiation and death. Curr Opin Genet Dev 15: 563-568.
    • (2005) Curr Opin Genet Dev , vol.15 , pp. 563-568
    • Miska, E.A.1
  • 22
    • 80655144743 scopus 로고    scopus 로고
    • Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability
    • Sarma NJ, Yaseen NR, (2011) Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability. J Biol Chem 286: 38989-39001.
    • (2011) J Biol Chem , vol.286 , pp. 38989-39001
    • Sarma, N.J.1    Yaseen, N.R.2
  • 23
    • 33645986652 scopus 로고    scopus 로고
    • Progression of fibrosis in hepatitis C with and without schistosomiasis: correlation with serum markers of fibrosis
    • Kamal SM, Turner B, He Q, Rasenack J, Bianchi L, et al. (2006) Progression of fibrosis in hepatitis C with and without schistosomiasis: correlation with serum markers of fibrosis. Hepatology 43: 771-779.
    • (2006) Hepatology , vol.43 , pp. 771-779
    • Kamal, S.M.1    Turner, B.2    He, Q.3    Rasenack, J.4    Bianchi, L.5
  • 24
    • 51349083802 scopus 로고    scopus 로고
    • Serum fibrosis markers can predict rapid fibrosis progression after liver transplantation for hepatitis C
    • Pungpapong S, Nunes DP, Krishna M, Nakhleh R, Chambers K, et al. (2008) Serum fibrosis markers can predict rapid fibrosis progression after liver transplantation for hepatitis C. Liver Transpl. 14: 1294-1302.
    • (2008) Liver Transpl , vol.14 , pp. 1294-1302
    • Pungpapong, S.1    Nunes, D.P.2    Krishna, M.3    Nakhleh, R.4    Chambers, K.5
  • 26
    • 84865536932 scopus 로고    scopus 로고
    • Hepatic activation of IKK/NF-kappaB signaling induces liver fibrosis via macrophage-mediated chronic inflammation
    • Sunami Y, Leithauser F, Gul S, Fiedler K, Guldiken N, et al. (2012) Hepatic activation of IKK/NF-kappaB signaling induces liver fibrosis via macrophage-mediated chronic inflammation. Hepatology.
    • (2012) Hepatology
    • Sunami, Y.1    Leithauser, F.2    Gul, S.3    Fiedler, K.4    Guldiken, N.5
  • 27
    • 5444244544 scopus 로고    scopus 로고
    • [Expression of CCAAT/enhancer-binding protein in cultured rat hepatic stellate cells and its significance]
    • Huang J, Zhang JS, Huang GC, Tang QQ, Chen C, et al. (2004) [Expression of CCAAT/enhancer-binding protein in cultured rat hepatic stellate cells and its significance]. Zhonghua Gan Zang Bing Za Zhi 12: 259-262.
    • (2004) Zhonghua Gan Zang Bing Za Zhi , vol.12 , pp. 259-262
    • Huang, J.1    Zhang, J.S.2    Huang, G.C.3    Tang, Q.Q.4    Chen, C.5
  • 28
    • 84862793486 scopus 로고    scopus 로고
    • C/EBP-alpha ameliorates CCl(4)-induced liver fibrosis in mice through promoting apoptosis of hepatic stellate cells with little apoptotic effect on hepatocytes in vitro and in vivo
    • Tao LL, Cheng YY, Ding D, Mei S, Xu JW, et al. (2012) C/EBP-alpha ameliorates CCl(4)-induced liver fibrosis in mice through promoting apoptosis of hepatic stellate cells with little apoptotic effect on hepatocytes in vitro and in vivo. Apoptosis.
    • (2012) Apoptosis
    • Tao, L.L.1    Cheng, Y.Y.2    Ding, D.3    Mei, S.4    Xu, J.W.5
  • 29
    • 65849375498 scopus 로고    scopus 로고
    • Reduced expression of C/EBP alpha protein in hepatocellular carcinoma is associated with advanced tumor stage and shortened patient survival
    • Tseng HH, Hwang YH, Yeh KT, Chang JG, Chen YL, et al. (2009) Reduced expression of C/EBP alpha protein in hepatocellular carcinoma is associated with advanced tumor stage and shortened patient survival. J Cancer Res Clin Oncol 135: 241-247.
    • (2009) J Cancer Res Clin Oncol , vol.135 , pp. 241-247
    • Tseng, H.H.1    Hwang, Y.H.2    Yeh, K.T.3    Chang, J.G.4    Chen, Y.L.5
  • 30
    • 79958161701 scopus 로고    scopus 로고
    • Hepatitis C virus NS3 protein can activate the Notch-signaling pathway through binding to a transcription factor, SRCAP
    • Iwai A, Takegami T, Shiozaki T, Miyazaki T, (2011) Hepatitis C virus NS3 protein can activate the Notch-signaling pathway through binding to a transcription factor, SRCAP. PLoS One 6: e20718.
