Who Starts? Factors Associated with Starting Antiretroviral Therapy among Eligible Patients in Two, Public HIV Clinics in Lilongwe, Malawi

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Feldacker, Caryl ^a,b   Johnson, Derek ^c   Hosseinipour, Mina ^c,d   Phiri, Sam ^a   Tweya, Hannock ^a  

^a LIGHTHOUSE TRUST   (Malawi)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF NORTH CAROLINA PROJECT   (Malawi)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; COTRIMOXAZOLE;

ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; BODY MASS; DEMOGRAPHY; EMPLOYMENT; FEMALE; GENDER; HEALTH CARE ACCESS; HEALTH CENTER; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALAWI; MALE; MOTIVATION; OUTCOME ASSESSMENT; PUBLIC HEALTH SERVICE; TUBERCULOSIS; WORLD HEALTH ORGANIZATION;

ADULT; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; FEMALE; HEALTH FACILITIES; HIV INFECTIONS; HUMANS; LOGISTIC MODELS; MALAWI; MALE; MULTIVARIATE ANALYSIS;

EID: 84870604031     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050871     Document Type: Article

References (43)

1. Tayler-Smith K, Zachariah R, Massaquoi M, Manzi M, Pasulani O, et al. (2010) Unacceptable attrition among WHO stages 1 and 2 patients in a hospital-based setting in rural Malawi: can we retain such patients within the general health system? Transactions of the Royal Society of Tropical Medicine and Hygiene 104: 313-319.
2. Larson BA, Brennan A, McNamara L, Long L, Rosen S, et al. (2010) Early loss to follow up after enrolment in pre-ART care at a large public clinic in Johannesburg, South Africa. Tropical Medicine & International Health 15: 43-47.
3. Lessells RJ, Mutevedzi PC, Cooke GS, Newell ML, (2011) Retention in HIV care for individuals not yet eligible for antiretroviral therapy: rural KwaZulu-Natal, South Africa. Journal of acquired immune deficiency syndromes (1999) 56: e79.
4. Kranzer K, Zeinecker J, Ginsberg P, Orrell C, Kalawe NN, et al. (2010) Linkage to HIV care and antiretroviral therapy in Cape Town, South Africa. PLoS One 5: e13801.
5. Fox MP, Rosen S, (2010) Patient retention in antiretroviral therapy programs up to three years on treatment in sub-Saharan Africa, 2007-2009: systematic review. Tropical Medicine & International Health 15: 1-15.
6. Geng EH, Bangsberg DR, Musinguzi N, Emenyonu N, Bwana MB, et al. (2010) Understanding reasons for and outcomes of patients lost to follow-up in antiretroviral therapy programs in Africa through a sampling-based approach. JAIDS Journal of Acquired Immune Deficiency Syndromes 53: 405.
7. Brinkhof MWG, Dabis F, Myer L, Bangsberg DR, Boulle A, et al. (2008) Early loss of HIV-infected patients on potent antiretroviral therapy programmes in lower-income countries. Bulletin of the World Health Organization 86: 559-567.
8. Harries AD, Zachariah R, Lawn SD, Rosen S, (2010) Strategies to improve patient retention on antiretroviral therapy in sub-Saharan Africa. Tropical Medicine & International Health 15: 70-75.
9. Brinkhof MWG, Pujades-Rodriguez M, Egger M, (2009) Mortality of patients lost to follow-up in antiretroviral treatment programmes in resource-limited settings: systematic review and meta-analysis. PLoS One 4: e5790.
10. Rosen S, Fox MP, Gill CJ, (2007) Patient Retention in Antiretroviral Therapy Programs in Sub-Saharan Africa: A Systematic Review. PLoS Medicine 4: e298.
