Exercise and diet affect quantitative trait loci for body weight and composition traits in an advanced intercross population of mice

Physiological Genomics

Volumn 44, Issue 23, 2012, Pages 1141-1153

  Leamy, Larry J ^a   Kelly, Scott A ^b   Hua, Kunjie ^c   Pomp, Daniel ^c  

^a UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

^b OHIO WESLEYAN UNIVERSITY   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Percentage fat and lean tissue; Voluntary wheel running; Weight loss

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CHROMOSOME 13; CHROMOSOME 18; CHROMOSOME 3; CHROMOSOME 8; CONTROLLED STUDY; DIET; EXERCISE; FEMALE; GENE REPLICATION; GENETIC ASSOCIATION; GENOTYPE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS;

ADIPOSITY; ANIMALS; BODY COMPOSITION; BODY WEIGHT; CROSSES, GENETIC; DIET; DIET, HIGH-FAT; FEMALE; GENOTYPE; LOD SCORE; MALE; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; PHENOTYPE; PHYSICAL CONDITIONING, ANIMAL; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; TIME FACTORS;

MUS;

EID: 84870654247     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00115.2012     Document Type: Article

References (62)

1. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 30: 97-101, 2002.
2. Almind K, Kahn CR. Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice. Diabetes 52: 3274-3285, 2004.
3. Basterra-Gortari FJ, Bes-Rastrollo M, Pardo-Rernandez M, Forga L, Martinez JA, Martinez-Gonzalez MA. Changes in weight and physical activity over two years. Span Alum Med Sci Sports Exer 41: 516-522, 2009.
4. Beavis W. The power and deceit of QTL experiments: lessons from comparative QTL studies. Proc Corn Sorghum Indust Res Conf 49: 250-266, 1994.
5. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc B 57: 289-300, 1995.
6. Blair SN, LaMonte MJ, Nichman MZ. The evolution of physical activity recommendations: how much is enough? Am J Clin Nutr 79: 913S-920S, 2004.
7. Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S,Højlund K, Gygi SP, Spiegelman BM. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481: 463-468, 2012.
8. Chakravarthy M, Booth F. Eating, exercise, and "thrift" genotypes: connecting the dots toward an evolutionary understanding of modern chronic diseases. J Appl Physiol 96: 3-10, 2004.
9. Cheng R, Abney M, Palmer PP, Skol AD. QTLRel: an R package for genome-wide association studies in which relatedness is a concern. BMC Genetics 12: 66, 2011.
10. Cheng R, Lim JE, Samocha KE, Sokoloff G, Abney M, Skol AD, Palmer AA. Genome-wide association studies and the problem of relatedness among advanced intercross lines and other highly recombinant populations. Genetics 185: 1033-1044, 2010.
11. Cheverud J, Routman E, Duarte F, van Swinderen B, Cothran K, Perel C. Quantitative trait loci for murine growth. Genetics 142: 1305- 1319, 1996.
12. Cheverud J., Ehrich TH, Vaughn TT, Koreishi SF, Linsey RB, Pletscher LS. Pleiotropic effects on mandibular morphology II: Differential epistasis and genetic variation in morphological integration. J Exper Zool (Mol Dev Evol) 302B: 424-435, 2004.
13. Cheverud J., Lawson HA, Fawcett GL, Wang B, Pletscher LS, Fox AR, Maxwell TJ, Ehrich TH, Kenney-Hunt JP, Wolf JB, Semenkovich CF. Diet-dependent genetic and genomic imprinting effects on obesity in mice. Obesity (Silver Spring) 19: 160-170, 2011.
14. Churchill GA, Doerge RW. Empirical threshold values for quantitative trait mapping. Genetics 138: 963-971, 1994.
15. Collaborative Cross Consortium. The genome architecture of the collaborative cross mouse genetic reference population. Genetics 190: 389-401, 2012.
16. Corva PM, Medrano JF. Quantitative trait loci (QTLs) mapping for growth traits in the mouse: a review. Genet Select Evol 33: 105-132, 2001.
17. Darvasi A, Soller M. Advanced intercross lines, an experimental population for fine genetic mapping. Genetics 141: 1199-1207, 1995.