    • (2011) PLoS One , vol.6
    • Iwai, A.1    Takegami, T.2    Shiozaki, T.3    Miyazaki, T.4
  • 31
    • 77953541796 scopus 로고    scopus 로고
    • Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor
    • Saad S, Stanners SR, Yong R, Tang O, Pollock CA, (2010) Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor. Int J Biochem Cell Biol 42: 1115-1122.
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 1115-1122
    • Saad, S.1    Stanners, S.R.2    Yong, R.3    Tang, O.4    Pollock, C.A.5
  • 32
    • 84859270591 scopus 로고    scopus 로고
    • Notch signaling mediates TGF-beta1-induced epithelial-mesenchymal transition through the induction of Snai1
    • Matsuno Y, Coelho AL, Jarai G, Westwick J, Hogaboam CM, (2012) Notch signaling mediates TGF-beta1-induced epithelial-mesenchymal transition through the induction of Snai1. Int J Biochem Cell Biol 44: 776-789.
    • (2012) Int J Biochem Cell Biol , vol.44 , pp. 776-789
    • Matsuno, Y.1    Coelho, A.L.2    Jarai, G.3    Westwick, J.4    Hogaboam, C.M.5
  • 33
    • 78049449123 scopus 로고    scopus 로고
    • Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans
    • Bielesz B, Sirin Y, Si H, Niranjan T, Gruenwald A, et al. (2010) Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans. J Clin Invest 120: 4040-4054.
    • (2010) J Clin Invest , vol.120 , pp. 4040-4054
    • Bielesz, B.1    Sirin, Y.2    Si, H.3    Niranjan, T.4    Gruenwald, A.5
  • 34
    • 79953760895 scopus 로고    scopus 로고
    • Notch1 differentially regulates oncogenesis by wildtype p53 overexpression and p53 mutation in grade III hepatocellular carcinoma
    • Lim SO, Park YM, Kim HS, Quan X, Yoo JE, et al. (2011) Notch1 differentially regulates oncogenesis by wildtype p53 overexpression and p53 mutation in grade III hepatocellular carcinoma. Hepatology 53: 1352-1362.
    • (2011) Hepatology , vol.53 , pp. 1352-1362
    • Lim, S.O.1    Park, Y.M.2    Kim, H.S.3    Quan, X.4    Yoo, J.E.5
  • 35
    • 34247549347 scopus 로고    scopus 로고
    • Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma
    • Wurmbach E, Chen YB, Khitrov G, Zhang W, Roayaie S, et al. (2007) Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma. Hepatology 45: 938-947.
    • (2007) Hepatology , vol.45 , pp. 938-947
    • Wurmbach, E.1    Chen, Y.B.2    Khitrov, G.3    Zhang, W.4    Roayaie, S.5
  • 36
    • 80555129351 scopus 로고    scopus 로고
    • Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think
    • Lobry C, Oh P, Aifantis I, (2011) Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think. J Exp Med 208: 1931-1935.
    • (2011) J Exp Med , vol.208 , pp. 1931-1935
    • Lobry, C.1    Oh, P.2    Aifantis, I.3
  • 37
    • 80052833369 scopus 로고    scopus 로고
    • Involvement of the NF-kappaB pathway in multidrug resistance induced by HBx in a hepatoma cell line
    • Liu Y, Lou G, Wu W, Zheng M, Shi Y, et al. (2011) Involvement of the NF-kappaB pathway in multidrug resistance induced by HBx in a hepatoma cell line. J Viral Hepat 18: e439-446.
    • (2011) J Viral Hepat , vol.18
    • Liu, Y.1    Lou, G.2    Wu, W.3    Zheng, M.4    Shi, Y.5
  • 38
    • 79959753610 scopus 로고    scopus 로고
    • The role of miRNAs in cytokine signaling
    • McCoy CE, (2012) The role of miRNAs in cytokine signaling. Front Biosci 17: 2161-2171.
    • (2012) Front Biosci , vol.17 , pp. 2161-2171
    • McCoy, C.E.1
  • 39
    • 78649674133 scopus 로고    scopus 로고
    • Correlation between microRNA expression levels and clinical parameters associated with chronic hepatitis C viral infection in humans
    • Marquez RT, Bandyopadhyay S, Wendlandt EB, Keck K, Hoffer BA, et al. (2010) Correlation between microRNA expression levels and clinical parameters associated with chronic hepatitis C viral infection in humans. Lab Invest 90: 1727-1736.