11. Zachariah R, Tayler-Smith K, Manzi M, Massaquoi M, Mwagomba B, et al. (2011) Retention and attrition during the preparation phase and after start of antiretroviral treatment in Thyolo, Malawi, and Kibera, Kenya: implications for programmes? Transactions of the Royal Society of Tropical Medicine and Hygiene. Aug 105(8): 421-30.
12. Scott V, Zweigenthal V, Jennings K, (2011) Between HIV diagnosis and initiation of antiretroviral therapy: assessing the effectiveness of care for people living with HIV in the public primary care service in Cape Town, South Africa. Tropical Medicine & International Health 16: 1384-1391.
13. Rosen S, Fox MP, (2011) Retention in HIV Care between Testing and Treatment in Sub-Saharan Africa: A Systematic Review. Plos Medicine 8: 16.
14. Kitahata MM, Gange SJ, Abraham AG, Merriman B, Saag MS, et al. (2009) Effect of early versus deferred antiretroviral therapy for HIV on survival. New England Journal of Medicine 360: 1815-1826.
15. Keiser O, Anastos K, Schechter M, Balestre E, Myer L, et al. (2008) Antiretroviral therapy in resource-limited settings 1996 to 2006: patient characteristics, treatment regimens and monitoring in sub-Saharan Africa, Asia and Latin America. Tropical Medicine and International Health 13 (7): 870-9.
16. Lawn SD, Harries AD, Anglaret X, Myer L, Wood R, (2008) Early mortality among adults accessing antiretroviral treatment programmes in sub-Saharan Africa. Aids 22: 1897-1908.
17. Government of Malawi Ministry of Health (2011) Quarterly HIV Progranmme Report,. Lilongwe, Malawi: HIV/AIDS Unit, Department of Clinical Services.
18. World Health Organization (2004) Perspectives and Practice in Antiretroviral Treatment: The Lighthouse, A centre for comprehensive HIV/AIDS treatment and care in Malawi. A case study. Case Study. Geneva: World Health Organization.
19. Phiri S, Khan PY, Grant AD, Gareta D, Tweya H, et al. (2011) Integrated tuberculosis and HIV care in a resource limited setting: experience from the Martin Preuss centre, Malawi. Tropical Medicine & International Health 16 1397-1403.
20. Douglas GP, Gadabu OJ, Joukes S, Mumba S, McKay MV, et al. (2010) Using touchscreen electronic medical record systems to support and monitor national scale-up of antiretroviral therapy in Malawi. PLoS Medicine 7: e1000319.
21. Ministry of Health and National AIDS Commission, editor (2011) Malawi Integrated Guidelines for Clinical Management of HIV, 2011, First Edition. 3rd ed. Lilongwe: Government of Malawi.
22. Ministry of Health Malawi (2008) Treatment of AIDS: Guidelines for the use of antiretroviral therapy in Malawi.
23. Weigel R, Hosseinipour MC, Feldacker C, Gareta D, Tweya H, et al. (2012) Ensuring HIV-infected pregnant women start antiretroviral treatment: an operational cohort study from Lilongwe, Malawi. Tropical Medicine & International Health: DOI: 10.1111/j.1365-3156.2012.02980.x.
24. Google Inc. (2011) Google Earth [Software]. Mountain View, CA., USA: Google Inc.
25. STATA (2010) 11.0. Stata Statistical Software: Release 12. College Station, TX: StataCorp LP.
26. McGrath N, Glynn JR, Saul J, Kranzer K, Jahn A, et al. (2010) What happens to ART-eligible patients who do not start ART? Dropout between screening and ART initiation: a cohort study in Karonga, Malawi. BMC Public Health 10: 601.
27. Lahuerta M, Lima J, Elul B, Okamura M, Alvim MF, et al. (2011) Patients Enrolled in HIV Care in Mozambique: Baseline Characteristics and Follow-Up Outcomes. Jaids-Journal of Acquired Immune Deficiency Syndromes 58: E75-E86.
