Low testosterone concentrations in men contribute to the gender gap in cardiovascular morbidity and mortality

Gender Medicine

Volumn 9, Issue 6, 2012, Pages 557-568

  Haring, Robin ^a   John, Ulrich ^a   Völzke, Henry ^a   Nauck, Matthias ^a   Dörr, Marcus ^a   Felix, Stephan B ^a   Wallaschofski, Henri ^a  

^a UNIVERSITY MEDICINE GREIFSWALD   (Germany)

Author keywords

cardiovascular disease; epidemiology; gender gap; mortality; testosterone

Indexed keywords

TESTOSTERONE;

ADULT; AGED; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; COHORT ANALYSIS; CONTROLLED STUDY; DYSLIPIDEMIA; FEMALE; GERMANY; HUMAN; HYPERTENSION; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MORBIDITY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; POISSON DISTRIBUTION; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; SEX DIFFERENCE; TESTOSTERONE BLOOD LEVEL;

ADULT; AGED; CARDIOVASCULAR DISEASES; DIABETES MELLITUS, TYPE 2; DYSLIPIDEMIAS; FEMALE; FOLLOW-UP STUDIES; GERMANY; HUMANS; HYPERTENSION; INCIDENCE; KAPLAN-MEIER ESTIMATE; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MULTIVARIATE ANALYSIS; OVERWEIGHT; POISSON DISTRIBUTION; PREVALENCE; PROPORTIONAL HAZARDS MODELS; RISK FACTORS; TESTOSTERONE; YOUNG ADULT;

EID: 84870558923     PISSN: 15508579     EISSN: 18787398     Source Type: Journal    
DOI: 10.1016/j.genm.2012.10.007     Document Type: Article

References (54)

