메뉴 건너뛰기




Volumn 6, Issue 7, 2012, Pages 467-474

Evaluation of protective and antioxidant activity of thyme (Thymus vulgaris) Extract on paracetamol-induced toxicity in rats

Author keywords

Antioxidants; Hepatotoxicity; Nephrotoxicity; Paracetamol; Rats; Thyme

Indexed keywords


EID: 84870683677     PISSN: 19918178     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (24)

References (45)
  • 1
    • 17744366461 scopus 로고    scopus 로고
    • Vitamin C may be beneficial in the prevention of paracetamol-induced renal damage
    • Abraham, P., 2005. Vitamin C may be beneficial in the prevention of paracetamol-induced renal damage. Clin. Exp. Nephrol., 9: 24-30.
    • (2005) Clin. Exp. Nephrol , vol.9 , pp. 24-30
    • Abraham, P.1
  • 2
    • 84859959146 scopus 로고    scopus 로고
    • Protective Effect of Spathodea Campanulata Bark against Paracetamol Induced Nephrotoxicity in Rats
    • Abubaker Siddiq, I. Shanmukha, S.V. Rajendra and S. Ramachandra Setty, 2012. Protective Effect of Spathodea Campanulata Bark against Paracetamol Induced Nephrotoxicity in Rats. Intern. J. Pharm. Tech. Res., 4: 398-403.
    • (2012) Intern. J. Pharm. Tech. Res , vol.4 , pp. 398-403
    • Siddiq, A.1    Shanmukha, I.2    Rajendra, S.V.3    Ramachandra, S.S.4
  • 3
    • 0021318441 scopus 로고
    • Catalase in vitro
    • Aebi, H., 1984. Catalase in vitro. Methods Enzymol., 5: 121-126.
    • (1984) Methods Enzymol , vol.5 , pp. 121-126
    • Aebi, H.1
  • 4
    • 68949129138 scopus 로고    scopus 로고
    • Efficacy and safety of folic acid during toxic hepatitis induced by acute overdose of paracetamol. Intern
    • Al-Sowyan, N.S., 2009. Efficacy and safety of folic acid during toxic hepatitis induced by acute overdose of paracetamol. Intern. J. Pharmacol., 5: 208-214.
    • (2009) J. Pharmacol , vol.5 , pp. 208-214
    • Al-Sowyan, N.S.1
  • 5
    • 84870671217 scopus 로고    scopus 로고
    • Antioxidant activity and free radical-scavenging capacity of ethanolic extracts of thyme, oregano, and marjoram
    • Amarowicz, R., Z. Zegarska, R. Rafałowski, R.B. Pegg, M. Karamac and A. Kosin, 2008. Antioxidant activity and free radical-scavenging capacity of ethanolic extracts of thyme, oregano, and marjoram. Eur. J. Lipid Sci. Technol., 110: 1-7.
    • (2008) Eur. J. Lipid Sci. Technol , vol.110 , pp. 1-7
    • Amarowicz, R.1    Zegarska, Z.2    Rafałowski, R.3    Pegg, R.B.4    Karamac, M.5    Kosin, A.6
  • 7
    • 33750542944 scopus 로고    scopus 로고
    • The epidemiology of acute renal failure: 1975 versus 2005
    • Bellomo, R., 2006. The epidemiology of acute renal failure: 1975 versus 2005. Curr. Opin. Crit. Care., 12: 557-560.
    • (2006) Curr. Opin. Crit. Care , vol.12 , pp. 557-560
    • Bellomo, R.1
  • 8
    • 73649194769 scopus 로고
    • Improved method for the determination of blood glutathione
    • Beutler, E., O. Duron and B. Kelly, 1963. Improved method for the determination of blood glutathione. J. Lab. Clin. Med., 61: 882-88.
    • (1963) J. Lab. Clin. Med , vol.61 , pp. 882-888
    • Beutler, E.1    Duron, O.2    Kelly, B.3
  • 9
    • 0001706319 scopus 로고    scopus 로고
    • Acetaminophen-induced hepatotoxicity
    • Plaa, G.L. and W.R. Hewitt, Taylor & Francis, Philadelphia, pp
    • Cohen, S.D., D.J. Hoivik and E.A. Khairallah, 1998. Acetaminophen-induced hepatotoxicity, In: Plaa, G.L. and W.R. Hewitt eds, Toxicology of the Liver, Taylor & Francis, Philadelphia, pp: 159-186.
    • (1998) Toxicology of the Liver , pp. 159-186
    • Cohen, S.D.1    Hoivik, D.J.2    Khairallah, E.A.3
  • 10
    • 33947504242 scopus 로고    scopus 로고
    • Effects of selected plant essential oils on the growth and development of mouse preimplantation embryos in vivo
