Ensuring HIV-infected pregnant women start antiretroviral treatment: An operational cohort study from Lilongwe, Malawi

Tropical Medicine and International Health

Volumn 17, Issue 6, 2012, Pages 751-759

  Weigel, Ralf ^a,b   Hosseinipour, Mina C ^c   Feldacker, Caryl ^a,d   Gareta, Dickman ^a   Tweya, Hannock ^a,e   Chiwoko, Jane ^a   Gumulira, Joe ^a   Kalulu, Mike ^a,f   Mofolo, Innocent ^c   Kamanga, Esmie ^c   Mwale, Gertrude ^c   Kadzakumanja, Angela ^c   Jere, Edward ^c   Phiri, Sam ^a  

^a KAMUZU CENTRAL HOSPITAL   (Malawi)

^b LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^c UNIVERSITY OF NORTH CAROLINA PROJECT   (Malawi)

^d UNIVERSITY OF WASHINGTON   (United States)

^e INTERNATIONAL UNION AGAINST TUBERCULOSIS AND LUNG DISEASE   (France)

^f District Health Office   (Malawi)

Author keywords

Antiretroviral treatment; HIV; HIV prevention of mother to child transmission; Malawi; Pregnancy; Referral system strengthening; Sub Saharan Africa

Indexed keywords

BIOLOGICAL UPTAKE; DISEASE TRANSMISSION; DISEASE TREATMENT; ENVIRONMENTAL MONITORING; HEALTH RISK; HUMAN IMMUNODEFICIENCY VIRUS; INFECTIVITY; PREGNANCY; WOMENS HEALTH;

ADULT; AMBULATORY CARE; ARTICLE; CD4 LYMPHOCYTE COUNT; COHORT ANALYSIS; FEMALE; HEALTH CARE POLICY; HEALTH PROGRAM; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALAWI; MATERNAL CARE; PATIENT REFERRAL; PREGNANT WOMAN; PRENATAL CARE; SYSTEM ANALYSIS; TREATMENT DURATION;

ADOLESCENT; ADULT; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; COHORT STUDIES; CONTINUITY OF PATIENT CARE; FEMALE; FOLLOW-UP STUDIES; HEALTH SERVICES ACCESSIBILITY; HIV INFECTIONS; HUMANS; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MALAWI; POINT-OF-CARE SYSTEMS; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PRENATAL CARE; REFERRAL AND CONSULTATION; URBAN POPULATION; YOUNG ADULT;

LILONGWE; MALAWI; SUB-SAHARAN AFRICA;

EID: 84861716356     PISSN: 13602276     EISSN: 13653156     Source Type: Journal    
DOI: 10.1111/j.1365-3156.2012.02980.x     Document Type: Article

References (33)

