Solution structure of the regulatory domain of human cardiac troponin C in complex with the switch region of cardiac troponin I and W7: The basis of W7 as an inhibitor of cardiac muscle contraction

Journal of Molecular and Cellular Cardiology

Volumn 48, Issue 5, 2010, Pages 925-933

  Oleszczuk, Marta ^a   Robertson, Ian M ^a   Li, Monica X ^a   Sykes, Brian D ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Drugs; Inhibition; Mechanism; Structure; Troponin

Indexed keywords

ALIPHATIC COMPOUND; AROMATIC COMPOUND; CALCIUM ION; METHYL GROUP; N (6 AMINOHEXYL) 5 CHLORO 1 NAPHTHALENESULFONAMIDE; TROPONIN C; TROPONIN I;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONTROLLED STUDY; DRUG DESIGN; HEART CONTRACTION; HUMAN; HYDROPHOBICITY; MOLECULAR INTERACTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MYOCARDIAL CONTRACTION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SULFONAMIDES; TROPONIN C; TROPONIN I;

EID: 77951623621     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2010.01.016     Document Type: Article

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