    • Domaracky, M., P. Rehak, S. Juhas and J. Koppel, 2007. Effects of selected plant essential oils on the growth and development of mouse preimplantation embryos in vivo. Physiol. Res., 56: 97-104.
    • (2007) Physiol. Res , vol.56 , pp. 97-104
    • Domaracky, M.1    Rehak, P.2    Juhas, S.3    Koppel, J.4
  • 11
    • 0034026567 scopus 로고    scopus 로고
    • Antimicrobial Plants: Antibacterial Activity of Plant
    • Dorman, H.G.D. and S.G. Deans, 2000. Antimicrobial Plants: Antibacterial Activity of Plant. Appl. Microbiol., 88: 308-316.
    • (2000) Appl. Microbiol , vol.88 , pp. 308-316
    • Dorman, H.G.D.1    Deans, S.G.2
  • 12
    • 0000187728 scopus 로고
    • Effect of Liv-52 on different biochemical parameters in alcoholic cirrhosis
    • Dubey, G.P., A. Agrawal and S.P. Dixit, 1994. Effect of Liv-52 on different biochemical parameters in alcoholic cirrhosis. Antiseptic., 91: 205-208.
    • (1994) Antiseptic , vol.91 , pp. 205-208
    • Dubey, G.P.1    Agrawal, A.2    Dixit, S.P.3
  • 13
    • 79956357870 scopus 로고    scopus 로고
    • Antioxidant properties of Thymus vulgaris oil against aflatoxin-induced oxidative stress in male rats
    • El-Nekeety, A.A., S.R. Mohamed, A.S. Hathout, N.S. Hassan, S.E. Aly and M.A. Abdel-Wahhab, 2011. Antioxidant properties of Thymus vulgaris oil against aflatoxin-induced oxidative stress in male rats. Toxicon., 57: 984-991.
    • (2011) Toxicon , vol.57 , pp. 984-991
    • El-Nekeety, A.A.1    Mohamed, S.R.2    Hathout, A.S.3    Hassan, N.S.4    Aly, S.E.5    Abdel-Wahhab, M.A.6
  • 14
    • 0015123663 scopus 로고
    • A single reagent manual method for directly determining urea nitrogen in serum
    • Foster, L.B. and J.M. Hocholzer, 1971. A single reagent manual method for directly determining urea nitrogen in serum. Clinical Chemistry, 17: 921-925.
    • (1971) Clinical Chemistry , vol.17 , pp. 921-925
    • Foster, L.B.1    Hocholzer, J.M.2
  • 16
    • 84865552689 scopus 로고    scopus 로고
    • Antioxidant and hepatoprotective effects of Thymus vulgaris extract in rats during alfatoxicosis
    • Hamzawy, M.A., E.S.M. El-Denshary, N.S. Hassan, F. Manaa and M.A. Abdel- Wahhab, 2012. Antioxidant and hepatoprotective effects of Thymus vulgaris extract in rats during alfatoxicosis. Global J. Pharmacol., 6: 106-117.
    • (2012) Global J. Pharmacol , vol.6 , pp. 106-117
    • Hamzawy, M.A.1    el-Denshary, E.S.M.2    Hassan, N.S.3    Manaa, F.4    Abdel-Wahhab, M.A.5
  • 17
    • 33847780698 scopus 로고
    • Colorimetric determination of total protein
    • Harper and Row Publ., New York, USA
    • Henry, R.J., 1964. Colorimetric determination of total protein. In: Clinical Chemistry. Harper and Row Publ., New York, USA, pp: 181.
    • (1964) Clinical Chemistry , pp. 181
    • Henry, R.J.1
  • 18
    • 33751037571 scopus 로고    scopus 로고
    • Chirality influences the effects of linalool on physiological parameters of stress
    • Höferl, M., S. Krist and G. Buchbauer, 2006. Chirality influences the effects of linalool on physiological parameters of stress. Planta Med., 72: 1188-1192.
    • (2006) Planta Med , vol.72 , pp. 1188-1192
    • Höferl, M.1    Krist, S.2    Buchbauer, G.3
  • 23
    • 33750981814 scopus 로고    scopus 로고
    • Assesment of the pro-oxidant activity of uranium in kidney and testis of rats
    • Linares, M.V., M. Bellés, M.L. Albina, J.J. Sirvent and D.J. Sanchez, 2006. Assesment of the pro-oxidant activity of uranium in kidney and testis of rats. Toxicol. Lett., 167: 52-61.
    • (2006) Toxicol. Lett , vol.167 , pp. 52-61
    • Linares, M.V.1    Bellés, M.2    Albina, M.L.3    Sirvent, J.J.4    Sanchez, D.J.5
  • 24
    • 0343770901 scopus 로고
    • Assessment of liver function and diagnostic studies
    • Freidman, L.S and E.B. Keefe (Eds.), Churchill Livingstone, Philadelphia, pp
