Molecular Basis of Calcium-Sensitizing and Desensitizing Mutations of the Human Cardiac Troponin C Regulatory Domain: A Multi-Scale Simulation Study

PLoS Computational Biology

Volumn 8, Issue 11, 2012, Pages

  Kekenes Huskey, Peter Michael ^a   Lindert, Steffen ^a   McCammon, James Andrew ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM COMPOUNDS; MOLECULAR DYNAMICS;

CA 2+; CARDIAC TROPONIN C; CYTOSOLIC; MOLECULAR BASIS; MULTI-SCALE SIMULATION; MYOCYTES; REGULATORY DOMAIN; SIMULATION STUDIES; TROPONIN; TROPONIN C;

CALCIUM;

CALCIUM ION; TROPONIN C;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; REACTION TIME; RESIDUE ANALYSIS; SENSITIVITY ANALYSIS; STATIC ELECTRICITY; WILD TYPE;

EID: 84870693969     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002777     Document Type: Article

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