1. Barigye H, Levin J, Maher D et al. (2010) Operational evaluation of a service for prevention of mother-to-child transmission of HIV in rural Uganda: barriers to uptake of single-dose nevirapine and the role of birth reporting. Tropical Medicine and International Health 15, 1163-1171.
2. Betancourt TS, Abrams EJ, McBain R & Fawzi MC (2010) Family-centred approaches to the prevention of mother to child transmission of HIV. Journal of the International AIDS Society 13(Suppl. 2), S2.
3. Black V, Brooke S & Chersich MF (2009) Effect of human immunodeficiency virus treatment on maternal mortality at a tertiary center in South Africa: a 5-year audit. Obstetrics & Gynecolology 114(2 Pt 1), 292-299.
4. Bwirire LD, Fitzgerald M, Zachariah R et al. (2008) Reasons for loss to follow-up among mothers registered in a prevention-of-mother-to-child transmission program in rural Malawi. Transactions of the Royal Society of Tropical Medicine and Hygiene 102, 1195-1200.
5. Chinkonde JR, Sundby J & Martinson F (2009) The prevention of mother-to-child HIV transmission programme in Lilongwe, Malawi: why do so many women drop out. Reproductive Health Matters. 17, 143-151.
6. Douglas GP, Gadabu OJ, Joukes S et al. (2010) Using touchscreen electronic medical record systems to support and monitor national scale-up of antiretroviral therapy in Malawi. PLos Medicine 7, e1000319. doi:10.1371/journal.pmed.1000319.
7. Fitzgerald FC, Bekker LG, Kaplan R, Myer L, Lawn SD & Wood R (2010) Mother-to-child transmission of HIV in a community-based antiretroviral clinic in South Africa. South African Medical Journal 100, 827-831.
8. Gilles KP, Bobrow EA, Zimba C et al. (2009) Counseling facilitates women's utilization of CD4 count testing in Lilongwe, Malawi, 5th IAS Conference on HIV Pathogenesis and Treatment, Abstract no. MOPEC024, Cape Town, South Africa.
9. Ginsburg AS, Hoblitzelle CW, Sripipatana TL & Wilfert CM (2007) Provision of care following prevention of mother-to-child HIV transmission services in resource-limited settings. AIDS 21, 2529-2532.
10. Hoffman RM, Black V, Technau K et al. (2010) Effects of highly active antiretroviral therapy duration and regimen on risk for mother-to-child transmission of HIV in Johannesburg, South Africa. Journal of Acquired Immune Deficiency Syndrome 54, 35-41.
11. Hosseinipour M, Weigel R, Mofolo I et al. (2007) Implementation of routine antenatal CD4 count testing: targeting women eligible for ART, 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention, Abstract no. WEPEB065, Sydney, Australia.
12. Kaplan R, Orrell C, Zwane E, Bekker LG & Wood R (2008) Loss to follow-up and mortality among pregnant women referred to a community clinic for antiretroviral treatment. AIDS 22, 1679-1681.
13. Killam WP, Tambatamba BC, Chintu N et al. (2010) Antiretroviral therapy in antenatal care to increase treatment initiation in HIV-infected pregnant women: a stepped-wedge evaluation. AIDS 24, 85-91.
14. Kurewa NE, Munjoma MM, Chirenje ZM, Rusakaniko S, Hussain A & Stray-Pedersen B (2007) Compliance and loss to follow up of HIV negative and positive mothers recruited from a PMTCT programme in Zimbabwe. Central African Medical Journal 53, 25-30.
15. Mandala J, Torpey K, Kasonde P et al. (2009) Prevention of mother-to-child transmission of HIV in Zambia: implementing efficacious ARV regimens in primary health centers. BMC Public Health 9, 314.
16. Manzi M, Zachariah R, Teck R et al. (2005) High acceptability of voluntary counselling and HIV-testing but unacceptable loss to follow up in a prevention of mother-to-child HIV transmission programme in rural Malawi: scaling-up requires a different way of acting. Tropical Medicine and International Health 10, 1242-1250.
17. Mbizvo MT & Zaidi S (2010) Addressing critical gaps in achieving universal access to sexual and reproductive health (SRH): the case for improving adolescent SRH, preventing unsafe abortion, and enhancing linkages between SRH and HIV interventions. International Journal of Gynaecology and Obstetrics 110(Suppl.), S3-S6.
18. van der Merwe K, Chersich MF, Technau K, Umurungi Y, Conradie F & Coovadia A (2006) Integration of antiretroviral treatment within antenatal care in Gauteng Province, South Africa. Journal of Acquired Immune Deficiency Syndrome 43, 577-581.
19. Ministry of Health (2006) Treatment of AIDS. Guidelines for the Use of Antitretroviral Therapy in Malawi, 2nd edn. Available at:.
20. Ministry of Health (2008) Prevention of Mother-to-Child Transmission of HIV and Paediatriic HIV Care Guidelines in Malawi, 2nd edn. Available at:.
21. Ministry of Health (2011a) Quarterly HIV Programme Report. HIV Testing and Counseling, Antiretroviral Therapy, Prevention of Mother to Child Transmission, Treatment of Sexually Transmitted Infections, July-September 2010. Available at:.
22. Ministry of Health (2011b) Malawi Integrated Guidelines for Clinical Management of HIV, 1st edn. Available at:.
23. Mirkuzie AH, Hinderaker SG & Morkve O (2010) Promising outcomes of a national programme for the prevention of mother-to-child HIV transmission in Addis Ababa: a retrospective study. BMC Health Services Research 10, 267.
24. Moses A, Zimba C, Kamanga E et al. (2008) Prevention of mother-to-child transmission: program changes and the effect on uptake of the HIVNET 012 regimen in Malawi. AIDS 22, 83-87.
25. National Statistical Office (NSO) [Malawi] & ORC Macro (2005) Malawi Demographic and Health Survey 2004. NSO and ORC Macro, Calverton, MD.
26. Reece M, Hollub A, Nangami M & Lane K (2010) Assessing male spousal engagement with prevention of mother-to-child transmission (pMTCT) programs in western Kenya. AIDS Care 22, 743-750.
27. Schouten EJ, Jahn A & Midiani D (2011) Prevention of mother-to-child transmission of HIV and the health-related millennium development goals: time for a public health approach. Lancet 378, 282-284.
28. Stinson K, Boulle A, Coetzee D, Abrams EJ & Myer L (2010) Initiation of highly active antiretroviral therapy among pregnant women in Cape Town, South Africa. Tropical Medicine and International Health 15, 825-832.
29. Tsague L, Tsiouris FO, Carter RJ et al. (2010) Comparing two service delivery models for the prevention of mother-to-child transmission (PMTCT) of HIV during transition from single-dose nevirapine to multi-drug antiretroviral regimens. BMC Public Health 10, 753.
30. WHO (2007) Guidance on Provider-Initiated HIV Testing and Counselling in Health Facilities. Available at:.
31. WHO (2010a) Antiretroviral Drugs for Treating Pregnant Women and Preventing HIV Infection in Infants: Towards Universal Access. Recommendations for a Public Health Approach (2010 version). Available at:.
32. WHO (2010b) PMTCT Strategic Vision 2010-2015. Preventing Mother-to-Child Transmission of HIV to Reach the UNGASS and Millennium Development Goals. Available at:.
33. Zolfo M, De WA, Schouten E & Lynen L (2010) Time for "test and treat" in prevention of mother-to-child transmission programs in low- and middle-income countries. Journal of Acquired Immune Deficiency Syndrome 55, 287-289.