1. A. Nobile Male excess mortality between biology and culture Springer Genders in the Life Course 2007 New York Location 249281
2. G.L. Drevenstedt, E.M. Crimmins, S. Vasunilashorn, C.E. Finch The rise and fall of excess male infant mortality Proc Natl Acad Sci U S A 105 2008 5016 5021
3. F.C. Wu, A. von Eckardstein Androgens and coronary artery disease Endocrine Rev 24 2003 183 217
4. M. Hyvarinen, Q. Qiao, J. Tuomilehto The difference between acute coronary heart disease and ischaemic stroke risk with regard to gender and age in finnish and swedish populations Int J Stroke 5 2010 152 156
5. R.G. Rogers, B.G. Everett, J.M. Onge, P.M. Krueger Social, behavioral, and biological factors, and sex differences in mortality Demography 47 2010 555 578
6. S. Torkler, H. Wallaschofski, S.E. Baumeister Inverse association between total testosterone concentrations, incident hypertension and blood pressure Aging Male 14 2011 176 182
7. S.M. Haffner, L. Mykkanen, R.A. Valdez, M.S. Katz Relationship of sex hormones to lipids and lipoproteins in nondiabetic men J Clin Endocrinol Metab 77 1993 1610 1615
8. R. Haring, S.E. Baumeister, H. Völzke Prospective association of low total testosterone concentrations with an adverse lipid profile and increased incident dyslipidemia Eur J Cardiovasc Prev Rehabil 18 2011 86 96
9. R. Haring, H. Volzke, S.B. Felix Prediction of metabolic syndrome by low serum testosterone levels in men: Results from the study of health in pomerania Diabetes 58 2009 2027 2031
10. V. Kupelian, F.J. Hayes, C.L. Link Inverse association of testosterone and the metabolic syndrome in men is consistent across race and ethnic groups J Clin Endocrinol Metab 93 2008 3403 3410
11. V. Kupelian, S.T. Page, A.B. Araujo Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men J Clin Endocrinol Metab 91 2006 843 850
12. S.M. Haffner, R.A. Valdez, L. Mykkanen Decreased testosterone and dehydroepiandrosterone sulfate concentrations are associated with increased insulin and glucose concentrations in nondiabetic men Metab Clin Exp 43 1994 599 603
13. D.E. Laaksonen, L. Niskanen, K. Punnonen Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men Diabetes Care 27 2004 1036 1041
14. A.B. Araujo, J.M. Dixon, E.A. Suarez Endogenous testosterone and mortality in men: a systematic review and meta-analysis J Clin Endocrinol Metab 96 2011 3007 3019
15. R. Haring, M. Nauck, H. Volzke Low serum testosterone is associated with increased mortality in men with stage 3 or greater nephropathy Am J Nephrol 33 2010 209 217
16. R. Haring, H. Volzke, A. Steveling Low serum testosterone levels are associated with increased risk of mortality in a population-based cohort of men aged 20-79 Eur Heart J 31 2010 1494 1501
17. H. Völzke, D. Alte, C.O. Schmidt Cohort profile: the study of health in Pomerania Int J Epidemiol 40 2011 294 307
18. R. Haring, D. Alte, H. Volzke Extended recruitment efforts minimize attrition but not necessarily bias J Clin Epidemiol 62 2009 252 260
19. I. Kawachi, B.P. Kennedy The relationship of income inequality to mortality: does the choice of indicator matter? Social Sci Med 45 1997 1121 1127
20. D. Alte, J. Luedemann, H.J. Rose, U. John Laboratory markers carbohydrate-deficient transferrin, gamma-glutamyltransferase, and mean corpuscular volume are not useful as screening tools for high-risk drinking in the general population: results from the study of health in pomerania (SHIP) Alcohol Clin Exp Res 28 2004 931 940
21. G. Mancia, G. De Backer, A. Dominiczak 2007 Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC) J Hypertens 25 2007 1105 1187
22. A. Berrington de Gonzalez, P. Hartge, J.R. Cerhan Body-mass index and mortality among 1.46 million white adults N Engl J Med 363 2010 2211 2219
23. G. Winkler, A. Doring Validation of a short qualitative food frequency list used in several german large scale surveys Z Ernahrungswissenschaft 37 1998 234 241
24. D. Mozaffarian, A. Kamineni, M. Carnethon Lifestyle risk factors and new-onset diabetes mellitus in older adults: the Cardiovascular Health Study Arch Intern Med 169 2009 798 807
25. Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report Circulation 106 2002 3143 3421
26. R. Haring, H. Wallaschofski, M. Nauck Total and cardiovascular disease mortality predicted by metabolic syndrome is inferior relative to its components Exp Clin Endocrinol Diabetes 118 2010 685 691
27. D.M. Lloyd-Jones, E.P. Leip, M.G. Larson Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age Circulation 113 2006 791 798