    • Martin, P. and L.S. Friedman, 1992. Assessment of liver function and diagnostic studies. In: Freidman, L.S and E.B. Keefe (Eds.), Hand Book of Liver Disease. Churchill Livingstone, Philadelphia, pp: 1-14.
    • (1992) Hand Book of Liver Disease , pp. 1-14
    • Martin, P.1    Friedman, L.S.2
  • 25
    • 0008917028 scopus 로고
    • The kidneys and renal calculi
    • 6th ed. Edward Arnold Publications, London, pp
    • Mayne, P.D., 1994. The kidneys and renal calculi. In: Clinical chemistry in diagnosis and treatment, 6th ed. Edward Arnold Publications, London, pp: 2-24.
    • (1994) Clinical Chemistry In Diagnosis and Treatment , pp. 2-24
    • Mayne, P.D.1
  • 26
    • 0031578440 scopus 로고    scopus 로고
    • The contribution of oxidation and deacetylation to acetaminophen nephrotoxicity in female Sprague-Dawley rats
    • Mugford, C.A. and J.B. Tarloff, 1997. The contribution of oxidation and deacetylation to acetaminophen nephrotoxicity in female Sprague-Dawley rats. Toxicol. Lett., 93: 15-28.
    • (1997) Toxicol. Lett , vol.93 , pp. 15-28
    • Mugford, C.A.1    Tarloff, J.B.2
  • 28
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa, H., W. Ohishi and K. Yagi, 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 95: 351.
    • (1979) Anal. Biochem , vol.95 , pp. 351
    • Ohkawa, H.1    Ohishi, W.2    Yagi, K.3
  • 29
    • 7444231721 scopus 로고    scopus 로고
    • Drug yield and essential oil of Thymus vulgaris L. as in influenced by ecological and ontogenetical variation
    • Ozguven, M. and S. Tansi, 1998. Drug yield and essential oil of Thymus vulgaris L. as in influenced by ecological and ontogenetical variation. Tr. J. of Agriculture and Forestry, 22: 537-542.
    • (1998) Tr. J. of Agriculture and Forestry , vol.22 , pp. 537-542
    • Ozguven, M.1    Tansi, S.2
  • 30
    • 0035020673 scopus 로고    scopus 로고
    • Chemopreventive activity of Withania somnifera in experimentally induced fibrosarcoma tumors in swiss albino mice
    • Prakash, J., S.K. Gupta, V. Kochupillai, N. Singh, Y.K. Gupta and S. Joshi, 2001. Chemopreventive activity of Withania somnifera in experimentally induced fibrosarcoma tumors in swiss albino mice. Phytother. Res., 15: 240-244.
    • (2001) Phytother. Res , vol.15 , pp. 240-244
    • Prakash, J.1    Gupta, S.K.2    Kochupillai, V.3    Singh, N.4    Gupta, Y.K.5    Joshi, S.6
  • 31
    • 33646107617 scopus 로고    scopus 로고
    • Ultra structural studies on antimicrobial efficacy of thyme essential oils on listeria monocytogenes
    • Rasooli, I., M.B. Rezaei and A. Allameh, 2006. Ultra structural studies on antimicrobial efficacy of thyme essential oils on listeria monocytogenes. International Journal Infectious Diseases, 10: 236-241.
    • (2006) International Journal Infectious Diseases , vol.10 , pp. 236-241
    • Rasooli, I.1    Rezaei, M.B.2    Allameh, A.3
  • 32
    • 66349129125 scopus 로고
    • Colorimetric method for determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases
    • Reitman, A. and S.A. Frankel, 1957. Colorimetric method for determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Am. J. Clin. Path., 28: 56-63.
    • (1957) Am. J. Clin. Path , vol.28 , pp. 56-63
    • Reitman, A.1    Frankel, S.A.2
  • 35
    • 22444438269 scopus 로고    scopus 로고
    • Thyme (Thmus Vulgaris L.) Leaves and its constituents increase the activities of xenobiotic-metabolizing enzyme in mouse liver
    • Sasaki, K., K. Wada, Y. Tanaka, T. Yoshimura and K. Matuoka, 2005. Thyme (Thmus Vulgaris L.) Leaves and its constituents increase the activities of xenobiotic-metabolizing enzyme in mouse liver. J. Med. Food, 8: 184-189.
    • (2005) J. Med. Food , vol.8 , pp. 184-189
