An inexpensive system for evaluating the tussive and anti-tussive properties of chemicals in conscious, unrestrained guinea pigs

Journal of Pharmacological and Toxicological Methods

Volumn 66, Issue 3, 2012, Pages 232-237

  Daller, J R ^a   Wong, J ^a   Brooks, B D ^a   McKee, J S ^a  

^a BAXTER HEALTHCARE CORPORATION   (United States)

Author keywords

Antitussive agents; Cough; Guinea pigs; Methods; Transient receptor potential channels

Indexed keywords

METHYLCELLULOSE; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; VANILLOID RECEPTOR 1;

AIRFLOW; ARTICLE; ATMOSPHERIC PRESSURE; BODY PLETHYSMOGRAPHY; CONTROLLED STUDY; COUGHING; DRUG EFFICACY; DRUG MECHANISM; GUINEA PIG; INHALATION; MICROPHONE; NEBULIZATION; NONHUMAN; SCANNING ELECTRON MICROSCOPY; SNEEZING; WAVEFORM;

ANIMALIA; CAVIA;

EID: 84870679639     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2012.07.001     Document Type: Article

References (23)

1. Andre, E., Gatti, R., Trevisani, M., Preti, D., Baraldi, P., Patacchini, R., et al. (2009). Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents. British Journal of Pharmacology, 158, 1621-1628.
2. Belvisi, M., & Geppetti, P. (2004). Cough 7: Current and future drugs for the treatment of chronic cough. Thorax, 59, 438-440.
3. Belvisi, M., Patel, H., Freund-Michel, V., Hele, D., Crispino, N., & Birrell, M. (2008). Inhibitory activity of the novel CB2 receptor agonist, GW833972A, on guinea-pig and human sensory nerve function in the airways. British Journal of Pharmacology, 155, 547-557.
4. Bhattacharya, A., Scott, B., Nasser, N., Ao, H., Maher, M., Dubin, A., et al. (2007). Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs. Journal of Pharmacology and Experimental Therapeutics, 323, 665-674.
5. Birrell, M., Belvisi, M., Grace, M., Sadofsky, L., Faruqi, S., Hele, D., et al. (2009). TRPA1 agonists evoke coughing in guinea pig and human volunteers. American Journal of Respiratory and Critical Care Medicine, 180, 1042-1047.
6. Birring, S. (2009). Developing antitussives: The ideal clinical trial. Pulmonary Pharmacology & Therapeutics, 22, 155-158.
7. Canning, B., Farmer, D., & Mori, N. (2011). Mechanistic studies of acid-evoked coughing in anesthetized guinea pigs. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 2006(291), R454-R463.
8. Dicpinigaitis, P. (2011). Cough: An unmet clinical need. British Journal of Pharmacology, 163(1), 116-124.
9. Final rules: Animal welfare; 9 CFR parts 1 and 2. Federal Register, 54(168). (1989)., 36112-36163 (August 31).
10. Geppetti, P., Patacchini, R., Nassini, R., & Materazzi, S. (2010). Cough: The emerging role of the TRPA1 channel. Lung, 188(Suppl. 1), S63-S68.
11. Joad, J., Munch, P., Bric, J., Evans, S., Pinkerton, K., Chen, C., et al. (2004). Passive smoke effects on cough and airways in young guinea pigs. American Journal of Respiratory and Critical Care Medicine, 169, 499-504.
12. Kotzer, C., Hay, D., Dondio, G., Giardina, G., Petrillo, P., & Underwood, D. (2000). The antitussive activity of δ-opioid receptor stimulation in guinea pigs. Journal of Pharmacology and Experimental Therapeutics, 292(2), 803-809.
13. Kunkler, P., Ballard, C., Oxford, G., & Hurley, J. (2011). TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation. Pain, 152(1), 38-44.
14. Leung, S., Niimi, A.,Williams, A., Nath, P., Blanc, F., Dinh, Q., et al. (2007). Inhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist, VII2220. Cough, 3, 10-14.
15. McLeod, R., Fernandez, X., Correll, C., Phelps, T., Jia, Y.,Wang, X., et al. (2006). TRPV1 antagonists attenuate antigen-provoked cough in ovalbumin sensitized guinea pigs. Cough, 2(10), 1-7.
16. Mokry, J., & Nosalova, G. (2011). The influence of PDE inhibitors on cough reflex in guinea pigs. Bratislavské Lekárske Listy, 112(3), 131-135.
17. Moran, M., McAlexander, M., Biro, T., & Szallasi, A. (2011). Transient receptor potential channels as therapeutic targets. Nature Reviews Drug Discovery, 10, 601-620.
18. Morice, A., Fontana, G., Belvisi,M., Birring, S., Chung, K., Dicpinigaitis, P., et al. (2007). ERS guidelines on the assessment of cough. European Respiratory Journal, 29, 1256-1276.
19. National Research Council (1996). Guide for the care and use of laboratory animals. Washington, DC: The National Academies Press.
20. Schroeder, K., & Fahy, T. (2002). Systematic review of randomized controlled trials of over the counter cough medicines for acute cough in adults. British Journal of Pharmacology, 324, 329-331.
21. Tanaka, M., & Maruyama, K. (2005). Mechanisms of capsaicin- and citric-acid-induced cough reflexes in guinea pigs. Journal of Pharmacological Sciences, 1-6.
22. Venkatasamy, R., McKenzie,A., Page, C.,Walker,M., & Spina,D. (2010). Use ofwithin-group designs to test anti-tussive drugs in conscious guinea-pigs. Journal of Pharmacological and Toxicological Methods, 61, 157-162.
23. Xiang, A., Uchida, Y., Nomura, A., Iijima, H., Dong, F., Zhang, M., et al. (1998). Effects of airway inflammation on cough response in the guinea pig. Journal of Applied Physiology, 85(5), 1847-1854.