Testing but not treating: Missed opportunities and lost lives in the South African antiretroviral therapy programme

AIDS

Volumn 24, Issue 8, 2010, Pages 1233-1235

  Jarvis, Joseph N ^a,b,c,d   Meintjes, Graeme ^a,b,d   Wood, Robin ^b   Harrison, Thomas S ^c  

^a GF Jooste Hospital   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^d Department of Medicine   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT;

CD4 LYMPHOCYTE COUNT; CRYPTOCOCCAL MENINGITIS; DRUG EFFICACY; DRUG INDICATION; DRUG SAFETY; FOLLOW UP; HEALTH CARE ACCESS; HEALTH CARE DELIVERY; HEALTH CARE POLICY; HEALTH PROGRAM; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LABORATORY TEST; LETTER; MORTALITY; PATIENT ATTITUDE; PRIORITY JOURNAL; SOUTH AFRICA; WORLD HEALTH ORGANIZATION;

AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; DIRECTLY OBSERVED THERAPY; FEMALE; HIV INFECTIONS; HUMANS; MALE; MENINGITIS, CRYPTOCOCCAL; SOUTH AFRICA;

EID: 77951832171     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e3283383aeb     Document Type: Letter

References (16)

1. World Health Organization. Rapid advice: antiretroviral therapy for HIV infection in adults and adolescents. WHO press 2009, November 2009. (www.who.int/entity/hiv/pub/arv/rapi-d-advice-art.pdf, accessed 8 December 2009).
2. NIH News Release. Starting antiretroviral therapy earlier yields better clinical outcomes, Interim analysis of CIPRA HT 001. 8 June 2009. (http://www3.niaid.nih.gov/news/newsreleases/2009/CIPRA-HT-01.htm, accessed 8 December 2009).
3. Granich RM, Gilks CF, Dye C, De Cock KM, Williams BG. Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet 2009; 373:48-57.
4. Lawn SD, Myer L, Harling G, Orrell C, Bekker LG, Wood R. Determinants of mortality and nondeath losses from an anti-retroviral treatment service in South Africa: implications for program evaluation. Clin Infect Dis 2006; 43:770-776. (Pubitemid 44330743)
5. BBC News. South Africa vows to treat all babies with HIV. 2009. (http://news.bbc.co.uk/2/hi/africa/8388178.stm, accessed 1 December 2009).
6. Mirza SA, Phelan M, Rimland D, Graviss E, Hamill R, Brandt ME, et al. The changing epidemiology of cryptococcosis: an update from population-based active surveillance in 2 large metropolitan areas, 1992-2000. Clin Infect Dis 2003; 36:789-794. (Pubitemid 36337986)
7. Jarvis JN, Boulle A, Loyse A, Bicanic T, Rebe K, Williams A, et al. High ongoing burden of cryptococcal disease in Africa despite antiretroviral roll out. AIDS 2009; 23:1181-1185.
8. Bicanic T, Meintjes G, Wood R, Hayes M, Rebe K, Bekker LG, Harrison T. Fungal burden, early fungicidal activity, and outcome in cryptococcal meningitis in antiretroviral-naive or antiretroviral-experienced patients treated with amphotericin B or fluconazole. Clin Infect Dis 2007; 45:76-80. (Pubitemid 46984619)
9. Fairall LR, Bachmann MO, Louwagie GM, van Vuuren C, Chikobvu P, Steyn D, et al. Effectiveness of antiretroviral treatment in a South African program: a cohort study. Arch Intern Med 2008; 168:86-93.
10. Ojikutu B, Jack C, Ramjee G. Provision of antiretroviral therapy in South Africa: unique challenges and remaining obstacles. J Infect Dis 2007; 196 (Suppl 3):S523-S527. (Pubitemid 351417249)
11. Guidelines: antiretroviral therapy in adults. Southern African Journal of HIV Medicine 2008, Summer 2008. pp. 18-31. (www.hst.org.za/uploads/files/ clinicalguide-adults.pdf).
12. Grimwood A, editor. National Antiretroviral Treatment Guidelines, 1st ed. National Department of Health, South Africa. Johannesburg: Jacana Press; 2004.
13. Amuron B, Namara G, Birungi J, Nabiryo C, Levin J, Grosskurth H, et al. Mortality and loss-to-follow-up during the pretreat-ment period in an antiretroviral therapy programme under normal health service conditions in Uganda. BMC Public Health 2009; 9:290.
14. Mills EJ, Nachega JB, Buchan I, Orbinski J, Attaran A, Singh S, et al. Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis. JAMA 2006; 296:679-690. (Pubitemid 44200639)
15. Amico KR, Harman JJ, Johnson BT. Efficacy of antiretroviral therapy adherence interventions: a research synthesis of trials 1996to 2004.J Acquir Immune Defic Syndr 2006; 41:285-297.
16. Boulle A, Bock P, Osler M, Cohen K, Channing L, Hilderbrand K, et al. Antiretroviral therapy and early mortality in South Africa. Bull World Health Organ 2008; 86:678-687.