    • Sasaki, K.1    Wada, K.2    Tanaka, Y.3    Yoshimura, T.4    Matuoka, K.5
  • 36
    • 78651156110 scopus 로고
    • Critical evaluation of plasma creatinine as a test of glomerulus filtrate
    • Schirmeister, J., H. Willmann and H. Kiefer, 1964. Critical evaluation of plasma creatinine as a test of glomerulus filtrate. Verh Dtsch Ges Inn Med., 70: 678-681.
    • (1964) Verh Dtsch Ges Inn Med , vol.70 , pp. 678-681
    • Schirmeister, J.1    Willmann, H.2    Kiefer, H.3
  • 37
    • 0016860489 scopus 로고
    • Serum bilirubin determination in newborn infants. A new micromethod for the determination of serumof plasma bilirubin in newborn infants
    • Schmidt, M. and J. Eisenburg, 1975. Serum bilirubin determination in newborn infants. A new micromethod for the determination of serumof plasma bilirubin in newborn infants. Fortschr Med., 93: 1461-1466.
    • (1975) Fortschr Med , vol.93 , pp. 1461-1466
    • Schmidt, M.1    Eisenburg, J.2
  • 39
    • 0038008675 scopus 로고    scopus 로고
    • Protective effects of melatonin, vitamin E and N-acetylcysteine against acetaminophen toxicity in mice
    • Sener, G., A. Sehirli and G. Ayanog ̌lu-Dülger, 2003. Protective effects of melatonin, vitamin E and N-acetylcysteine against acetaminophen toxicity in mice. A comparative study. J. Pineal. Res., 35: 61-68.
    • (2003) A Comparative Study. J. Pineal. Res , vol.35 , pp. 61-68
    • Sener, G.1    Sehirli, A.2    Ayanoǧlu-Dülger, G.3
  • 40
    • 84870664361 scopus 로고    scopus 로고
    • Identification of volatile components in basil and thyme leaves and their antioxidants properties
    • Seung, L., U. Katumi, S. Takayki and L. Kwang-Geum, 2005. Identification of volatile components in basil and thyme leaves and their antioxidants properties. Food. Chem., 91: 131-137.
    • (2005) Food. Chem , vol.91 , pp. 131-137
    • Seung, L.1    Katumi, U.2    Takayki, S.3    Kwang-Geum, L.4
  • 41
    • 68649089012 scopus 로고    scopus 로고
    • Effects of water extracts of thyme (Thymus vulgaris) and ginger (Zingiber officinale Roscoe) on alcohol abuse
    • Shati, A.A. and F.G. Elsaid, 2009. Effects of water extracts of thyme (Thymus vulgaris) and ginger (Zingiber officinale Roscoe) on alcohol abuse. Food Chem. Toxicol., 47: 1945-1949.
    • (2009) Food Chem. Toxicol , vol.47 , pp. 1945-1949
    • Shati, A.A.1    Elsaid, F.G.2
  • 42
    • 0030434803 scopus 로고    scopus 로고
    • Nephrotoxicity of acetaminophen in male Wistar rats: Role of hepatically derived metabolites
    • Trumper, L., L.A. Monasterolo and M.M. Elias, 1996. Nephrotoxicity of acetaminophen in male Wistar rats: role of hepatically derived metabolites. J. Pharmacol. Exp. Ther., 27: 548-554.
    • (1996) J. Pharmacol. Exp. Ther , vol.27 , pp. 548-554
    • Trumper, L.1    Monasterolo, L.A.2    Elias, M.M.3
  • 44
    • 84861699222 scopus 로고    scopus 로고
    • Hepato-protective activity of Phyllanthus emblica against paracetamol induced hepatic damage in wister albino rats
    • Vidhya Malar, H.L. and S. Mary Mettilda Bai, 2009. Hepato-protective activity of Phyllanthus emblica against paracetamol induced hepatic damage in wister albino rats. African Journal of Basic & Applied Sciences, 1: 21-25.
    • (2009) African Journal of Basic & Applied Sciences , vol.1 , pp. 21-25
    • Vidhya, M.H.L.1    Mary, M.B.S.2
  • 45
    • 0027740934 scopus 로고
    • Andrographolide protects rat hepatocytes against paracetamol -induced damage
    • Visen, P.K.S., B. Shukla, G.K. Patnaik and B.N. Dhawan, 1993. Andrographolide protects rat hepatocytes against paracetamol -induced damage. J. Ethnopharmacol., 40: 11-136.
    • (1993) J. Ethnopharmacol , vol.40 , pp. 11-136
    • Visen, P.K.S.1    Shukla, B.2    Patnaik, G.K.3    Dhawan, B.N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.