Molecular mechanisms of RADA16-1 peptide on fast stop bleeding in rat models

International Journal of Molecular Sciences

Volumn 13, Issue 11, 2012, Pages 15279-15290

  Wang, Ting ^a   Zhong, Xiaozhong ^b   Wang, Songtao ^a,c   Lv, Fei ^a   Zhao, Xiaojun ^a  

^a SICHUAN UNIVERSITY   (China)

^b JIANGHAN UNIVERSITY   (China)

^c National Engineering Research Center for solid state fermentation   (China)

Author keywords

Hemostasis; Nanofiber scaffolds; RADA16 1; Self assembly

Indexed keywords

HEMOSTATIC AGENT; PEPTIDE RADA16-1; TISSUE SCAFFOLD; UNCLASSIFIED DRUG; COAGULATING AGENT; NANOFIBER; PEPTIDE; RADA16-I;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOMIC FORCE MICROSCOPY; BETA SHEET; BLEEDING; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG MECHANISM; DRUG SOLUBILITY; ELASTICITY; EXPERIMENTAL MODEL; FLOW MEASUREMENT; HEMOSTASIS; HYDROGEL; HYDROPHILICITY; HYDROPHOBICITY; NONHUMAN; PROTEIN ASSEMBLY; RAT; RIGIDITY; STORAGE MODULUS G'; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DISEASE MODEL; HEMORRHAGE; PROTEIN SECONDARY STRUCTURE; ULTRASTRUCTURE;

ANIMALS; COAGULANTS; DISEASE MODELS, ANIMAL; HEMORRHAGE; MICROSCOPY, ATOMIC FORCE; MODELS, MOLECULAR; NANOFIBERS; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; RATS;

EID: 84870697437     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms131115279     Document Type: Article

References (35)

