Developing antitussives: The ideal clinical trial

Pulmonary Pharmacology and Therapeutics

Volumn 22, Issue 2, 2009, Pages 155-158

  Birring, Surinder S ^a  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

Antitussives; Clinical trials; Cough; Cough monitor; Quality of life

Indexed keywords

ANTITUSSIVE AGENT; VANILLOID RECEPTOR 1;

ARTICLE; BRAIN DISEASE; CLINICAL TRIAL; CONSCIOUSNESS DISORDER; COST EFFECTIVENESS ANALYSIS; COUGHING; DISEASE SEVERITY; DRUG ABUSE; DRUG EFFICACY; DRUG FATALITY; DRUG MISUSE; DRUG OVERDOSE; DRUG SCREENING; DRUG SYNTHESIS; DRUG UTILIZATION; DRUG WITHDRAWAL; HALLUCINATION; HEART ARRHYTHMIA; HUMAN; METHODOLOGY; OUTCOME ASSESSMENT; PATIENT MONITORING; PATIENT SELECTION; PRIORITY JOURNAL; QUALITY OF LIFE; SAMPLE SIZE; SIDE EFFECT; SYMPTOM; UPPER RESPIRATORY TRACT INFECTION;

ACUTE DISEASE; ANTITUSSIVE AGENTS; CHRONIC DISEASE; CLINICAL TRIALS AS TOPIC; COUGH; DRUG DELIVERY SYSTEMS; DRUG DESIGN; HUMANS; PATIENT SELECTION; RESEARCH DESIGN; RESPIRATORY TRACT INFECTIONS;

EID: 61649113719     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2008.10.012     Document Type: Article

References (28)

1. Sharfstein J.M., North M., and Serwint J.R. Over the counter but no longer under the radar - pediatric cough and cold medications. N Engl J Med 357 23 (2007) 2321-2324
2. Smith S.M., Schroeder K., and Fahey T. Over-the-counter medications for acute cough in children and adults in ambulatory settings. Cochrane Database Syst Rev 1 (2008) CD001831
3. Brignall K., Jayaraman B., and Birring S.S. Quality of life and psychosocial aspects of cough. Lung 186 Suppl 1 (2008) S55-S58
4. Prudon B., Birring S.S., Vara D.D., Hall A.P., Thompson J.P., and Pavord I.D. Cough and glottic-stop reflex sensitivity in health and disease. Chest 127 2 (2005) 550-557
5. Morice A.H., Fontana G.A., Belvisi M.G., Birring S.S., Chung K.F., Dicpinigaitis P.V., et al. ERS guidelines on the assessment of cough. Eur Respir J 29 6 (2007) 1256-1276
6. Morice A.H., McGarvey L., and Pavord I. Recommendations for the management of cough in adults. Thorax 61 Suppl 1 (2006) i1-24
7. Irwin R.S., Baumann M.H., Bolser D.C., Boulet L.P., Braman S.S., Brightling C.E., et al. Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines. Chest 129 1 Suppl (2006) 1S-23S
8. Morice A.H., and Geppetti P. Cough. 5: The type 1 vanilloid receptor: a sensory receptor for cough. Thorax 59 3 (2004) 257-258
9. Raj A.A., and Birring S.S. Clinical assessment of chronic cough severity. Pulm Pharmacol Ther 20 4 (2007) 334-337
10. Birring S.S., Brightling C.E., Symon F.A., Barlow S.G., Wardlaw A.J., and Pavord I.D. Idiopathic chronic cough: association with organ specific autoimmune disease and bronchoalveolar lymphocytosis. Thorax 58 12 (2003) 1066-1070
11. Birring S.S., Murphy A.C., Scullion J.E., Brightling C.E., Browning M., and Pavord I.D. Idiopathic chronic cough and organ specific autoimmune diseases: a case-control study. Respir Med 98 3 (2004) 242-246
12. Gilron I., Bailey J.M., Tu D., Holden R.R., Weaver D.F., and Houlden R.L. Morphine, gabapentin, or their combination for neuropathic pain. N Engl J Med 352 13 (2005) 1324-1334
13. Birring S.S., Prudon B., Carr A.J., Singh S.J., Morgan M.D., and Pavord I.D. Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire (LCQ). Thorax 58 4 (2003) 339-343
14. French C.T., Irwin R.S., Fletcher K.E., and Adams T.M. Evaluation of a cough-specific quality-of-life questionnaire. Chest 121 4 (2002) 1123-1131
15. Baiardini I., Braido F., Fassio O., Tarantini F., Pasquali M., Tarchino F., et al. A new tool to assess and monitor the burden of chronic cough on quality of life: Chronic Cough Impact Questionnaire. Allergy 60 4 (2005) 482-488
16. Raj A.A., Pavord I.D., and Birring S.S. What is the minimal important difference of the Leicester Cough Questionnaire?. In: Chung K.F., and Widdicombe J. (Eds). Pharmacology and therapeutics of cough (2009), Springer, Berlin 311-320
17. Morice A.H., Menon M.S., Mulrennan S.A., Everett C.F., Wright C., Jackson J., et al. Opiate therapy in chronic cough. Am J Respir Crit Care Med 175 4 (2007) 312-315
18. Dicpinigaitis P.V., and Alva R.V. Safety of capsaicin cough challenge testing. Chest 128 1 (2005) 196-202
19. Birring S.S., Passant C., Patel R.B., Prudon B., Murty G.E., and Pavord I.D. Chronic tonsillar enlargement and cough: preliminary evidence of a novel and treatable cause of chronic cough. Eur Respir J 23 2 (2004) 199-201
20. Birring S.S., Matos S., Patel R.B., Prudon B., Evans D.H., and Pavord I.D. Cough frequency, cough sensitivity and health status in patients with chronic cough. Respir Med 100 6 (2006) 1105-1109
21. Birring S.S., Fleming T., Matos S., Raj A.A., Evans D.H., and Pavord I.D. The Leicester cough monitor: preliminary validation of an automated cough detection system in chronic cough. Eur Respir J 31 5 (2008) 1013-1018
22. Matos S., Birring S.S., Pavord I.D., and Evans D.H. An automated system for 24-h monitoring of cough frequency: the Leicester cough monitor. IEEE Trans Biomed Eng 54 8 (2007) 1472-1479
23. Matos S., Birring S.S., Pavord I.D., and Evans D.H. Detection of cough signals in continuous audio recordings using hidden Markov models. IEEE Trans Biomed Eng 53 6 (2006) 1078-1083
24. Birring S.S., Mann V.M., Matos S., Yousaf N., Wood C., Fleming T., et al. The Leiceseter cough monitor. Eur Respir J 32 (2008) 530-531
25. Savani A, Wood C, Cox D, Fleming T, Matos S, Pavord ID, et al. The assessment of cough severity with a novel cough monitor. Thorax 2008;63:S42.
26. Barry S.J., Dane A.D., Morice A.H., and Walmsley A.D. The automatic recognition and counting of cough. Cough 2 (2006) 8
27. Coyle M.A., Keenan D.B., Henderson L.S., Watkins M.L., Haumann B.K., Mayleben D.W., et al. Evaluation of an ambulatory system for the quantification of cough frequency in patients with chronic obstructive pulmonary disease. Cough 1 (2005) 3
28. Smith J.A., Earis J.E., and Woodcock A.A. Establishing a gold standard for manual cough counting: video versus digital audio recordings. Cough 2 (2006) 6