    • (2010) Lab Invest , vol.90 , pp. 1727-1736
    • Marquez, R.T.1    Bandyopadhyay, S.2    Wendlandt, E.B.3    Keck, K.4    Hoffer, B.A.5
  • 40
    • 80055103381 scopus 로고    scopus 로고
    • Serum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma
    • Bihrer V, Waidmann O, Friedrich-Rust M, Forestier N, Susser S, et al. (2011) Serum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma. PLoS One 6: e26971.
    • (2011) PLoS One , vol.6
    • Bihrer, V.1    Waidmann, O.2    Friedrich-Rust, M.3    Forestier, N.4    Susser, S.5
  • 41
    • 77955373730 scopus 로고    scopus 로고
    • miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis
    • Liu G, Friggeri A, Yang Y, Milosevic J, Ding Q, et al. (2010) miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med 207: 1589-1597.
    • (2010) J Exp Med , vol.207 , pp. 1589-1597
    • Liu, G.1    Friggeri, A.2    Yang, Y.3    Milosevic, J.4    Ding, Q.5
  • 42
    • 84856186747 scopus 로고    scopus 로고
    • Hepatocyte-derived micrornas as serum biomarker of hepatic injury and rejection after liver transplantation
    • Farid WR, Pan Q, van der Meer AJ, de Ruiter PE, Ramakrishnaiah V, et al. (2011) Hepatocyte-derived micrornas as serum biomarker of hepatic injury and rejection after liver transplantation. Liver Transpl.
    • (2011) Liver Transpl
    • Farid, W.R.1    Pan, Q.2    van der Meer, A.J.3    de Ruiter, P.E.4    Ramakrishnaiah, V.5
  • 43
    • 79953244924 scopus 로고    scopus 로고
    • Characterization of HCV-specific CD4+Th17 immunity in recurrent hepatitis C-induced liver allograft fibrosis
    • Basha HI, Subramanian V, Seetharam A, Nath DS, Ramachandran S, et al. (2011) Characterization of HCV-specific CD4+Th17 immunity in recurrent hepatitis C-induced liver allograft fibrosis. Am J Transplant 11: 775-785.
    • (2011) Am J Transplant , vol.11 , pp. 775-785
    • Basha, H.I.1    Subramanian, V.2    Seetharam, A.3    Nath, D.S.4    Ramachandran, S.5
  • 44
    • 80052008851 scopus 로고    scopus 로고
    • Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease
    • Cermelli S, Ruggieri A, Marrero JA, Ioannou GN, Beretta L, (2011) Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease. PLoS One 6: e23937.
    • (2011) PLoS One , vol.6
    • Cermelli, S.1    Ruggieri, A.2    Marrero, J.A.3    Ioannou, G.N.4    Beretta, L.5
  • 45
    • 64949190804 scopus 로고    scopus 로고
    • miR-449a targets HDAC-1 and induces growth arrest in prostate cancer
    • Noonan EJ, Place RF, Pookot D, Basak S, Whitson JM, et al. (2009) miR-449a targets HDAC-1 and induces growth arrest in prostate cancer. Oncogene 28: 1714-1724.
    • (2009) Oncogene , vol.28 , pp. 1714-1724
    • Noonan, E.J.1    Place, R.F.2    Pookot, D.3    Basak, S.4    Whitson, J.M.5
  • 46
    • 79954507936 scopus 로고    scopus 로고
    • miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells
    • Noonan EJ, Place RF, Basak S, Pookot D, Li LC, (2010) miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells. Oncotarget 1: 349-358.
    • (2010) Oncotarget , vol.1 , pp. 349-358
    • Noonan, E.J.1    Place, R.F.2    Basak, S.3    Pookot, D.4    Li, L.C.5
  • 47
    • 76749102887 scopus 로고    scopus 로고
    • E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis
    • Lize M, Pilarski S, Dobbelstein M, (2010) E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis. Cell Death Differ 17: 452-458.
    • (2010) Cell Death Differ , vol.17 , pp. 452-458
    • Lize, M.1    Pilarski, S.2    Dobbelstein, M.3
  • 48
    • 84857147817 scopus 로고    scopus 로고
    • Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells
    • Du R, Sun W, Xia L, Zhao A, Yu Y, et al. (2012) Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells. PLoS One 7: e30771.
    • (2012) PLoS One , vol.7
    • Du, R.1    Sun, W.2    Xia, L.3    Zhao, A.4    Yu, Y.5


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