18. Ehrich TH, Hrbek T, Kenney-Hunt JP, Pletscher LS, Wang B, Semenkovich CF, Cheverud JM. Fine-mapping gene-by-diet interactions on chromosome 13 in a LG/J X SM/J murine model of obesity. Diabetes 54: 1863-1872, 2005.
19. Falconer DS, Mackay TFC. Introduction to Quantitative Genetics. Essex, UK: Longman, 1996.
20. Farooqi IS, O'Rahilly S. Leptin: a privotal regulator of human energy homeostasis. Am J Clin Nutr 89: 1S-5S, 2009.
21. Feldmann HM, Golozoubova V, Cannon B, Nedergaard J. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab 9: 203-209, 2009.
22. Garenc C, Perusse L, Bergeron J, Gagnon J, Chagnon YC, Borecki IB, Leon AS, Kinner JS, Wilmore JH, Rao DC, Bouchard C. Evidence of LPL gene-exercise interaction for body fat and LPL activity: the HERITAGE family study. J Appl Physiol 91: 1334-1340, 2001.
23. Garver WS. Gene-diet interactions in childhood obesity. Curr Genom 12: 180-189, 2011.
24. Gordon RR, Hunter KW, Sorensen P, Pomp D. Genotype X diet interactions in mice predisposed to mammary cancer. I. Body weight and fat. Mamm Genome 19: 163-178, 2008.
25. Grediagin A, Cody M, Rupp J, Bernardot D, Shern R. Exercise does not affect body composition in untrained, moderately overfat women. J Am Diet Assoc 95: 661-665, 1995.
26. Haley CS, Knott SA. A simple regression technique for mapping quantitative trait loci in line crosses using flanking markers. Heredity 69: 315-324, 1992.
27. Harper JM, Galecki AT, Burke DT, Pinkosky SI, Miller RA. Quantitative trait loci for insulin-like growth factor I, leptin, thyroxine, and corticosterone in genetically heterogeneous mice. Physiol Genomics 15: 44-51, 2003.
28. Hinney A, Hebebrand J. Three at one swoop! Obes Facts 2: 3-6, 2009.
29. Hinney A, Vogel CIG, Hebebrand J. From monogenic to polygenic obesity: recent advances. Eur Child Adolesc Psychiat 19: 297-310, 2010.
30. Jakicic JM, Marchs BH, Gallagher KI, Napolitano M, Lang W. Effect of exercise duration and intensity on weight loss in overweight, sedentary women. J Am Med Assoc 290: 1323-1330, 2003.
31. Kelly SA, Nehrenberg DL, Hua K, Garland T Jr, Pomp D. Exercise, weight loss, and changes in body composition in mice: phenotypic relationships and genetic architecture. Physiol Genomics 43: 199-212, 2011.
32. Kelly SA, Nehrenberg DL, Hua K, Gordon RR, Garland TG Jr, Pomp D. Parent-of-origin effects on voluntary exercise levels and body composition in mice. Physiol Genomics 40: 111-120, 2010.
33. Kelly SA, Nehrenberg DL, Peirce JL, Hua K, Steffy BM, Wiltshire T, Pardo-Manuel de Villena F, Garland T Jr, Pomp D. Genetic architecture of voluntary exercise in an advanced intercross line of mice. Physiol Genomics 42: 1909-200, 2010.
34. Lane PW, Bronson R, Spencer C. Rostral cerebellar malformation. Mouse Genome 86: 237, 1990.
35. Leamy L, Cheverud J. Quantitative genetics and the evolution of ontogeny. II. Genetic and environmental correlations among age-specific characters in randombred house mice. Growth 48: 339-353, 1984.
36. Leamy LJ, Pomp D, Lightfoot JT. Genetic variation for body weight change in mice in response to physical exercise. BMC Genet 10: 58, 2009.
37. Leamy LJ, Pomp D, Lightfoot JT. Genetic variation in the pleiotropic association between physical activity and body weight in mice. Genet Sel Evol 41: 41, 2009.
38. Lynch M, Walsh B. Genetics and Analysis of Quantitative Traits. Sunderland, MA: Sinauer Associates, 1998.
39. Ma S, Yu H, Zhao Z, Luo Z, Chen J, Ni Y, Jim R, Ma Wang P L, Zhu Z, Li L, Zhong J, Liu D, Nilius B, Zhu Z. Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity. J Mol Cell Biol 4: 88-96, 2012.
40. Manichaikul A, Dupuis J, Sen S, Broman KW. Poor performance of bootstrap confidence intervals for the location of a quantitative trait locus. Genetics 174: 481-489, 2006.