28. Geng E, Nash D, Kambugu A, Zhang Y, Braitstein P, et al. (2010) Retention in care among HIV-infected patients in resource-limited settings: emerging insights and new directions. Current HIV/AIDS Reports 7: 234-244.
29. Yu JKL, Chen SCC, Wang KY, Chang CS, Makombe SD, et al. (2007) True outcomes for patients on antiretroviral therapy who are "lost to follow-up" in Malawi. Bulletin of the World Health Organization 85: 550-554.
30. Bassett IV, Wang B, Chetty S, Mazibuko M, Bearnot B, et al. (2009) Loss to care and death before antiretroviral therapy in Durban, South Africa. Journal of Acquired Immune Deficiency Syndromes (1999) 51: 135.
31. Katz IT, Essien T, Marinda ET, Gray GE, Bangsberg DR, et al. (2011) Antiretroviral therapy refusal among newly diagnosed HIV-infected adults. AIDS 25: 2177-2181.
32. Amuron B, Namara G, Birungi J, Nabiryo C, Levin J, et al. (2009) Mortality and loss-to-follow-up during the pre-treatment period in an antiretroviral therapy programme under normal health service conditions in Uganda. BMC Public Health 9: 290.
33. McGuire M, Munyenyembe T, Szumilin E, Heinzelmann A, Le Paih M, et al. (2010) Vital status of pre-ART and ART patients defaulting from care in rural Malawi. Tropical Medicine & International Health 15: 55-62.
34. Jarvis JN, Meintjes G, Wood R, Harrison TS, (2010) Testing but not treating: missed opportunities and lost lives in the South African ART programme. AIDS (London, England) 24 (8): 1233-1235.
35. Kohler PK, Chung MH, McGrath CJ, Benki-Nugent SF, Thiga JW, et al. (2011) Implementation of free cotrimoxazole prophylaxis improves clinic retention among antiretroviral therapy-ineligible clients in Kenya. AIDS 25: 1657.
36. Pepper DJ, Marais S, Wilkinson RJ, Bhaijee F, De Azevedo V, et al. (2011) Barriers to Initiation of Antiretrovirals during Antituberculosis Therapy in Africa. PLoS One 6 (5): e19484.
37. Phiri S, Khan PY, Grant AD, Gareta D, Tweya H, et al. (2011) Integrated tuberculosis and HIV care in a resource-limited setting: experience from the Martin Preuss centre, Malawi. Tropical Medicine & International Health 16: 1397-1403.
38. Zachariah R, Harries K, Moses M, Manzi M, Line A, et al. (2009) Very early mortality in patients starting antiretroviral treatment at primary health centres in rural Malawi. Tropical Medicine & International Health 14: 713-721.
39. Maskew M, MacPhail P, Menezez C, Rubel D, (2007) Lost to follow up- contributing factors and challenges in South African patients on antiretroviral therapy. South African Medical Journal 97 (9): 853-7.
40. Losina E, Bassett IV, Giddy J, Chetty S, Regan S, et al. (2010) The "ART" of Linkage: Pre-Treatment Loss to Care after HIV Diagnosis at Two PEPFAR Sites in Durban, South Africa. PLoS One 5 (3): e9538.
41. Jani IV, Sitoe NE, Alfai ER, Chongo PL, Quevedo JI, et al. (2011) Effect of point-of-care CD4 cell count tests on retention of patients and rates of antiretroviral therapy initiation in primary health clinics: an observational cohort study. The Lancet 378(9802): 1572-9.
42. Faal M, Naidoo N, Glencross DK, Venter WDF, Osih R, (2011) Providing Immediate CD4 Count Results at HIV Testing Improves ART Initiation. Jaids-Journal of Acquired Immune Deficiency Syndromes 58: E54-E59.
43. Tweya H, Gareta D, Chagwera F, Ben-Smith A, Mwenyemasi J, et al. (2010) Early active follow-up of patients on antiretroviral therapy (ART) who are lost to follow-up: the 'Back-to-Care' project in Lilongwe, Malawi. Tropical Medicine & International Health 15: 82-89.