1. Ellis-Behnke, R.; Liang, Y.; Tay, D.; Kau, P.; Schneider, G.; Zhang, S.; Wu, W.; So, K. Nano hemostat solution, immediate hemostasis at the nanoscale. Nanomedicine 2006, 2, 207-215.
2. Alam, H.B.; Burris, D.; DaCorta, J.A.; Rhee, P. Hemorrhage control in the battlefield: Role of new hemostatic agents. Military Med. 2005, 170, 63-69.
3. Blocksom, J.M.; Sugawa, C.; Tokioka, S.; Williams, M. The Hemoclip: A novel approach to endoscopic therapy for esophageal perforation. Dig. Dis. Sci. 2004, 49, 1136-1138.
4. Kaplan, M.; Bozkurt, S.; Kut, M.S.; Kullu, S.; Demirtas, M.M. Histopathological effects of ethyl 2-cyanoacrylate tissue adhesive following surgical application: An experimental study. Eur. J. Cardio-Thorac. Surg. 2004, 25, 167-172.
5. Luo, Z.L.; Zhao, X.J.; Zhang, S.G. Structural dynamic of a self-assembling peptide d-EAK16 made of only D-amino acids. PLoS One 2008, 3, e2364.
6. Genove, E.; Shen, C.; Zhang, S.G.; Semino, C.E. The effect of functionalized self-assembling peptide scaffolds on human aortic endothelial cell function. Biomaterials 2005, 26, 3341-3351.
7. Zhang, S.G.; Holmes, T.; Lockshin, C.; Rich, A. Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane. Proc. Natl. Acad. Sci. USA 1993, 90, 3334-3338.
8. Zhang, S.G.; Lockshin, C.; Cook, R.; Rich, A. Unusually stable beta-sheet formation in an ionic self-complementary oligopeptide. Biopolymers 1994, 34, 663-672.
9. Ye, Z.Y.; Zhang, H.Y.; Luo, H.L.; Wang, S.K.; Zhou, Q.H.; Du, X.P.; Tang, C.K.; Chen, L.Y.; Liu, J.P.; Shi, Y.K.; et al. Temperature and pH effects on biophysical and morphological properties of self-assembling peptide RADA16-1. J. Pept. Sci. 2008, 14, 152-162.
10. Asakura, T.; Sugino, R.; Okumura, T.; Nakazawa, Y. The role of irregular unit, GAAS, on the secondary structure of Bombyx mori silk fibroin studied with C-13 CP/MAS NMR and wide-angle X-ray scattering. Protein Sci. 2002, 11, 1873-1877.
11. Wang, Y.D.; Ameer, G.A.; Sheppard, B.J.; Langer, R. A tough biodegradable elastomer. Nat. Biotechnol. 2002, 20, 602-606.
12. Ruan, L.P.; Zhang, H.Y.; Luo, H.L.; Liu, J.P.; Tang, F.S.; Shi, Y.K.; Zhao, X.J. Designed amphiphilic peptide forms stable nanoweb, slowly releases encapsulated hydrophobic drug, and accelerates animal hemostasis. Proc. Natl. Acad. Sci. USA 2009, 106, 5105-5110.
13. Zhang, S.G. Building from bottom up: Fabrication of materials using peptide motifs. Am. Chem. Soc. 2005, 229, U715-U716.
14. Zhang, S.G.; Holmes, T.C.; Dipersio, C.M.; Hynes, R.O.; Su, X.; Rich, A. Self-complementary oligopeptide matrices support mammalian-cell attachment. Biomaterials 1995, 16, 1385-1393.
15. Cylwik, D.; Mogielnicki, A.; Kramkowski, K.; Stokowski, J.; Buczko, W. Antithrombotic effect of L-arginine in hypertensive rats. J. Physiol. Pharmacol. 2004, 55, 563-574.
16. Petersen, B.; Barkun, A.; Carpenter, S.; Chotiprasidhi, P.; Chuttani, R.; Silverman, W.; Hussain, N.; Liu, J.; Taitelbaum, G.; Ginsberg, G.G. Tissue adhesives and fibrin glues. Gastrointest. Endosc. 2004, 60, 327-333.
17. Wang, Y.Y.; Tang, Z.Y.; Dong, M.; Liu, X.Y.; Peng, S.Q. Inhibition of platelet aggregation by polyaspartoyl L-arginine and its mechanism. Acta Pharmacol. Sinica 2004, 25, 469-473.
18. Huang, W.L.; Lu, L.; Shao, X.M.; Tang, C.K.; Zhao, X.J. Anti-melanoma activity of hybrid peptide P18 and its mechanism of action. Biotechnol. Lett. 2010, 32, 463-469.
19. Tang, C.K.; Shao, X.M.; Sun, B.B.; Huang, W.L.; Qiu, F.; Chen, Y.Z.; Shi, Y.K.; Zhang, E.Y.; Wang, C.; Zhao, X.J. Anticancer mechanism of peptide P18 in human leukemia K562 cells. Org. Biomol. Chem. 2010, 8, 984-987.
20. Koutsopoulos, S.; Zhang, S. Two-layered injectable self-assembling peptide scaffold hydrogels for long-term sustained release of human antibodies. J. Control. Release 2012, 160, 451-458.
21. Yokoi, H.; Kinoshita, T.; Zhang, S.G. Dynamic reassembly of peptide RADA16 nanofiber scaffold. Proc. Natl. Acad. Sci. USA 2005, 102, 8414-8419.
22. Ellis-Behnke, R.G.; Liang, Y.X.; You, S.W.; Tay, D.K.C.; Zhang, S.G.; So, K.F.; Schneider, G.E. Nano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. Proc. Natl. Acad. Sci. USA 2006, 103, 5054-5059.
23. Sharma, H.S.; Ali, S.F.; Tian, Z.R.; Hussain, S.M.; Schlager, J.J.; Sjoquist, P.O.; Sharma, A.; Muresanu, D.F. Chronic treatment with nanoparticles exacerbate hyperthermia induced blood-brain barrier breakdown, cognitive dysfunction and brain pathology in the rat. Neuroprotective effects of nanowired-antioxidant compound H-290/51. J. Nanosci. Nanotechnol. 2009, 9, 5073-5090.
24. Mi, K.; Wang, G.X.; Liu, Z.J.; Feng, Z.H.; Huang, B.; Zhao, X.J. Influence of a self-assembling peptide, RADA16, compared with collagen I and matrigel on the malignant phenotype of human breast-cancer cells in 3D cultures and in vivo. Macromol. Biosci. 2009, 9, 437-443.
25. Liu, J.P.; Song, H.; Zhang, L.L.; Xu, H.Y.; Zhao, X.J. Self-assembly-peptide hydrogels as tissue-engineering scaffolds for three-dimensional culture of chondrocytes in vitro. Macromol. Biosci. 2010, 10, 1164-1170.
26. Liu, X.; Wang, X.M.; Horii, A.; Wang, X.J.; Qiao, L.; Zhang, S.G.; Cui, F.Z. In vivo studies on angiogenic activity of two designer self-assembling peptide scaffold hydrogels in the chicken embryo chorioallantoic membrane. Nanoscale 2012, 4, 2720-2727.
27. Meng, H.; Chen, L.Y.; Ye, Z.Y.; Wang, S.T.; Zhao, X.J. The effect of a self-assembling peptide nanofiber scaffold (peptide) when used as a wound dressing for the treatment of deep second degree burns in rats. J. Biomed. Mater. Res. B 2009, 89B, 379-391.
28. Song, H.; Zhang, L.L.; Zhao, X.J. Hemostatic efficacy of biological self-assembling peptide nanofibers in a rat kidney model. Macromol. Biosci. 2010, 10, 33-39.
29. Qiu, F.; Chen, Y.Z.; Cheng, J.Q.; Wang, C.; Xu, H.Y.; Zhao, X.J. A simple method for cell sheet fabrication using mica surfaces grafted with peptide detergent A(6)K. Macromol. Biosci. 2010, 10, 881-886.
30. Wu, M.; Ye, Z.Y.; Liu, Y.F.; Liu, B.; Zhao, X.J. Release of hydrophobic anticancer drug from a newly designed self-assembling peptide. Mol. Biosyst. 2011, 7, 2040-2047.
31. Koutsopoulos, S.; Kaiser, L.; Eriksson, H.M.; Zhang, S.G. Designer peptide surfactants stabilize diverse functional membrane proteins. Chem. Soc. Rev. 2012, 41, 1721-1728.
32. Gelain, F.; Bottai, D.; Vescovi, A.; Zhang, S.G. Designer self-assembling peptide nanofiber scaffolds for adult mouse neural stem cell 3-dimensional cultures. PLoS One 2006, 1, e119.
33. Sharma, H.S.; Ali, S.; Tian, Z.R.; Patnaik, R.; Patnaik, S.; Lek, P.; Sharma, A.; Lundstedt, T. Nano-drug delivery and neuroprotection in spinal cord injury. J. Nanosci. Nanotechnol. 2009, 9, 5014-5037.
34. Liu, J.P.; Zhang, L.L.; Yang, Z.H.; Zhao, X.J. Controlled release of paclitaxel from a self-assembling peptide hydrogel formed in situ and antitumor study in vitro. Int. J. Nanomed. 2011, 6, 2143-2153.
35. Lakshmanan, A.; Zhang, S.G.; Hauser, C.A.E. Short self-assembling peptides as building blocks for modern nanodevices. Trends Biotechnol. 2012, 30, 155-165.