28. R.B. D'Agostino Sr, R.S. Vasan, M.J. Pencina General cardiovascular risk profile for use in primary care: the Framingham Heart Study Circulation 117 2008 743 753
29. N. Friedrich, H. Volzke, D. Rosskopf Reference ranges for serum dehydroepiandrosterone sulfate and testosterone in adult men J Androl 29 2008 610 617
30. R. Haring, T. Ittermann, H. Volzke Prevalence, incidence and risk factors of testosterone deficiency in a population-based cohort of men: results from the study of health in pomerania Aging Male 13 2010 247 257
31. A.A. Afifi, J.B. Kotlerman, S.L. Ettner, M. Cowan Methods for improving regression analysis for skewed continuous or counted responses Ann Rev Public Health 28 2007 95 111
32. P. Jousilahti, E. Vartiainen, J. Tuomilehto, P. Puska Sex, age, cardiovascular risk factors, and coronary heart disease: a prospective follow-up study of 14 786 middle-aged men and women in finland Circulation 99 1999 1165 1172
33. S. Natarajan, Y. Liao, G. Cao Sex differences in risk for coronary heart disease mortality associated with diabetes and established coronary heart disease Arch Intern Med 163 2003 1735 1740
34. L. Pilote, K. Dasgupta, V. Guru A comprehensive view of sex-specific issues related to cardiovascular disease Can Med Assoc J 176 Suppl 2007 S1 S44
35. M.J. Pencina, R.B. D'Agostino Sr, M.G. Larson Predicting the 30-year risk of cardiovascular disease: the Framingham Heart Study Circulation 119 2009 3078 3084
36. M. Luy Causes of male excess mortality: insights from cloistered populations Population Dev Rev 29 2003 647 676
37. M. Beekman, C. Nederstigt, H.E. Suchiman Genome-wide association study (gwas)-identified disease risk alleles do not compromise human longevity Proc Natl Acad Sci U S A 107 2010 18046 18049
38. D.G. Meyers, J.S. Neuberger, J. He Cardiovascular effect of bans on smoking in public places: a systematic review and meta-analysis J Am Coll Cardiol 54 2009 1249 1255
39. D. Mozaffarian, R. Micha, S. Wallace Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials PLoS Med 7 2010 e1000252
40. S. Capewell, M. O'Flaherty Can dietary changes rapidly decrease cardiovascular mortality rates? Eur Heart J 32 2011 1187 1189
41. D.E. King, A.G. Mainous 3rd, M.E. Geesey Turning back the clock: adopting a healthy lifestyle in middle age Am J Med 120 2007 598 603
42. C.D. Lee, X. Sui, S.N. Blair Combined effects of cardiorespiratory fitness, not smoking, and normal waist girth on morbidity and mortality in men Arch Intern Med 169 2009 2096 2101
43. L.B. Yates, L. Djousse, T. Kurth Exceptional longevity in men: modifiable factors associated with survival and function to age 90 years Arch Intern Med 168 2008 284 290
44. L. Djousse, J.A. Driver, J.M. Gaziano Relation between modifiable lifestyle factors and lifetime risk of heart failure JAMA 302 2009 394 400
45. L. Wilhelmsen, K. Svardsudd, H. Eriksson Factors associated with reaching 90 years of age: a study of men born in 1913 in gothenburg, sweden J Intern Med 269 2011 441 451
46. B. Chock, T.C. Lin, C.S. Li, A. Swislocki Plasma testosterone is associated with Framingham risk score Aging Male 15 2012 134 139
47. M. Maggio, S. Basaria Welcoming low testosterone as a cardiovascular risk factor Int J Impot Res 21 2009 261 264
48. B.B. Yeap, O.P. Almeida, Z. Hyde Healthier lifestyle predicts higher circulating testosterone in older men: the health in men study Clin Endocrinol (Oxf) 70 2009 455 463
49. G. Sartorius, S. Spasevska, A. Idan Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self-reporting very good health: the Healthy Man Study Clin Endocrinol (Oxf) 77 2012 755 763
50. L.M. Robertson, F. Douglas, A. Ludbrook What works with men? A systematic review of health promoting interventions targeting men BMC Health Services Res 8 2008 141
51. N.T. Artinian, G.F. Fletcher, D. Mozaffarian Interventions to promote physical activity and dietary lifestyle changes for cardiovascular risk factor reduction in adults: a scientific statement from the american heart association Circulation 122 2010 406 441
52. M.M. Fernandez-Balsells, M.H. Murad, M. Lane Clinical review 1: adverse effects of testosterone therapy in adult men: A systematic review and meta-analysis J Clin Endinocrinol Metab 95 2010 2560 2575
53. F.C. Wu, A. Tajar, J.M. Beynon, S.R. Pye Identification of late-onset hypogonadism in middle-aged and elderly men N Engl J Med 363 2010 123 135
54. A. Vermeulen, G. Verdonck Representativeness of a single point plasma testosterone level for the long term hormonal milieu in men J Clin Endinocrinol Metab 74 1992 939 942