Anti-melanoma activity of hybrid peptide P18 and its mechanism of action

Biotechnology Letters

Volumn 32, Issue 4, 2010, Pages 463-469

  Huang, Wenli ^a   Lu, Li ^a   Shao, Ximing ^a   Tang, Chengkang ^a   Zhao, Xiaojun ^a,b  

^a SICHUAN UNIVERSITY   (China)

^b Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Anticancer; Antimelanoma; Melanoma cells; Membrane permeability; Peptide P18; Plasma membrane

Indexed keywords

AMPHIPHILICS; ANTICANCER PROPERTIES; ANTIMELANOMA; APOPTOSIS; CYTOTOXIC ACTIVITIES; ELECTROSTATIC INTERACTIONS; HELICAL STRUCTURES; HYBRID PEPTIDES; ION CHANNEL; LOW TOXICITY; MECHANISM OF ACTION; MELANOMA CELLS; MEMBRANE PERMEABILITY; PLASMA MEMBRANE PERMEABILITY; PLASMA MEMBRANES; TRANSMEMBRANE POTENTIALS;

BIOELECTRIC POTENTIALS; CAPILLARITY; CELL DEATH; CELL MEMBRANES; DERMATOLOGY; ONCOLOGY; PEPTIDES;

MEMBRANES;

ANTIMICROBIAL CATIONIC PEPTIDE; ANTINEOPLASTIC AGENT; P18 ANTIMICROBIAL PEPTIDE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL MEMBRANE POTENTIAL; CELL STRAIN 3T3; CELL SURVIVAL; CONFOCAL MICROSCOPY; DOSE RESPONSE; DRUG EFFECT; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; MELANOMA; METABOLISM; MOLECULAR GENETICS; MOUSE; PATHOLOGY; TUMOR CELL LINE;

AMINO ACID SEQUENCE; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HUMANS; MELANOMA; MEMBRANE POTENTIALS; MICE; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; NIH 3T3 CELLS;

EID: 77951768817     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-009-0175-2     Document Type: Article

References (15)

1. Bae J, Jang K, Yim H et al (2005) Polysaccharides isolated from Phellinus gilvus inhibit melanoma growth in mice. Cancer Lett 218: 43-52.
2. Barros LF, Castro J, Bittner CX (2002) Ion movements in cell death: from protection to execution. Biol Res 35(2): 209-214.
3. Cruciani RA, Barker JL, Zasloff M et al (1999) Antibiotic magainins exert cytolytic activity against transformed cell lines through channel formation. Proc Natl Acad Sci USA 88: 3792-3796.
4. Dekker N, Cox RC, Kramer RA et al (2001) Substrate specificity of the integral membrane protease OmpT determined by spatially addressed peptide libraries. Biochemistry 40(6): 1694-1701.
5. Dobrzynska J, Szachowicz-Petelska B, Sulkowski S et al (2005) Changes in electric charge and phospholipids composition in human colorectal cancer cells. Mol Cell Biochem 276: 113-119.
6. Gawlitta D, Oomens CWJ, Baaijens FPT et al (2004) Evaluation of a continuous quantification method of apoptosis and necrosis in tissue cultures. Cytotechnology 46: 139-150.
7. Giuliani A, Pirri G, Nicoletto SF (2007) Antimicrobial peptides: an overview of a promising class of therapeutics. Central Eur J Biol 2: 1-33.
8. Hancock RE, Chapple DS (1999) Peptide antibiotics. Antimicrob Agents Chemother 43: 1317-1323.
9. Kalkman E, Baxter G (2004) Melanoma. Clin Radiol 59: 313-326.
10. Malafa MP, Fokum FD, Mowlavi A et al (2002) Vitamin E inhibits melanoma growth in mice. Surgery 131: 85-91.
11. Oh D, Shin SY, Kang JH et al (1999) NMR structural characterization of cecropin A (1-8)-magainin 2 (1-12) and cecropin A (1-8)-melittin (1-12) hybrid peptides. J Pept Res 53: 578-589.
12. Shin SY, Lee SH, Yang ST et al (2001) Antibacterial, antitumor and hemolytic activities of α-helical antibiotic peptide, P18 and its analogs. J Pept Res 58: 504-514.
13. Tsukimoto M, Harada H, Ikari A et al (2005) Involvement of chloride in apoptotic cell death induced by activation of ATP-sensitive P2X7 purinoceptor. J Biol Chem 280(4): 2653-2658.
14. Yoon WH, Park HD, Lim K et al (1996) Effect of O-glycosylated mucin on invasion and metastasis of HM7 human colon cancer cells. Biochem Biophys Res Commun 222: 694-699.
15. Zachowski A (1993) Phospholipids in animal eukaryotic membranes: transverse asymmetry and movement. Biochem J 294: 1-14.