41. Meek TH, Eisenmann JC, Garland T. Western diet increases wheel running in mice selectively bred for high voluntary wheel running. Int J Obes 34: 960-969, 2010.
42. Nehrenberg DL, Hua K, Estrada-Smith D, Garland T Jr, Pomp D. Voluntary exercise and its effects on body composition depend on genetic selection history. Obesity (Silver Spring) 17: 1402-1409, 2009.
43. 10 LG,SM advanced intercross. Mamm Genome 20: 224-235, 2009.
44. Pavlicev M, Kenney-Hunt JP, Norgard EA, Roseman CC, Wolf JB, Cheverud J. Genetic variation in pleiotropy: differential epistasis as a source of variation in the allometric relationship between long bone lengths and body weight. Evolution 62: 199-213, 2008.
45. Pérusse L, Bouchard C. Gene-diet interactions in obesity. Am J Clin Nutr 72, Suppl: 1285S-1290S, 2000.
46. Pomp D, Nehrenberg D, Estrada-Smith D. Complex genetics of obesity in mouse models. Ann Rev Nutr 28: 331-345, 2008.
47. Raabe M, Flynn LM, Zlot CH, Wong JS, Veniant MM, Hamilton RL, Young SG. Knockout of the abetalipoproteinemia gene in mice: reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes. Proc Natl Acad Sci USA 95: 8686-8691, 1998.
48. Rankinen T, Bouchard C. Gene-physical activity interactions: overview of human studies. Obesity 16, Suppl: S47-S50, 2008.
49. Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G, Walts B, Pérusse L, Bouchard C. The human obesity gene map: the 2005 update. Obesity (Silver Spring) 14: 529-644, 2006.
50. Rocha JL, Eisen EJ, Van Vleck D, Pomp D. A large-sample QTL study in mice: I. Growth. Mamm Genome 15: 83-99, 2004.
51. Seidell JC. Dietary fat and obesity: an epidemiologic perspective. Am J Clin Nutr 67, Suppl: 546S-550S, 1998.
52. Smith CM, Lawrence AJ, Sutton SW, Gundlach AL. Behavioral phenotyping of mixed background (129S5:B6) relaxin-3 knockout ice. Ann NY Acad Sci 160: 236-241, 2009.
53. Sternfeld B, Wang H, Quesenberry P Jr, Abrams B, Everson-Rose SA, Greendale GA, Matthews KA, Torrens JI, Sowers M. Physical activity and changes in weight and waist circumference in midlife women: findings from the study of women's health across the nation. Am J Epidemiol 160: 912-922, 2004.
54. Sullivan PM, Mezdour H, Aratani Y, Knouff C, Najib J, Reddick RL, Quarfordt SH, Maeda N. Targed replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis. Am J Biol Chem 272: 17972-17980, 1997.
55. Surwit BS, Feinglos MN, Rodin J, Sutherland A, Petro AE, Opara EC, Kuhn CM, Rebuffé-Scrive M. Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice. Metabolism 44: 645-651, 1995.
56. Suto J, Sekikawa K. A quantitative trait locus that accounts for glucose intolerance maps to chromosome 8 in hereditary obese KK-A(y) mice. Int J Obes Rel Metab Dis 26: 1517-1519, 2002.
57. Sutton SW, Shelton J, Smith C, Williams J, Yun S, Motley T, Kuei C, Vonaventure P, Gundlach A, Liu C, Lovenbert T. Metabolic and neuroendocrine responses to RXFp3 modulation in the central nervous system. Ann NY Acad Sci 1160: 242-249, 2009.
58. Swallow JG, Carter PA, Garland T Jr. Artificial selection for increased wheel-running behavior in house mice. Behav Genet 28: 227-237, 1998.
59. Swinburn BA, Sacks G, Lo SK, Westerterp KR, Rush EC, Rosenbaum M, Luke A, Schoeller DA, Delany JP, Butte NF, Ravussin E. Estimating the change in energy flux that characterize the rise in obesity prevalence. Am J Clin Nutr 89: 1453-1456, 2009.
60. Teran-Garcia M, Rankinen T, Bouchard C. Genes, exercise, growth, and the sedentary, obese child. J Appl Physiol 105: 988-1001, 2008.
61. Vaughn TT, Pletscher LS, Peripato A, King-Ellison K, Adams E, Erikson C, Cheverud JM. Mapping quantitative trait loci for murine growth: a closer look at genetic architecture. Genet Res (Cambridge) 74: 313-322, 1999.
62. Yoshiokia M, Bolduc C, Raymond V, St-Amand J. High-fat mealinduced changes in the duodenum mucosa transcriptome. Obesity (Silver Spring) 16: 2302-2307, 2008.